Systemic lupus erythematosus (SLE) - causes, symptoms, diagnosis & pathology

What is systemic lupus erythematosus (SLE)? SLE's an autoimmune disease that can affect any tissue or organ in the body, but most often affects the skin, kidneys, and joints. Find our full video library only on Osmosis: osms.it/more.
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[@dashcamera_daily]

This channel is a gift to medical students

[@eseoghenetamesere1006]

this is a very true statement

[@vuongvo7863]

Necromancer Nazi wff

[@ramsuresh1942]

totallyyy

[@ramsuresh1942]

Once I start making some money...will surely take the subscription and donate as well

[@laurenlerma9360]

& pre-meds

[@vineethvishnu9975]

My lecturer took 1 hour for this topic.. and you guys nailed it in 11 mins...

[@georgebadia9518]

haaaaa

[@habibmate8466]

Mate I’m sure your lecturer gets payed hourly or per lecture he teaches, Id bet money that he’s wasting time on purpose 😂

[@user-op7zi3ml1h]

if only you knew how much time it gets to make 1 video

[@hafizhmanaf1459]

And i didn't uderstand that much from my lecturer

[@intrestingindia5897]

Is there any treatment.....plz help

[@michaelmccray7782]

"Avoid sunlight". Maybe the word "Lupus" is a historical reference to having to stay out of the sun...? (Werewolves only come out at night)

[@ramsuresh1942]

Michael McCray ha ha..great

[@davidhoward2487]

No, it's called Lupus because it's like a wolf (Lupus) in sheep's clothing...mimics so many symptoms of other diseases...

[@micaelpompermayer9548]

So, shouldn't it be named "wolf-rash"? Just saying.@Chaston Ellis

[@mohammadsultan8894]

Michael McCray wow

[@jerrymartin5922]

I agree with all these answers. I have lived with lupus for many years but diagnosed in 2016. Stay strong! May is also Lupus awareness month!

[@leslieware2125]

I am a registered nurse with 13 years of experience and diagnosed with SLE approximately 5 years ago. This is the first time that I completely understand the disease process and why each of these tests are ordered during times of disease activity. Thank you!

[@yazminmojica4458]

Me too 😢

[@nimeshamperera3644]

😊😊😊

[@nimeshamperera3644]

😮

[@pratiksharma13]

How to cure this I am 1 year in this

[@whackwhack6554]

@@pratiksharma13u cant u just have to keep it in control

[@AdrianaMartinez-mv8js]

I was diagnosed in ‘98 and I’m 2009 I got a kidney transplant but it only lasted 4 years. I am now doing peritoneal dialysis and going through the Transplant Work Up again to try and get on The List once again and hopefully I will get that amazing gift. I have a gorgeous daughter and 3 amazing and gorgeous grandchildren 💖. This video was spot on. I pray for all of us and everyone that is going through some kind of illness. Stay Strong 💪🏼💜💜💜

[@user-wf9gv4rl9o]

الشفاء العاجل أن شاء الله

[@Wildewhitley]

I have had APS/ autoimmune illness all my life and have finally learned it comes from food!!!! I went 100% organic and have had more progress in 5 months than I've had with any treatment over my 34 years of seeking help. I had to give up all the goodies, you might only need to give up 1, or 3 like red meat, gluten, dairy, nightshade vegetables, caffeine, sugar, and anything highly processed. It's amazing! Actually feeling healthy!!!! Goodbye life long illness!!!!!!

[@sarahmina1442]

"It's HIP to get lupus" mnemonic for drug inducing lupus: Hydrazaline, Isoniazide, Procainamide.

[@laurakeyse9944]

I'm allergic to sulphur drugs..and Sulphates ... Which means no wine for me..although there are some non sulphate wines out there..expensive..sulphate are used as preservatives in a whole lot of stuff.

[@johnsonlee4130]

I want you to know that there is a cure for lupus and I cured mine with herbal remedy form Dr Ehime who I met on KZbin channel. His name is Dr Ehime.

[@banplastic111]

Hydralazine*,Isoniazid*

[@jamilahadade4412]

Thanks for this great explanation of Lupus. I’ve been recently diagnosed with Lupus but the doctor didn’t give me any information on this disease. Now I understand what type of this disease this is. Lupus sounds like a complicated disease. It’s quite scary. Everything’s in God’s hands. Hopefully they’ll be a cure soon since so many people suffer from this destructive disease.

[@ellaelliott4415]

It's complicated and scary but can be manageable. I'm sorry you didn't get information from your doctor. Being in the dark is the worst. I've had it for a few years now, but the good thing is, new treatments are in the works.

[@mistysimms2708]

My mom was just diagnosed as well. Doctor gave her any information either 😢

[@rudransh8829]

​@@mistysimms2708at what age your mom diagnosed?

[@queenfae2182]

I'm being investigated for lupus and this video helps me understand the disease a lot better. Thank you 🙂

[@osmosis]

Hope our video helped! 🙏🏼

[@lisamarie5536]

Same here!

[@nancycarlos5695]

I have been suffering from Lupus disease for some year without having a solution to it until i done a research on KZbin i come and cross Dr.Auchi on KZbin channel. That was were i find effective herbal medicine to cure my Lupus disease permanently without having side effect from the herbal product.. i recommend Dr.Auchi herbal medicine for Lupus disease cure...

[@sm.663]

What symptoms u are having?

[@nancycarlos5695]

@@sm.663 I was having hair lost as my lupus symptoms..

[@vegliberationx]

Wowwwww absolutley amazing, you need only 11 minutes in explain this pathology. I understood very well, much better than book. Thank you for this!

[@osmosis]

Perfect! You're welcome AJ.

[@AiSHAisasingleladyAb]

Osmosis please can you Translate to Arabic، I really need this to understand medical words well! Thanks. 😊☺

[@ralphkeeldar4726]

Nice of you to say that. On my place on this website i will tell people what they can do if the treatment of the doctors don't help. Good luck !

[@intrestingindia5897]

Is their any treatment.....plz help

[@binjai3747]

With this video my headache while learning is gone thanks !

[@osmosis]

You're welcome! 🤓

[@jordani024]

Shoutout to Osmosis for getting me through 4 years of Nursing School

[@mehressagreen4615]

Thank you so much for this video, I was diagnosed with severe SLE and Antiphospholipid antibody syndrome around 7 months ago, and although I know the medications and treatments, I want to understand the aetiology and how to interpret my blood results. This is empowering and invaluable. From reading the comments there are so many other sufferers and desperate medical students who feel the same. You've now given me a springboard of terminology research into further

[@deltabravo4589]

"desperate" lmao

[@Sergios985]

Mehressa Green how old are you?

[@chandrahasp6697]

How is your health now?

[@raheemprime6860]

@@chandrahasp6697 he's RIP

[@maymuhamad777]

@@raheemprime6860 r u serious?? So sad for him peace to his soul

[@kanelikes19]

" Alright. Systemic Lupus Erythematosus... 'Kay, we totally got this.." Lol

[@juliocsepulveda]

Hehehe...Immunology is extremely difficult and complex.

[@ramsuresh1942]

ha haa

[@ramsuresh1942]

Julio Sepulveda and poorly understood

[@TheNexusChronus]

kassiani. When your immune system hates your guts...and your heart, kidneys, brain, jionts, skin, pleura and itself :D

[@julioperez5380]

Omg my name is julio too

[@kevinfeliciano5959]

Still watching this in 2019. Even though the criteria has changed, the very essence of the disease mechanism is very much briefly explained without missing any important info. Thank you as always, Osmosis!

[@PasanBhathiya]

I really like the casual tone of these videos, saying "alright!" and "okay!" often. 😊

[@Ed-lw8bw]

Can’t trust anyone, not even your own cells

[@lencovic9571]

I can't believe how brilliant these videos are - you are doing everyone a big favor, I'm certain you'll get more traction

[@osmosis]

+Lencovic Thanks so much!!

[@rahmatansari6623]

Meeting Dr Ewi1 on KZbin has really been one of the best day of my life after years of suffering I have been finally cured from lupus thanks doc God bless you,

[@shaaperas]

The best SLE video I have seen. Thank you.

[@osmosis]

Thanks!

[@intrestingindia5897]

Is there any treatment plz help

[@shaaperas]

@@intrestingindia5897 Generally, the treatment plan depends on the severity of the disease ranging from the use of Hydroxychloroquine, NSAIDS, to corticosteroids and immunosuppressants. As with many autoimmune disorders, a specialist is essential for proper treatment. I hope it helps.

[@rosestone5091]

Best comprehensive yet understandable explanation of lupus I have seen! Thanks.

[@ggwyn6206]

I was diagnosed with this recently - with 7 of the criteria met. I’m a freshman in college but I want to be a (cardio thoracic ) surgeon eventually so I found this incredibly interesting, thank you very much.

[@VuelaBand]

I go to Harvard Medical School and my professor posted one of your videos as a resource. Now I've been using Osmosis for months and can honestly say it's one of the best resources on youtube. Thanks so much for the amazing videos! Please keep em coming

[@ralphkeeldar4726]

Good for you !

[@annesofiebille747]

Thank you for explaining this complicated stuff so well! I suffer from SLE and have struggled to understand for ages.Now both me and my husband are more clarified.

[@uglyindian69420]

Hi. How are you now ? My mother had it before having me. I'm 24 now. She's facing some comlexities now.

[@intrestingindia5897]

Is there any treatment plz help

[@user-ki6kv2xd7g]

@@intrestingindia5897 yes I suffer from it too There are immune modulating drugs to improve it , but SLE chronic and u should continue to these drugs

[@kobeni1524]

@@intrestingindia5897 I honestly don't think so, but you can make your life easier with medicine and taking care of food / less salt / taking care of yourself :)

[@gunhildrandom]

Best explanation of lupus I’ve encountered so far. Thanks for it!

[@fabmedici1703]

I have been a doctor for over 5 years now but I don’t think I ever understood SLE before! Thank you!

[@osmosis]

Glad to help ❤️

[@FirasRabi]

Very well done video. Went through the complex pathophysiology in an easy-to-follow step-by-step process that greatly simplified it, and did it without the boring non-informative and non-beneficial information that plagues other teaching videos. Thank you and keep up the good work.

[@Gnokhi]

Nice guys..One suggestion.... Kindly update this SLE video.... The DIAGNOSTIC CRITERIA HAVE BEEN CHANGED since 2012. Thanks in advance.... Keep posting more...

[@catheryneclark5055]

Osmosis can explain a disease more quickly and better than anything. Such an aid in research papers and in nursing school studies! Thanks osmosis!

[@quality169]

I wish I knew people with lupus. I was diagnosed 2 months ago, I’m currently 16 and I feel so alone, I don’t know why there aren’t any teen support groups anywhere, I’ve been searching for awhile

[@sakurarosabellmathews]

Well, now you do. I have sle lupus.

[@mihaelatepsic3264]

What are first symptoms?

[@nahomycallejas3632]

I feel you, I was diagnosed when I was 13 years old. I'm 19 and I still haven't met any teenager with lupus

[@quality169]

@@mihaelatepsic3264 For me I thought I had carpal tunnel syndrome for the longest time, I’d have really bad pains in my joints and I couldn’t even sleep at night. My hands and feet would get swollen and I was really sick. You’ll know when or if somethings wrong, I had to spend a week in the hospital when I was first diagnosed because my lungs were collapsing and I had a few other issues. Hope you’re doing well.

[@mihaelatepsic3264]

@@quality169 any rash?

[@kitt1226]

My mother was diagnosed with SLE and she’s having a flair up… she has it pretty severe and it’s really hard to watch. I’ve had to call my dad to rush her to the hospital bc of serious high fever and bp. She was delirious and in and out of consciousness. I’ll have to leave the country soon to go to the military and try to support my family. My mom is 48 and my dad 49, I’m 17 (18 in a month) and we can barely pay rent… I’m so worried for them but this is the only way they’ll be able to live at least semi comfortably in the last 30 or so years of their lives. I just hope I can get her help and although I care we have a rough relationship and her marriage is not going well either. This just have to get better ❤️‍🩹

[@osmosis]

We're rooting for you, Kitt! We admire your resilience! 💖

[@kitt1226]

@@osmosisthank you so much, she’s doing better now and finally out of bed. I can just hope for the best now🙂

[@nancycarlos5695]

I have been suffering from Lupus disease for some year without having a solution to it until i done a research on KZbin i come and cross Dr.Auchi on KZbin channel. That was were i find effective herbal medicine to cure my Lupus disease permanently without having side effect from the herbal product.. i recommend Dr.Auchi herbal medicine for Lupus disease cure...

[@labyrinthdrew9543]

@@kitt1226 how long did it take for her to get out of bed? Pls tell... I'm 17 and my mother is going through the same, she is in bed... Bad condition.. Idk what to do

[@user-wf9gv4rl9o]

كان الله في عونك اخي والشفاء العاجل للوالده

[@user-ku5nn2pk2b]

Man ur a savior.literally saved my pathology singlehandedly

[@basitahmad1943]

Wow I'm in love with this channel. So helpful and saved me having to do loads of research.

[@bloodreno]

Came here after my dad had a fall. He’s getting older and he has lupus which has brought along arthritis. I’ve always known he had it but today I couldn’t sleep thinking about him and found this video. Thank you for the knowledge. I always avoided my dads disease but only out of ignorance

[@osmosis]

We hope this video was able to help, Julian 🙏🏼

[@kimurakala7450]

This is the best youtube medical lecture channel I have ever seen. Thank you so much.

[@osmosis]

Thank you!!

[@KatalinaLaughs]

This channel is a life saver , my pathology teacher she gives us packets and powerpoints but I learn and understand the material better in a video and someone explaining it in full detail with photos. Thank you 😊

[@3kbschannel288]

You (guy or guys) are so great. Thank you so much. The speaker is great too -but I'd recommend him to slow down at the important points and leave his fast speech for the already (ought-to-be) known facts.- He's great. Thanks so much ❤️

[@skylark5789]

My God, this guy's a genius. Thank God for people who did their homework in school, took their studies seriously, had supportive parents and family and the means to go to medical school. He rattled off his medical jargon and terminology like a total pro. Great explanation of a very, very complex disease.

[@nene7626]

I was just diagnosed. Thank you for this video.

[@ZuZiCkA413]

This channel is the best for understanding disease for everyone! Thank you for your excellent work.

[@drkashishtarwani8493]

One can only explain simply when one has understood clearly...same goes for u Osmosis...thanks for the beautiful channel!

[@alondramarrero924]

thank you so much as a science student I can finally understand my illness at a molecular level

[@coewayboulder]

So fantastically done - concise but yet mentioning every important detail - great job!

[@osmosis]

Thank you, Coeway! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ

[@rahmatansari6623]

Meeting Dr Ewi1 on KZbin has really been one of the best day of my life after years of suffering I have been finally cured from lupus thanks doc God bless you,

[@faithoyende868]

Your channel is a gift, thank you so much!

[@mariuspheiffer214]

Best I have seen on this topic! Keep up the good work!

[@zas881]

Thank you so much from 2020. What a development though!

[@ElectricAMV]

Absolutely amazing video, this channel will blow up soon!

[@osmosis]

Thanks!

[@aishwaryachawla7334]

Love love love love your videos! Best ever ! My concepts achieved a clarity finally🙃

[@annt2070]

This channel is AMAZING. 100000 karma points to you for helping a desperate medical student in the middle of the night! :D

[@meredithchairez4157]

🤣🤣🤣

[@intrestingindia5897]

Is there any treatment plz help

[@aubreymagasoa9050]

Thumbs up. This is very helpful.Thank you

[@kitkat7370]

This is such a good overview! Was initially panicking about this topic, but this video made it so simple :D

[@Aleyah]

Thanks a lot for the wonderful videos. Wish I had this when I was studying. Congratulations again!

[@jannmikoingelrabagogamingc6012]

Ah, at last - Dr. House's most famous diagnosis, for every single one of his patients, really.

[@jameslight8746]

Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..

[@HeindsAG]

My mom has lupus and very bad medical issues, she had surgeries and she has a metal hip and died, brough back to life and was handicapped. It’s 2022 now my mom has a room for heels and she drives a Mercedes and when she gets out she is wearing 42 inch stilettos 💀💀, this video taught me that my 41 year old mom that drives a Mercedes’ C class and wears 78 inch stilettos has nuclear cells in her-

[@labyrinthdrew9543]

I'm so glad... Hope she stays for more time

[@tanvi2011luv]

You guys are soooo good! I'm an img studying for USMLE and this is like a god gift! Texting all of my friends about you guys asap! 💖

[@Juliana-yh4mj]

Thank you!!! I'm a medical student and the videos are incredible !

[@divyasingh1295]

I got to know from Quora about this channel and it seems as if I have discovered a treasure.Kudos to the team who are so efficient in explaining the topics in such a short span.Very helpful❤

[@temihannah874]

I truly appreciate the admin for uploading this primitive video.. Very useful information was given out.. thanks for the video. **This is my healing testimony comment about how I was healed from Genital Herpes. I am recommending "Molemen Herbs" on KZbin or Facebook. They have the best holistic natural remedies for better treatment and everlasting cure to all diseases and viruses. You can reach them on phone/ WhatsApp at [phone]..

[@ivodelgado1433]

First of all, Congrats i'm a big fan of your videos. As far as I know the anti-dsDNA and Anti-Sm are antinuclear antibodies as well, so, it should´t be described as "other autoantibody", am i right ?. Thanks for your videos !

[@berliantisalamahu730]

I have my block exam the day after tmrrow and I think this will save me a lot of time. Thank you so much!

[@EiliyaLavasani]

Your channel is amazing, I'm actually watching every related video to a specific disease before diving into my books! Thank you very much for your great channel 😎❤

[@osmosis]

Most welcome 💕

[@mlilylotha8696]

Please tell me,sle specialist doctors lam sle patient

[@demothi1]

Been suffering from SLE and then I have Anisocytosis, anemia, chronic urticaria, and other blood related illnesses. Are they related?

[@LordShrub]

Thanks for the explanation! I just went to the doctor about a persistent malar rash so I am going to get tested against these antibodies as well as anti-Ro and anti-La antibodies for suspicion of SLE.

[@NiVofHiR]

AWESOME VIDEO, GREAT SPEED AND DELIVERY, LEARNED LOTS! THANKS!

[@cuorenerazzurro1661]

For 2 years my doctors, many rheumatologist and immunologists thought I was fool and tried to convince me I didn t have it. The disease progressed and I needed to go to a clinic in Russia with physicians for them to do deeper analysis and put a diagnosis just more than a month ago. This disease is the worst possible thing with some of other AD and cancers, after my stem cell treatment hope will be better and I have nothing to lose. The worst thing is that after plenty researches I understood that I m the only responsible because the lifestyle I had during the 2016-2017 academic year... So frustrating

[@pc-vv8uv]

How did your treatment go

[@janebrazeau-stgermain2627]

So happy I found Osmosis! Wonderful teaching tool and enriching for students in class mid-lecture. Thank you +++

[@thelifeofmadisona8211]

Thankful for the support system that surrounds lupus!

[@sairammangalapally9602]

This is so very good! THANKYOU!!! such a nice presentation!!!!!

[@paulineneal5851]

Really like your videos.... you explain things so well.would love to see you make a video about nf1 and chiari. Thank you.

[@jameslight8746]

Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..

[@danielpoblano2141]

This is incredible, what recommendations could you give me to be a good researcher?

[@skylark5789]

Study. Study your little heinie off! And read about one thing after another, like a trail of breadcrumbs that leads you to your answer. Oh, and Curiosity. Have it ALWAYS in your heart. You'll be great, I know, because you cared enough to ask. Looking forward to the great work you give to the world!

[@profLidiaRudnicka]

Great videos! Congratulations! It requires a lot of brains to make complicated things simple to understand and memorize !

[@Dr.Nantiwa]

Wow yesterday a patient came in with the exact set of symptoms. It all makes sense thanks! It was really helpfull

[@osmosis]

We're glad to know that this video was able to help! 🙏🏼

[@parveenapsana6517]

I was diagnosed with lupus 5 months ago.. For me there were many symptoms.. I went through so many struggles it affected my kidneys. Currently I am taking medications and the disease is in control.. Anyone have gone through lupus blood clots in legs?? If yes please reply me in this..

[@trevorhawkins5559]

I will advised you to contact Dr. Odion herbal remedies on you for your permanent cure

[@jameslight8746]

Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..

[@razahaider5088]

Very informative thank you very much for explanation in detail

[@osmosis]

Glad you appreciate it, Raza! 🙏

[@Claudia112005]

I accidentally typed SLE instead of sleep. I was looking for sleep videos. This put me to sleep quicker than any sleep meditations I used before. I now listen to this to fall asleep. Goodnight.

[@user-qs2fz5yl9j]

I love when he said we totally got this. I made me let out a sigh of relief thanks osmosis!! the first semester of advanced patho, and these vids are helping tremendously!!

[@osmosis]

Always our pleasure to help! 🥰

[@twistedoracle1144]

I love your videos

[@antoniocaioalmeidarosal1664]

goshhh, this is perfect. Tks sooo much, kisses from brazil

[@osmosis]

Most welcome, Antonio! 🥰❤️🙏🏼

[@jameslight8746]

Having Shingles Virus is not the end of life , I got cured after using Doctor Ani John herbal supplement within 14days..

[@cyranodebergerac5817]

I comprehended deeply this topic by watching you instead of reading Basic Pathology of Robbins, thank you very much

[@jeank5821]

Hi! I'am colombian doctor and you videos are very specials, of great helps for patients! Congratulations!!! Kepp going

[@mawaddashaban477]

awsome ,you dont know how much you help us with your videos 🙆👍👍👍👍

[@whothefuckusedmynick]

Maybe you could do Still's disease. Is even rarer than lupus, although it is very similar.

[@osmosis]

We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis

[@doctorsweety1976]

I've exam on my head and I was so anxious about that.. But reading comments down here I took a deep breath after coming to know so many people are suffering from this destructive disease and I'm worry to just memorize it. We're not same folks 😢

[@rubasarkez9917]

The best description for SLE ever ❤❤👍thank you

[@DSquad]

All I know is Selena Gomez has it so I looked it up. Only one?? Ok

[@subrinaonookdai5843]

Bruh same here

[@easter.a1722]

Me

[@aoibhetraynor8399]

I know same! I remember hearing her having a kidney transplant back in 2017 before I was a fan of hers. For some reason I got really interested and started looking up about lupus. After that I became a huge fan of hers. She's very opened about talking about lupus. I remember I felt really bad for her when I watched Selena and Chef and when she does her make up her hand keeps shaking because of her Lupus. She's going through so much and people still make fun of her illness. I think she's very inspiring about opening up about her mental health❤

[@ralphkeeldar4726]

Sorry for her. You should know what to eat, and what not depending on your "immune system". I will cover this subject and other autoimmune diseases in my place on this website. Good luck !

[@ralphkeeldar4726]

@@miriamkanana423 Hopefully you're feeling good. I will cover this topic one day in my place on this website.

[@dr.rihamalkhazrajee2485]

Really it's amazing video

[@osmosis]

Thank you!

[@drblaneyphysics]

low dose naltrexone also being used to lower inflammatory reactions in lupus. thank you for this fine video. much appreciated.

[@mondragonleonel]

Love your videos. I hope to sponsor you guys when I graduate and work as an MD very soon.

[@MickeyTech]

Ooo this is the ANA test for lupus I heard in House md....

[@Sergios985]

what if the susceptibility genes of less effective clearance is the main, primary reason why B-cells is produce antigens, i mean they produce because macrophages are presenting host-"antigenes" to the Th-cells, and those one are taking a decision to stimulate B-cells and "attack" host cells... is it mean that main problem in Th-cells and bad differentiation at thymus???? and what about less effective clearance? how does it work? the macrophages error?)

[@amiraemam4802]

Thanks a ton for making the self-learning much easier

[@banuibrahim8676]

Finally found an interesting way to study pathology... Really very helpful

[@mohakkwy3276]

Thanks a lot

[@osmosis]

No worries! 🥰

[@petrprecious4345]

his herbal medication is 100% Cure for Shingles virus and any disease virus and STDs I was cured after 12days of using the herbal medicine I ordered from Dr.Ani John contact him now and get your permanent cure

[@mrinaliniagrawal2554]

Please do an update in the criteria of diagnosis - SLICC

[@mrinaliniagrawal2554]

You've done an amazing job though!! 👍🏼😁

[@Gossypol]

Congratulations Osmosis for 800K. Keep up the good work. ♥️

[@Ahmad-vu8uj]

THANK YOU VERY MUCH well demonstrated

[@jamiesuzette666]

thank you for this well informative video. I have been trying to explain these things to ppl for a very long time. Diagnosed in 1992.... I posted this on my Facebook page, and I know it will be viewed there.

[@osmosis]

Thanks!

[@baboom007]

Hey. My mother was Diagnosed 2 month ago. How do you get through this. How are you feeling. Can u live with this?

[@snowinseptember7939]

apoptosis does not lead to an inflammatory reaction! in apoptosis the cell is divided into many vesicles with an eat-me signal on the outside of their membrane. the vesicles then get digested by macrophages. this way nothing from the inside of the cell (proteins, dna, etc) gets outside the cells which would trigger an inflammatory reaction. what's described in the video is necrosis, which is unprogrammed cell death and in which the cell bursts and cell contents are released and trigger an inflammatory reaction.

[@merleh9455]

snowinseptember 7 thats right!

[@DadeReLLiK]

There seem to be important distinctions between the two processes, Necrosis and Apoptosis, that would warrant a possible edit to the video. Are there no methods to induce apoptosis in these damage cells so that inflammation isn't triggered?.

[@andreab1805]

You can have inflammation from apoptosis if the clearance is slow

[@KristinaTheCoolGirl]

I think they just forgot to mention that in SLE, you have impaired apoptosis process so apoptosis resembles necrosis.

[@mariakanilab9847]

necrosis is not programmed cell death,

[@shantanurout]

Today was my pathology exam and I just watched this video the previous night as I could not understand the text. It was so helpful. I got question on SLE in the exam. Thank you so much for such crisp summary of one of the major diseases in medicine.

[@osmosis]

Hi Shantanu! Thanks for sharing! We're glad that our video was able to help in your exam! ❤️

[@monashalaby9656]

Thank you for this incredible explanation💓

[@ariellam510]

Excellent!But 1 question here, shouldn't anti-dsDna and anti-smith be classified as 1 of the ANAs? I just saw wiki wrote that @@

[@mehressagreen4615]

Haha, it was on wiki though :/