Pharmacology - ANTIDEPRESSANTS - SSRIs, SNRIs, TCAs, MAOIs, Lithium ( MADE EASY)

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Antidepressants are drugs used for the treatment of major depressive disorders as well as other conditions including anxiety disorders, obsessive compulsive disorders (OCD), eating disorders, insomnia, post-traumatic stress disorder and some chronic pain. Most antidepressants act by increasing the synaptic availability of serotonin, norepinephrine, or dopamine. This pharmacology lecture covers topics such as monoamine hypothesis of depression, bipolar disorder, role of serotonin, norepinephrine, dopamine, monoamine receptors, mechanism of action of antidepressants; selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), atypical antidepressants, and Lithium. Antidepressants mentioned include: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Maprotiline, Nortriptyline, Protriptyline, Isocarboxazid, Phenelzine, Tranylcypromine, Selegiline, Bupropion, Mirtazapine, Trazodone, Nefazodone, Vilazodone, and Vortioxetine.
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00:00 Monoamine Hypothesis
1:55 Overview
2:36 Serotonergic & Noradrenergic neurons
4:40 SSRIs
7:05 SNRIs
8:30 TCAs
10:52 MAOIs
13:44 Atypical Antidepressants
16:07 Lithium

[@SpeedPharmacology]

🚀 Elevate Your Pharm Game! 📚 Join Patreon for A+ Study Notes! 👉 www.patreon.com/speedpharmacology 👈

[@KrazeeMee]

Everything before Lithium: What you learn in class Lithium: The test

[@viralload7086]

award winning comment

[@lightbeingpontifex]

What does lithium do,,

[@Adaughtersheart-Isa53]

hahhaha, truth!

[@boomerbutler7569]

Pharmacology (made easy) (except the Lithium part)

[@bibidd98]

Im sick rn and have a pharmacology exam on Friday, so this helps a lot! 😊 Update: turned out to be covid, got into hospital, still managed to pass the exam😇 (it was online)

[@amohamoud3992]

omg this is me right now :( praying this sticks for my exam! it's online so i can't even reschedule d/t being sick

[@adcppk9884]

И аз утре имам изпит по фармак. хаха.

[@bibidd98]

@@adcppk9884 Успех!!!

[@adcppk9884]

@@bibidd98 Благодаря

[@malavpatel8142]

Hey

[@DanielSRosehill]

As a layman/patient/somebody simply taking one of these drugs, I found this explanation to be extremely useful and understandable and really spelled out the differences in mechanism of action between the successive classes of antidepressant drugs. I firmly believe that being able to explain something complicated to a non-expert audience is the hallmark of good teaching!

[@danielbecker2309]

word!

[@META4Music]

As a pre-pharmacy student i find it extremely useful as well. He certainly is an exceptional educator!

[@HamzaAfridi999]

@@META4Music lol it’s not that easy! This is just an overview!

[@marcinkene]

Wonderful lesson! Thank you! 10 minutes and memories of Stahl's psychopharmacology is waking up in my brain. Been studying it during my training 5 years ago. Impossible to imagine better explanation!

[@luu4448]

That sad banana spoke to me on a deep level.

[@stefannr1302]

Blessed are the poor in spirit, for theirs is the kingdom of heaven. Blessed are those who mourn, for they will be comforted. Blessed are the meek, for they will inherit the earth. Blessed are those who hunger and thirst for righteousness, for they will be filled. Blessed are the merciful, for they will be shown mercy. Blessed are the pure in heart, for they will see God.Blessed are the peacemakers, for they will be called children of God. Blessed are those who are persecuted because of righteousness, for theirs is the kingdom of heaven

[@mindofakiller5990]

ahahahaha

[@ChodeMaster]

@@stefannr1302 nutjob

[@panedole]

Just wonderful, I have been researching "all natural depression treatments" for a while now, and I think this has helped. Have you heard people talk about - Hanincoln Nanlivia Framework - (do a google search ) ? Ive heard some pretty good things about it and my buddy got cool results with it.

[@Neurosociologist]

You are hilarious!

[@TeresaDupuis]

Thanks for explaining these beyond how they function, and explaining the pros and cons with the visual example.

[@burn1672]

Everyone gangsta 'till the Lithium starts droppin'.

[@Alfemist]

This should be the top comment.

[@samstits8982]

I don’t get it lol

[@priyankakashyap6087]

kzbin.info/www/bejne/gHjMqZmdnNR7grM

[@safa982]

@@samstits8982 me too

[@josephmapuor3998]

@@safa982 and @Sam Stits It means everything was easy to understand until Lithium which was hard to understand lol.

[@sigurdsnokle4549]

As a molecular biology student who is currently suffering from GAD and depression, this video was helpful. It was nice knowing exactly why SSRI take some time working

[@fearNaiomii]

1:00- Monoamine Hypothesis 1:55- Pharm Overview 2:36- Neurons Review 4:28- Mentions MAO 4:45- SSRIs 7:05- SNRIs 8:30- TCAs 10:51- MAOIs 13:44- Atypical Antidepressants 16:07- Lithium

[@twoleftfeet9626]

Helpful, thankyou

[@breesechick]

Thanks

[@rahemiin7]

Perfect... someone Pin this post on Top!

[@thisumamarasinghe8171]

Thanks

[@Uzourob]

Thanks

[@Dr.Shubhangijain]

M a medical student preparing for entrance exams and This was really helpful. Thank you for going through all the background studying and distilling of this complex topic.. And make it more palatable. Kudos! U have attained one more subscriber.

[@spiggs2182]

I believe you have one of the best channels on KZbin. Thank you for all your hard work. Amazing job.

[@emmab.3567]

AMAZING! Simply OUTSTANDING. You knocked out Psychopharm! Spot-on, simplified, engaging - even a 5th grader can understand it. Who are you? I would love to support this channel. Keep up the good work.

[@christinao7533]

this channel is literally saving me with pharmacology, sooo helpful :) thank you!!

[@choy1217]

Thanks for such an informative video! I was curious about SSRIs, and now I think I partly understood how they works for me :)

[@enzyme20056]

This video is quite excellent in summarising such a complex field of mood disorders and the different treatments. I predict that atypical antidepressants will become the dominant “class” of medicine marketed. There are just so many different molecules that seem to have some positive effect on mood. What class people respond to is still a lottery; even if geneotyping becomes involved in predicting the probability of success to one drug over another.

[@sigmundfreud5592]

This is a tremendous blessing..it's so easy

[@michelecatarinella1208]

I have been struggling to have it right in my head all the time, this video makes it so clear.... Thanks a lot

[@mobiusstripper7279]

This is very useful for me. I needed some help to understand and navigate the seemingly scary world of antidepressants, so thank you.

[@soulfuzz368]

We are so good at treating symptoms and so bad at understanding why we have these problems in the first place.

[@vikidavis876]

Mine is strongly genetic. So glad my dr knew this and didnt make me suffer through years of phsicotherapy. I was the first woman in my family line to receive help to live a normal life. Those before mt were tortured in mental hospitals. My mother was just a shell of herself after months of archaic treatments when I was eight years old. I'm so grateful for my treatment path. I got mentally I'll at age 27 just like all of my ancestors and was treated and able to have a wonderful marriage raise to boys and have grands and great grands. I did have to change drugs about every 7 to 10 yrs . That wasn't pleasant but better than the alternative.

[@kmosher8]

its all done on purpose, pharma is a billion dollar business and have corrupt governement officials on their payroll. being the most powerful country in the world we have so many smart people. they know that curing disease is a loosing business. they surpress natural medicine and dont approve treatmnets that they know will help people and they no longer have their business. make drugs that keep people from getting better and add side effects to make them worse and on more drugs.

[@arajo5773]

Research will get there one day. Some are due to genetics and some early childhood experiences.

[@clausmehl8731]

@@kmosher8 if there is a God he must be a ignorant asshole, us will be gods own country. Its money owns country

[@sabahnazer5349]

Try ayurvedic treatments They do treat diseases from the root..

[@eget4144]

Teacher: What did you learn? ME: I cant remember clearly but it was something to do with femur, tibia and knee joint

[@MrStoffzor]

He even included the kneecap!

[@ayubenlightenment5690]

Me too, I can't remember anything since I have been on escitalopram. If anybody knows any alternative please let me know

[@klaudiobrozi6325]

@@ayubenlightenment5690 I used escitalopram for 6 month. It's been 5 month sience i stopped using this medicine, and now i can't concentrate and can't remember nothing. Today I cut my hair an hour ago, and for a few moments I thought I cut it yesterday. It was very strange. The psychiatrist told me that i should have accompanied escitalopram with brain vitamins. Tomorrow I will go buy some vitamins and hopefully I will regain my memory. Did you you took vitamins?

[@ayubenlightenment5690]

Klaudio Brozi never took vitamin for brain

[@101AMBear]

I like knowing the science behind this.

[@rebiegriffith7464]

loved this video- currently in mental health rotation and this will help me to remember my meds for exams :*)

[@keziahgift471]

Straight to the point! U the best thing that has happened to my pharmacology 😘😘

[@stefannr1302]

Blessed are the poor in spirit, for theirs is the kingdom of heaven. Blessed are those who mourn, for they will be comforted. Blessed are the meek, for they will inherit the earth. Blessed are those who hunger and thirst for righteousness, for they will be filled. Blessed are the merciful, for they will be shown mercy. Blessed are the pure in heart, for they will see God. Blessed are the peacemakers, for they will be called children of God. Blessed are those who are persecuted because of righteousness, for theirs is the kingdom of heaven

[@knightlykin1499]

I've always wandered, what would happen if instead of spending $600 billion a year on our defense budget, we spent $600 billion a year on medical research and development. One can only dream.

[@gregorymalchuk272]

We need more research for stem cell research to regrow penises for circimcised men.

[@gregorymalchuk272]

@Eat Our Babies The punishment should be hanging.

[@tadams1969]

We'd quickly be overwhelmed by our enemies comrade.

[@LolLol-zp4jy]

Protector 95 the one country that protects the world from dystopia would crumble under foreign influence and the money to pay for $600 billion would not exist and it would go to the communist government of america for their own interests

[@ob1934]

@Eat Our Babies lol doctors don't decide if kids are circumcised, the parents do. Instead of making a scapegoat (Jews) blame the parents

[@paulowen3271]

Tomorrow my medication will change from citalopram to effexor. This video has been extremely helpful and has also made a very confusing Illness somewhat easier to understand. Thank you

[@usulgekte2]

thank you so much for posting! My teacher keeps saying i don't have to know how these medicines work but i do need to know the side effects. Because of this video i can finally relate the drug to the side effects.

[@bhblueberry]

Thank you for this material, it puts everything in place :)

[@aiamanshahzad3952]

I just want to say thanks. For making these videos. I got first poisition in pharma term tests because of you. Can you please make the cardiovascular pharmacology videos like soon plz. Xoxo 😍😍

[@pezdemonte708]

here are several ideas you can try Find the reasons why you suffer from depression - the first step in solving an issue is understanding why you have it. Be at ease with yourself - this makes it easier Challenge yourself - you will feel better by doing things - especially by doing things that push your limits. (I read these and more tips on Martos Magic Method site )

[@TheEnigma7111]

huh?????????????????????????????

[@TrinhTran-wn2iy]

here's several suggestions you can try Work out why you are shy - the first step in solving a problem is understanding why it is there. Be comfortable with yourself - this makes it less difficult Just do it - you will feel better by taking action - especially by doing activities which stretch your boundaries. (I read these and more tips on Martos Magic Method website )

[@rem2510]

interesting points ,if anyone else wants to uncover treating depression try Elumpa Cure Depression Alchemist ( search on google ) ? Ive heard some interesting things about it and my colleague got great success with it.

[@ygatesatellite4964]

I have spent months investigating treating depression at home and discovered a great resource at Sebs shy remedy (look it up on google)

[@RockerProf]

Thank you for making this video. By the way, serotonin is serOtonin. And the primary site of action of monoamine oxidase is in the synapse, not inside the neuron axon.

[@geovanadaniel1906]

Thank you for the amazing video!! This channel is the best, it saved my classes!

[@TheApprentice007]

This video is incredible. I showed some people who were too scared to try them, and they've now been on them for a while and doing great.

[@adamjohnson4975]

TheApprentice007 everyone I know who took these went insane

[@tp6535]

Nailed it. That was awesome, I just had a boost of serotonin with the video.

[@b_rabbit435]

@@OreElect1 oh shut up with your copy pasta. I hope you get your account shut down for spreading lies

[@Diego-ll6ne]

@@OreElect1 please, show the references.

[@b_rabbit435]

@@OreElect1 Not seeing how that is relevant to what i just said. Keep on trying dumbass, and stop liking your own comments.

[@tuanz8009]

I used to have anxiety disorder. Ever since taking antidepressant medication I feels like I just came back to life

[@amazinggreatdanesbreeders6216]

If you're interested in getting some top quality pills and good xannax you can go get it from; pharmamedshop.com

[@aml2463]

Same here with depression

[@commonercoffeeaddict]

Have you experienced emotional numbing?

[@joydenferreras7728]

Whats medicine do you take?? Any tips?

[@commonercoffeeaddict]

@Σά ββας are you still taking them?

[@trenishasmith2080]

This made everything sooo clear !

[@sunilprajapati841]

A great way of making it comprehensive... Really thankful.

[@Mishel33020]

Thanks for breaking it down easy. I just didn't get it and with all the new medicaions names I need to learn my brain is mush.

[@Vid594]

Great video, super helpful for my psych studies!

[@parnate6382]

I would second-guess textbook explanations regarding MAOIs. I have reviewed professional pharmacology textbooks on this point and none has shown any signs of having read any advances on this subject in the last 30 years. If they had, they would have discovered that not only do MAOIs increase serotonin levels to a greater degree than the newer SSRIs, but also that MAOIs are highly unlikely to cause dangerous Serotonin Syndrome by themselves unless taken with a Serotonin Reuptake Inhibitor, or to a lesser degree a serotonin releaser like MDMA. There's also nowadays very little danger of dangerous hypertension with MAOIs, as foods have practically no tyramine anymore.

[@GFCmedia666]

gaf?

[@lisarm100]

This was incredibly helpful! Thanks for the visuals! I’m a visual learner!

[@mistysworld_]

Very helpful!! Clear and informative! Thanks!!!

[@ItendshereXiii]

Thank you so much for such a great explanation for a hard topic 👍🏻👍🏻👍🏻👍🏻👍🏻

[@stefannr1302]

Blessed are the poor in spirit, for theirs is the kingdom of heaven. Blessed are those who mourn, for they will be comforted. Blessed are the meek, for they will inherit the earth.Blessed are those who hunger and thirst for righteousness, for they will be filled. Blessed are the merciful, for they will be shown mercy. Blessed are the pure in heart, for they will see God.Blessed are the peacemakers, for they will be called children of God. Blessed are those who are persecuted because of righteousness, for theirs is the kingdom of heaven.Zobraziť viacej

[@carriefawcett9990]

This video was so clear and informative, thank you! I'm on day 5 of lexapro ( escitalopram). I'm hoping I start to feel better in a few weeks. I've been depressed for a decade. I've had drowsiness, chills, nausea this week. And a severe panic attack on day 3 of this medication. I'm starting to feel better physically, but looking forward to feeling better mentally. I've been in low, foul mood for so long. 😞

[@Emma-rr2ll]

If you haven't already, I would recommend getting bloodwork done to make sure you don't have any thyroid issues or vitamin deficiencies that could be making the depression worse. I would also recommend asking your psychiatrist about genetic testing (like genesight) that can help you weed out the medications that may have worse side effects for you and can also tell you if you have a mutation in the mthfr gene (in which case you may need to take methylated b12 and L methylfolate) Also, don't take your medications with a drink containing citric acid. Only water or milk. The citric acid could make the meds less effective.

[@aljames7839]

Hang on in there because they normally take 2 to 6 weeks to feel better , you will feel your mood getting better, I've been on those for a while, I changed to mirtazipine, sertraline and now fluoxetine, anyway I hope you give them time to get into your system you will feel better

[@AliceP.]

I'm on day 5 of Reconter (which is escitalopram as well). I'm surprised that you had so many effects with Lexapro, I've been told it is more expensive because it brings milder side effects. Anyway, it's been 6 months... How are you? Do you still take it? Are you feeling better? :)

[@dr.house.md.3969]

Thanks for showing up on my feed.

[@META4Music]

Love this topic; I’m glad I found your channel. Keep up the fantastic work!

[@pawelsliwa6191]

Everything was clear then lithium popped up

[@Waelalshami]

and the real criminal behind all this was GSK-3 which thx to Lithium its inhibited

[@natsuki3526]

Exactly!

[@haroonpanezai6881]

😂

[@Riostunning]

true

[@jersonbestavillarn]

HAHAHHAA I FEEL YOU

[@royalvargas7777]

The side effects and dependency are two crucial variables. Think I’m gonna change my diet, start exercising more, counseling and most importantly rediscover my faith. Thank you for the education in this video. Extremely helpful! 😊

[@edenreid6341]

Hey I'll b in the same boat soon if u dont mind thanks for giving me a heads up in a way...

[@dinobussanich3017]

That is awesome, I'm gonna do the same.

[@DaFinkingOrk]

A form of one-on-one counseling that suits you has been great for me, just slow, slowly understanding things better and being far more able to control or accept or handle sudden issues without freaking out and feeling hopeless. But YRMV with all that stuff, it has to suit you (just like medications I guess, but more personal).

[@imarchello]

May Satan bless you.

[@spaceship2221]

@@dinobussanich3017 there's substitute you know

[@RM23459]

Great and easy way to understand this complex material. Great job. Thanks.

[@zeeshanmughal7622]

This’s a amazing video, i can’t believe you teach so clearly, gramercy ❤️😍

[@Amy_lase]

I love your videos! They are so helpful and I feel more prepared for my exams. Can you maybe please make a video about nitric oxid and how it affects the smooth muscles?

[@HafizahHoshni]

Awesomely informative and perfectly explained! Thank you so much! 😊😊 20/3/2019

[@rowaidaosama235]

شكرا لكم على هذه الفيديوهات القصيرة الأكثر من رائعه 💖❤ i love it

[@cat-xb3oc]

wonderful lesson. you make pharmacology much more understandable and memorable. please don't be afraid to give more details, since some of viewers are medical professionals or students. Thanks a lot

[@duser]

This video makes everything so much easier. But damn the uses and names are still so hard!

[@pj7919]

My Psych Doc has been practicing Forensic Psychiatry/Addiction Medicine since 1978. He won’t prescribe Lithium anymore, he said 90% of patients end up with Kidney/Thyroid problems down the road. It’s inevitable. 😔

[@ixiaorage]

P J it has the best evidence for mood stabilisation in the long term. Renal effects are eventually unavoidable, but that’s why it is monitored. Like many things, it’s a balance - without it you may experience a greater number of relapses and brittle illness, and thus worse quality of life

[@xDomglmao]

@@RobespierreThePoof There is hope

[@JL-jw1nn]

@@ixiaorage To you and all those who support these toxic methods to treat humans--Please- TAKE THE DRUG YOURSELF FIRST, FOR AT LEAST A YEAR. Thank you.

[@edenreid6341]

Idk if this might help but I'm grandmother has a kidney problem u dont mind me saying this I know what she needs is lemon water and apple cider vinegar uhm yea my grandmother wont mind me saying this hope this helps... yea laterz

[@kmosher8]

@@ixiaorage its junk science.safe alternatives are being supressed and the goverenment refuses to fund real reliable studies towards much more safer and effective treatments. its digusting theymanaged to convince millions of citizens to except the use of these drugs that have no cure and have deadly side effects and cause horrible conditions way worse the mental disorder. i refuse to accept that in 2020 there only remedy are drugs barely studied given to us by doctors that hardly have an idea about these drugs they push. pharma is a mass genocide on humanity.

[@asifalishah8502]

Really impressed...i usually look for speedy pharmacology when i search any pharma topic..

[@danasaurlicious]

Brill! Definitely helped me with understanding my lectures

[@chaeripie2422]

Hey everybody taking antidepressants! If the medication isn’t working for you, 1. talk to your doctor (psychiatrist) 2. Remember you aren’t depending on the antidepressants 3. If you believe that it works, it will work. Believe in it. Believe in yourself. You’ll get better! I promise. As long as you think you can get better you will. I’m here to talk to so if any of you are going through anything, reply to this comment. You’re anonymous and I am too. You’re safe. There’s always someone there.

[@alexgamerxny6906]

Just the fact you names FBI gives me hope

[@frankestrada357]

Im going thru it. :/

[@skye9181]

i got diagnosed with nearly severe depression and severe anxiety yesterday, and i feel so much worse knowing i have depression and anxiety now. i feel uncomfortable everywhere i go, and im never proud of myself for leaving the house :(

[@alexgamerxny6906]

skye eee exactly the same here I have every reason to be happy but I just feel empty I can never talk I don’t like being around people and I usually just stay in my room all the time

[@skye9181]

AlexGamer XnY omg- and u feel like you literally dont know what to do? it feels like ur kinda drowning. you lose focus on everything, you honestly font care anymore and cant even look after yourself, youve fully given up. i hope you recover ❤️

[@stevenhernandez6025]

Awesome video! This really helped me understand the processes and how each of them worked, if there's any chance that may you could link the source in future videos in the description, it would be super helpful! Besides that, I loved it :)

[@spaceship2221]

Rollandbruce01💢💥💢

[@spaceship2221]

On lπstagram..💥

[@karti8641]

Thanks. This was easy to understand and very helpful!!!

[@florial322]

Perfect, this video just pop in the right time

[@katerinarich9626]

Awesome :D Is there any way to get those pictures in PDF?

[@christinefilippelli2709]

Well done! THANKS for this creation. ( New Subscriber )

[@jianweichin7513]

Thank you so much for making this video!!!

[@breesechick]

Thanks for making it interesting to watch with the drawings.

[@ihague4568]

Most studies show that the serotonin transporter is actually (already) reduced in patients with MDD (medication free). This would argue against the idea that SSRIs are really normalizing that system. As mentioned, other theories, may be more likely relevant.

[@maxglendale]

Your videos are fantastic!!! Can you make some on Antihypertensives, Diruretics, Heart Failure, Hyperlipdemia?

[@samdot876]

kzbin.info/www/bejne/Y17XfGqJgJiDrqc anti anxiety drugs mnemonics

[@billybandyk0720]

This channel alrdy has such vids.

[@RP-ul2tf]

The best channel for pharm....😍🙏

[@montheramier1556]

Sir, i can't tell you how your videos are helpful!! my exam is after couple of days ,, & i got to review all PHRAMA chapters that i've studied during the year.. it's so boring job! but with the Appetizers 'Speed Pharma' it's so joyful i start with watching your videos first, and then jump to the chapters like a monster :D Thanks you & God bless you 🌷

[@rynojaffey1972]

MAOIs now diet-safe. No decarboxylating enzymes in foods anymore to create tyramine, meaning no tyramine to lead to high blood pressure. Food and nutrition journals have been doing these analyses for 20 years now.

[@WaqarAhmed-ec5xp]

your videos are great.. subscribed mate 👍👍 please do one on cardiovascular drugs..

[@honidaalnigai3288]

Thanks for every single second.

[@Anonymous00tttt]

There is another explanation for slower onset of action by these drugs. This explanation is quite logical. It says that these drugs tend to bind more avidly to the presynaptic receptors initally inhibiting neurotransmitter release. Only when these receptors get desensitized they start showing there effect. Kindly correct me if I'm wrong

[@enzyme20056]

It is a shame that selective reversible MAOIs like moclobemide (auroix) aren’t mentioned as an alternative to irreversible non selective MAOIs. Moclobemide is considered “weak”, but at the higher doses I got quite a boost from it, with very little side effects.

[@RichardRobertsonP]

I got depression trying to memorize antidepressants. Thank you speed Pharmacology you made me actually understand everything, and not try to brute force it like I was trying to do.

[@victoriajuarez8049]

Beautiful video, I struggle w/pharm n this helped tremendously

[@veraz8959]

Very detailed. Thank you

[@nomnom112]

Surprised you don't mention brain zaps as one of the withdrawal symptoms.

[@JohnSmith-oh5zp]

nomnom112 literally going through that now. Such a pain

[@wowftw120]

Which medication are you referring to?

[@prettywoman2085]

SSRIs can cause permanent sexual dysfunctions!!!

[@Sketch1994]

@• 9 years ago What part of permanent confuses you? Once you notice, it might already be too late to do anything...

[@duckygibson2075]

I couldn't help but laugh at the banana used for erectile dysfunction. I'm not a med student or anything, but I'm interested and this is a very good presentation! Also your accent is very cute :)

[@stefannr1302]

Blessed are the poor in spirit, for theirs is the kingdom of heaven. Blessed are those who mourn, for they will be comforted. Blessed are the meek, for they will inherit the earth. Blessed are those who hunger and thirst for righteousness, for they will be filled. Blessed are the merciful, for they will be shown mercy. Blessed are the pure in heart, for they will see God. Blessed are the peacemakers, for they will be called children of God. Blessed are those who are persecuted because of righteousness, for theirs is the kingdom of heaven

[@jooikw]

Dear Stefan taken your med...?

[@justsomevids4541]

@Pet your cats stefan's comment is super random but it's not nonsense, when historical facts regarding the resurrection of Jesus shows that the resurrection hypothesis is the only explanation that is actually possible: kzbin.info/www/bejne/d2HMdYGCrdKKjK8 you can watch this video if u want to look at the facts and different theories (this video is part of a playlist so be sure to watch the other videos as well on his channel)

[@prekshisanwal3259]

thnku really a great deal of help in clearing up my concepts

[@rickspeight5108]

Thank you for this easy to understand video! much appreciated!

[@yomommashaus]

16:58 Lithium - watch at 2x speed, you'll thank me later..... ie. you'll be done faster...

[@danceballetacro]

I'm a graduate student in social work and am aspiring to be a mental health therapist

[@TheMisslili8]

thank you

[@alphabet2818]

This is amazing. Thank you

[@Sweetheart-mv8zr]

Thanks for making this video. God bless you.

[@dhams2525]

Thank you... But lithium was headache.,😄

[@niharikaanantoji2014]

Please make a video on antipsychotic drugs too

[@jigsaw2253]

Kustom Denver wait what ?

[@TheQueenofNeckbeards]

This is such an informative video, thank you!

[@guidaribeiromap]

Excellent material! Beautiful job. Thank you.

[@Dayserking]

The video states that activating “the bad” serotonin receptor, 5-HT2A, actually induces depression, yet research on Psilocibin (magic mushrooms) microdosing suggests the contrary. Any neuroscience/psychopharmacology grad students got any input on this? 🤔

[@messiah_genes1117]

I'm not a neuroscientist but this confuses me too. 5hta2 agonists like shrooms somehow bring about cascading events leading to neurogenesis. But then 5hta2 antagonists such as seroquel are sometimes used as an augment treatment for major depression disorder. I think ultimately, we can't isolate receptors since I think there is cross talk between them. 5hta2 antagonists for example often being anti psychotics shutting down trips but psychosis being more associated with dopamine elevation.

[@Do0odiie]

It was all going great until you reached Lithium haha but thanks for the great video :D

[@bitteroldwizard]

Great videos! Thank you!

[@Think.helpful]

Amazing video! V easy and complete

[@alexbuerckholtz5734]

"Hi Everybody! It's Doctor Nick!"

[@whiteshadow59]

Hahah that's what i thought

[@DihelsonMendonca]

You forgot the most important MAOi inhibitor: Moclobemide, which is reversible, and doesn´t has the problems of old MAOi inhibitors.

[@parnate6382]

Moclobemide also doesn't increase serotonin NEARLY to the degree of the irreversible MAOIs like Tranylcypromine.

[@parnate6382]

Moclobemide is not the "most important MAO inhibitor", it is simply the weakest and most recent. Have a look at a journal article for once in your life.

[@eveninggreys3190]

Parnate I'm on it right now. Is it really the weakest? I opted for it because it had the fewest sexual side effects

[@akahassan2527]

Very good video exactly what i was looking for!!! Thanks and well done!!

[@Estabanwatersaz]

Very informative! Thank you 🙏

[@kasiaaniaflora]

ARRRGGGHHH it just started to get interesting about the lithium and you cut me off WHAAAAAHHH

[@elatab11]

I was trying to listen to this video but then my adhd kicked in now im confused and depressed

[@dinobussanich3017]

My mind was wandering too, as always. Its really frustrating man.

[@spaceship2221]

I can recommend you to where I get my stuff he's got Shrooms, psychedelics, Microdose, Dmt, Vape Pens, Carts, and other products well refined too, ships to anywhere also guides you if you're a newbie

[@spaceship2221]

He's on Instagram, with the below handle

[@spaceship2221]

Rollandbruce01

[@shankarverma9646]

You explained very easily thanks 🙏🙏🙏

[@fruitybubbles]

Excellent explanations!