Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR | WIRED

CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED has challenged biologist Neville Sanjana to explain this concept to 5 different people; a 7 year-old, a 14 year-old, a college student, a grad student and a CRISPR expert.
Find out more about Neville's work at:
www.sanjanalab.org
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Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR | WIRED

[@Arrowo]

Level 1 : what you learn Level 5 : what you get on a test

[@deadmanperipherals]

lmao

[@alastairhewitt380]

Find a way to talk about Jurassic Park and you'll be fine.

[@julianacaro496]

@@alastairhewitt380 hahaha you're right

[@jackvanwykay9012]

Level 5: what i learn Level 1: the test fml

[@spcmartin420]

For some reason I keep getting the 666th like of things

[@captainwafflez3630]

Level 1: Explaining Level 2: Deeper Explaining Level 3: Conversation Level 4: Discussion Level 5: *Interview*

[@demodema5192]

Underrated comment there buddy😂😂😂😂😂nice one

[@princessalia6]

Exactly what I was thinking XD He didnt need to explain when the people already knew xD

[@gewuerzgurkeev]

As it should be

[@sohamkarandikar6726]

True af buddy 🤣🤣

[@caisis4929]

I was going to say they just tricked me into watching an interview with two experts on crispr.

[@gummyjellyfishy9430]

"i'm allergic to penicillin and azithromycin" - round of applause for the parents

[@shinesbrighter]

I’m surprised he knows how to say it properly as well! I’m allergic to clindamycin and I always question if I’m saying it correctly lollll

[@anvikomatreddy5666]

The kid said penicillin and amoxicillin

[@angryblobfish570]

666 likes

[@flowerdolphin5648]

@@anvikomatreddy5666 no, he did say azithromycin

[@smileyfacegummies]

I will always be grateful to my parents for teaching me what I'm allergic to and memorizing their phone numbers by the age of 7

[@andee6245]

Level 2: my knowledge before a test Level 5: what my classmates are discussing before a test

[@arsicle]

Underrated AF.😆

[@bhavikakshaj7991]

100% true mate!

[@vindhya8498]

Soo true!!!!😂

[@flowerdolphin5648]

That's how I passed one of my literature exams 😂 eavesdropping on other students' conversations

[@faith9196]

LMAO the accuracy

[@thisguy8943]

Notice how the video shifts from explaining crispr to debating crispr.

[@HahnenschreidesPositivismus]

It is not really explaining if the people he explains to already now about it. Maybe different people should have been picked like younger or from different fields.

[@ruoweilim7334]

ooh see that's what happens with increasing complexity.

[@FourTwentyMagic]

No, there is much more to CRISPR and all of its variants than what he explained up to the teen. After that it was a discussion in bioethics, which frankly is much broader than CRISPR and gene editing. There are many variants of CRISPR, Cas9 being only one of them, some are nickases others nucleases. They can be used in different scenarios for a desired outcome. There is also a whole lot of research on the precision of CRISPR - cutting only the desired target whilst minimising off-target cuts. This is no easy feat. Then you can look at this at an even deeper level. How does this system actually work, on a molecular dynamics level. What changes occur in the protein from binding the target to the actual process of cutting etc.

[@VatersTochter99]

This Guy Hahn I wrote this comment on accident with my wet hair.

[@AdictoALosCantaritos]

i think this is mainly because is more interesting to hear the opinion of an expert rather than the complex and tecnical explanation of how crispr works

[@rustydynamo1088]

Poor dude, as soon as he gets to lvl 4 and 5, he doesn't even get to talk anymore.

[@springysloth1186]

RustyDynamo Ya, I feel like he was a little embarrassed because they might’ve known more than him in some sections.

[@DanielDavies-StellularNebulla]

He still explained it to us even if it was through asking questions / making statements to the other person and not talking solely by himself.

[@michaeldgn9813]

The people at level 4 and 5 obviously know what CRISPR is so why would he try to explain it to them? At that level it was just the discussion around the ethics and potential of the technology.

[@DanielDavies-StellularNebulla]

@@michaeldgn9813 He wasn't explaining it to them. THEY were explaining it to US

[@michaeldgn9813]

Stellular Nebulla “Biologist Explains one Concept at 5 levels of difficulty” ...he was the one who was supposed to be, but at the higher levels its not going to be a direct explanation. Why bring in an expert if you are just going to tell them something they already know?

[@JET7C0]

2:44 I love how she just drops the P53 protein knowledge out there all the sudden. Definitely subverted the expectations of a lot of viewers there I bet.

[@viepng]

Definitely an ap bio student

[@andyzhang3683]

Just started uni and that was the first time I've ever heard of that gene...

[@francklin97]

Completely! It's so specific that even here in the comments it almost got no attention. That girl is going places :D

[@sophiisherman7463]

@@viepng if she was an AP bio student she’d probably already know what CRISPR is.

[@amakaokafor7624]

@@sophiisherman7463 I was an AP bio student and I didn't know what CRISPR was until freshman year of college. Then again, I don't know if I can call my AP bio teacher a teacher if he didn't teach...

[@trashfourlife]

7:17 *Level 5* Me: _hol up....... theres a little under 10 mins left there_

[@aaanawaleh]

You've got to give time to the experts so they can give you their lecture.

[@chrisbotos]

And I am glad there was😂

[@feiyuin4178]

lv 1: teaches CRISPR lv 2: quizzes CRISPR lv 3: surveys CRISPR lv 4: reviews CRISPR lv 5: advertises CRISPR

[@nayantara252]

Wow clever

[@neighbor-j-4737]

Um, this whole thing is an advertisement...

[@reinatr4848]

@@neighbor-j-4737 for what? "GET YOUR OWN PERSONAL GENE EDITING TOOL FOR ONLY $49.99 TODAY! DON'T MISS!" or something?

[@hadesdedov8560]

@@reinatr4848 yuh yuh no cap

[@jameson1239]

@@reinatr4848 you can actually do your own gene editing a gene costs roughly .05 cents a base pair which would still be very expensive

[@enderninja319]

Level 1: who Level 2: whom Level 3: whomst Level 4: whomst'd Level 5: whomst'd've

[@LowkeyGungnir]

Level 5: whomstest

[@TheDarkblader39]

Whomst've'd

[@Gamesforus1]

All I think when I see this is Vinny Vinesauce

[@sneal8526]

Level 6: whomst'd've'ly Level 7: whomst'd've'ly'yaint Level 8: whomst'd've'ly'yaint'nt Level 9: whomst'd've'ly'yaint'nt'ed Level 10: whomst'd've'ly'yaint'nt'ed'ies Level 11: whomst'd've'ly'yaint'nt'ed'ies's Level 12: whomst'd've'ly'yaint'nt'ed'ies's'y Level 13: whomst'd've'ly'yaint'nt'ed'ies's'y'es

[@MM-vs2et]

Level 69 : whomst'd've'ly'yaint'nt'ed'ies's'y'es

[@melvingroenewold7366]

Exactly how my biology degree is going, the more you learn the more it goes into ethics

[@DashonEugeneJerez]

In this specific conversation that’s good because science and ethics go hand and hand. If it didn’t it would only be a matter of time before man crosses the line.

[@wasordx3245]

​@@DashonEugeneJerezwhy does ethics even matter? It's just holding innovation back why does it even exist

[@Happy-dq1uo]

Level 1: he teaches Level 2: he teaches a little bit deeper Level 3: he has a basic conversation, but he knows a little more Level 4: they both know about the same and have a back and forth discussion Level 5: *he gets taught by the interviewee*

[@freshavocado8572]

Stolen comment

[@nelson8555]

Stolen

[@Happy-dq1uo]

Idgaf

[@atleastimnotgae2124]

Donl Duck shameless

[@jonathanodude6660]

he did not know about the same as level 4 wtf

[@mark7384]

Level 1: Explaining basics Level 2: Asking questions Level 3: Explaining technical level Level 4: Agreeing about everything Expert Level: CRISPR's actually kinda shitty tbh let's talk about Jurassic Park instead homie

[@outwardpeak1764]

Forreal though

[@osiria4877]

Lmao you just made my day

[@asutoshbiswal8906]

This is a great comment.

[@paulinatamez747]

spot on!

[@TianXiaoMao]

Good times were had by all.

[@30for30Freestyle]

kid: “I’m allergic to penicillin and azithromycin” me: *is wondering how i skipped all the way to the grad student*

[@fr-it6iw]

I'd be a bit concerned if you didn't know exactly what you were allergic to even at that age

[@hauntedshadowslegacy2826]

Depending on the severity or prominence of an allergy, kids as young as two may need to know the names of their allergens. Penicillin is pretty common, so of course he'd need to know. One of my allergies is a somewhat uncommon medicine component, and my reaction to it isn't life-threatening, so it took me a few years to nail down the name of it. If I were deathly allergic to, say, peanuts, I'd've had to learn about it before even starting kindergarten.

[@30for30Freestyle]

yall really taking this comment seriously 😳😳

[@vlsparrowlv3396]

I’m also allergic to penicillin

[@mariaa.echeverri2969]

Damien Gallegos Im so proud he knows how to pronounce them

[@cai3763]

Child: im allergic to penicillin Expert: i love jurassic park oH mY-

[@steelsaber5431]

Jurassic Park is lit

[@nder767]

"If you can't explain it simply, you don't understand it well enough" -Albert Einstein

[@ahmednedjmeeddineadnane8677]

I thought that this was feynman original

[@nabhchandra_]

this might be one of those few quotes that i dont like

[@oliverdiamond6594]

whoa...

[@oliverdiamond6594]

@@nabhchandra_ i love it

[@justsomeguy6545]

@@nabhchandra_ mind if I ask why

[@frann8552]

People: i just don’t think people should be able to use it for cosmetic purposes Scientists: bold of you to assume we know how to do that.

[@boh7816]

Hahahahha🤣🤣

[@harshnaveen5276]

Ikr

[@gotatoka8114]

L Zil that would make it worse the child would be love unconditionally because if you really love your child you wouldn’t changed his facial structure of gene medication for cosmetic

[@Nickiisqueenofrap]

I want to be 7 feet tall like peppa so hopefully crispr will do that to me

[@wonder052]

LMAOO TRUE

[@iwillbustyou]

"If you can't explain a subject simply, then you don't know it well enough" - Einstein

[@yasminaburger1957]

Mr. Rubicon that’s not true lmao

[@giorgoszervas4330]

"Almost all of my quotes aren't real" Einstein

[@DuongPhan-ku7xz]

@@giorgoszervas4330 Even they're not real, they are still true =))

[@MrChunior99]

Mr. Rubicon I’m pretty sure that’s a Feynman quote

[@zach9529]

“Hiroshima got deaded” Albert Einstein

[@Skyjy10]

How an oversea student feels about this video clip: Level 1: English Beginners Level 2: English course textbooks Level 3: What IELTS/TOEFL will test on Level 4: Daily conversation Level 5: University Lectures

[@TIRFemcel]

1. Easily Understandable 2. Easily Understandable 3. Easily Understandable 4. Understandable 5. Mostly Understandable

[@charlenef]

Level 3 is so true😂😂 ive taken toefl twice and this is golden

[@DianaDiana-kl2gm]

Tbh, level 5 was kinda easier to understand than level 4

[@alfredojoselito5108]

For me ia actually almost all understandble, because my mother tongue (portuguese) is a latin one and the english high vocabulary is mostly latin rip offs. So, it's actually really easy for a brazilian/portuguese person that speaks avarage english to understand the "expert" conversstion.

[@mischazimny4066]

@@charlenef Toefl is really easy IMO. No need to learn anything just basics.

[@dishaaithal1223]

Lvl 1: I understood Lvl 2: hmm interesting Lvl 3: I am lost Lvl 4: still lost wait what Lvl 5: I am in space

[@Omprakash-fd2pc]

Lvl 6 : gone back to big bang

[@davieskamanda6622]

I understood all of it

[@wooooo0oo]

@@DSam-de1fr bye

[@cameronmartin7613]

@@DSam-de1fr I love u wish you the best but I'm not reading all of this see your smart I'm smart but I'm the type of smart person who dont like doing stuff (lazy) stay smart an dont be like me

[@voxtur__7]

@@DSam-de1fr As a high school graduate with particular interests in biology, I daresay the expert level conversation was not as incomprehensible as these people in the comments section consider it to be. They used terminology that I could understand. Further, they were just communing about concepts and possibilities, as opposed to "discussing" the actualities in detail, which I think is reasonable as deliberating on known and proven facts is not as productive as doing likewise with outcomes, or in general, more subjective matters. Albeit I did understand majority of the conversation, I would love to do more research on it. Wikipedia! Here I come.

[@samsaw11]

Do you know what CRISPR is? Me: Yes I believe every potato chip could be CRISPR.

[@Vergil7799]

I like this joke.

[@zayonakbelfield]

im deaaaad

[@hipeople9856]

I'm deceased

[@rebeccaandersen9684]

Sam Saw i laughed way too much reading this

[@immissliss9843]

that’s me lol

[@cloroxbleach7554]

Level 1: Kid Level 2: Teen Level 3: College Level 4: Grad student Level 5: Expert Level 6: Random Chinese kid

[@inmessionante1722]

Clorox Bleach Best comment I’ve seen so far 😂

[@mirel4478]

😂😂😂😂😂😂✈️💥🏢🏢

[@Quoidx]

@@mirel4478 are YOU DESTROOOYING THE TWIN TOWERS

[@jayb6535]

😂😂😂

[@mirel4478]

maybe 👀

[@zipity2782]

I love how at first he’s teaching them, by end he’s getting taught like literally just listening.

[@viepng]

The teen is definitely in ap bio, sis knew what the p53 gene was lmao

[@alwaysprocrastinating355]

lmao and I was so shocked cause it said she was 14 meaning she was a freshman and I pretty sure most people don't even let freshmen take APs (mine didn't at least). I took AP bio sophomore year which to some is early but her being a freshman is super impressive

[@kojo6387]

@@alwaysprocrastinating355 I’m taking AP Bio as a freshman, since it’s virtual I barely understand much ;-;

[@chiffy755]

I'm taking normal biology, and I knew about CRISPR and how it works, at basically Level 3. I'm not actually sure it has to be AP Bio, although maybe I just have a good teacher - he gave us some really cool reading and it was very interesting, however it left me with a lot of questions, such as how guide RNA works. I'm just thinking she'd probably know about CRISPR if she was taking AP Bio

[@JoaoLeote7331]

We are taught that at school

[@sarimkamal5649]

Lol i thought it was written 'play station 3'

[@lexodius]

Level 1: What is CRISPR Level 2: What is CRISPR Level 3: ETHICS Level 4: ETHICS Level 5: Dino's!

[@kennedylawless6259]

Spot on!

[@Omprakash-fd2pc]

Level 100 : i can edit by my sight

[@jasonophee6153]

and here I am wanting to use it to gain superpowers

[@abhinavajith92]

Mitochondria are the powerhouses of the cell.

[@Niskiss]

I wrote this on my cell biology exam. I passed.

[@primodiscepolopingu373]

darkmanne

[@kaneminik]

*Are

[@wassolldasdenn]

Yea, that's exactly the thing that needs to be changed about our education system.

[@werderdley245]

OSMOSIS

[@denoseyhan98]

I’m doing a Master’s Degree in Genetics and CRISPR-Cas9 is my favorite subject. The level 5 conversation is music to my ears ❤️

[@peekabooo292]

i really find genetics interesting and would like to master in that. what did you study after your high school? do you need an mbbs degree?

[@denoseyhan98]

@@peekabooo292 Genetics is the best subject in the world so keep going on that path ;) You don't need a medicine degree at all to study genetics. I simply studied biology for my Bachelor's Degree, along with taking genetics, cell biology & molecular biology courses along the way. Good luck!

[@thedeviouspanda]

Genetics is so interesting but any amount of chemistry makes my brain shut all the way down 😔

[@peekabooo292]

@@denoseyhan98 thank you sp much!!!

[@nullify2750]

@@thedeviouspanda ikr 😢

[@lachlanroche1373]

Job interviewer: so what made you want to be a bio engineer? Neville: Um I watched some movies on dinosaurs and stuff Interviewer: O.O you’re hired

[@risktaker7996]

Good idea

[@aaimaayub7713]

Its true.. Jurrasic park and cloning were definately the reasons why I chose this field😂

[@resrevr]

I'm in the level between child and the exact moment before the teen mentioned P53

[@gauravgummaraju]

resrevr This comment needs to be on the top

[@nolan5386]

bruh

[@oreofatcat]

Gaurav Gummaraju this is a comment to help get OP on top.

[@2074red2074]

She almost certainly knows that from either a paper she wrote in science class or reading on her own. P53 is not generally mentioned even in college biology.

[@HKspec009]

Well first time I learned about P53 was my 2nd year in undergrad med.sci. I'd assume most people with physiology majors or even minors would know what P53 would be.

[@Ascii89]

To kid: have you heard of CRISPR? Do you know what the genome is? To expert: can we have Jurassic Park?

[@TOMMII0108]

Do you have any idea how fun hypothesizing extremes are with fellow scientists??

[@kyallokytty]

Anything you got a lot of knowledge about, imagining the extremes is fun

[@LifeinBonnieland]

😂🏆

[@ricobrinson6198]

So amazing that you pointed that out. 🤣😂😂🤣😂🤣😂🤣😂🤣😂🤣

[@helenamannkopf8695]

HAHAHAH LOVE THAT

[@shreyassuresh7924]

I’m a biochem major, the level 5 was really interesting. CRISPR has huge possibilities, but it going wrong in a patient could have huge repercussions. Tread lightly scientists

[@RuleroftheWorld]

I like how in most of these type of videos, when they get to a professional, it's someone they've met before and it's as if they're just catching up.

[@Draxis32]

"Well I'm allergic to Penicillin and Azithromycin" WOA WOA HOLD UP THERE! I THOUGHT YOU WERE THE KID NOT THE GRADUATE STUDENT

[@yeahkeen2905]

Draxis32 this deserves more likes. Honestly it surprised me that the kid could pronounce those words.

[@infinite5imal]

As a person with TONS of allergies I can tell you that it may be the parents' merit. Knowing your allergies at a young age can quite literally save your life

[@Helmy___]

I think the kids had a lot of experience with antibiotics. Maybe few series of internal bacterial infection. So I think he heard those a lot.

[@maureenlaneski4309]

Um, we call it AZT cause it' shard to say...

[@jacksonsingleton7572]

I’m allergic to those same things and more antibiotics. And TRUST ME, after having life threatening reactions to both of them at a young age, I definitely learned their names lol

[@katielaine28]

Child: Genomes Expert: Jurassic Park

[@vidivici9564]

Lol

[@heartsdeprived]

This is why peer review is SO IMPORTANT. It’s a checks and balances system for both the primary scientist and the society as a whole.

[@allisond.46]

When the guy said “mistakes... and people get sick”, he probably wasn’t talking about allergies, but he went with it anyway.

[@jonathanodude6660]

allergies are genetic but not really present in your genome

[@ianmathes5414]

Level 6: KZbin commenter

[@user-hi4sm3ig5j]

Ian Mathes I'm pretty sure that's level 0 for most of us.

[@SteamyMerlin]

lvl:-1

[@XxXNOSCOPEURASSXxX]

Level 1000000000: Roblox let's players

[@DanielRenardAnimation]

*(Level 6: KZbin commenter)* Hai crispur i wunna hitler t-rex with laz0r bim eyes 4 next xmas, kthx bai

[@JoaoVictorPacifico]

that would be level 0

[@jessicajnsm]

After the teen, these just became normal dual sided conversations rather than explanations 😂

[@taniani884]

jessicajnsm mostly because he doesn’t need to explain them, which I think is part of the point

[@hj2479]

why was the teen so uninformed. All students should be taught basic cell and molecular biology which covers the genome, DNA, Plasmids, etc. As a high school student, I had to learn all of these and more and used them in a professional lab setting aId i could keep up with the college students.

[@PaulTheSkeptic]

Yeah, true but it would be an insult to explain how it works to a colleague. I could imagine explaining how to operate an 18 wheeler to a road veteren of 20 30 years.

[@yaboi6851]

@@hj2479 didnt it say the teen was 14 years old? most likely she just hadnt had a class on it yet

[@greatdanelegend7001]

Then the grad student started explaining the stuff to HIM

[@MaddyBlu9724]

Woah, I have a biology degree and I have to say, the college student they picked had a waaay better understanding of CRISPR than your average randomly picked bio student would. I have to assume that either he learned it really recently or he specialized into more molec bio/genetics study. Or he is just way smarter than me and the people I've been around!

[@theemilyguy52]

First watched this video as a science-curious high schooler, now rewatching it as a junior molecular biology major who is actually doing CRISPR in the lab ❤

[@niko-pp]

can you explain memes in 5 levels of difficulty

[@somespaghetti9301]

Niko i would be the expert

[@shannonbear8807]

Make this top comment 😂

[@nightangel3578]

No, you dumb shit.

[@ladynoluck]

Niko Memes are actually a real psychology/sociology concept, so they actually could talk about it (internet memes still fall under this concept of memes, btw).

[@epoch7136]

I am god-like in the deparment of Memeology

[@kingdrew5083]

I was able to comprehend every level with full understanding and i am only 5 months old. The secret to becoming an intellectual is watching Rick and Morty

[@bookedroomer]

I watched rick and morty twice so I don’t have 200 iq I have 400 iq

[@ok-sj7bx]

@@bookedroomer Because that is how iq works. (Even tho iq max is 200, if i remember right)

[@ayaazbukhari8654]

ok ummm it was a joke

[@kingdrew5083]

Mithun Nathan Good stuff fellow intellectual brother. Keep it up and continue to fill your brain with knowledge and you will have the mind of a deity.

[@elliottscully]

ok 200 is not the maximum, just very uncommon for people to have an IQ above that. There have only been a handful of confirmed cases.

[@maryaurelio1835]

I attended high school in Italy and i learned about Crisper during biology class like it was at the same level of knowing the mitochondria is the power house of the cell. I think its really nice how they teach biotechnology in high school here!

[@hydropage2855]

I love how, when it got to talking to the expert, he started asking questions

[@DhiaAbdelli]

I like how he changes his sitting position depending on the level. Also, the amount of information he's providing decreases by levels and it becomes more of a conversation than some kind of course. Great video!

[@flavioluiscc]

I believe that was unintentional. People just had more to say.

[@PongoXBongo]

Agreed. When you're less informed you're more hesitant to speak as you may "say something stupid". Whereas when you're more informed you're more confident in speaking up.

[@vancekangyishu]

He turned from the explainer to the explained

[@piteoswaldo]

This is inevitable, I think. When casually talking to persons with increasing level of understanding of the subject, it is expected that the conversation goes from explanations, questions, and answers, to ideas and perspectives.

[@danengo2]

yi shu From questioner to questioned.

[@akaashisbtch4138]

Professionals: You know what this is? Me as college student: Absolutely not

[@Manly-Tears]

Me IRL : dude you're supposed to explain this to ME.

[@kimmyurii]

Manly Tears honestly, only bio majors would really know what it is.

[@anieee96]

I study medicine, and we’ve touched on this in medical genetics. If you’re not doing a biology or chemistry course with focus on genetics definitely do not feel bad. It’s a niche concept for most non-biology/medical geneticists/medical doctors:

[@terripricher6378]

peanut's daisy basically there’s this guide RNA and it matches up with a specific part in the DNA. The guide RNA is connected to a protein that’s like biological scissors called Cas9 and when the guide RNA makes that match, Cas9 can do it’s thing and cut the DNA, allowing for biologists to take out specific parts of the DNA or put in new DNA so as to fix mutations or cause new mutations and see whether they have a positive or negative effect on that cell’s DNA.

[@SLEEVEASMR]

FR 😭

[@penguin0101]

Level 5: When Sam Smith altered his DNA and decided to be a scientist

[@mdadil1456]

Lol

[@gluedglued1252]

tranpshobia is not cute

[@flowerbed7757]

Transcareeria

[@user-gt1kd9rv1w]

Lmaoooooo

[@DoctorJack16]

CRIPR and what Alphafold 2 just did with protein folding is going to change so much of the biomedical sciences and so much more. It made my list of most amazing scientific and technological breakthroughs that happened in 2020 in my KZbin video. This was really cool to watch the levels of understanding. So important to be able to explain things like this. Keep spreading the knowledge!

[@iLuvTofu20]

Low key I'm pretty impressed this teenager knew about p53 hahaha

[@AndriyLinnyk]

it is something they probably went over in highschool

[@esnipopulate9607]

Gus She just has biology class. That's where she learned it.

[@hat12071997]

Gus maybe she had someone in her family with cancer caused by a p53 mutation or has an interest in genetics.

[@ellasnow3575]

We learn that in the molecular genetics portion of Biology (9th grade)

[@charltonlepkofker2711]

+ESN iPopulate nah I bet she just looked up some information online surrounding the topic she was told she'd be discussing. She appeared uncomfortable with the teens she was using.

[@youtubian2500]

These 5 levels of difficulty videos are awesome.

[@KimiHayashi]

Erratic & Static 1st to comment a 1.2k liked comment. I feel wow

[@SnoFitzroy]

Zed The Master of Shadows you deserve more likes than the original comment tbh

[@majncriftgamapleys9928]

stfu @zed pleb

[@AliciaZapata]

I love them, I hope they keep making more and about different topics

[@starchaser28]

Agreed, such a great learning tool.

[@jacksonh3457]

Love how the grad student only talked about the ethics of it but barely any of the actual science

[@ivanjoelarias628]

As a Biology Major Undergrad, This is amazing!♥️ I kind of get some techniques how to explain concepts in Biology in the most simplest to more technical way♥️

[@sabrinathewitch6396]

His body language says a lot about him he's very ambitious willing to share and learn more but also he's really competitive

[@Ice.muffin]

It was more like really attentive to the matters discussed and willing to absorb but also self-confident in his own knowledge and status to me..

[@michelleobamafootcream9292]

yo is u the fbi

[@Nizana3]

@N. Am Lol! Always.

[@saisab1412]

I wanna like this but its at 420

[@ellayatchi3721]

@@saisab1412 its not anymore:(

[@OmarDelawar]

So we are just going to ignore all the paintings in the background that are on tripods? Really people? lol

[@audreychapin9561]

Omar Delawar yeah there’s no way for them to be mounted on the wall

[@audreychapin9561]

Omar Delawar i think it looks kinda cool ;)

[@bananabonanza3562]

😂

[@purple.cube.]

There weren't there until you said it

[@AuntyAwesome]

@Taylor Ross actually if you look at the bottom of the video you will see a light brown flooring, and then white where the wall begins, so they could go on the wall.

[@PKAmedia]

Me someone who actively trying to keep on topic of medical knowledge. A modern teen: p53 Me: furiously googling

[@jonathanodude6660]

its the gene for the protein that checks dna for errors i think. if youve got an error in the error checking gene, things are way more likely to go wrong.

[@Labbaik1212]

@@jonathanodude6660 "Error in the error checking gene" I dont know why but i laughed at this line

[@boredweegie553]

He's so good at explaining this to kids.❤️

[@momekh]

Why does a 14 year old know about p53 mutation... ? How can we have more 14 year olds like that?

[@cswess7256]

Momekh biology class? most kids take it in 9th grade, whether or not they remember it is a different question of course, and i guess she did. kids arent as dumb as you may think

[@Kerigen]

Yeaahhhh I'm a freshman and knew about that😂😅

[@florianwicher]

We can make more of those using CRISPR ;D

[@jamarihamilton1126]

AP Bio

[@gautam8072]

everyone knows that i think

[@sarahctic1865]

I live how the expert gets half the video

[@theultimatereductionist7592]

I, too. Except, they end up talking at the dumbed down 0 level anyway.

[@michaelvenezia9673]

You have just clued yourself into what this video is....... it's not a normal conversation where LET'S JUST RECORD TWO PEOPLE CONVERSING ..... it's a commercial for something we need to get used to.....

[@AC_Blanco]

Those god damn changes! Everything is moving so fast, let's go backwards.

[@zakman246]

Maybe you should watch "Kids react to" as it may be more your cup of tea.

[@trenzinhodaalegria8012]

The expert already knew about it and instead of just listening to an unnecessary explanation he started to talk about it and basically trade ideas, predictions and etc with the biologist.

[@Peahes2001]

I love the progression of information in this video!! Well laid out

[@anishelali8217]

This makes me feel so proud that i could understand what they were saying at level 5. i'm first year master's degree in biotechnology and molecular pathology, and although i'm not quite a genetics expert but i guess it was enough to stay in line with them

[@asdfghyter]

Level 1: Biologist explains CRISPR to 7 year-old Level 2: Biologist explains CRISPR to 14 year-old Level 3: Collage student explains CRISPR to Biologist (who clarifies it a bit) Level 4: Biologist discusses ethical issues about CRISPR with grad student. Level 5: Biologist discusses CRISPR with expert (and explains some of the concepts they are talking about to the audience).

[@malisarai6516]

asdfghyter collage 😂

[@diol9313]

I feel like this is the spreadsheet of learning no matter what subject it is lol

[@Chiosucks]

collage

[@thecanucklehead3034]

asdfghyter honestly I like this way of explaining things. You get the layman's terms as well as in depth discussions including potentials and controversies. Not just the same thing with longer words every time

[@Edsel_A]

College*

[@batmate8288]

the more he goes up , the less he talks.

[@gauravgummaraju]

Batman 4ever Makes sense, doesn't it?

[@UprightEnjoyment]

i think he would have a lot to say if you were the one who talked to him

[@BiscuitDelivery]

I mean, it would be redundant to repeat what someone already knows back to them in such a manner. A grad student specializing in stem cell research and bio med will probably already know the majority of the subject matter in a closely related field such as CRISPR. Since the previous three iterations were mostly there to ease the viewer into the topic, it would serve no purpose to reinforce the very basics yet again.

[@yussifjaber7915]

He actually takes the same methodology for all levels: He first asks what they know, then expands on what they know, then he opens the floor for questions and possibilities.

[@foxwolf4608]

Obviously..

[@jiniahaldar9339]

I love what they said at the end about funding more basic research - there's too much attention right now on "one-hit wonder" papers that show positive results of something ground-breaking (many of which aren't even reproducible, anyway), and that's pushing out 1) research that shows no correlation/null hypothesis and 2) research that might not seem to go anywhere now, but (with further probing) could lead to something revolutionary down the line. Anyway, lovely video! I really enjoyed the different perspectives and points brought up with each person and how Dr. Sanjana made sure to still explain some of the terms used in the Level 5 conversation for the viewers - much appreciated!

[@saurabhnaik430]

This is a great a way of understanding at many different difficulty levels. Was looking for these kind of videos and just found the right ones. One suggestion though, it would be great if entire narrative is woven and in question answers and part of a story. Currently the level jumps isn't smooth.

[@bungusgrumble7524]

Level 6: Rick and Morty viewer

[@kacesux7712]

Bungus Grumble 😂

[@nguyenchihieu7332]

Hmmm that gonna be hard :v

[@kingviper5700]

200 IQ too smert

[@CartoonKidOLLY]

Lol

[@armitage5855]

This is the only type of bullying I enjoy.

[@seamuscallaghan8851]

By the time he got to level 4, they were explaining the concept to him.

[@leorYJackanory]

The tables have turned

[@sizzlinsj8135]

Yeah also he started asking doubts to them... lol

[@JoaoVictorPacifico]

They're in University level and what we do in classes in university level is more like that.

[@aon02b]

Level 3 actually :l

[@Cannongabang]

Well not really, more of a conversation; anyway, 666 likes, good

[@xavierbenedictsambilay3849]

Level 1: Very Short Level 2: Short Level 3: Long Level 4: Very Long Level 5: 9 min. 7 sec.

[@roarindragonfruit]

I am the kid. The actual conversation lasted 2 hours lok

[@Austin-mo1vy]

What’s pretty cool is that my high school dual credit professor (high school aged, college class) actually worked on the human genome project. She had lots of knowledge about genomes and how it can affect so many things in nature.

[@conradkai9705]

Yeah, that's right. Only expert level discussions involve Jurassic Park

[@lisilein2]

I think you'd be surprised how many movie's are referenced during a conversation between experts (of any field).

[@jinnie6292]

Amit Sethi I wAnT ScEcHwAn SaUcE!! XDXD

[@littlemisstoes]

OMG Rick and morty fanboys are insufferable. You don't need a high IQ to understand that show, get over yourself.

[@olliveraira6122]

I got the idea of editing DNA (in humans as example) for Jurassic Park, today its really my biggest dream in my life, to change DNA, modify, make improvements/changes in different animal lifeforms EDIT: Im not a expert on anything within the medical world, Im just a dreamer (Referring to Tomorrowland, the movie)

[@shottotheface75]

littlemisstoes it's a joke

[@hanifwardhana8633]

this guy is great. he really know how to start a conversation.

[@sebastiansebastian5270]

Hanif Wardhana Agreed

[@kevinkelly8896]

Shoulda seen how fast he got me in bed.

[@hxcAMBERhxc]

And he has great socks.

[@MoeMentos]

Hanif Wardhana Not really. His tone is really condescending. Talks to everyone like they're a child.

[@fatsacktony1]

CRISPR leads to hundreds of unwanted untargeted mutations. It is hardly safe.

[@toribarron8937]

I really love the idea of CRISPR and I am actually really excited to see the development of this and the application. Biology is so fascinating. I think CRISPR can go above and beyond what science has already done. It can help unlock things that were otherwise unknown to us, like what the one person was saying about the gene that controls eye color and height, it will help find those things that make us, who we are. It will not only help Cancer patients, but also find what causes Hyper and Hypothyroidism, what causes some people to have chemical imbalances, and maybe cure thing like depression and other disorders that are only controlled by medicine. That is another thing, what will application imply? My focus is mostly on the endless possibilities, I have several people in my life that have autoimmune disorders, and I can't help but think how CRISPR can help them, and maybe future generations. Yes, there will be side effects and the Ethics will have to be ironed out, but all in due time. When I say I am excited to learn more about this, I over the moon right now!!!

[@macacothe9428]

Level 1: Ohh. Cool. Level 2: Ohh.. Even cooler. Level 3: Ohhhh. Interesting. Level 4: ... shut up, girl. Level 5: Scrolling down comments section time.

[@Coffeeisnecessarynowpepper]

Macaco, The omg sooooo meeeeee

[@evelynchristina3214]

Legit what I did

[@Tingveluv]

i'm already scrolling and it's only level 4

[@anastasia.beaverhausen]

Omg who taught that child about p53? Bless her science teachers ...

[@JollyWanker]

We learned about p53 in high school biology, 6th grade during carcinogenesis lessons. Is it really that special in the USA to know about this? Lmao

[@MeganMarieT]

I took honors biology last year (my freshman year of highschool) and we learned a little bit about cancer but we didn’t learn anything about p53. We did a lot of DNA and genetics though

[@kathleenl1882]

@@JollyWanker yeah, it's that special. In 5th-6th grade, the "p" i knew wah photosynthesis. Then in junior high, the "p"I knew are photochemical reaction and pen*s. In my highschool, finally I knew "p" with some numbers, p680 & p700 photosystem. Yea, my whole point is, that's just how advanced you are, compared to most south east asians...

[@nuclearclarity3778]

p53 is taught in freshman biology in the US it’s really not that abnormal

[@jessicabraud3307]

Yeah I learned that last year in Freshman biology. It definitely depends on if they remember it or not lol. The school system sets it up to where you remember everything for the test and then forget it right after

[@nixel1324]

That blue cushion looks edited in.

[@Okay-vz3qw]

They added it in with CRISPR

[@meghanaroy16]

FEED ME omfg! This reply is underrated 😂

[@nixel1324]

@@meghanaroy16 Can you really call it underrated when it was only 5 hours old?

[@meghanaroy16]

Nixel well yeah..because sometimes you can get more likes even in 5 hrs and no seeing it has been 2 days and only 9 likes it is def underrated

[@susy14valentine]

The yellow one too😂😂😂

[@yasminasar6534]

Ilove that college student....he talked and he listened too! He shared his knowledge withoutshowing it off:))

[@dustypumpkin]

OMG Teigen is so cute! I love how cute his voice is. And he looks so adorable 😭😭💛

[@flying_phanny5704]

The explanations just kept getting crisper and crisper...

[@hiffahyphae6707]

Omfg I hate you

[@sabrina3138]

Lol

[@muzammilhalim3188]

LVL 6: KZbin COMMENTERS "Do you know what CRISPR is?" "THEY'RE TURNING THE FROGS GAY!"

[@user-wk7ff7vu5s]

I know he’s explaining about going in genomes and editing or increasing some parts of your DNA to help get rid of some health issues but embryonic stem cells and gene cloning popped into my mind too as he was talking about this new technology

[@I_THE_ME]

That college student knew a lot more than people would have expected him to know. Actually every single person who were asked about CRISPR in the video had much more knowledge about biology/the subject than one should expect.

[@BellaDiDomenico]

Thank you for having me on this! I loved working with all of you!!

[@samithjay5569]

WOAH WHAT IS THAT YOU

[@yashagarwal3946]

Nice job

[@gauravgummaraju]

Bella DiDomenico The interviewer guy was really impressed you knew about p53. Great job

[@BellaDiDomenico]

I was the teen they interviewed!!

[@butters5373]

Damn check you out

[@calummcgee4122]

I'd love to see a linguistic version of this 😊 these videos are great, I love them

[@ipodhel4u]

Calum McGee -a--

[@Rolando_Cueva]

I second this

[@lukeburke8787]

Me as well

[@superP00Pscooper]

YES

[@jiehanaldicho3710]

Indeed! Most people have misconception about linguistics

[@1995marixsa]

Lv1: Teacher Lv2: Lecturer Lv:3 Chair professor Lv:4 intelectual debate Lv:5 Mutual understanding and sharing of ideas and opinions and information

[@gooblette]

I leaned about CRISPR in agriculture class around 4 months ago I’m so surprised not many people are talking about it

[@ganjiraja9407]

Quantum computing or Quantum physics explained in 5 levels of difficulty.....That would really be interesting trust me.

[@lammy3055]

But you can't explain at levels 0-4, and at level 5 you just admit that you don't get it

[@zetharic1610]

Lamanite Flarpleston yeah..... that thing is complex.... even the logic behind gravitional waves is beyond me even though it seems perfectly logical :(

[@angeah.6555]

u sound stupid

[@themegacurly2]

Yesssss. Please. This is a promising idea

[@gardenofeden9217]

Ganji Raja its easier to do rocket science than quantum mechanics or any concept of quantum physics.

[@LelouchVelvet]

Funny when you're the age of Level 5 but knowledge of Level 1.

[@aliceliddell8413]

And vice-versa #HumbleBrag

[@charlotted4642]

Alice Liddell you’re 7?

[@aliceliddell8413]

Not that literal, and also, that was only a joke ;-; I'm not that smart T-T

[@clashcrafter]

Yeah he's a 7 year old CRISPR Expert, who researches it in the lab. duh

[@eternaldesolution6205]

It's not about age, it is about education level and knowledge.

[@petrichor9417]

It's interesting how up to the grad student, he's talking about how great CRISPR is as an editing. With the expert he is talking more about kinks that have to be worked out and what the opportunities are...

[@eonni160]

@6:26 such an abrupt cut off

[@highonglucose1168]

You see how the biologists body language changed when the expert started talking 😂

[@RoyalRahim]

HighOnGlucose commenting so u know how many likes you have

[@medjov1061]

Because instead of explaining its more of discussing thoughts and ideas to each other and explaining it to us viewers

[@highonglucose1168]

@@RoyalRahim nope didn't realize

[@alextrevino1067]

HighOnGlucose indeed I saw that and at 6:24 he interrupted her because she was knowing to much and she went over the subject of what the biologist was talking about

[@yowisarias1433]

@@alextrevino1067 epigenetics or gene expression is relevant tho?

[@Lord_and_Savior_Gay_Jesus]

5 levels of crispy: There is a baked food, like bread, with a crispy exterior caused by convection. Fried foods which gain crispiness from boiling fats. There is crispy from a food left out that oxidizes from the air around it..There....oh, he said crispr. I don't know what that is, so let the expert tell us

[@creepypasta5818]

Crisper is the drawer in the refrigerator where you keep the vegetables to keep them crisp. 😀

[@emmab4587]

Literally Shitler I love you

[@user-yb7el8ky6h]

Literally Shitler Hahahahahhahahahah

[@P1an0Freak]

I thought i was the only one Thank you sir for tthe laughs

[@p_santamaria]

Thanks for the laugh

[@muskaangupta8546]

I'm a biology undergrad student and I'm so glad that not only did I understand level 5 easily, I found it fairly basic and general. :)

[@Junipire]

Weird flex but sure, good for you

[@joellenlin1212]

I wish the video goes into more depth about the concept, how it works at the mechanical level, an update on the current research/break through/challenges, and their implications/applications in the near term (next 5-10 years). way to much proportion on ethics and re-creating species that went extinct at level 4 and 5, which was the language and complexity of level 2 and 3.

[@amedyr863]

I love this series, especially how they don't dumb things down from the very first level of difficulty.

[@tuomio5043]

Ann Wright "don't dumb things down"

[@TheRealOtakuEdits]

Emil Aaltonen All he does is use more accessible language while getting to the gist of things more concisely.

[@tuomio5043]

OtakuEdits really, he didn't bring almost anything up with the kid. obviously this is understandable.

[@linuxd]

Emil Aaltonen which is a great place to start especially for those who never went through modern schooling like I have, in which I was literally taught a little bit about all of these complex sciences that effect our society so much today, and also for those who need a brush up...like I did because I'm not looking at DNA, RNA, Proteins, and this kind of work on a daily basis. lol

[@tuomio5043]

Rory M that's the point. he's dumbing things down because the kid obviously doesn't know about crispr. I'm not saying it's a bad thing, just that the original comment was wrong.

[@EatsRainbows15]

I love watching these as I can learn something new level by level; I slowly begin to learn it

[@ngand660]

AnOwlThatEatsRainbows that is how it works

[@antdx316]

Maybe the idea is to make a database DNA system for all people who are born and alive 1st before trying to modify it? You start modifying things before mastering how the base is you will have no idea what is truly going on.

[@TricksterRad]

We're actually already building extensive databases of the human genome.

[@noggest5904]

No you don't, if you were to take a test from a course on relevant material you'd fail it

[@TheEnglishRogue]

lmao savage

[@bandreon]

Daring statement, I know, but this is arguably the most important KZbin channel ever.

[@maltegittel4855]

Love that we learn stuff explained in level 4 in grade 11 in Germany

[@theabrasileno1921]

Wow didn't know Sam Smith was a CRISPR scientist.

[@gf1x119]

Lol

[@ndpd7695]

Hahaha

[@SinoLegionaire]

A true renaissance man. www.realmadrid.com/img/vertical_380px/benzema_380x501_20191221090937.jpg; he also plays for Real Madrid.

[@ikz8439]

Lmao

[@beetlejuiceisreal238]

@@SinoLegionaire oh man, what a genius.

[@CommanderBalok]

While the ethical considerations are important, I wanted more about how it actually works.

[@haileywang3434]

CommanderBalok level 3 kinda already explained it well using gRNA and Cas9 protein to nick out a piece. Or iCRIPSR/aCRISPR for easy editing by phosphorylation

[@XMysticHerox]

It’s a complex between a protein called Cas9 and a short palindromic RNA sequence which corresponds to a repeated palindromic sequence (a CRISPR) in the DNA of the target organism. Using the guiding RNA Cas9 can find the sequence and make a cut allowing for various ways to insert something new in the gap or cutting something out.

[@boxelder9167]

It’s like a Ninja but for DNA.

[@Michelleiscul]

@@boxelder9167 Yes, basically. 😂😂😂 Good comparison.

[@SV-fq9kl]

Yes and the melatonin undergoes expohilyation, which deteriorates the plasmid solution , thus enabling the catarctrophylic sect to change the gremlin in the DNA

[@saumyamathur4862]

I first watched this video when I started my undergraduate degree in Life Sciences, & now I’m back as a Synthetic Biology grad student using CRISPR techniques regularly. wild.

[@zawardo111]

the expert looks both intimidating and kind