How Alzheimer’s Disease Affects Your Brain Cells

MEDICAL ANIMATION TRANSCRIPT: The brain's cognitive functions include memory, which is the process of information retention and retrieval. Memories form in the hippocampus, which consists of information-processing cells called neurons. Each neuron receives chemical messages from other neurons via dendrites, then converts the message to an electrical charge called an action potential. In the space between them, neurons release stimulatory chemicals called neurotransmitters, which bind with receptors on the receiving cell and transfer information. Alzheimer's disease is a gradual, degenerative brain condition in which neurons in the memory and other cognitive areas of the brain lose function and die, resulting in progressive memory loss first, then difficulties learning and communicating, and, eventually, failing basic functions like breathing. In healthy neurons, enzymes help process a protein called amyloid precursor protein into fragments which help with normal cell function. In Alzheimer's, abnormal enzymatic processing produces fragments that include a sticky peptide called beta amyloid. Beta amyloid accumulates in the extracellular space, forming clumps called amyloid plaques. These clumps block the electrical and chemical connections between neurons. Inside healthy neurons, microtubules and tau proteins form an orderly structure that carries ions and nutrients within the cell. In Alzheimer's, chemical changes inside the neurons damage tau, twisting microtubules abnormally into neurofibrillary tangles, which disrupts ion and nutrient delivery within the cell. As the plaques and tangles multiply throughout brain tissue, neural connections diminish, and the malnourished cells lose function, resulting in widespread neural death, reduced brain mass, and severe cognitive and functional impairment. There is no cure for Alzheimer's, but current treatments include cholinesterase inhibitors, which delay the breakdown of acetylcholine, a neurotransmitter important for memory and learning, and antiglutamatergic medications, which regulate the activity of glutamate, another neurotransmitter essential for memory and learning, by blocking excessive glutamate binding to neurons, thus preventing neuronal dysfunction and death. ♪ [music] ♪
#AlzheimersDisease #MemoryLoss #BrainCells
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[@cryalot378]

jesus, I always thought Alzheimer’s only affects your memory, now I realize it's basically a slow death sentence

[@josedorianlopesdasilva2939]

Infelizmente a maior parte das pessoas pensa dessa forma também 😢

[@bio366geethasankar7]

🙏🏻🙏😢

[@saadmeer6293]

You put so much effort in these videos . From animation to key words to explain the procedures are top notch.

[@skz262]

Could u make a video about coma patients?

[@minwoojo1798]

Thanks to those animators who put so much efforts to make videos from this channel. I love your channel.

[@OceanSwimmer]

The visual representation of neurons, neurotransmitters, and normal function is very helpful; it's easy to say "memory" and define the term, but the visual representation of normal versus abnormal function clearly demonstrates exactly what happens in Alzheimer's disease. Very well done! Thank you.

[@Dr.Ibrahim.Hassuna]

وحش ولى

[@RicardoBatistaPassos]

Love you guys at Nucleus Medical Media, Thanks for sharing amazing quality videos for education purpose!

[@brainstormingsharing1309]

As usual, always keep it up! 👏

[@flabagaster7218]

Very insightful, thank you

[@komalshah1535]

Excellent video! Thanks.

[@brandonfarfan1978]

Thanks for this informative vid. That disease is scary.

[@Algebrainiac]

Amazing presentation. I learned this in biological psych. Great job. 💖

[@mawooee8751]

Awesome video dude

[@dreams1569]

Well explanation!

[@artrologybyaiza]

it is soo informative and knowledgeful❤❤❤

[@vishakhasangale3445]

Veryyy nice video👍👍👍thanks

[@ritwikjana8700]

Excellent 👌

[@wednesdaychild2408]

❤❤❤❤❤❤❤❤❤❤❤big big thumb up to your channel👍. Appreciate your precious infos and most of all , the superb animation work.❤ than you.

[@lauragadille3384]

My dad passed from this. I hope I don't get this horrible diease.

[@dressrosarc]

So sorry to hear that may he rest peacefully :(

[@jhalak831]

Kindly tell me, When that occurred and when they died?

[@Meredythe]

I have provided care to many patients with Alzheimer's and Dementia, it's heartbreaking to see the disease progress and worsen.

[@technicalhelpdesk6620]

What is the treatment of it plzz 🎉❤

[@Meredythe]

@technicalhelpdesk6620 I'm a caregiver, not a doctor. However, different medications are used to slow down the progression of the disease. I remember aricept and namenda being medications that help. There are many others. I do the daily tasks of bathing, dressing, feeding (etcetera) of these folks. Also constantly reassuring they are safe.

[@navyasridasari75]

Hey ! This comment is hope for me, my mother is fighting with Alzheimer's, can you please please help me with some tips that would be helpful for us , we are caregivers for her, love from India

[@lakshmilucky3972]

​@@navyasridasari75 hello sis ...my father was also suffering with alziemers...can you tell me what are the changes u have noticed in your mother ...by the way ur name seems to be a South India and I'm a native telugu girl.. so can I reach u to know about you mother's symptoms as I'm suffering a lot with my father's increased progression day to day .

[@androidgamerz9955]

Yay i've been waiting for this thanks nucleus medical media

[@sajalkhan4377]

Can you tell me disorders related to hippocampus with amygdala and hypothalamus?

[@kaystephan2610]

Was the video set to 0.8 speed or so? Cause when I turn it to 1.25 speed it sounds perfectly normal but when I leave the playback speed at 1 it sounds super slowed down.

[@SudeepAdhikari0611]

Wow😮❤

[@AditiNath1234]

Nice

[@ISAAC_69000]

Why is the voice really calm and patient?

[@kaleastudiosofficial]

So the words are easier to hear and understand

[@berryforce6017]

Because it's AI-generated.

[@BryleMilan]

@@berryforce6017 Damn, i didn't know Sara weaver was actually a robot

[@berryforce6017]

@@BryleMilan Ok, I was just guessing. I was going to point out the monotony and never gasping for air were giveaways for someone just lending their voice as a template but listening closely with headphones, there are actual variations. The narrator is just that good!

[@BryleMilan]

@@berryforce6017

[@augustinenayagam3840]

🤷Could you make a video about before, when and after stimulating inside the ear by bird's feather🕊️

[@ramanjitsingh4340]

Sometimes I forget names is that the early sign ?

[@drghomadrghom7290]

Wow ❤❤❤❤

[@Edge1588]

Gotta ask the question though. What causes it to be in that specific order. Seems like it's the brains way of losing expendable parts first. So what's making it want to do that?

[@berryforce6017]

What do you think?

[@BryleMilan]

dna gets broken but not fixed so the cell read its dna wrong and makes the wrong proteins and makes wrong decisions

[@Edge1588]

@@berryforce6017 Cell membrane loss of integrity. Alzheimer's is often seen with type 2 diabetes and statin use. The brain is a cholesterol gold mine. Combine the current low fat/calorie diet with statin use, it isn't a stretch to hypothesize that cholesterol is being stripped away for more important cells to use.

[@Zartowxyx]

igrotum is a game-changer for Alzheimers patients, providing relief and tangible improvements in memory recall and cognitive abilities.

[@shema3579]

Could u make Dementia patients

[@yash_agrahari]

I completed it first

[@etpaprika]

👍

[@yash_agrahari]

Didn't start it though. : )

[@Mitzi-chan224]

Ok

[@hala-ml6qt]

Alzheimers may be a tough adversary, but igrotum is proving to be a formidable opponent. Experiencing encouraging changes in daily life.

[@GhimireGhanashyam-cr3ci]

Alzheimers struggles are met with determination, and igrotum is leading the charge. Noticing encouraging improvements in memory and mental clarity.

[@bio366geethasankar7]

🙏🙏🙏

[@pankajchoudhary5162]

I completed it 3rd

[@RrequiemStudios]

I dont remember watching this

[@meetdave6599]

I completed this at 2😅

[@truthboom]

wouldn't want nano-plastic to touch brain neuron 💀

[@worldwatch6701]

❤

[@missspell1714]

❤❤❤❤❤❤

[@summerbreeze5115]

How to prevent?😮

[@Pjhchase]

getting enough sleep is very important

[@summerbreeze5115]

@@Pjhchase thanks MONKE!!

[@dudegamers5865]

Hai

[@Twoidiots...AndSometimesAthird]

Has this scared anyone else?

[@dumdum_plays]

hi

[@PyrocatSuppressor]

Educational video and all but I must say, It's like a sloth is talking.

[@Dzeyn31]

❤😊

[@davidcovington901]

Video was posted 4 minutes ago but is out of date.

[@kiayatwixxer4736]

And this is how you die :D

[@ultramarine7602]

気

[@ley292nr29]

tasty!

[@user-pd5mz6ou7y]

igrotum is a reliable companion in the Alzheimers battle, offering support and positive changes in cognitive function.

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