#Pharmacophore

[@Shyamsundar_Ind]

Very good video, I learn several Softwares from a single video. More useful to researchers in the drug discovery field, Thank u.

[@aalilouyoussra3365]

a lot of love for ndian people with their generosity

[@premkumarb7862]

Thank you Sir. Very useful and simple step by step explanation, useful to many researchers

[@Dockingbydushyanthreddy]

Please subscribe and share my lectures and feel free to contact me on Watsapp 8919754133 [e-mail]

[@rahimeeshaghimalekshah3471]

your teaching is very simple and great, I definitely learn it, thank you, Dr Malekshah from Iran

[@Dockingbydushyanthreddy]

Great welcome please subscribe and share my lectures with your friends and others feel free to contact me on WhatsApp or email [e-mail]

[@rahimeeshaghimalekshah3471]

@@Dockingbydushyanthreddy I want to learn Qsar, how do I learn it?

[@Dockingbydushyanthreddy]

I will teach you

[@Dockingbydushyanthreddy]

Contact me on Watsapp 8919754133

[@rahimeeshaghimalekshah3471]

@@Dockingbydushyanthreddy thank you? how? in this youtub?

[@madhavimadhavaram1686]

Super sir really nice

[@Dockingbydushyanthreddy]

Keep watching enjoy and share my lectures

[@arkamondal8872]

Thank you sir for your videos.it is really very helpful for any beginners. Waiting for your more videos. Please add more videos on autodock

[@Dockingbydushyanthreddy]

Please subscribe and share my lectures please specify which topic you are interested

[@Matladi474]

Thank you very much for this well articulated video. I am new to Pharmacophore Modeling and I have perfomed docking on a protein and ligand (drug), so my question is how do I know which pharmacophores are responsible for the interactions between the two?. Can I assume that the descriptors I am getting after loading the two before "submit query" is what is responsible for the interactions?. If so how do I download the table of this descriptors ? and picture of my protein-ligand complex?.

[@Dockingbydushyanthreddy]

Dear viewer; please note that thorough literature to be done and find the pharmacophore and its descriptors and u may design similar descriptors and try to impose on the exiting pharmacophore this technique is called as DYLLOMS

[@ManhaClub]

Sir gene related disease ka receptor kese find kre ge for drug design plz guide me

[@padmak1657]

Thankyou 👍

[@Dockingbydushyanthreddy]

Welcome to my channel Please Subscribe and share my lectures as much as you can feel free to contact me on watsapp @8919754133

[@bmnangat]

I have an out of context question, can you demonstrate Lumo properties of a methyl side chain against an amine side chain let say in the activity of a propionic acid group which is responsible for antiinflammatory activity.

[@Dockingbydushyanthreddy]

dear student; homo lumo and discrete docking studies require DFT perturbations and simultaneous docking which is not performed here

[@rashmimahabal212]

Sir can we add our own designed molecules for pharmacophore mapping

[@Dockingbydushyanthreddy]

yes for that you need to use technique dyloms and proprietary software

[@shakibavahdat9869]

Thank you so much for your video, I would what to know after I got my hits , how do I decide which one to choose for further study? Based on SAR ? or best overlay? Thanks

[@Dockingbydushyanthreddy]

score of resemblence

[@elainejoytorre2191]

May I ask why it is called Ligand-based modelling if the protein is added on ZincPharmer? I'm confused, can you help me? Thank youp

[@Dockingbydushyanthreddy]

It’s not a ligand based mondeling ....it can be called only once an ensemble of ligands are used to generate a common pharmacophore...here it is interactive ligand receptor based pharmacophore ...here pharmacophore is specific. To active site ...it is mostly can be termed as receptor based or interactive ligand based ...don’t confuse yourself ....please subscribe and share with your friends and others feel free to call me on WhatsApp or email at 8919754133 [e-mail]

[@VikasKumar-bn6rf]

From whre we can add filters while selecting ligands for Lipinski rule and all after getting hits after zinc software

[@Dockingbydushyanthreddy]

Welcome to my channel please subscribe and share my lectures with your friends and others feel free to contact me on Watsapp 8919754133

[@jagdishchand9321]

Sir the hit molecules after submit query...how to do docking for best hits compunds other than the CLC GENOMIC WORKBENCH.. as this software is paid. Please can you tell some other softwares that are free. Thank you.

[@Dockingbydushyanthreddy]

autodock

[@abhikkumarray91]

Very nice lots of things clear. Sir! I want to read some articles. please send me some articles. How could I contact with you?

[@Dockingbydushyanthreddy]

Subscribe to my channel and share my lectures as much as you can ....you can contact me on watsapp 8919754133 and gmail [e-mail]

[@uzairmarwat4539]

Your videos are really very helpful. could you please make a video about Pharmacophore modeling via MOE?

[@Dockingbydushyanthreddy]

I am not familiar with moe

[@shilpivats3207]

Sir, can you make video on pharmacophore modelling manually as it is available in Free Discovery studio visualizer?

[@Dockingbydushyanthreddy]

Please subscribe and share my lectures with your friends and others feel free to call me on WhatsApp [phone] surely I will make video new lectures will add up in next week thank you

[@shilpivats3207]

@@Dockingbydushyanthreddy thanks sir

[@anweshadas6077]

Respected sir... Can we do pharmacophore modelling using only the ligand molecule?

[@Dockingbydushyanthreddy]

yes u can

[@anweshadas6077]

@@Dockingbydushyanthreddy thank you sir

[@mahmoudmustafa2805]

Hi Dr Dushyanth It's pleasure to write you. actualy i have a problem with Zincpharmer. could you help me to solve this problem. Error connecting to search engine. Please try again later and if the problem persists, contact the administrator. keep in contact. best regards Mahmoud

[@Dockingbydushyanthreddy]

its is evident that u might be performing some errors kindly follow steps provided

[@manjiris.shinde4302]

Sir, from where did you removed heteroatoms? I'm not finding my notepad file

[@Dockingbydushyanthreddy]

Welcome to my channel please subscribe and share my lectures and contact me on Watsapp 8919754133

[@esraaabdelmoniem9874]

Hello sir, Every time I tried to submit a query in the zincpharmer gives me a server error. Could you tell me what is the problem

[@Dockingbydushyanthreddy]

Welcome to my channel subscribe to my channel and share my lectures contact me on email or Watsapp 8919754133 [e-mail]

[@esraaabdelmoniem9874]

I tried the whatsapp no. but I think something wrong with no. Could you tell me what is the key no of your country

[@Dockingbydushyanthreddy]

Esraa Abdelmoniem [phone]

[@shyamdholakia4270]

How you did the virtual screening? Software?

[@Dockingbydushyanthreddy]

Contact me on Watsapp 8919754133 and subscribe and share my lectures....

[@pharma-infowithsubhasis2752]

Sir,while loading features,everytime it appears server error processing ligand.how can it be solved?

[@Dockingbydushyanthreddy]

Can’t understand your question contact me on Watsapp 8919754133 during office hours

[@pharma-infowithsubhasis2752]

@@Dockingbydushyanthreddy thank you Sir.

[@Dockingbydushyanthreddy]

Subscribe and share my lectures

[@pharma-infowithsubhasis2752]

@@Dockingbydushyanthreddy sure Sir.gud nt.

[@way2pharma463]

sir, its showing 0 hits, then what to do

[@Dockingbydushyanthreddy]

Please subscribe and share my lectures you need to refine the search by editing the descriptors in the pharmacophore step by step by selecting various descriptors alternatively

[@madhavimadhavaram1686]

Sir is it possible to screen aquari results using MVD

[@Dockingbydushyanthreddy]

What do u mean by Aquari

[@madhavimadhavaram1686]

Sorry sir that is query

[@Dockingbydushyanthreddy]

Yaa u can do

[@madhavimadhavaram1686]

I got 37 thousand hits by screening pharmacophors, but I don't know weather my MVD screens this large number of compounds

[@Dockingbydushyanthreddy]

Yes u can dock even with lakhs ....

[@stanzinstan6669]

Hlo sir...... Can u help me do pharmachophore model for metallobetalactamase enzyme

[@Dockingbydushyanthreddy]

Subscribe to my channel and share among your friends contact me on Watsapp tomorrow 8919754133

[@zahidnaseem4572]

Very useful video, Thanks. Could you please upload a tutorial for the docking of Zn database using MOE?

[@Dockingbydushyanthreddy]

Please subscribe and share my lectures with your friends and others feel free to call me on my Watsaap 8919754133 or by email [e-mail]

[@Dockingbydushyanthreddy]

Moe and zinc are two different things can’t be clubbed

[@zahidnaseem4572]

First of all thanks for your response. Secondly, I mentioned Zn database not Zn. Zn database is actually a database containing a large no of chemical structures, can be docked against different proteins to have potential hits.

[@Dockingbydushyanthreddy]

My lectures is on zinc database obviously it will explain about database regarding moe multiple pharmacophores can’t be loaded into zinc database for virtual screening

[@zahidnaseem4572]

You mean we can't dock the zinc database using MOE, if I am not wrong.

[@yusufganteng78]

Hello sir

[@Dr.Cheminformatics]

This is a useful video on how to create a structure-based pharmacophore kzbin.info/www/bejne/sH7IenWrgtt-grc