Palladia for Dogs | Dr. Megan Duffy

Summary:
Veterinary oncologists are using the drug Palladia for dogs with many types of cancer now. Dr. Megan Duffy explains why.
Notes:
Is Palladia safe? Does it have a lot of side effects? Does giving my dog a cancer drug at home multiple times a week make my dog “toxic”? Can my dog with other health problems take this drug safely?
Palladia was approved for dogs with high-grade mast cell tumors in dogs over a decade ago. But since then, veterinary oncologists have started using it in many solid tumor types. They’ve also tweaked the doses to lessen the risk of side effects.
Veterinary oncologist Dr. Megan Duffy joins us for an in-depth look at this “kind of weird, exciting drug.” She explains a little about how it works, when it is used, and answers ALL the questions that came up in our Facebook Dog Cancer Support Group about this drug.
If your veterinarian wants to start your dog on Palladia, and you’re wondering why … this is a must-watch video for you because Dr. Duffy has advice about how to know if Palladia might help YOUR dog’s case.
Join our Facebook support group at dogcancer.com/support
Call [phone] to leave a question on our Listener Line for a future show!
Related Videos:
Our first show on Palladia many years ago: • Palladia the New Cance...
Chemotherapy for Dogs Demystified: • Chemotherapy for Dogs ...
A wonderful show about how Regular Veterinarians Can Offer Chemotherapy: • Can Regular Vets Do Ch...
Related Links:
Our DogCancer.com article on Palladia: www.dogcancer.com/articles/dr...
Our DogCancer.com article about whether chemotherapy for dogs is worth doing: www.dogcancer.com/articles/dr...
Dr. Duffy mentioned using Palladia at the same time as metronomic chemotherapy. Here’s our DogCancer.com article about that: www.dogcancer.com/articles/di...
Chapters:
00:00 Welcome to Dog Cancer Answers
01:20 Palladia’s Effectiveness for Uncommon Tumor Types in Dogs
02:13 Palladia is labeled for mast cell tumors, but it can also be used in carcinomas, endocrine tumors … and even in cats!
02:52 Why choose Palladia for “weird” tumors that don’t have standard treatment options.
03:30 Is Palladia a chemotherapy drug? Not technically. It’s an antiangiogenic anti-cancer drug.
04:48 Palladia is taken at home, which opens up cancer treatment to more patients.
05:52 Common dosing schedules for Palladia for dogs: Monday, Wednesday, Friday.
06:25 How long dogs stay on Palladia - the million dollar question!
07:38 How much does Palladia cost? It depends upon several factors.
08:40 Does Palladia cure cancer in dogs?
09:25 Does Palladia help with metastasis after surgery?
09:59 When Palladia is used “off-label” how do veterinary oncologists know to use it?
11:48 Palladia’s a pioneering targeted anti-cancer drug. Is it being used in anything other than cancer cases?
12:20 Dr. Megan Duffy provides medical review for DogCancer.com, better information today, for no regrets tomorrow, where you can do your own research safely.
14:43 How to give Palladia at home: with food? Gloved?
16:18 Handling Palladia Safely: Precautions for toxicity and rapidly dividing cells in pregnant women and children.
17:32 Cleaning up poop and pee when your dog is on Palladia.
19:25 Is it safe to play with and cuddle your dog when they’re on Palladia?
19:54 Is it safe to let your dog on Palladia lick you?
21:00 How often do you see your veterinarian while using Palladia? What tests do veterinarians use to monitor health with Palladia use?
22:56 What are common Palladia side effects, and how soon do they start?
23:52 Using Palladia for two weeks before committing to long-term use.
24:14 What percentage of dogs aren’t compatible with Palladia?
24:40 Lack of appetite, vomiting, and diarrhea in 20% of dogs on Palladia and how to help them.
26:15 How do I assess if my dog is a good fit for Palladia?
26:45 The history of dosing for Palladia, including the original labeled maximum tolerated and current biologically effective doses.
28:30 How the small community of veterinary oncologists talk to each other to reach a consensus.
30:08 Do the side effects stop if my dog stops taking Palladia?
37:46 Questions should I ask my veterinarian about Palladia?
38:52 Dr. Duffy’s predictions about take-home anti-cancer medications for dog cancer.
40:20 Dr. Duffy discusses companies that sequence genomes for dog cancer tumors.
41:48 Dr. Duffy’s parting thoughts on Palladia.
42:14 James Jacobson’s parting words.
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Get to know Megan Duffy, DVM, ACVIM (Oncology): www.dogcancer.com/people/mega...
For more details, articles, podcast episodes, and quality education, go to the episode page: www.dogcancer.com/podcast/

[@Ronnie-qd3xd]

My pit mix has an inoperable adrenal gland tumor. She was diagnosed at 8 yrs. She started Palladia and was on it for quite some time but then the side effects (diarrhea, stmoxh problems became too much and was effecting her quality of life so we stopped it. She is now 11 yrs old and although the tumor grew after stopping it she is still with us!

[@DogCancer]

Thank you so much for sharing your experience, and we're so glad to hear your girl is still with you!

[@tomcourtney8104]

Excellent podcast. My dog Toby (8yrs chocolate Labrador) had a high grade MCT removed August 2022 with evidence of some splenic and liver involvement. Commenced Palladia September 2022. Tolerated it pretty well and continues to take it after a break for a few months. Cancer currently in remission. Great drug administered in my case by a super team of oncologists in UCD Veterinary Hospital, Dublin, Ireland.

[@DogCancer]

Thank you for sharing, and that's such wonderful news!

[@shannafloyd3998]

We use Palladia for 2 different dogs. One has an inoperable thyroid tumor. He has been on Palladia for about 6-7 months now. The mass has shrunk over 3 cm, which is amazing. Our other dog has an inoperable heart mass (chemodectoma). He has been on Palladia for about 3 months now. We had our follow-up echo today, and we are happy to say that his mass has shrunk a small amount! We are so thankful for our oncology team and Palladia!

[@SenatusWealth]

Excellent video. Does anyone have any cat stories to share on Palladia? Patches our cat has carcinomatosis.

[@sarahjackson7271]

My dog isn't tolerating Palladia, but we tried and are choosing to let her live with the disease now. She had very bad gastric issues and her quality of life wasn't good. 9kilo (35mg dose 3days per week and Omeprazole) I'm glad we tried and we have to live with our discission. Thank you for the video. We still would recommend trying.

[@DogCancer]

Thank you so much for your share, and we're so glad your girl is still with you.

[@maureencash7587]

My dog Jake was diagnosed with Oral Squamous Cell Carcinoma. Surgeon after biopsy sent him home to die. Didn't listen and opted to go to the oncologist. He has been on palladia and piroxicam. He started on January 12 and is doing great. Tumor is gone, lung nodule is gone. Not bad side effects. His appetite is again veracious. We give him Cerenia on palladia nights and pepcid on the piroxicam nights just in case. He has other health issues but he has been doing awesome - and we are staying the course. It really is a miracle for him.

[@CALIFORNIATEXTILEGROUP]

Thank you - Roseanne also has squamous cell carcinoma and will start Palladia tomorrow - I am scared to start but reading your comment is reassuring. Thanks

[@Trish_PNW]

Thank you for this timely video! My vet oncologist recommended we start it as treatment for TCC and an adrenal/lymph node tumor in hopes it will treat both. Trying to absorb all the info I can!

[@DogCancer]

So happy to have helped even just a little bit. Using Palladia in a case like your dog's makes a lot of sense, because it's going to possibly help limit the growth and spread of BOTH! Best of luck to you and your pup -- meanwhile, here's our article on TCC: www.dogcancer.com/articles/types-of-dog-cancer/bladder-cancer-in-dogs-including-transitional-cell-carcinoma/

[@maryannehatch3564]

We’ve just had a very extreme reaction to chemo (doxorubicin) and I am looking for this type of alternative. How do we try to see if this is a possibility and how do we access this?

[@aaricamo]

Thank you for the video! Great information needed to ease my mind a little. My dog has been on Palladia and prednisone for a little over two weeks and I’m trying to figure out a homemade diet. We’ve made the switch but not sure she’s getting in every nutrient that is vital. There isn’t a animal dietitian in my area that our veterinarian can refer us to. I guess my only worry if that I’m not giving her all the nutrients she needs. What can we supplement with this drug or is there anything we should avoid? Can I give milk thistle and medicinal mushrooms?

[@DogCancer]

Here's our article on Palladia that goes over the meds to avoid. Check with your veterinarian for your dog specifically though! www.dogcancer.com/articles/drugs/palladia-for-dogs/ For a multivitamin, a lot of us use EverPup, it's a great multi plus more. And here's our articles on milk thistle and medicinal mushrooms, both of which usually can be given with Palladia, however, it's always best to check with your veterinarian, of course: www.dogcancer.com/articles/supplements/medicinal-mushrooms-for-dogs/ www.dogcancer.com/articles/supplements/milk-thistle-for-dogs/

[@thebizydogvlog5409]

So my dog has Renal Lymphoma. We took out the kidney, no signs of metastasis.... So would this be an option for her even though she has lymphoma to help prevent other pop up tumors (presumably?)

[@DogCancer]

Check with your veterinarian or oncologist -- it's not necessarily going to help with systematic cancers like lymphoma, but if they are only occurring in an organ ... maybe?

[@thebizydogvlog5409]

@@DogCancer thank you! There is only one oncologist in the whole city of 510,000 people currently so my veterinarian and I are trying to figure this out. Thanks again!

[@user-pe5im7el6r]

Can this be used for lymphoma?

[@DogCancer]

This drug is typically used in solid tumors, so not typically with lymphoma. But ask your veterinarian about it. Here's our article on it: www.dogcancer.com/articles/drugs/palladia-for-dogs/

[@user-pe5im7el6r]

Can this be used for Uk

[@DogCancer]

We believe that it is available in the UK, yes -- ask your veterinarian!

[@garimamatta716]

what is the appropriate dose for a 40 kg dog

[@DogCancer]

Hi! Dosing is always based on weight generally, but other factors will influence what dose your veterinarian recommends to start. Depending upon how your dog tolerates the drug, that might be increased or decreased over the course of taking it. Here's our article with the details: www.dogcancer.com/articles/drugs/palladia-for-dogs/

[@melissabuckholtz6888]

Has anyone tried using this drug for hepatocellular carcinoma (liver mass)? My 10 yo Irish Setter has had 3 removed so far, and now he has a fourth. We do not want to subject him to another surgery… 😢

[@DogCancer]

Definitely ask your oncologist about this. According to Dr. Duffy, it's being used on many solid tumors, even ones that you wouldn't immediately think of.