Parkinson's Disease:- "What if I discovered the Silver Bullet?" by Dr. Jonathan Sackner-Bernstein

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Motivated by a friend’s suffering from Parkinson’s, Dr. Sackner-Bernstein focused on a gap in our understanding of the disease: no one had so far measured the amount of dopamine in the dopaminergic neurons of people with Parkinson’s. This is critically important because he believes dopamine is toxic to these cells, which would then be a driver of neuron dysfunction and death, leading to disease progression.
He published his analysis last summer in the Journal of Parkinson’s disease showing that these critical neurons do not lack dopamine - they have excess dopamine. This led him to design a clinical trial to test a drug that addresses this newly defined mechanism of disease.
About Jonathan:-
Dr. Jonathan Sackner-Bernstein was a renowned clinical trialist in cardiology before leaving academics to pursue medical product development, including drug, device, and biologic therapeutics.
He served as associate director of the FDA’s device center, where he led diverse programs highlighted by the White House’s first Entrepreneurs-in-Residence program, the Center’s innovation initiative that led to the Breakthrough Devices program and a collaboration between FDA and DARPA to develop systems and products for the Medical Countermeasures Program (focused on responses to chemical, biologic and radiologic mass casualty events).
After serving at the FDA, Jonathan consulted for DARPA, with responsibilities including regulatory strategy and commercial transition of their programs/projects. Jonathan supported the launch of DARPA’s Biological Technologies Office, with a primary focus on neuroscience and big data programs.
Jonathan’s academic experience ranges from First-in-Human to international trials, as a clinical investigator and trial leader. Sackner-Bernstein held academic appointments in cardiology at Columbia University and North Shore LIJ Health System (Northwell) following training at Mount Sinai Medical Center. He earned his undergraduate degree in electrical engineering at the University of Pennsylvania.
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[@johnmurphy116]

Regardless of the validity of the argument, it is very reassuring to see a scientist being so careful. He knows he could be wrong, and is prepared to admit it. The biggest curse of modern life, is having people who are absolutely convinced they are right to the extent they would jail those who disagree with them.

[@waynemarkman]

Super interesting, out of the box thinking, goes against the tide, brave, refreshing, controversial!

[@valeriechambers5509]

Makes logical sense that less of something is more beneficial I hope you keep on going with this and well done so far

[@jackienolan9859]

I see this was recorded over a year ago. . .wondering where the progress stands? It's been about a year since I've been diagnosed at 56 yrs old with Parkinson's. Levodopa working well for me but I am trying to reduce dosage while this question of levodopa being ultimately toxic. . .Would love to know more about this and would consider being part of a study. . .Are there any trials going on now?

[@katbartley5658]

I'm interested in learning more about this. I have severe dyskinesia. What you are hypothesising makes sense to me. I'd like to follow your success. Thank you for your research.

[@lindascanlan6317]

I think he's really on to something.

[@lindascanlan6317]

My hunch is you're on to something groundbreaking...keep going....!

[@richardevans2739]

Fantastic to think that someone is thinking out of the box as it were, I have PD and I'm determined to get over it in good time. I found a few years ago my neurologist was just adding on more of the same - whether it was an agonist / or madopar whatever it was I wasn't getting any better, so I decided to cut down on treatment to the stage I've recently gone off everything. I feel no worse for doing this. I've now got ( very recently ) a CUE 1 device which is helping me walk better already, so I'm sure I'm on the right path. I wish this doctor every success in his trials - how can we keep up with his progress?

[@teacherslearn]

I fully understand why someone asked what dopamine toxicity looks like in a healthy person. The diagnosis is never 100%. And often we are told that if we take L dopa for a few months and it doesn't help, then we might know it's NOT PD. So you dodged that question, and that's a shame. You didn't answer what the toxicity looks like at all. This is such good and hopeful info, and when you dodge such a simple question, you call into question your credibility. And that is sad.

[@ziontours5893]

It's a pity that Michel didn't jog him to answer the question. Since L-dopa doesn't have any effect on my PD, despite taking it firstly in the form of Stalevo and now Dopicar, I was also disappointed that he didn't answer the question about refraining from taking L-dopa, but more importantly would like to know where he stands today with his research because it would be great to have some medication which could alleviate the imbalance and Brady-kinesia, etc.

[@lindascanlan6317]

Your questions are riveting...

[@lindascanlan6317]

Go ask Bill Gates who has PD and $10 mil in his petty cash drawer...please continue with this research. ..Enzymes are the key!

[@MrManidos]

The research takes a lot of time and it should be sped up. I mean, it's possible -- just look at what happened with covid vaccines. Anyway, what a regular person can do to accelerate research/development in this area? We need a practical guide so that anyone can contribute. Millions of people are fighting PD and this channel has only 1.6K subscribers. Something is not right. What would be the most effective way to spend a dollar to advance this cause?

[@user-ds8uu5dx5b]

After watching the video I was reading an article on how to lower your dopamine. It has some of the same advice my Neurologist gave. Avoid stress and caffeine and try to get a good night's sleep. I think your on to something.

[@louthomas4524]

The presenter argues that Parkinson's is not a disease of dopamine deficiency, based on the observation that the amount of dopamine inside individual dopamine neurons is higher in Parkinson's patients. But this overlooks the fact that the total number of dopamine neurons in a Parkinsonian brain is reduced to, initially, about half of normal levels at the time of diagnosis, and continues to decline from there. So, although it has multiple causes, Parkinson's *is* most definitely a disease that *involves* dopamine deficiency. Because even if the remaining individual dopamine neurons have on average more dopamine in them, there are a lot *fewer* such neurons, and so there is a lot less dopamine overall. So the above seems like a fundamental error is this presentation. The conclusion that Parkinson's patients need less dopamine, not more dopamine, is based on the above false reasoning. It seems clear to me that Parkinson's patients have too little dopamine, and that any therapy intended to reduce dopamine would be counterproductive for Parkinson's patients. Another important problem with this presentation is that it assumes that since dopamine can be a source of oxidative stress for dopamine neurons, thus contributing to their downfall, that it is dopamine that is *mainly* responsible for the continuing death of dopamine neurons that drives Parkinson's progression. But in fact the main driver of the death of dopamine neurons in Parkinson's is attacks on dopamine neurons by the immune system. Aggregated alpha-synuclein develops inside dopamine neurons, and these neurons also contain much higher amounts of neuromelanin (a major stimulator of immune system activity) than any other neurons in the brain. So as dopamine neurons are damaged and die, they release neuromelanin and aggregated alpha-synuclein, and these substances function as Damage Associated Molecular Patterns (DAMPs) which stimulate innate immune cells (microglia) to generate cytokines that attack additional "bystander" dopamine neurons, causing them to die in a never-ending inflammatory furnace. This inflammatory feedback loop is the main process that fuels Parkinson's progression, so far as motor symptoms are concerned. Excess dopamine in individual neurons is at most a minor contributing factor. So these are the two main errors in this presentation in my very humble opinion (I have no medical background, but have studied these processes on my own to help an ailing person in my household). I'd be delighted and interested to hear a response from the posters of this video regarding the above objections.

[@YesPlease1]

Thank you for writing such a detailed and thoughtful comment. Your PwP is lucky to have someone like you so dedicated to understanding the condition so that they can have the best possible outcome. Based on your research, what are you finding are the treatment options with the most promise? My research so far has me thinking that 1) high dose Thiamine HCL and 2) Photobiomodulation (PMB) aka red and near-infrared light therapy are two of the most promising modalities. But I'm open to exploring more avenues.

[@cherylmcduff5388]

@@YesPlease1 I have read many good papers on Thiamine. It helps a lot of people

[@realcapitalist1462]

"But this overlooks the fact that the total number of dopamine neurons in a Parkinsonian brain is reduced to, initially, about half of normal levels at the time of diagnosis, and continues to decline from there." Could not the root cause of the initial reduction be the excess dopamine in the neurons that have died? When I read Mr Sackner-Bernstein my initial reaction was he will run into resistance from the established orthodoxy who, let's face it, won't appreciate a cardiologist questioning their decades long research. But as a computer engineer I do appreciate lateral thinking in problem solving. What I am struggling with is any evidence of progress with the trials proposed by Mr Sackner-Bernstein. Said trials will ultimately prove/disprove the theory!

[@youssefgmail7]

In any case, whatever has been done till now by the medical establishment resulted in ZERO succes! Levodopa does NOT stop progression and does NOT cure. So the whole theory as you are presenting hasn't lead to anything in 50 years. This man in the video at least thinks out of the box.

[@sutirtha86]

​@nosilverbullet4pd998 is it possible any longer to get a response from the speaker on this very interesting counter to his theory about dopamine excess causing neuronal death?

[@Rosie_Apple_Delight]

Dr. Sackner Bernstein, increasing choline during your trial could reduce the need for CL. It is perplexing that increasing Acetyl choline reduces PD symptoms but it does. Dr. Laurie Mischley discusses this. Regarding the Neuroprotective ability of Rasagaline, I no longer believe it is. But it does reduce oxidative stress so it is that which might have made it seem to be Neuroprotective

[@Rosie_Apple_Delight]

A few questions as I’m re-listening to this. Instead of targeting the dopamine neurons that already have too much dopamine in them, would addressing the underlying process that causes this to occur be an option? Would removing the cause of the excess dopamine in the neurons stop the the pressure, on the neurons to to take in more dopamine and relieve the sufferer of this in a gentler way? If the cause of the excess dopamine in the neurons is unclear, then the sufferer of this will need this med indefinitely, correct? Could the excess dopamine in the neurons be at least in part due to Excitotoxicity?

[@robert9248]

So why is the an excess of intracellular dopamine? Aren’t dopamine molecules encapsulated or did I miss that and should watch it again? If something is breaking down the encapsulation process, should work be done on that?

[@MrPiano2000]

How to contact you to participate in the trial, if you are still recruiting the candidates for your 2nd trial?

[@nosilverbullet4pd998]

drop us an email at [e-mail] and we will forward to Dr. Sackner-Bernstein

[@barbaranytko9692]

For those presenting information, please make sure your volume is turned up or try to speak up louder. Thank you.

[@nosilverbullet4pd998]

Noted

[@Andy-se4sl]

so its the metabolites of dopamine that are toxic rather than the dopamine itself?? so would inhibiting breakdown... for example by inhibiting MAOA and B with tyrsol (olive oil/rhodiola) mitigate the toxic effect??

[@brettamberson5352]

Are lacking dopamine or the benefits of dopamine effects only

[@Gundog55]

I was diagnosed with PD two years ago but probably had it for five years prior. I started on an exercise program that took me from stage 2 back to stage 1. This included a 29lbs weight loss through diet and exercise. I saw a lecture where the neurologist recommended taking L-Tyrosine and have been taking it for several months. I’d be Interested in your opinion on taking this supplement for PD since you mention it in your lecture.

[@cherylmcduff5388]

Have you looked into Thiamine?? Great results for some people

[@Gundog55]

@@cherylmcduff5388 Funny that you mentioned that, I have just started looking into B1 because I noticed that the current B complex I take doesn’t have it included.

[@clint4004]

Creatine is supposed to help mitochondria produce more energy and if you do any exercise it should add some strength. Even a protein supplement or pre workout with some should be plenty..

[@Gundog55]

@@clint4004 I take creatine too

[@keitymarley733]

Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine from Dr Madida that truly works that helped treat, cure and reversed all his symptoms. My Dad is well again🎉🎉 🎉

[@trishkparker]

This was pretty interesting. I can never understand the host. Talking with an accent so fast. Please slow down and enunciate.

[@TW-il4vy]

He sounds French. caption helps!

[@SouLightness]

Yet again i sometimes dont understand someone from some usa states with strong accents..

[@ronroesler7555]

Does anyone know of a Parkinson’s suffer among those populations who are primarily carnivore such as populations in the Arctic? Has anyone been able to reverse symptoms by using fasting and or eliminating plant products? I have experienced the elimination of symptoms.

[@MrJohnnyrskiwi]

Afaik no one has had proven reversal of the underlying disease. Do you mean your symptoms have been alleviated?

[@i-bux]

There are people who overcame PD: check out Howard Shifke”s book and blog.

[@ronroesler7555]

Up until my 2019 experience, I believed the old party line of “You can’t get rid of Parkinson’s”. Turns out, if you don’t have symptoms, you don’t have Parkinson’s. I don’t mind people telling me I still have Parkinson’s IF I don’t have to continue suffering the symptoms and having to take those horrible drugs.

[@MrJohnnyrskiwi]

@@ronroesler7555 have any neurologists studied you before & after?

[@ronroesler7555]

Mr Boyle, I had the traditional neurologist from diagnosis through her weening me off the meds after I no longer had symptoms. I do have all my medical records. I did the fast to try to stay off dialysis because of failing kidneys. At my 90 day check up (after the 62 day fast) with my nephrologist, he told me I had improved my kidney function over 50% and was good to go. During the later part of the fast and for 30-60 days into the OMD carnivore diet, my Parkinson’s symptoms seemed to melt away. My neurologist agreed that I no longer needed the meds. I was asked not to come back to PD exercise therapy because the disappearance of my symptoms was causing too many PD patients to question what I had done. Their curiosity caused some to doubt their traditional “treatments”. Since the whole therapy program was funded by Big Pharma, they couldn’t have someone demonstrating another approach to the whole Parkinson’s protocol. My neurologist could not explain my experience, but agreed that if I didn’t exhibit any symptoms, I did not need to continue the drugs so she weened me off over a month. I asked a different neurologist to check me out after about 18 months, and he could not diagnose me with Parkinson’s at all and said he wasn’t interested in my case. Dr Phillips, NZ, is the only neurologist I’ve found who has expressed any interest in my case. Neither have I found another Parkinson’s sufferer who has tried what I did or is willing to try anything close to what I did. Most are reluctant to try because all they’ve ever heard is nothing can be done to prevent or reverse PD except taking drugs. I’ll soon be 77 and am frustrated reading and listening to so many suffering with this and other neurological diseases, but are completely unwilling to consider doing something that has little if any downside, relatively quick/easy and is free. Please understand that I didn’t do the fast, or take plant products out of my diet, to eliminate my Parkinson’s, but I’m sure not going to complain that it happened. I am currently in my second experiment to see if I can repeat the results for the third time. So far so good. Thanks for your time. Good luck to you. Ron Roesler

[@fliss362]

Now at Dec 22. Any progress with funding?

[@nosilverbullet4pd998]

An update is coming in Jan

[@sutirtha86]

​@@nosilverbullet4pd998 is there another related update on this topic on this channel yet?

[@Mike-hr6jz]

B1 high doses, changes everything

[@rschennai6997]

i have PD but take medicines that make me sleepy I just get along.