Lysosomal Storage Diseases (HIGH YIELD UPDATE!)

[@ayaatkhan6850]

MET ARYL BROken DAD(met a real broken dad) MET - metachromatic leukodystrophy ARYL - arysulfatase A def BROken - cereBROside sulfate acc D - demyelination central + peripheral A - ataxia D - dementia

[@lovelylibra7349]

thanks alot for this, i never didn't know much about pokemon so this works!

[@dons731]

He killed it with that Metapod reference; i will never forget this easily forgettable disease; thank your Sir DIrty

[@robert11411]

단데기!

[@jzee100]

Thank you for the update! That metapod mnemonic is absolute GOLD. One more thing for everyone else: all the diseases mentioned have autosomal recessive inheritance, except for Fabry disease and Hunter syndrome, which have X-linked recessive inheritance.

[@DrMon0818]

THANKS!

[@mirriellebienaime2876]

Thanks

[@sagarsaga00]

Hunter was wearing a FAbulous Bra

[@jzee100]

@@sagarsaga00 😂 nice one

[@theusualbrownie]

Fabry Hunter = Family HisTory = FHx

[@ch3p1ncheung]

another cool way i learn to remember which has hepatosplenomegaly in Niemann - pick dx and Tay- sac is the follow: Think about the first word as liver and the second word as spleen. Tay- sac = both short words = no hepatosplenomegaly Niemann - Pick = long first word and second word = hepatosplenomegaly

[@jaiahuja]

use me as a im worried about step but dirty relieves my anxiety button

[@eduardoantoniovillapallare3881]

Dirty is saving my mental health!!!

[@saga7956]

That sounds like some mnemonic haha!

[@sKHANcreative]

Thank you Sir from the bottom of my heart from the bottom of my heart to be so hugely helpful and impactful in student studies. I am a big fan. I am in a financial truffle right now because as you know the MLE's are very expansive especially for foreign graduates. But once I am stable enough I will definitely be providing support. Thank you Sir and please keep up this going because you might be having no idea how much helpful this is for foreign graduates who's trying to save every penny to finally be able to give this exam and your free channel is a huge impact because it doesn't drain them financially while providing excellent top notch content for free. I have the utmost RESPECT for the services that you are providing!

[@JizzXpert]

Just watched the old one yesterday but don’t mind watching it again my king

[@dr.tarun27]

3:06 Where the video actually starts. Guys please help this guy as much as u can. he is a gift to all medicos anywhere in the world

[@rameshjaikaranpoonai3228]

God bless you doc 🙏 You have been so helpful to thousands of IMG. English Guyana/ Cuba Havana medical graduate !

[@serendipity7467]

Thank you very much, that's gold! For non-pokemoners, I attempted to make a Game of Thrones mnemonics: Arya's brain was catastrophic: demyelinated, dementious and ataxic Arya for ARYLSULFATASE, brain for cerebrum i.e. CEREBROSIDE SULFATE, catasTROPHIC for the metachromatic leukodysTROPHY, the rest are the symptoms (all three remind of problems related to brain). Am open for better mnemonics ;)

[@1hrchallenge]

Thanks for the mnemonic , I modified it slightly: Arya’s cerebrum has Catastropic ADD-A-Ataxic, Demylinated, Dementious

[@labbad3421]

Tysm ❤ i was mixing up the enzymes for fabry and krabbe as both have the galaxy reference but then i added "bro" at the end of krabbe's mnemonic. "The Glob of GOOey Krabbe meat is out of this world, bro" Fabry: galaxy without "bro" for Alpha galactosidase Krabbe: "this world,bro" for GALACtocereBROsidase hope this helps someone

[@muks277]

It does help , thanks!!

[@migs6869]

i was looking for this, thanks man

[@labbad3421]

Glad it helped someone ^^ hope u guys do well

[@styx5565]

if you aren't familiar with pokemon this is the one I came up with "sulfur has a really meta color" sulfur for arylSULFatase and cerebroside SULFATE. meta means you have to think a lot about it = CNS defects. and Color to remember that the nerves stain yellow brown. :)

[@LillyB-fg9sm]

I am very thankful and grateful for all of your hard efforts! I was literally a biochemistry hater at medical school! But you made me love it I swear! You saved my study and my time! Huge thanks Dirty Medicine!

[@kevouyreid4518]

I cannnot begin to quantify how helpful these Dirty Medicine mnemonics are, the information just sticks in your brain after he teaches. Then you go read the chapters in the books and further consolidate. Thank you very much.

[@komaldiptianandmaisuriya4301]

PASSED STEP 1 , STILL COMING BACK FOR MY PEDIA FINAL EXAM REVISON. THANKS A LOTTTT

[@nicolebrent9351]

I am signing up! Because honestly you are the best! 4.99 that a starbucks latte

[@DirtyMedicine]

Thank you for being a Dirty Medicine member!

[@masterimbecile]

Check this cool person out!

[@Ammar88ist]

Wish starbucks was that cheap here xD

[@RoxannaHymanson]

You will be the reason I even have a chance sitting for boards. Thanks Dirty!

[@Kanorr]

There was a "high yield question bank" question about the treatment of Gauchers. It's just exogenous glucocerebrosidase Also, I use "Hunters have clear I's 2 shoot" for the hunters.

[@DrMon0818]

THANKS!

[@rayannebarreto7070]

Hi! how can I found this HY question bank? thank you :)

[@markdagosta6825]

My study partner and I were literally talking about adding clinical finding mnemonics to your awesome video when I saw this update. Perfection!

[@danielir]

Your videos and mnemonics have gotten me a handful of points on every test I have taken in medical school. You’re the man, Dirty! Keep up the good work!

[@doom_inik]

for those who never really got into pokémon i have for you: clumsy cerebrities ride real sulfurous & dented metallic chrome cars. clumsy=ataxia cerebrities ride=cerebroside sulfate real sulfurous=arylsulfatase A dented=dement/demyelin metallic chrome=metachromatic leukodystrophy you can imagine some old clumsy celebrity driving a car that's just as old and clunky as them (or picture a scene out of Mad Max if you at least get that pop culture reference)

[@DvIzAdvocate]

Awesome!! Thank you sooooo much. Crazy crazy helpful!! Suggestion: Try "(in a crying voice) OMGauch, he's such a SWEET BRO" (sweet for "gluco")

[@erikb6576]

Spring-boarding off your Tay-Sach mnemonic, I just wanted to connect it to the dz name - so I made the gang a bit more aggressive (and apparently cruel): "A Gang of Six small Jews kicked me in the Sach" Happy studying everyone

[@quazar420]

😊

[@bananaphone16]

So glad I waited until a week before my test to care about these so I could learn them from this video :)

[@ryanbrown9017]

Great minds think alike

[@bananaphone16]

@@ryanbrown9017 i KNEW someone i knew would come find me on here hahaha.......miss you!!! best of luck!

[@ryanbrown9017]

@@bananaphone16 Good luck next week!

[@DirtyMedicine]

Good luck to both of you

[@DirtyMedicine]

PS caps stink

[@robbysimz4339]

This is amazing!! Small thing but I found it a little tricky to differentiate the enzyme/accumulations for Gaucher vs Krabbe so for Gaucher I just added "sweet bro" to remind myself of the 'gluco' in glucocerebrosidase: OMGauch ... he is such a sweet bro

[@212_subashg3]

thanks my bro:)

[@PowderChaser]

Much appreciated, Dirty!

[@melaniejordantorres2006]

Thank you so much for this video, as soon as I can I will join and support yourself, totally deserved!

[@nnag1990]

Bro is a 🐐. Just discovered the channel. I’m boutta binge all ur vids thank you

[@lucyalvarez1288]

The hyphen detail is brilliant thank uuuu for ever 🙏

[@fatemaha7453]

Thank you for this! I’m about to take my first final in med school and this really helped!

[@madzzzz3189]

the old video is the 1st vid i watched on ur channel a few weeks ago!! thanks for updating!

[@RethseEcinue12]

One of the best! Thank you for helping me to memorize these diseases.

[@hassanabdigedi4502]

Thanks for your support 🎉

[@Ash-hz1eh]

Not familiar with Pokemon but I now feel like I know all about Metapod! Thanks!

[@mahnoorzia1274]

although a little long one but: hunter and hurler are son of iodine both have skin and liver condition, hurler is the alpha but hunter aims for X spot. son of iodine= iduronate 2 sulphate, alpha 2 iduronitase skin and liver= dermatan sulphate and heparan sulphate hurler is alpha= alpha 2 iduronitase hunter aims X spot= x linked recessive

[@marwan8055]

The best of all time. Absolutely genius! 🎯

[@umerramzan5552]

heres a mnemonic for 'HURLER" syndrome. H: Hepatosplenomegaly (enlarged liver and spleen) U: Upper airway obstruction R: Rough or coarse facial features (skeletal anomalies) L: Learning difficulties (developmental delay) E: Enzyme deficiency (alpha-L-iduronidase) R: Retinal abnormality(corneal clouding)

[@sidc1759]

awesome video thanks so much!.. for gaucher.. OMG he's such a SWEET bro (to remind u its glucocerbro).. since a bunch of them have BRO in the name! again, thanks for all of your videos

[@jeffyvianneys2341]

tats the exact addition I was using toooo..... coincidence? XD XD

[@saadia1403]

I made a mnemonic "HUNT FOX" - Hunt for hunter and F for Fabry - X for xlinked recessive :) . The remaining are AR.

[@nehadharap700]

for the people that do not know much about Pokémon : “Leuk at me! I’m aryl broken man” Leuk & me - metachromatic leucodystrophy Aryl = Arylsulphatase A Broken = cerebroside sulphate Man = DeMENtia

[@rababhaddad8892]

thank you for making biochemistry bearable

[@vpriya1992]

Fantastic video (old and new both) !!! mnemonics really help in memorizing the details. Thank you so much :D

[@emilyi771]

Great update - i was wondering how i was going to remember the clinical presentation of these diseases. Thank you! About to go look up a clip of Metapod Pokemon right now :)

[@michaelgoldstein8516]

I don't know anything about pokemon except pikachu, but that Metapod mnemonic is great.

[@bkpark0813]

"Bro" is part of other enzyme names so maybe add "sweet" modifier (from gluco-, the prefix for sugar) to bro for Gaucher.

[@SK1MD]

Wow, thank you so much! God Bless!❤

[@shaynemcgowan4049]

Once you get me to residency with these videos I will be a member lol

[@juanbonilla1744]

the Krabbe disease mnemonic word "world" for "gala-" might get confused with "gala-" in Fabry disease also. I'd like to add that globoid cells look kind of like a brain (galacto-cerebro-sidase)

[@basitokunlola3757]

Thank you so much for the videos. X marks the spot for the aggressive hunter

[@YT_watcher7385]

Had to pause this video to watch every single episode of Pokémon before continuing with the lesson. For science!

[@EIonsMusk]

That metapod mnemonic would make butterfree proud!

[@hypercaffeinated699]

Thankyou, your videos are life-savers.

[@maziarashid3694]

Your mnemonics are also high yield can't be forgotten

[@desireejennings1713]

Gold! Thank u so much!! When i get into residency i will pay back all you have given me!! ❤️❤️❤️❤️❤️❤️❤️🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻💪🏻💪🏻💪🏻💪🏻💪🏻💪🏻

[@DirtyMedicine]

hey just be a good doctor to your patients, thats all I/we need

[@owa1si]

10:23 Wouldn't it be better to say, "the GLOB of GOO-ey Krabbe meat can't be neGALACTed" ?

[@challengeselfnow4393]

literally googled Metapod's evolution after finished this.

[@sandeepkumar35]

Sadly am not sure about others... but no one will forget Metapod in Metachormatic leukodystrophy

[@christinac1195]

Thank you so much! I didn't know I could laugh while studying this topic :') The pokemon reference was amazing. "He can literally only say his name." Ded.

[@foodiesworldUSA]

Yes I love u and I used all your videos for step 1 and now step 2

[@bajrangsinghdeora3193]

Hey dirty can you plz make a video on glut receptors ...if possible than 🙏

[@ahmadchindo3153]

Watch Kaplan..u'll never forget or miss it again

[@syphoresdrow5077]

Simply the best !! Thank you

[@syphoresdrow5077]

😂

[@foodiesworldUSA]

I love how u said bastards that’s exactly my rxn when people say something like this and start laughing like obnoxious creeps

[@Its_semio]

I was just watching the old lysosomal storage disease video, such a coincidence!

[@tahiyyakhan3189]

Can you please make a video explaining the ventilator settings/ waveforms? Thanks

[@nearlyheadlessmedstudent9892]

another hook-on is Gauche - Paper Mache - tissue paper cytoplasm.

[@mmansay]

Thank you, Dirty!!!!!! Great take on Metapod reference!!!!!!!!

[@townmayor461]

Since Gaucher's and Metachromatic Leukodystrophy both have just BRO for the accumilation, one way to remember meta is Cerebroside *SULFATE*, just imagine a shiny metapod and pretend it is close enough to the color of sulfur

[@gracenoonan8353]

you are seriously the best.

[@michellerueff9791]

SODM - School of Dirty Medicine or DSOM - Dirty's School of Medicine or SOMeDs - "School of Medical education - Dirty Style" ... there is something there... I'm DME "dirty medicine educated"

[@michellerueff9791]

"SOMeDs" is my favorite haha "School of Medical education - Dirty Style"

[@zzzgful]

The Globoid KRABBE is out of this Big Galaxy Bro.

[@DarthAndre24]

BRUH JUST LET ME PASS MY BOARDS AND I WILL FUCKING JOIN UR MEMBERSHIP You've been a great help to me and I wish that every high yield concept appears in our boards.

[@Gasmanz]

Can you do a video on the different types of spondyloarthropathies?

[@DirtyMedicine]

Thank you for being a Dirty Medicine member!

[@Gasmanz]

@@DirtyMedicine happy to support the channel! I’m a second year med student about to start dedicated for step 1, and I wouldn’t be where I am today without these videos.

[@dr.strugglebus4386]

Bruh went in on metapod! Like damn 😂😂😂

[@rougbak]

U deserve to be supported 👏

[@masterimbecile]

12:11 since my school is testing us on I-cell disease, maybe we can throw this in as well: "I-cell" is hyphenated, therefore it causes cherry-red spot on macula. Also a Hunter uses his Eye to aim and hunt Zebras (lamellated zebra bodies in lysosomes), so "Eye-cell" is "Hunter-like" (technically it's pseudo-Hurler, but transitive property says it is therefore pseudo-Hunter). Since this pseudo-hunter probably lives a healthy lifestyle, we won't find weird stuff in his urine (no GAG in urine vs. Hurler/Hunter).

[@島影ふじえ]

You are an amazingly cool teacher!! I love your style!

[@AnshulRaman]

Great video! Gonna extend the Tay Sach's one into "A Gang of Six Small Jews eating Tay-ter tots and Onion rings with Red ketchup"

[@jordanmarquez153]

for those of us who might not have watched pokemon you could say that "METApod is ARYL BROken pokemon who is a CAD"

[@DirtyMedicine]

I would be remiss if I didn't put a plug in to watch the original Pokemon indigo league (season 1). Quality television

[@christophermcloughlin157]

this is unreal your the GOAT

[@RohanPurohit]

This video made me join your channel! You're amazing dirty!

[@배부른녀석]

OMG!!!(crying) thank you for all these high-yield mnemonics!! here i want to share some modification with you guys "the GLOB of KRABBE meat is Out Of this GALCTY(galaxy)"

[@sandytrenholm9965]

Mr Dirty, I actually love Pokemon so thanks a lot

[@flimsyflamingo2054]

Yay *dances in high yield* lolol

[@monzilachowdhury6590]

Hey, thank you for all you do :)

[@drdhirajrajregmi]

For Tay Sach's Disease, you can remember Hexosaminidase A by remembering Tay Sichs/Six disease in addition to A gang of 6 Jews.

[@dub7782]

In First AID 2022, Huler Syndrome is listed as having a α-l-iduronidase deficiency. You have alpha-2-iduronitase listed. Are both of these enzymes correct, or did you make a typo?

[@pathologywithfaizansaqib1064]

Shukriya Ustad G

[@xaaboopinkly]

Huge thanks as always sir..

[@ZaWakingEagle]

Oml I adored the metapod mnemonic :)

[@rickypen]

Thank you. I added "Oh My Gauch, hes such a Sweet Bro" to remember its Glucocerebroside, cause all the others with bro confuse me lol. I has smooth brain

[@lukedebenham208]

great summary for this godforsaken aspect of medical school

[@TheMiniWumbo]

Me watching this the morning of my exam... METAPOD SHEDS, CANT WALK, AND IS DEMENTED!

[@3catsand3humans]

Somebody pleeeease give him the Nobel prize 제발 누군가 이 사람에게 노벨상 좀 주세요..

[@joaoedsonprediger3409]

Hey, U can use for " Krabbe disease" : CRAB with MILK sauce, BRO, is really GOOD ;)

[@umeshthapa6030]

Starts at 3:05

[@rayannebarreto7070]

thank you...!

[@rosemaryvallejohassan9445]

I love you, little one. Greetings from the DR.

[@ShahadAtif-bh7tr]

Life saver!! Thankyouuu

[@sadaf3999]

Thank you for the brilliant and funny video 😁

[@MrEman4740]

Thanks!