Imprinting and Uniparental Disomy for the USMLE Step 1

[@telatti]

the best video on uniparental disomy i've found! thank you so much :)

[@physeo-USMLE]

Thanks for the support! We're glad you like it!

[@telatti]

@@physeo-USMLE thank you for helping me learn :) struggling med student from czech republic

[@physeo-USMLE]

@@telatti You've got this!

[@faiziiiiii]

love you, just in the first 2 minutes you explained what I've been trying to understand for years. I am beyond greatful for this! Thank you again!

[@vineshmanohar2060]

Can’t get any clearer than this. Thank u so much :)

[@physeo-USMLE]

❤😎

[@pawandeepkour544]

Best video on Imprinting and Uniparental disomy I have come across.👌🏼

[@Alexandra-sd4yy]

My colleagues need to know about this channel! Thank you for the beautiful teaching!

[@ashozy1003]

Excellent video which is underrated.. I'm not a native speaker or from US, but sir I loved your video it's very helpful. Thank you !

[@riflemusket]

OK. For proper cytogenetic nomenclature, 15q11 is read as "Fifteen-Q-One-One", not "Fifteen-Q-Eleven". Same with 15q13 -> Fifteen-Q-One-Three.

[@opoppo6413]

the best I found on KZbin I think

[@batol5361]

You are such a legend. Thank you helped a lot truly! Keep up the good work!🥰

[@workation6663]

thank you so much)))) u helped a lot

[@amiramadhi2074]

Best video on uniparental disomy thank u so much 🌸

[@mandyads]

5:47 for heterodisomy vs. isodisomy

[@DazeOpYT]

In your question about Prader Willi Syndrome, it's also likely that the father underwent a mutation in the imprinting gene which causes the methylation of the paternal PWS-gene and thus the wrong imprinting pattern. Just a side note, your video explains it very well :D

[@DazeOpYT]

@Rudolph Rudolph Not necessarely, there can also be a misstep in the meiotic splicing of the cell which causes the child having to maternal copies.

[@saadsohail9379]

cant thanks enough........ May Allah blessed u

[@pallaviguha9354]

Thank you so much! I was having such a hard time understanding uniparental disomy😭!

[@abijeyarajan2173]

Very clear explanation on imprinting. Thank you 😊

[@saul3965]

Spectacular, Im reading over this for my medical genetics and the book did not make it easier.

[@sadmanchowdhury9823]

Incredible well explained. God bless you!!

[@azadbharath7444]

In a RFLP related question -boy has symptoms of praderw ,means paternal deletion,means at the time of fertilitzn incompatible trisomy caused by incoming spem,so incoming paternal gene chr deleted,is that so is only possible by maternal disomy by nondisjunction M-1#opt-a???&M-2,means is aspermatogenes view na ,so paternal disomy -un compatible trisomy by incoming maternal ova.

[@maryamhani7725]

Nice presentation

[@cakuh8900]

in Germany we dont say "good video" we say: "geiles Video Bruder, du bist ein geisteskranker Ehrenmann", and i think thats beautiful.

[@studiesaura]

This is lit 🔥 Thank you so much.

[@divyeshkhatri2538]

Excellent explanation 😋😋😋😋

[@umerkhan7545]

Very nicely done

[@andrewpleva]

Great video thank you you much!

[@juliaaysenurturkozeaston]

Thank you so much 😊

[@nesrinech3967]

you made it so easy to understand , thanks a lot.

[@markmegaly1626]

Awesome Content! Keep it up. Thank you

[@arzofaqiri-aksoy6857]

thanks a lot, best explanation ever

[@phantasmalphasmidzoo8280]

So if an embryo has a deletion of the pws gene of the male side, can you avoid Prader Willi by demethylating the pws gene on the female side??

[@benjaminazumah9833]

No because unlike histone methylation, DNA (cystine) methylation is almost always irreversible.

[@cubba20]

amazing video

[@namrtasharma335]

best video, appreciate ur work

[@Salopovpaz]

Thank you very much. God bless you 🙏

[@Robertson284]

awesome. thanks a lot

[@Sparrow6_]

That’s a very good explanation 🤝🤝

[@revanthsurapaneni6258]

Thank you man!

[@lotfiadj5896]

much love from algeria

[@ivangrishin8547]

Perfect explanation

[@faizanshahzad8598]

Awesome vid with a clear explanation, Kudos 2 u :)))

[@salehFayoumi]

thanks a ton , many many thanks

[@physeo-USMLE]

❤

[@muntehakhatun7783]

Thanks👍

[@drswekcharanjan7481]

Really good

[@jared394]

Killed it!

[@burns1606]

great video!

[@ishanisingh862]

Thank you 😊

[@crichighlights2612]

Nice explanation bro! Couldn’t understand the concept in other channel videos.✌️

[@oviyagnanasekaran2756]

How exactly does the cell loose a chromosome during fertilisation?

[@Alexandra-sd4yy]

so is it a problem if it is heterodisomy? the cromosomes are different, one from grandpa and one from grandma, right???

[@femidaelettil1002]

Thanks a lot

[@GermanHeul]

Amazing thx 💗

[@iw16n17]

thank you so much

[@manuelgoncalves9753]

great video

[@ahlamal-bloshi9656]

THANK YOU

[@ibraheemalma]

beautiful thank you sir

[@DoctorKlenk]

4:35 B is just as likely

[@arnebshaikh]

😍😍👍🏻👍🏻

[@samarthchauhan6289]

what about monosomy rescue? can't this mean PWS can occur following nondisjunction in sperm

[@iknowiamwrong.butstill...2073]

amazing

[@mellowdoctor9029]

Boss of the bosses

[@mellowdoctor9029]

❤️

[@jesiraj2448]

It is a clear explanation, but please do not say q eleven instead it is q one- one ...

[@zainab_abd3776]

مرحبا ممكن أعرف اذا كنت بدرس دروس خصوصية لمواد المجموعة الطبية ؟؟؟

[@jrh1677]

Wow

[@jenniferjdaidani1397]

THANK YOU

[@rawanaimat2367]

thanks a lot