Pain Physiology 3: Central Transmission, Sensitisation and Modulation

Welcome to Soton Brain Hub - the brain explained!
This is the final video (3 of 3) in our pain physiology mini series. In this one Ali tackle's the tough stuff and helps to make it as simple as possible for medical students (or anyone else for that matter!).
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[@yurineri2227]

thanks a lot, this is the best video on youtube about Sensitisation :)

[@SotonbrainhubUk1]

Cheers bro!

[@fisalbarca]

No words can describe what you have done, thank you very much

[@Cleisthenes2]

Depolarization increases the excitability of neurons?

[@SotonbrainhubUk1]

Yep…makes the neuron less negative (more positive) and if it reaches threshold, then let the fun times begin 👌🏻

[@Cleisthenes2]

@@SotonbrainhubUk1 Fun here meaning pain?

[@suwanihansika8379]

I have a question. You are telling a threshold potential of glutamate receptors. But glutamate receptor is a chemical gated channel not a voltage gated channel. So how it can have a threshold potential?

[@Grunfeld]

Thank you. Dense but really well structured and paced in delivery. Looking forward to reviewing them and hoping some more of it sticks!

[@PEMF.Hydrogen.LLLT.Experts]

Excellent work!

[@SotonbrainhubUk1]

Glad you like it!

[@gggaemer8200]

Hello, your 3 videos on the physiology of pain are very interesting. Can I have your references? I would like to know in depth .

[@johnathanabrams8434]

Woopy doo. Now what ? Chronic pain is the reason most people visit doctors. It costs the United States a half a trillion dollars a year. Doctors suck at treating chronic pain

[@SotonbrainhubUk1]

Steady on. Do some breathing exercises or something 🫡

[@johnathanabrams8434]

@@SotonbrainhubUk1 veterinarians know more and how to treat pain better than medical doctors. By all means, animals cannot verbalize their pain with language.

[@lululove6175]

@@SotonbrainhubUk1Breathing. Are u kidding.? Thats like a drop in a gallon bucket. You have to rewire your whole limbic system even though you know you have a structural and pathological proven diseases. Steady on. Yea, t hanks for the help.