Phosphatidylcholine and TMAO

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Күн бұрын

Пікірлер: 49

@DrMatthewMarcotte 2 ай бұрын

Great info! do you have any data or have seen any that supplementation orally versus? I am injectables of phosphating TMAO.?

@jesseputzier7868 Жыл бұрын

Does betaine hcl have the same effect as tmg?

@chrismasterjohn Жыл бұрын

Plus the acidity.

@jesseputzier7868 Жыл бұрын

@@chrismasterjohn Thank you. I thought it didn't based off my searches and responses I found.

@MorningClarity Жыл бұрын

Excellent.

@Aviation_Professional Жыл бұрын

Agreed

@giorgikuprava1055 Жыл бұрын

How would supplemental TMG dosage compare to supplementary PC? Can I take TMG as a dietary choline substitute?

@giorgikuprava1055 Жыл бұрын

Like, 1G of TMG = how much endogenous PC?

@giorgikuprava1055 Жыл бұрын

Okay, I watched your video on that. For others, 500mg TMG equals (approx.) 300mg choline. Disclaimer, as I understood, you should only depend on it for the half requirement.

@chrismasterjohn Жыл бұрын

I have detailed equivalencies in the Cliff Notes: chris-masterjohn-phd.myshopify.com/products/the-vitamins-and-minerals-101-cliff-notes

@giorgikuprava1055 Жыл бұрын

@@chrismasterjohn Okay, now I see.

@beautyandthebudget3642 9 ай бұрын

Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial This study might be of interest

@jirihutecka9020 Жыл бұрын

I take around 20g of sunflower lecithin to fix my liver(can't eat cholesterol from yolks due to high oxidative stress from free copper..) and 500mg of TMG as well. Chris do some video on silica. What form is best to take etc.. Nobody is talking about silica, but it is so important for human body..

@SkedgySky Жыл бұрын

That's 2 servings worth. You don't get any side effects? Non of that scary sounding "sludge syndrome" from too much choline ingestion? ... Don't you feel "backed up" or physically full from so much?

@jirihutecka9020 Жыл бұрын

@@SkedgySky I am less hungry since I started taking it, but I don't feel any negative effect so far. I take like 5-8g three times a day with meals..

@petrichor100 Жыл бұрын

What is the rational behind eliminating diety cholesterol?

@jirihutecka9020 Жыл бұрын

@@petrichor100 I have high free copper. Free copper can and will oxidize everything that comes into contact with it in the blood. So I am trying to lower intake of everything that can get oxidized and damage my cardiovascular system even more so not just cholesterol, but also PUFA etc.. People think that cholesterol is good for everyone or some people think it's bad for everyone. But it is not so simple. If you don't have any issues like I have for example cholesterol is good for you. But if you have for example low thyroid function you can't use cholesterol properly and it will just build up in the blood. It is about the context...

@petrichor100 Жыл бұрын

@@jirihutecka9020 makes sense. How do u know u have excess free copper? Is it genetic, e.g, WD? What are your Ceruplasmin and copper?

@richieheetebrij8189 Жыл бұрын

I have had 2 mini stroke like episodes while taking TMAO. They didn’t come back after stopping choline. I eat a few eggs almost every day and don’t experience these episodes. Was taking for brain fog and memory and it was working for that. To make things even more strange I took meldronium to increase energy as I get Neuro problems and heart palpitations from caffeine and I got crazy heart beat irregularities, and had to stop after a week or so cause I thought I might have a heart attack. Meldronium is a carnitine blocker. Carnitine is also involved in TMOA production somehow. Meldronium should have decreased TMAO levels if carnitine is involved it TMAO. These experiences are opposite of what’s published? TMAO was high in those with endothelial injury, perhaps it should have been dysfunction actually? Thinking there is some interplay with homeocysteine, insulin issues, and uric acid but not sure how it’s all tied together.

@SkedgySky Жыл бұрын

Sunflower lecithin shows a whole serving is around 11 grams. Will people with poor PEMT genes be overwhelmed by taking in such large amounts of the various phospholipids found in lecithin? They say it's recommended for people with this enzyme mutation, but wouldn't it cause some kind of metabolic backlog to burden a slow enzyme with so much of this supplement?

@chrismasterjohn Жыл бұрын

The backlog is in making it, not utilizing it. But I think fixing anything quickly could lead to some transient adaptation symptoms.

@JCrow-kz4nw Жыл бұрын

Excellent

@giorgikuprava1055 Жыл бұрын

You haven't mentioned citicoline, which is a go-to in Alzheimer's disease patients. It differentiates into the body differently, as I know, so that can be used for its purpose.

@giorgikuprava1055 Жыл бұрын

How about cytidine?

@chrismasterjohn Жыл бұрын

Alpha GPC has good data behind it for AD

@giorgikuprava1055 Жыл бұрын

@@chrismasterjohn Its one mode of action out of many is considered to involve the release of free choline, which is then utilized for acetylcholine and phosphatidylcholine biosynthesis in the brain. It is very powerful and shouldn't be recommended as a dietary source of choline. It can cause dependence and withdrawals and can be counterproductive in high doses. Citicoline is different and has numerous advantages for the brain over Alpha-GPC.

@humblecourageous3919 Жыл бұрын

I've been getting CAC scans every two years. Statins increased the plaque in my arteries (when the cholesterol was 117). So I stopped and just took K2, D3, and magnesium. The plaque decreased somewhat in two years. But my cholesterol was 249. I wanted to lower it so my doctor would not recommend statins. I took 1 tablespoon of lecithin for two years. It lowered my cholesterol to 203. Great. However, it increased my arterial plaque score from 164 to 292. So I have stopped lecithin (unless I get a gallbladder attack because it can end that quicker than anything else available). I'm now looking for something that will lower my cholesterol but not increase the plaque.

@yiva2037 Жыл бұрын

nattokinase

@mreese8764 4 ай бұрын

Ignore the total cholesterol and get a cholesterol particle size test. Cholesterol isn't bad but the smaller ones can be.

@fidrewe99 9 ай бұрын

You are implying that only studies were done on (abnormal) mice, which is just not true. What do say about the studies on humans associating TMAO with health risks?

@David-tq5qm Жыл бұрын

Writing this comment for the 4th time as it keeps on disappearing: Hey Chris, would the twelve million patient study that was done in Korea change your mind in regards to the association of TMAO with heart disease? They used Alpha-GPC in the study.

@chrismasterjohn Жыл бұрын

If you want to ask me about a study, at least link to it.

@David-tq5qm Жыл бұрын

@@chrismasterjohn I tried zillion times.. It doesn't allow me to post it. EVERY SINGLE time it's getting deleted. The title of the study from Jama is: "Association of L-α Glycerylphosphorylcholine With Subsequent Stroke Risk After 10 Years".

@beautyandthebudget3642 9 ай бұрын

@@David-tq5qm KZbin removes links so provide the database name and study name perhaps

@MarkIron 7 ай бұрын

I'd love to know what Chris thiks of this study too. Here's the results of that study: Matched Cohort Results: Total Stroke: 43% higher risk (aHR, 1.43; 95% CI, 1.41-1.46). Ischemic Stroke: 34% higher risk (aHR, 1.34; 95% CI, 1.31-1.37). Hemorrhagic Stroke: 37% higher risk (aHR, 1.37; 95% CI, 1.29-1.46). Dose-Response Relationship: An increasing intake of α-GPC was linked to a higher risk of total stroke, indicating a dose-response effect. Seems like a massive increased risk

@MarkIron 7 ай бұрын

@@chrismasterjohn PMCID: PMC8613599 Matched Cohort Results: Total Stroke: 43% higher risk (aHR, 1.43; 95% CI, 1.41-1.46). Ischemic Stroke: 34% higher risk (aHR, 1.34; 95% CI, 1.31-1.37). Hemorrhagic Stroke: 37% higher risk (aHR, 1.37; 95% CI, 1.29-1.46). Dose-Response Relationship: An increasing intake of α-GPC was linked to a higher risk of total stroke, indicating a dose-response effect.