p53

This cell cycle control lecture explains the role of p53 in cell cycle control and tumor repression function and its importance in oncogenesis.
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[@waleedali356]

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The academic need good teacher like you! so precise and great explanation!

[@archivedaccount2049]

you are such a legend man. respect.

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[@archivedaccount2049]

@@shomusbiologyofficial no problem . Keep up the great content. I am a student and doing a research project on signal transduction pathways, I came to this video from the apoptosis videos you have made. so helpful - I have subscribed to your channel.

[@dr.mustafajawadal-imari7162]

thanks so much , but there was ATM, ATR serine-dependent protein kinase make phosphorylation to p53-MDM2 and release p53 in cytosol.

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[@alimamekhloufi9868]

we are in 2022 and i just want to thank you so much for you work you are a great teacher i wish you all the best brother

[@shomusbiologyofficial]

Thank you

[@LizAkyxl]

Excellent. One thing to mention is that however, p53 does not go by knudson two-hit hypothesis. It is a tetrameric protein, meaning it has 4 subunits. A mutation in one allele may lead to the combination of the single unit with wild type (normal p53 units) or all 4 units being the mutated form. I think this is crucial to mention. Normal tumour suppressor genes (TSG) require mutations in most alleles... But this is slightly different from p53. Great video regardless.

[@firstaid1883]

+Raw Beauty wow ur beautiful and smart

[@LizAkyxl]

+Boom Box Haha thank you! 😂👌🏼

[@firstaid1883]

Raw Beauty med school?

[@LizAkyxl]

+Boom Box nope, currently mastering. Maybe soon 😊

[@mrcarnegies694]

Yep, I was going to mention this error too. If one of the p53 alleles is mutated, p53 function is effectively lost for that cell. Its basic statistics, in this case there is only a 1/16 chance for the wild type subunits to combine to form a wild type tetramer and 15/16 chance a tetramer will have a mutated subunit. 1 mutated subunit is enough for the p53 tetramer to lose its wild type function. Also cells with 1 wild type and 1 mutated allele often lose that wild type allele due to loss of heterozygosity mutations (two hit hypothesis) very readily. In terms of p21, its binding (along with similar protein p27) with CDK4/6::cyclin D actually activates CDK4/6::cyclin D activity which hypophosphorylates pRb allowing the cell cycle to progress from G0/early G1 to late G1 as pRb dissociates from E2F. E2F then activates CDK2::cyclin E activity. The concentration of CDK4/6::cyclin D and CDK2::cyclin E is crucial at this point. p21 (along with p27) inhibits CDK2::cyclin E activity. CDK2::cyclin E is crucial in cell cycle progression because this complex hyperphosphorylates pRb pushing the cell cycle past the restriction point towards the S stage. Once its past the restriction point, it will complete the cell cycle (though it may temporarily halt at the other checkpoints). If enough CDK4/6::cyclin D is produced and binds to p21 (and p27), it will decrease the amount that is available to bind to CDK2::cyclin E.

[@theodorpostolache5616]

Thank you Sir, for help me have a better view of the situation than my textbook can offer!!

[@shomusbiologyofficial]

Glad to help you out

[@kuman309]

My man- you are saving me so much pain: sifting through a manuscript out of Princeton on the material and asking to write up a paper on it this helps tremendously as it has really no figures to speak of.

[@sooryachandran9114]

Tqu brother!! It was really helpful to prepare for my seminar today. Well explained!! Waiting for the next lecture

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@shaziamanzoor4688]

1st choice channel for understanding any topic Allah bless u more and more success آمین love from pakistan

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The best! You are simply the best.

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+Nilanjana Hazra Thank You

[@marshallking2384]

love the channel , helps a lot with the molecular biology exams !

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+Marshall King thank you. Glad you liked my lectures

[@shabnamnaderifar]

you teach in a perfect way , thank you

[@shomusbiologyofficial]

You're welcome

[@DuaneEseo-ul1bg]

Thanks for sharing your knowledge in genetics.. And i know how genes works...

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@pedrodias3491]

One of the best biology channels on youtube

[@bat-erd842]

I love the way you explain!! Thanks , pal

[@shomusbiologyofficial]

You're welcome

[@camman1056]

When you say "transcription regulators" is it the same meaning as transcription factor?

[@arubariaz64]

Yes

[@justinduffer9500]

Wow, what an intelligent young man

[@shomusbiologyofficial]

Thank you

[@crazyayush6682]

Thank you sir❤

[@shomusbiologyofficial]

You're welcome

[@1024DS]

Konse book se padna h yea topic p53 ? Please tell

[@sahibzada6411]

very nice video.... 😊😊 thanks for uploading such type of videos... 😊😊😍

[@shomusbiologyofficial]

Glad to help you out

[@soumitachowdhury7184]

Thank u so much for explaining this topic

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[@lucigleysonnascimento9560]

This is perfect, thank you from Brazil.

[@msadirkhan57]

thank u brother , i wached ur video its v good and impormative and there is 10/10 for u but sir with more respect u did't explaine this one in good way bcz there is too much doubt of me are not clear in this videos . btw good luck and keep it up , but if u explain it more like how p53 activate etc then it will b more helpful thank u and respect fore u brother /

[@anaherrera4805]

Thank you

[@shomusbiologyofficial]

You're welcome

[@bimaleshdutta624]

If there is an mutation in Tp53 happens then what are the treatment options are there...

[@LionKingInHeart]

fantastic video, thanks Shomu

[@sjchun79]

Thank you. Great lecture.

[@franciscoalbertobelliard2952]

What food help the production of proteins p53??

[@mayukhroy5393]

Sir this video was helpful.

[@shomusbiologyofficial]

Thank you

[@krinapatel707]

Thank you sir . Nice explanation

[@shomusbiologyofficial]

You're welcome

[@josefvymazal7091]

Thanks for explanation! Josef

[@shomusbiologyofficial]

You're welcome

[@diannewellems9553]

Awesome lecture!

[@karabeebaishya2060]

Thank you very much 🙏🙏🙏🙏

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@mdriajuddinrony1377]

love you brother

[@rituparnaraul4720]

Sir can you tell me which protein is responsible for causing melanoma

[@amerali2022]

Excellent lecture. Thank you very much.

[@Chrysolite-kn3mz]

Thank you Sir!

[@shomusbiologyofficial]

You're welcome

[@tripathyseema]

nice lecture

[@shomusbiologyofficial]

Thank you

[@ALCchoir]

can u pls teach STAT 3 pathway for lung cancer?

[@fatimaumairasaeed4765]

Can you please explain about Rb protein.

[@vikasdongardive1210]

thank u .. very well explained... if u could work on sound quality of mike that will be better

[@jonathans3927]

excellent explaination

[@ncertstudy5845]

Sir,, aap hi h ye🤔 ki aapke koi bhai h,, m hmesha confuse rhti hu Pr jo b ho,, video is superbb👏👏

[@shomusbiologyofficial]

Thabk you so much for appreciating my efforts

[@lyznnylde5080]

Thank you so much !!!

[@shomusbiologyofficial]

You're welcome

[@noxaki3621]

Ohh woww Thanks Sir

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@satyabharathigullapalli7035]

Thank u very much very nice lecture

[@suganyasunder6420]

Sir, please do video about p53-MDM2 interation

[@shomusbiologyofficial]

Okay

[@honestangel8119]

Excelent explanation ! thank you :D

[@kumarshubham6016]

Thanks a lot

[@shomusbiologyofficial]

You're welcome

[@TheClare87]

Thank you so much, I finally understand it :)

[@nishaambade1142]

I humbly request to you Sir. . Hindi me bhi video provide kre . Please

[@shomusbiologyofficial]

Thank you

[@vuxqaz]

Thanks, finally i can remember it

[@hegebjelland8384]

Thank you so much! I finally understand it :D

[@vignesh1688]

hii bro, your explanation is very excellent. but i need explanation of glis 3 gene regulation. please give try to good explanation. thank you.

[@kalyanilunge4204]

Thnx sir

[@shomusbiologyofficial]

You're welcome

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I'm Pakistani but I like your lectures

[@shomusbiologyofficial]

Thank you

[@amnasaeed2176]

@@shomusbiologyofficial you're welcome bro

[@dharsanasasidharan182]

Can I write this in effects of tumour supressor genesand their role in cancer.p53.

[@mhmdhayek4433]

Hello dr, What molecular strategies can be used to make reactivation for p53? And can we make reactivation of p53 by overexpressing this p53 using a virus? And what is the side effect of this strategy?

[@sierrabotanicacollaborativ165]

I believe Vit. D upregulates p53

[@elizabeth4367]

thank u

[@shomusbiologyofficial]

You're welcome

[@khamikos1]

EXCELLENT. THANKS

[@suneethaindupalli1720]

Tq very informative

[@martindrewelius2425]

What do you do for work today?

[@shomusbiologyofficial]

Teaching CSIR NET aspirants. PFA, see the amt of work I put into this channel. It's a full time job

[@mm-oi3in]

thank you ..

[@ruqaraghuli9355]

dude explain to us the structure of P53 and its family! Its so confusing

[@hardz2110]

Are you referring to cyclin D or E?

[@sohambiswas123456789]

gradundefined med probably D

[@Ritu-jt9lz]

Plz sir make a vedio on tracer techniques in biology 🥺🥺

[@shomusbiologyofficial]

Later

[@Ritu-jt9lz]

@@shomusbiologyofficial oky sir 🙂

[@azrathaseen]

can you please make more videos related to cancer biology

[@shomusbiologyofficial]

It's already there.

[@priyanshu7821]

helpful video

[@aapra169]

thank you plz need to make a presentation first and explaining looking at the presentation more understandble for us thank you very much again

[@annonymsuser9756]

good

[@Subi_Meenu]

Sir your reference book please..!!

[@shomusbiologyofficial]

Thank you

[@minimalist5969]

Reference book??

[@sp12120]

Samra Ghafoor Albert..

[@rituparnaraul4720]

👍

[@martindrewelius2425]

P53 is a transcription factor.

[@shomusbiologyofficial]

Yes

[@LizAkyxl]

Both alleles I mean :)

[@AJITHKUMAR057]

Watching this DBT BET 2024

[@shomusbiologyofficial]

All the best

[@AJITHKUMAR057]

@@shomusbiologyofficial thank you sir ✨

[@eslamghanem6528]

علي النعمه اسيادنا رضين عليك

[@harshit.poojary]

Ab padne ki zarurt nhi 😅💯

[@shomusbiologyofficial]

You're welcome

[@arnauvizcarramiserachs6318]

MAN THIS IS JUST 1 % OF P53 -.-

[@shomusbiologyofficial]

+Arnau Vizcarra Miserachs yes.

[@payelmaitybiswas3165]

Arnau Vizcarra Miserachs LOL but u plz make a veidio of 100% and surely send meh d link..

[@shwetasharma5313]

please tell us the 100% of p53 or tell the name of reference book

[@archanapandey6350]

Thank You Sir😊

[@shomusbiologyofficial]

You're welcome

[@im6118]

Thank you

[@BiGPRacH]

Nice lecture

[@sabhaelasied9735]

thank you

[@shomusbiologyofficial]

You're welcome

[@var_shu]

thank you