Analgesic Pathway | Endogenous Opioid System

Рет қаралды 77,243

Күн бұрын

The body has its own pain relief system that gets activated when experiencing pain.
.
As a painful stimulus ascends to the cerebral cortex (to become consciously aware of the pain) it sends signals to multiple other areas of the brain. This includes:
- Amygdala (emotion)
- Hypothalamus (flight/fight response)
- Reticular formation (arousal and consciousness)
.
1️⃣All of these regions, including the cortex, will send a signal to the
2️⃣Magnus Raphe Nucleus (located at the midline of the medulla) and will
3️⃣Send a serotonergic signal to the spinal cord
4️⃣Stimulate a neuron in the spinal cord that releases Enkaphalin (opioid)
5️⃣Enkephalin will bind to opioid receptors (delta opioid receptors) of both the pre- and post- synaptic pain neuron.
6️⃣Stopping the pain signal!!
Listen to our podcast for more info: podcasts.apple.com/au/podcast...

Пікірлер: 84

@nimrakhan6143 2 жыл бұрын

Dr Mike you so simply and clearly explain in 10 mins what my teachers cannot explain even after hours of lectures.

@JL-dx1ov 3 жыл бұрын

Roger Federer makes tennis look easy, DR MIKE makes neuroscience look easy. Quality of the great. Thank you, namaste.

@colacolette19 3 жыл бұрын

excellent video! I've been looking for hours for the right video on ascending and descending pathways, and this is both informative and engaging! Tysm!

@wethenatureenthusiastssa1736 3 жыл бұрын

Thank you so much from the bottom of my ♥

@howtomedicate 4 жыл бұрын

Well explained video! It makes me also think of the fear-pain-cyclus. Where fear for pain, leads to tention which causes more pain. And this pain leads to more fear, and so on.

@Lisboacampelo 3 жыл бұрын

I'm a brazilian student, and your video really helped me. Thank you,.

@tarabrown8343 4 жыл бұрын

Love your style of teaching. I teach using the whiteboard too. So helpful. I also appreciate your explanation of everything. Your videos helped me so much for my uni exams. Thank you!

@gilbertocarrijodocoutofilh840 3 жыл бұрын

One thing is read and hardly imagine. Other different thing is see, understand and believe. Thanks, you cured my blindness about this Topic.

@hibar4852 4 жыл бұрын

THIS IS SO GOOD THANK YOU!!

@Pawsandclaws337 4 жыл бұрын

Awesome! Thank you so much! I love your videos!

@nohaali6176 3 жыл бұрын

Thank you, I was quite confused in this part until I watched this video

@unoriginalpotato4924 4 жыл бұрын

You are an amazing teacher!

@shahada8002 3 жыл бұрын

Perfect, thank you so much Doctor

@claregoodwin1694 2 жыл бұрын

Thank you, great video, it's helped me to get my head around this topic

@cbbhvjc 3 жыл бұрын

Amazing circuit so well explained!

@peterngangahsc9945 2 жыл бұрын

Here in Kenya we say "asante sana" in swahili language, meaning "thank you very much" the video is educative

@jessicarivera7059 4 жыл бұрын

Wonderful video!!! You're a great educator.

@53-priyankatodkar44 3 жыл бұрын

It really gives a clarity about this topic, Thanks 😊

@MT_Method 4 ай бұрын

Beautiful video, just have to say that it’s not mentioned the dorsal ganglia of the dorsal root. Thanks a lot Dr Mike!

@user-bb1fy2lu4j Жыл бұрын

Thank you very much doctor , we appreciate your hardwork now I finally understand this pathway 😊

@ahmadqurashy110 4 жыл бұрын

Amazing Thanks doctor ❤

@leticiabueno3761 2 жыл бұрын

amazing, thank you so much for this video :)

@jonatanduelund9123 Жыл бұрын

Excellent overview and summation thank you! PS great pacing

@alexandrashields2600 6 ай бұрын

Wonderful, thanks again for an amazing and easy to understand video!

@menamohamedelshehawi4271 3 жыл бұрын

I don't know if he is a reaaaally good teacher or if its his mcdreamy look but all in all I finallyyy understood this part of neurophysiology thank you

@brookeminihan4123 3 жыл бұрын

Great explanation!

@Aya-sp6xe 3 жыл бұрын

ماشاء الله هايل جدا هكذا تستحق لقب الدكتور

@juanluisfernandez5985 4 жыл бұрын

Your videos are awesome; because of that and to satisfy my curiosity, can I know a little bit about your professional background? Thanks

@floryriana641 Жыл бұрын

bro, i read multiple lecture notes and couldnt understand a thingg. But Dr Mike just explained all of those in just 9 minutessss!!

@Thomaseron2 3 жыл бұрын

Very educational, thank you! Wanted to know a bit more about pain relief since my cat bit me at the vet the other day. Got me thinking, if serotonin and opioids are released for pain relief that could possibly explain why some people with depression cut themselves.

@medsurgmaster 3 жыл бұрын

No matter how much my teachers explain I have become addictive Your videos have morphine like properties 😂 Thank you

@violetarlein 2 жыл бұрын

superb. thank you for having made this video

@MyNameisDianaa 4 жыл бұрын

incredible!!

@jasmineothman3492 Жыл бұрын

great! 🙏🌿

@AK.ALMAHASNEH 3 жыл бұрын

Thank you so much 🍀🍀♥️

@luckyhans6300 2 жыл бұрын

Wow ! u r just amazing

@lethargicguy3374 Жыл бұрын

Very clear and concise ⭐

@gordiking506 3 жыл бұрын

super cool!!

@haileymarshal8180 2 жыл бұрын

thanks

@booksetmore1219 3 жыл бұрын

Is the enkephalin synapse the same kind of synapse that is mentioned within the Gate Control theory? :) Great video, such a great visualization and explained well!

@asmaulhossain2320 3 жыл бұрын

Really superb ♥

@WannaCry_Alpha 3 жыл бұрын

Nice visualization... It made easier to understand...

@homeopathymedicos3849 3 жыл бұрын

Thanks sir ,

@I_love_BTS_2025 3 жыл бұрын

Thanks a lot for this awesome explanation😍🥰

@pocachontaspocachontas726 Ай бұрын

Thank you, Dr. 👍

@DrMattDrMike Ай бұрын

You're most welcome!

@zakirzak1494 4 жыл бұрын

Great video .... could you do a video about how they identify the receptors and the various Brian pathways so accurately. I mean micro details not the macro. Thank you 🙏

@asmaabbas1110 Жыл бұрын

Perfecto 👏

@pacifiquebusiness Ай бұрын

Thank You 🙏

@DrMattDrMike Ай бұрын

You’re welcome 😊

@PhysiologywithChristian 4 жыл бұрын

Great video!

@DrMattDrMike 4 жыл бұрын

Thanks Dr Christian!!

@mscrunchy68 3 жыл бұрын

When we are experiencing a lot of pain it's easy to think that our endogenous pain relief isn't doing very much but I had ABGs taken shortly after giving birth and couldn't feel anything more than a slight nudging at my wrist, so something was working.

@Tannyyyyyyyyyyy 3 жыл бұрын

Thanks sir😇

@hhhafyoo8510 4 ай бұрын

best of the best

@spidwars 3 жыл бұрын

Thamk you

@ploptunez5529 3 жыл бұрын

Probably should of watched this before doing my UNI quiz, 🤔 and the answer is Delta 🙌🙌, I answered MU because I had absolutely no idea 🙁

@sudeeptalapatra3982 Жыл бұрын

Hats of to you sir....I could not get this concept clearly from book, this video makes it crystal clear but you didn't explain pre and post synaptic inhibition by encaphalinergic interneuron i.e neurotransmitter block and K+ channel block.... add it sir...

@fahatmohamed7613 Жыл бұрын

Just wow

@kristilacey7802 Жыл бұрын

Absolute "🤩rippa" - Thanking you

@PureLogic777 4 жыл бұрын

Great lecture. Does this activation of the analgesic pathway by pain in one area of the body provide some body-wide analgesia? Or is it more focused than that? I've noticed when I eat pepper the mild burn in my mouth will stop a mild headache. Thanks

@cullis8327 3 жыл бұрын

In my experience, getting whipped is like taking a high dose of xanax, except you don't feel foggy, just kinda clear afterwards. And yeah, whole body. Obviously hard to OD or get addicted, it's exquisitely painful and thus only really an emergency fix.

@spiritlevelstudios 2 жыл бұрын

@@cullis8327 wtf

@cullis8327 2 жыл бұрын

@@spiritlevelstudiosi guess you're new to the world. That's how it works. Injury causes the body to release opioids it produces to counteract the pain. But if methods that just cause pain, without real injury are used, such as e.g. wide belts, you just get the opioids in exchange for brief, intense pain. It's pretty funny, because e.g. religious ascetics sometimes whip themselves on a faith basis. In essence and in effect, what they're doing is not much different than chewing down on some oxy pills. Still, it's impressive, because inflicting serious enough pain on yourself to trigger the opioid release is not easy, at all.