The Role of p53 in Cancer

p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely bind to the critical site. This means no decisions can be made about whether to repair DNA or destroy the cell. Without functional p53, cells can accumulate more and more DNA damage, possibly leading to cancer.

[@kanetao]

That rattle! I will never imagine DNA without that sound again.

[@marlondavid1108]

I’m from Germany and I’m 16 years old and no teacher in my school and no German video could help me more than you! Thank you now i understand :)

[@majadivjak4538]

Thank you so much for your kind message. I'm so happy this helped you!

[@7urak]

ohne witz

[@alexwhatever4757]

pretty much same here, I study in the French educational system, and to be fair I did understand all that before, but it's still oddly satisfying and pleasant to watch that video 😌

[@justlol9474]

ich auch! :))

[@PatientsPortal]

I just visited my friend in hospital day 36 at UCLA, who has the P53 mutation and Diffuse Large B-Cell Lymphoma (DLBCL). Seeing her strength firsthand, despite her white blood cell count being at 0.9, has been incredibly inspiring. It's true what they say: the best teacher is learning from a patient. My friend is the most resilient person I know, and their journey is a powerful reminder of the strength and courage in the face of adversity.

[@yunxizha2276]

I have my finals today. I never understood 053 throughout the semister. You helped me so much. THANKYOU!!!

[@pierpaolocasamassima8652]

Amazing animation and explanation, thanks

[@nightmaregamer3711]

Just what I was looking for. Great video; informative narration and superb visuals 🧬

[@peters972]

What a great video! It’s not that often I find out something new these days there is quite a lot of recycling. But this was new to me! Thank you.

[@josefvymazal7091]

A very good explanation. Thanks!! Josef

[@kamendinand7]

This is so well made and easy to understand. Thank you soo much for helping my study 🙏🙏

[@majadivjak4538]

Glad it helped!

[@EzioAuditore]

Wow such an amazingly well done presentation , great work!

[@majadivjak4538]

Thank you so much 😀

[@randjietsingh]

Extremely well explained. I did my minor on this subject. Also your vid sound like the inside of Starcraft Zerg hive, which makes it extra cool!

[@lisa-rouletlawfirm9307]

Excellent explanation, thank you!!!

[@hishamaly9090]

Excellent animation

[@israelfernhill]

Loved the video! Any chance that you guys could add the source of the information?

[@oliviapereira364]

Thanl you so much for the video and explanation! I don't get why cells with damaged DNA grow out of control... And if p53 does repairing, why doesn't it prevent mutagenesis instead of growing.. ? thanks!!!

[@katzinator5141]

Is it possible to construct P53 proteins with some sort of protection from getting controlled by the cancer cell, if yes they need to be created in a way that the immune system doesn't recognize them as an virus or bacterium

[@farahdeebakhan5322]

Wow what an amazing animation

[@katerinaslama312]

super video thank you

[@piamuller6744]

I could only focus on these sounds

[@joshuabowman7210]

How can P53 in us be tested to see if they are functioning properly ? I try to study Cancer be nice to chat with you like Bp3

[@JBulsa]

Inject photolayse into the bone and cleave the TT uvc bond with different wavelength of light?

[@fijianhustler6879]

This was helpful. Thanks!!! Bula from Fiji.

[@majadivjak4538]

Thank you!

[@islemabdelmalek1115]

Very well made

[@majadivjak4538]

Thank you!

[@larrybethune3909]

Quick two part question. How does the introduction of the spike protein impact the ability of p53 to bind to and repair or destroy damaged DNA strands? And does this have an impact on pathosis' like breast cancer?

[@Jo.King_]

mRNA spike protein binds p53 and other cancer suppressor genes. It is very clear and very frightening that these vaccines have several elements to cause a perfect storm in cancer development in those patients lucky enough to have avoided heart attacks, clots, strokes, autoimmune diseases and other common adverse reactions to the Covid vaccines. To advise booster vaccines, as is the current case, is no more and no less than medical incompetence; to continue to do so with the above information is medical negligence which can carry a custodial sentence. No ifs or buts any longer. All mRNA vaccines must be halted and banned now." Angus Dalgleish

[@cosmicsailor7329]

amazing

[@mukarambhat]

wow amazing

[@isapinales-torres5160]

That was great

[@JBulsa]

how does uv light cause the p53 to misshape to not bind? The uv light is absorbed? and locks the genes together same as preventing a virus from replicating. Can't unstick a fused bond p53 with a counter UV light wave because it's absorbed but, sound frequency wave could jolt fused area apart.

[@rodschmidt8952]

In my ignorance, I would suggest that the uv light contorts the p53 into a shape which has lower energy than its correct shape, so it sticks and stays that way. So it overcomes a potential barrier, as in many chemical reactions, leading to a lower energy (and dysfunctional) shape. If this is the case, then it is unlikely that any form of energy, having "jolted" it apart, would end up with it in the correct shape, since (having enough energy to do so) it would oscillate between the correct and incorrect shapes until that energy was dissipated, and when the available energy dropped below the potential barrier, the p53 would more likely end up in the lower-energy (incorrect) shape. Sorry. Good thinking tho. I expect that once it's in the wrong shape, it's ruined and can only be replaced and discarded.

[@themadcunt6948]

@@rodschmidt8952 Actually, to my knowledge; UV radiation induces mutations and DNA damages or breaks which result in the activation of DNA repair/ cell cycle arrest pathways. If one of these mutations happened to occur on the gene coding for p53, whether its heriditary or enviromental, this may result in an unfunctional protein if the mutation causes loss of function to the DNA binding domain. Thus, the p53 tetramer would be renedered unfunctional. Additionally, DNA comes in pairs, so if one p53 allele is damaged and the other the is normal this still results in dramatically reduced p53 function. Why? this is because p53 in its active form is a complex of 4 monomers to form a tetramer. So it only takes one mutated monomer to cause the complex to be unfuntional, this means that there is a 1 in 16 change of a functional p53 tetramer forming which translate to ther being only aprroximately only 6% functional p53 and 94% nonfunctional p53. In summary if DNA mutations by chance happens to occur in p53 gene the gene that repairs from DNA damage and controls programmed cell death then that cell no longer respond against DNA damage, which allows for more mutations to the genome to occur and proliferation. eventually one of these mutations may happen in other proto-oncogenes (cancer genes) this leads to cancer.

[@DrHimanshiTheUnicorn]

Amazing amazing

[@bio366geethasankar7]

🙏🏻

[@user-cd4bx6uq1y]

The better the video, the faster I eat the fruit, I ate very fast for this video.

[@arturlyaptyap4926]

The 21st century and scientists cannot figure out how to fix this gene so that the body can kill cancer cells itself. I have this gene and I have cancer and I want to be healthy

[@HL-qv3yd]

I agree with you, so many good souls suffer from this disease, yet all over the world governments pouring money on war and going Mars instead put the money cure this bloody disease, I'm upset for that reason.

[@daltonfreire6328]

Fasting is the solution to the body promote self healing. Even at DNA level. It promotes autofagy, and can reverse any chronic disease, includind cancer. Unfortunately, the medications industry don't invest in researches about fasting, for financial reasons.

[@SJ-wu9gx]

Exactly my thoughts ..

[@sagarikapati9612]

My mom has this

[@Nikthehermit]

Everyone has the p53. It is a gene that regulates cell proliferation. This means when a cell decides what to do with its energy potential, divide or die are the options. P53 regulates this, it is a gene which is part of your DNA. It’s how your DNA knows how to function, gene is like “key” or tool for your DNA. Deregulation of this cell can change the rate at which cells are created. When functioning properly in (remember when all this gene, put some have mutations) a human body it fights cancer, and viruses. It regulated any biological process related to the cell’s ability to reproduce. As cell may choose “Apotosis” and die, because it is corrupted. A cell would understand that it’s necessary to program its own death, due to it becoming a corrupted “file” in the body. Modulating this gene is difficult because it’s not so much amount turning it “up” or “down” it’s about getting it to regulate itself consistently where cell regulation is concerned. Hope this helps, best of luck.

[@fragrantbloom]

wow thnk u

[@highapproximate3358]

Hi can u give me the most simple information between the differences of gene and dna 😥😥 my teacher don't give me these information

[@PatientsPortal]

The best teacher is the patient.

[@pjaworek6793]

wow!

[@shengsheng3029]

Mmmmm.... Interesting

[@L.O.O]

🧬

[@leahmerlijn5473]

So this is the sound our DNA makes!??!?

[@johnwaas7958]

It must be so noisy deep down.

[@TheSintha13]

This made me sick to my stomach... 😕

[@lucyvonella5617]

Wow

[@JBulsa]

Instruct the cell that a new P53 is needed

[@ZuzannaSmolarek]

I would just like to mention that DNA code will not change (1:09). Amino acid which is encoded by a codon may, althoguh DNA code will remain the same.

[@tdu188]

DNA code will change in situations depending on how harsh the mutagenic agents are that are causing the DNA damage.

[@shannoncho5578]

Zuzanna Smolarek, you're incorrect. Mutations are, by definition, changes to the DNA code. They happen all the time, and we have repair mechanisms to try and mitigate that.

[@ritadecassia9616]

Sou brasileira e tô aqui😅😢

[@Bambotb]

This is an amazing channel...isn't this proof of God an intelligent being who designed everything? For people to deny it is pure arrogance and evil

[@nikotakai8796]

Calling people arrogant and evil just because of their belief. How ironic.

[@Bambotb]

@@nikotakai8796 because of their denial and irrational arrogant beliefs not their innocent beliefs...it's not like they said strawberry is better than banana

[@nikotakai8796]

@@Bambotb you mean people who believe in some mystic thing with absolutely no evidence?

[@Bambotb]

@@nikotakai8796 how is this in front lf you not evidence lol see you prove my point...you have no problem Hating on God yet...

[@nikotakai8796]

@@Bambotb are you high?

[@mightiestmouse8833]

Wonderful explanation! Thank you

[@majadivjak4538]

Thank you, glad you found it helpful.