Philadelphia chromosome | Chromosome 9 to 22 translocation | BCR-ABL translocation| CML pathology

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Animated biology With arpan

Күн бұрын

Пікірлер: 18

@YougiTune 9 ай бұрын

This was a very succinct and solid video. Thank you for your hard work.

@animatedbiologywitharpan 9 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@gladiateur27 Ай бұрын

Excellent video, thanks.

@Kabir_Khayer 9 ай бұрын

Thank you arpan da. Good quality good information. Deep 📚knowledgeable

@animatedbiologywitharpan 9 ай бұрын

Thanks a lot for the support

@anarcanum1 Ай бұрын

Tysm 👍🏻

@animatedbiologywitharpan Ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@anarcanum1 Ай бұрын

@animatedbiologywitharpan sure sir! I appreciate your hardwork 🤗🙌🏻

@anmolpardeshi3138 8 ай бұрын

good video, Arpan. just one clarification: at 1:13/14 you say "BCR gene is highly active that is why ABL leads to ABL kinase...." but its not clear why transcription of one gene leads to product of another gene. I'm assuming its a mistake?! if so pls clarify. thanks.

@animatedbiologywitharpan 8 ай бұрын

Sorry for the confusion. The BCR-ABL fusion protein results from the translocation of the BCR gene to the ABL gene, leading to increased kinase activity. The close proximity of the BCR gene to the ABL gene may alter the conformation of the ABL kinase domain, enhancing its expression and activity within the fusion protein.

@animatedbiologywitharpan 8 ай бұрын

Its the BCR enhancer region which is really strong , enhancer can act on any nearby location to increase transcription .

@animatedbiologywitharpan 8 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@anmolpardeshi3138 8 ай бұрын

@@animatedbiologywitharpan I dont think that was the point you were making because during that statement the BCR-ABL in the diagram were separate. but thanks for replying.. may be it be it will be more clear.

@letthedogsout66 7 ай бұрын

Good channel Dr

@animatedbiologywitharpan 7 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.