Pain 5, Analgesic pathways

[@elainesmyth68]

hi john, I cant thank you enough, I was struggling trying to understand how it all works, you're a brilliant teacher

[@eva4basketball]

THE BEST VIDEO ON THE ANALGESIA SYSTEM ON YOU TUBE! Thank you!!!! :)

[@carolynvittle1989]

OMG we nursing students adore your lectures - thank you so much for all you do - one day when I am not a poor student anymore I will be buying books for you to gift forward most definately

[@crystalloney7586]

Thank you. This really helped me with understanding the Guyton and hall text explanation. I like to watch a video before reading the details. This one was great

[@Campbellteaching]

Guyton is superb

[@guy_g704]

i literally mastered pain physiology by just listening to these videos.. asante sana sir.

[@stefaniacosta4925]

The best professor on youtube. So clear,thank you!!

[@howardngo6459]

You are great teacher. I wish to watch your lectures 30 years ago. Very clear in explaining the concept. Thank you so much.

[@edwardherrera4097]

Gabapentin does not bind to the GABA receptor despite the GABA in Gabapentin. It works on the Calcium channel.

[@Gpacharlie]

Amazing insight at the end. The “patient” does mentally manage their chronic pain. If they “must” be somewhere or are responsible for someone they are “forced” to mentally manage the pain. Once the required activity is done the pain intensity increases. Of course this is often subconscious and an exhausting roller coaster.

[@kasramd76]

Thank you.I am a pain specialist in Canada and I love the way you have simplified everything, your lectures has helped me better explain their pain and how nerve blocks I give them work

[@dr.akshayasharma1301]

Kasra Mike Haghighat hi

[@Partycornchips]

Brilliant! This is the first bit of content I've managed to find on pain pathways that has been clear enough for me to understand! (Vet Nursing student here!)

[@Mazyone_]

thank you sir, I really appreciate your brilliant explanations. I wish I could meet you in the real world just to thank you. you are really helping me a lot with medical studies.

[@rishavkant8253]

Great lecture!! Can't imagine how simplified you made such a difficult topic

[@danielacatalancarcamo8268]

I was having trouble to understand this until i find this! Thank you very much

[@rachelkenyon2836]

Wonderful!!!! Although if studying for pain pathways, you can start at about 3:45. Overall, such a clear tutorial!

[@Dr.Zainab-tahseen]

Hats off to you sir you just explaned in amazing way 🙏💓

[@godfather297]

This is Gold . Great examples for better understanding

[@abdulahb]

You're amazing my sir! - Your student from the other part of the world!

[@greyline1012]

Thank you so much for speaking in laymans terms. I really do find these lectures insightful and interesting. Thanks Doc x

[@ginavahle23]

You are an amazing professor. Your teaching is really helped me big time. Hope you continue sharing your amazing knowledge.

[@Campbellteaching]

Excellent, keep going

[@rakuldalsgaard5432]

You saved my life! I have an exam on monday, and this is one topic that i just didn´t understand! Now i fully understand it, so THANK YOU!!!!! :)

[@sarahbraga5589]

Thank you so much! I'm brazillian and it was very hard to find a video about endogenous analgesic system

[@Campbellteaching]

How easy did you find it to follow the language?

[@makhosazanasibeko906]

Thank you so much Dr.. I am a Physiotherapy student.. this comes in handy

[@samudrawijesundara1014]

it was great lecture . thank you doctor

[@georgialee1713]

You're great!

[@JessicaBlaisdell]

Thank you! You explain this system so clearly!

[@nellyhoffman6194]

thank you very much doctor ! god bless you !!

[@jkally1]

This is brilliant. I watch it at 2x speed for recap

[@zacsamuel7295]

thank you for such a clear description

[@leesakura952]

amazing and super helpful thank you dr.john

[@TakeMeBackTo1986]

Thanks Doc! I was wondering how my Hydrocodone worked! :) Cheers!

[@zahraaahmed6194]

You are the best , thanx

[@Campbellteaching]

Thanks, do give me likes on as many videos as you watch, this really helps the channel.

[@LogenBogen]

Thank you so much!!!! You're amazing dr!

[@vajihehjafari9682]

Wow!that was brilliant,thank you so much...

[@amalnemah3010]

It is an amazing explanation.thanks

[@hendokashaa6684]

THANK YOU SOOOOOO MUCH U R REALLY A GENIUS PERFECT TEACHER

[@ginavahle23]

By the way I am BSPT graduate and I am getting ready to take the NPTE. Your videos are of great help to me.

[@adxphantom8257]

Thank you. :) I love videos like this

[@lolitaching5887]

cough

[@marvinoagare4853]

I would also be fascinated if I lived 9 years ago

[@jasneetkaur6879]

really good examples!

[@karltampi]

very insightful.

[@محمدصبرينوار]

Excellent thanks for the effort

[@shoshoa1101]

? could you talk more about how GABA affect inhibiting pain and thank you

[@nitinsingh7197]

Can you please tell how that descending pathway gets activated by electrical stimulation

[@jawharahh.5222]

That was super helpful, THANK YOU!

[@Summer-ch7sv]

Sir! Would you mind explaining disinhibition of the descending pathway please? Thank you!

[@laibak2524]

Salam sir. Can you please explain where the pain signals are blocked in the diagram you drew first. Is it in the PAGM? And how?

[@mpachhangte9319]

Sir please reply as soon as possible. If the opiod receptors are present in the PAGM and other such structures involved in the Descending Inhibitory pathway, how does opioid administration stimulate the descending pathway. Shouldn't it inhibit it too by hyperpolarizatiin?

[@Campbellteaching]

Opioids will agonise the receptors in the pain inhibitory pathways. So opioids will increase the levels of depolarisation analgesic pathway neurones. This will increase the levels of neurological activity in the inhibitory pathways. As this increased activity inhibits the ascending afferent pain signals, the levels of pain impulses ascending to the thalamus is reduced.

[@Gpacharlie]

Dr. John Campbell I can testify!! Opioids are very important in chronic pain intensity reduction.

[@bullseye9572]

Amazing,, thanks alot

[@kasramd76]

And yes, you have a gift when it comes to teaching😀

[@amirsamar5802]

Great lecture.. Thank you

[@mahmoudabdou2098]

Amir Samar o

[@megharevaneti1042]

thankyou! this was extremely helpful!

[@nursyafinazhazahar3387]

Thank you so much!! You really help :)

[@ogooe1288]

Which is descending pathway of pain

[@yaseenalhumry7385]

Great lecture thank you

[@fancraze5218]

Thank You Sir...

[@mimizizi2373]

Thanks.. Merci ❣

[@kamomamashela8994]

thank you...AWESSSOOOOOMEEEEE

[@coolts93]

thank you dr

[@suhasdoreswamy4957]

Thank you sir

[@elliotte4]

the mind is not contained in the brain. mind and brain are completely different no?

[@Campbellteaching]

+Ell English I think the mind is an emergent property of the brain. I believe this because when we turn down brain activity, with a general anesthetic, the mind is no longer aware. Consciousness and awareness are generated by the brain. Specifically, a lot of our consciousness is generated in the reticular activating system of the brain stem. I believe, that as long as we are alive, the mind, (what is us) is generated by the brain. These scientific statements make no comment on the mind being generated by an alternative agency. However, biological life is imaginable for our current scientific study.

[@Gpacharlie]

Dr. John Campbell They are no doubt integrated.

[@peter357]

Fucking awesome, must link this to my professor :D That said, wish you mentioned if there is any other way to tap into this pain reducing system whiteout drugs...

[@hadilmab7353]

you are amazing Thank you so much

[@roland.j.ruttledge]

Many thanks

[@agalyailangovan]

grt docctorrrr

[@jstartech2812]

❤❤

[@wegdankalel2069]

thank you so much

[@KonstantinosEvgeniou]

thank you!!!

[@chrislacson8560]

The sound of the marker is terrible. Lol. But thank you for a great video!

[@hendashraf833]

Thank you so much

[@sarahrazaq8363]

Thank you

[@geojor]

thank you...

[@jehanzaibzafar9506]

Thankyou :)

[@ahamadali6963]

SOP Class of 2018

[@janakolosnjaj7054]

I love you

[@lenobenny1451]

Hi like u