Creatine’s Multiple Brain Effects

[@Physionic]

For those wanting more clinical data and information: kzbin.info/www/bejne/bavChGRtrb2tias

[@Danny-mg1hu]

Hey Superman! dont have much time but Creatine with all its benefits for the BRAIN.. its good for young folks now?? or the brain benefits are there for only elder individuals?

[@billkillernic]

I am very sceptic about your videos ever since you endorsed the use of collagen peptides... it's collagen! Buying thi supplement is no different (other than in price) as eating chicken skin or whatever.. Same with hyaluronic which you endorsed as well in the same video, digesting it will brake it down...

[@benstiller500]

Heyho :-) And what about the retina(s) ? Because it´s central nervous system as well...Greetings

[@notaras1985]

Was it creatine monohydrate?

[@Christopher-b1p]

Today's Tip: For those of us who listen without watching the screen, can you not say the exact opposite of what a study says.

[@marksamarin8536]

Thank you. One of the few You Tube channels that actually delivers useful and truthful information. Now, back to cat videos.

[@Physionic]

Ah yes, cat videos :)

[@DawnM-g3d]

Owl Kitty for sure.

[@YouTubecontent998]

That’s why I watch this channel as well. It’s hard to find respectable channels anymore.

[@nevisstkitts8264]

@@Physionic cats were very concerned with creatine-induced mouse brain improvements ...

[@genegayda3042]

@@Physionic Are there any studies of the affects of creatine on cats? 😁

[@axisludi]

what I love most about creatine is the recovery effect on the brain after a poor night sleep. I'd love a video dedicated to these mechanisms. I think creatine is the coolest supplement one of the reasons being that you can actually see it in your muscles, you know it's there supporting you

[@Physionic]

I thought about covering that paper, but wasn't sure if people would be interested - it's my favorite supplement, too

[@alwaysadaptivepodcast]

I actually just experienced this. Terrible nights sleep. Up since 3. Clients at 6 and 7am. I fully feel creatine helped me in that situation.

[@appliedgt]

@@Physionic At this point you might as well do a full creatine series on all effects on it - please cover that paper

[@axisludi]

@alwaysadaptivepodcast same here. I kinda discovered this effect by myself. if I forgot to take creatine in the morning, I'd take it in the evening and I realised I felt better in the morning. I often deal with poor sleep because of anxiety. at first I thought I just imagine it because I knew that creatine has positive effects on the brain, but then I found out about the study that shows short-term/immediate effects of creatine on recovery after poor sleep. now I'm just taking it in the evening 5-10 grams, and it's a massive life changer.

[@alwaysadaptivepodcast]

@@axisludi interesting that you take it in the evening. I take it first thing in the morning as soon as i open my eyes. Any particular reasoning behind the timing?

[@GraysonGates-bh9pt]

This is all so interesting to me. Most people don’t know this but our brains and muscles are linked in so many different ways that we have just started to explore. Creatine is one of the things that makes this connection more obvious.

[@ConniePretula]

Seriously! Your videos are not only very informative but your delivery along with a tad of humour, really make them the best on YT 😊

[@Physionic]

Thanks Connie!

[@TheCookiecupcakes]

Love the color coordination today. Your shirt brings out the deeper colors in the art behind you and matches the shadows created by your biceps.

[@goku445]

😂

[@drott150]

Get a room.

[@shrimp_p4rm]

He's in.

[@cookiedough641]

@TheCookiecupcakes 😳

[@TechPeasant404]

I have found that increasing creatine intake to a minimum of 15g a day has provided a profound improvement in my perceived cognitive function. The standard recommended dosage of 5g I could see no real change. It also took a few weeks of consistently taking 15g to notice the difference.

[@Physionic]

Thanks for sharing :)

[@Phoenix-ov5gg]

Interesting if true and not just placebo

[@joebartles3986]

@@TechPeasant404 I have heard similar comments from other people. Perhaps the standard 5g is not nearly enough.

[@ConniePretula]

I wonder if that would be based on the amount of lean muscle each person has? More lean muscle, higher dose. I’m smaller build so 5g works well for me. I have not tried higher doses though.

[@TechPeasant404]

@@ConniePretula from what i have heard lean body mass is a factor for dosage of creatine. the total amount of mitochondria corresponding to this somewhat. besides brown fat most fat cells have few mitochondria so body weight total is less important for dosage. i have also heard that some people are hyper responders to creatine some average and others respond less so the dosage may be more individual. the muscular benefit is seen at lower dosages than what is needed for cognitive benefit. I'm 200lbs with 20%bf it took several weeks of taking 15g a day (5g with each meal) to see a large cognitive benefit. age would also be an important variable. the body can produce creatine yet production declines with age.

[@flowerpt]

Thanks for including the electrophoresis images!

[@dande_lion]

Creatine helps me lots! I struggled with cognitive impairment due to Long Covid and MCAS. Just thinking made me rush into cognitive fatigue. This already changed 3 days in and now, only around 18 days in, I almost feel like brand new. My whole system feels like it gaining its old strength back. Sure, I will still be cautious to not overdo it but now I am very positive that I will be able to work again. And go surfing! 🙂 Regarding dosage: I just went with the standard of 4 g which seems to work well for me.

[@ALDUIINN]

Bro you are awesome, wish i knew you IRL

[@Holy.HannaH]

My guess would be that since Creatine allows energy to be recycled, meaning the mitochondria dont have to produce as much from scratch, the mitochondria is then not stealing as much GABA or HMB to utilize as a substrate in the TCA cycle. The increased presence of HMB would allow for more protein production and less protein degradation, thereby creating the increase in the protein mentioned in this study.

[@MelloCello55]

I like your germ art, or whatever that is on the wall.

[@gracewhite1601]

@@MelloCello55 it does look like pathogen art

[@themoodyteam]

Frozen raspberries? 🤢

[@larryc1616]

Killer T cells or macrophages

[@nathan-shearer]

How does Creatine affect people who are recovering from an injury or a bacterial/viral infection? Would it aid recovery or would the recovery be unaffected but their general performance is improved through the recovery?

[@mrniceguy4277]

Oh this brings back memories! I did Seahorse assays in my Master's. Nice method!

[@superpauleesworld8170]

..."with the solid assumption that it benefits our brain already in MIND." lol! -- pun intended? 🤪

[@fiddlerJohn]

Love your lessons. I'm learning.

[@Physionic]

Really glad :)

[@baconinvader]

Thank you for your work!

[@fabianaubry3555]

Hello! Could creatine be a positive add in a metabolic approach to treat or manage brain tumor like GBM? Thanks for your work :)

[@swamphawk6227]

Thomas DeLauer was saying the other day, that he takes like 15g daily. I usually forget to supplement, but I at least eat a few pounds of beef per day.

[@Physionic]

15 grams is fine, but less is likely effective, too

[@catlyn777]

IGF-1?

[@bunyip250]

Who's he?

[@swamphawk6227]

@ ... He's another fitness/nutritional influencer on KZbin that isn't quite as cool as Physionic

[@gorkemvids4839]

a beef per day might be pretty bad for you.

[@billtrudell1636]

Nice video thanks.

[@dimakolesik]

I knew i had to envy more that pumped mate from the gym. Not just he’s bigger, he’s smarter too

[@RoiPourpre]

How much do we need to take for maximum benefits ? Ty

[@Who_Does]

if I consume some meat (white/red) 2-3x a day, do I still need to supplement to get benefits?

[@hikedayley9309]

In other words, Start taking Creatine.

[@Raphanne]

Is it safe for prégnant women?

[@demonfedor3748]

Speaking of brain, I remember seeing a podcast with prof Thomas Dayspring about the potential of ApoA1 increasing therapy for people with high predisposition to Alzheimer's disease. Would that be an interesting topic to cover, Nic?

[@jaymehatfield9540]

Nice. This popped up as I had all the ingredients on the counter to make beef gelatin creatine gummy bears

[@Zanuka]

Is creatine still healthy/good even if you don't do much or any exercise/weight/resistance training?

[@rheaultm33]

Yes of course! Its naturally present in meat like beef and fish, so its natural for humans to eat

[@Zanuka]

@@rheaultm33 I mean as a supplement. Also, doesn't your body synthesise creatine?

[@rheaultm33]

@ i think in small amounts. But larger doses form supplements are safe and have lots of evidence for effectiveness

[@barbaralopez265]

You are a weather of information thank you for sharing

[@GraysonGates-bh9pt]

If these receptors are anchoring themselves to the the actin filaments they are likely connecting themselves to the microtubles as well - partially explaining the connection between enzymes, proteins, and quantum biology

[@peterbaldwin9532]

Do you have any data on the impact of creatine supplementation on sleep? On several youtube videos and reddit threads this issue has been raised, and large numbers of people have posted comments saying that they have had problems. If creatine increases sleeplessness, but counteracts the effects of sleeplessness, that does not necessarily seem like a good tradeoff.

[@ethiocomment1707]

It has effected my sleep badly, though I function well with small sleep because of creatine.

[@beatriceroosmark]

@@peterbaldwin9532 I’ve seen no issues with sleep and I’ve been using it for 3 years on and off 🙌

[@Mmcaree]

Any literature on Cr supplementation in stroke recovery?

[@bouvardpecuchet6368]

Can creatine could be usefull ponctually or its effects are dependents to a chronic use ?

[@4unoah]

Does this affect young adults as well?

[@user-ii7xc1ry3x]

Doesn't look like it

[@Physionic]

yes, see next video

[@nobrien1]

I wish I could take it. It ruins my digestive system!

[@JohnRambo-t6i]

Have you tried "Creapure"? It is Creatine Monohydrat with the highest purity and is made in Germany instead of cheap from Asia. And divide the daily dose into smaller individual doses throughout the day.

[@nobrien1]

@@JohnRambo-t6i Thank you. Supposedly the HCL version doesn't have the same impact but after the bad effects from the first try.......

[@JohnRambo-t6i]

@@nobrien1 In what dosage did you take it? It really helps to take smaller amounts at once and then possibly several times a day to reach your desired daily dose. e.g. 2.5g after lunch and 2.5g after dinner. And no loading phase

[@Codysurfsup]

It literally turns your sleep drive (ADP) into energy (ATP) which may not be good for insomniacs

[@OrtegaOY]

What are your thoughts on "CreGAAtine"?

[@Arunvinoths-b-Jo]

Does exogenous creatine supplement affect endogenous synthesis of creatine in kidney (it's 2g ) ... negativity feedback mechanism will turns on when there is no need of endogenous or de Novo synthesis of creatine

[@paulocic7092]

By the way, what kind of cells are in the picture behind you?

[@Physionic]

Stem cells

[@axisludi]

I love the matching colours on the background which also go well with the colour of his t-shirt. pretty neat

[@Marc83Aus]

Which earlier video was being referenced? I'm not sure based on the titles.

[@Physionic]

It’s pinned

[@Marc83Aus]

@@Physionic Thank you!

[@Ethan21428]

It's the best white powder for your brain there is.

[@LinusBerglund]

Anecdote time! The first time I heard about creatine was with you (or maybe Gil) and I decided to try it. I was only interested in (and only knew about) the muscle performance sides, but I have noticed quite a remarkable cognitive effect. After just a couple of days I felt that the world was "sharper". At first I thought that it was just better sleep (three kids. That parameter is hard to control), but the effect has persisted through some really sleep deprived periods. I started almost 7 months ago, and I have tried many different brands, out of fear the first one was spiked. I can compare it to that feeling when antidepressants kick in after a couple of weeks. I also eat a diet that has no creatine, which makes me suspect I was somehow "deficient" if that makes any sense.

[@Physionic]

Fascinating - thanks for sharing, Linus.

[@cachaça_baby]

I'm an accountant, but i really like your content.

[@80srenaissance67]

Mitachondria are the powerhouse of the cell

[@Physionic]

Impossible!! How did you know that??

[@martinmcroberts8568]

This sounds great and I'm genuinely interested but I take Allopurinol to control gout. Information I can find suggests Creatine could kick it off 😢

[@KingsHiway]

What's the difference between mono and hc?

[@Physionic]

Chemical structure - almost no functional difference

[@KingsHiway]

@Physionic that works, thanks

[@skssvs]

Can i start taking creatine in ramadan

[@peterpaul9320]

No Mohammed said no to Creatin on Ramadan

[@SpaceGoatCoastToCoast]

@@peterpaul9320 🤣

[@Christopher-b1p]

What's a good source of creatine? How does creatine cross the blood brain barrier?

[@RG-yz8ov]

Can you do an episode on methylene blue and mitochondrial function and if it increases h2o2

[@jamdec123]

Good job , like the channel, better than freebasing stoopidity everywhere else...

[@ulliramps4728]

Cr stand for Chrome. Bad abbreviation choice. Except for that, interesting

[@amillar7]

I wish my skin and teeth loved creatine as much as my brain and arms.

[@bradbaker4679]

What’s it do to your skin and teeth??

[@amillar7]

@@bradbaker4679 Acne and bleeding gums. Thank you for asking.

[@bhut1571]

Wonder what the t 1/2 is, and if there's and advantage to spreading the dose out during the day?

[@flowerpt]

My gut prefers it if I sip it spread throughout the day, at a 10mg dose.

[@vagabondcaleb8915]

But HOW MUCH? 3,5,10 grams? Edit: I wonder if there is an argument for increasing creatine intake to 10+ for the potential benefits, which could include placebo benefits, considering the low risks of creatine. Does anyone know the high end of what is safe to consume?

[@Physionic]

kzbin.info/www/bejne/jpTGYmSLd5aciJI

[@vagabondcaleb8915]

Thanks!

[@vagabondcaleb8915]

@ I wonder if there is an argument for increasing creatine intake for the potential benefits which could include placebo benefits considering the low risk of creatine. Does anyone know the high end of what is safe to consume?

[@liciniooliveira-becas3618]

The more damage you might have at the brain, the better the effects of protection/recovery with increased creatine amount. But it doesn't seem to do more at muscle level. So 5g seems about it.

[@bigw816]

Tsk, creatine is indeed a potent supplement. I just wish it doesn’t give me soreness on my love handles, this makes me scared that my kidneys were getting harmed I was on 5g daily, with plenty water intake and a very active individual, pee was clear also. But still i felt soreness kinda feelings on both of my sides(love handles). Im scared to go back lol

[@michael-qp9xd]

Some research creatine can affect homocysteine and BUN levels. If both near high acceptable end of range per quest labs - can still take without issue? Say take creatine and pushes a little higher but still in ok range. Still ok to take as little higher adn in range and not issue. This with creatinine and egfr and protein still in range ok too? Great video here adn thanks for all your efforts.

[@jps3275]

There is a lab test called Cystatin C that also measures kidney function, but doesn't rely on creatinine. You might ask your doctor about that. It is more expensive though so your insurance probably won't cover it.

[@galacticminx]

Can creatine supplementation help with brain damage from covid? Not sure if "damage" is the right word, but I definitely have reduced performance in mental agility and concentration. Not basic functioning, but the stuff that takes a lot of internal juggling and visualisation. Also my sense of smell has not returned to normal after seven months - not sure if that's brain related or not but I suspect it may be.

[@Christopher-b1p]

Dr Nic, nave you seen the new study on using brown fat cells to foght cancer?

[@KrynexYT]

Hey Nic, do you use BioRender for your schematics? :)

[@Chris-eo5zs]

From the graphic it looks like the researchers did in fact supplement the mouse feed with Chromium. I found some hexavalent stuff, I assume that's extra strength or something. What dosage would you suggest?

[@coolsatpalsingh2]

What about balding?

[@salleone6387]

You've talked before about how creatine has age related benefits for those over 65. In those studies that showed benefit, did the researchers tease out caloric intake, especially protein, for those individuals? Appetite reduction is pretty common as one's activities level decrease throughout the aging process. Could the benefit of creatine (for older individuals) just be supplementing where diet has been failing? Thanks for channel. Always enjoy the data, but stay for the humor.

[@soysanto9939]

Why does it cause insomnia in some people?

[@ethiocomment1707]

This is my problem, just horrible sleep but the cognitive and gym benefits is fantastic

[@TitusB-q8m]

Creatine supplementation has all sorts of benefits. As it can be synthesised by the body I would expect this to result in a substantial evolutionary drive for the body to produce the levels seen with supplementation. As it doesn't, could this suggest that there might be some disadvantage to high levels?

[@dreckigerdan2418]

A high meat diet does bring you to somewhere that amount

[@utica2burn]

Do we know how much the specific Creatine product matters? So many brands to choose from and they all claim to be premium.

[@Physionic]

Ignore it all - buy the cheapest (monohydrate).

[@x786x]

@@Physionic more than 5 grams safe to take?

[@JohnRambo-t6i]

Monohydrate is all you need. HCL or similar is unnecessary. However, there is a quality seal that you can look out for, called "Creapure". It has the highest purity and is made in Germany instead of cheap from Asia.

[@ZuziFox]

Does the study suggests dosage of creatine to actually have an impact on the PSD in humans?

[@Physionic]

Unfortunately no

[@justingirard7476]

LEGEND

[@ethiocomment1707]

Creatine ruined my sleep Am I the only one, yes I take it in the morning, reduced the dosage and drink water Just couldn't sleep well or feel rested I have to stop it.

[@Physionic]

Totally fair - I wouldn't take something that destroyed my sleep either. I haven't run across any reports that's the case, but I believe your experience.

[@ethiocomment1707]

Thanks 🙏 Good content as always

[@RainerMaelger]

Danke

[@differentone_p]

but body need to use less energy so it won't burn itself out of life. what about longevity correlation with use of creatine?

[@sultanofswingdrift3021]

This is not true, people who use more energy actually live longer. Athletes and fit people on average live much longer than sedentiary people..

[@differentone_p]

@sultanofswingdrift3021 , they do not use creatine. or can. we don't know. longevity is not about burning excessive amounts of energy but capacity to burn enough(not over the top) everyday. i think if we use too much, we can make ourselves live "brighter" but less in general.

[@ckatt352]

I wonder, all these supplements and the data showing some effects, how is that compared to exercise, and overall a healthy lifestyle? Can it compare.. i mean, if you have an unhealthy lifestyle ,supplements are a drop in the ocean , and if you have a very healthy lifestyle, maybe it really doesn't matter if you take some creatine or other compounds. I don't know ,just a thought

[@notaras1985]

What if you have weak kidneys filtration though and sluggish gallbladder? Isn't creatine supplementation contraindicated then?

[@natasad9266]

My dilemma as well.

[@ericvincentofinowicz5610]

Per the thumbnail why are you putting Chromium in my brain sir.

[@kevinbrown4947]

Is taking creatine supplement hard on the kidneys?

[@nababa5217]

According to Chat gpt No, taking creatine supplements is not hard on the kidneys for healthy individuals. Multiple studies have shown that even long-term creatine use (e.g., 3-5g per day) does not cause kidney damage in people with normal kidney function. When is Creatine Safe? ✅ Healthy individuals - No evidence of kidney harm, even with long-term use. ✅ Athletes & bodybuilders - Commonly used without negative kidney effects. ✅ Dosage within recommended limits - Standard doses (3-5g/day) are safe. When to Be Cautious? ⚠ Pre-existing kidney disease - If you have kidney issues, consult a doctor before using creatine. ⚠ High-dose loading phase - Some people take 20g/day for a week, but this is unnecessary and could increase strain on the kidneys. ⚠ Dehydration risk - Creatine pulls water into muscles, so drink plenty of water to avoid potential kidney stress. Scientific Evidence: A study on long-term creatine users found no negative effects on kidney function (measured by blood creatinine, GFR, and other markers). Another study on athletes using creatine for years showed no kidney damage compared to non-users. Conclusion: For healthy people, creatine is safe for the kidneys. If you have any kidney concerns, get a medical check-up before starting supplementatio

[@Ballistik-Knight]

one thing I've noticed with creatine is faster reaction time. I constantly catch things falling over which I was to sluggish to do before.

[@Physionic]

That's one of the outcomes assessed in the clinical data :)

[@bobkoure]

Re creatine and mitochondrial function, were these all cells from the same animal - or if not did they control for gender? Without getting too deeply into it, cells have two genomes For humans and mice (and probably other eucaryotes, but ?) the proteins that make up the ETC (notably complex 1) come from both genomes. These proteins need to fit within a couple of angstroms or electron transport degrades, past about ten it fails. I mention gender because there's been some work showing that a nuclear / mitochondrial mismatch is more likely in males. I'd be beyond curious to see any work comparing this mitochondrial shift in mice vs birds, as birds are more adapted to aerobic load (flight) and rodents are not. We humans land in the middle somewhere, which gets me thinking about the "born to run" hypothesis - but that's beyond off-topic here. Thanks for making these, trying to figure if my finances will allow another $$ subscription. I may need to wait for one of the journals to run out before I subscribe to your 'insiders'. Planning to do it, though.

[@kinpatu]

Is it feasible that some of the cognitive benefits attributed to DHA in fish consumption are in fact attributable to its higher creatine content?

[@Physionic]

No - most studies on DHA use isolated supplementation

[@swamphawk6227]

That's possible. Both are on my "must take" supplements list, since I don't eat a lot of fish at home.

[@kinpatu]

@@Physionic Good point. Thanks for the feedback.

[@Phoenix-ov5gg]

All I hear is how great Creatine is, but I feel the same when I take it.. maybe my muscles bloat a little and that’s it…

[@sunnyinaspen]

Love your content & delivery. I’d join but budget looks more like red ink bleed all over my checkbook. A quick question, what do you think of Pentadecapeptide BPC 157 Enhances the Growth Hormone?

[@sylviesumer7680]

Can you please explain why creatine give some people like me terrible insomnia and is there a way to counter act the insomnia side effect?

[@MBT372]

I got horrible insomnia from creatine as well.

[@senorpepper3405]

Any connection to creatine and high blood pressure ?

[@DoozyyTV]

can people with impaired kidney function still take creatine?

[@nicksmith-chandler458]

Mr Verhoeven in his red light district

[@NickEverhard]

Any link between creatine and loss of libido? Very few are posting/talking about this.

[@Droidman1231]

Very few people tend to talk about things that aren't real lol

[@flowerpt]

I find the opposite to be true though positive mental health benefits may be a confounding factor.

[@ykles24]

​​@@Droidman1231 Stop denying people's experience. It's infuriating.

[@founde4435]

I've read that creatine provokes hair loss. True?

[@gorkemvids4839]

I've used for 2 years when i was 30-32 yo. did not happen.

[@ReflectionsofChristianMadman]

@@founde4435 From what I recall Nick saying, that finding was from one study years ago and that finding hasn’t been replicated in any further studies. One theory is that those who suffered hair loss had elevated levels of testosterone which caused the hair loss, not the creatine directly.

[@flowerpt]

My hair is growing back (MPB). Better mitochondrial health, probably, but I also take MB 75mg.

[@ykles24]

There's anecdotal evidence. A small study on dht has been extensively disputed. I'd say it depends on the individual.

[@phoeniciangod3629]

What about the impact of creatine on testosterone, DHT to be more specific? And all that comes with it like increasing acne, androgenic alopecia, and mabe increasing the risk of BPH for older men...

[@lukedowneslukedownes5900]

Wow good way to capitalize from Mr beast. There is a contestant in the top 10 with the sun with a creatine disorder and it seems like you’re catching a lot of attention from the humans who have looked up the creatine disorder from Mrbeast show.

[@Physionic]

I'm confused how this relates to MrBeast?

[@xylivb]

what effects are proven for brain? There is this meta anaylsis with a big statisticial mistake: Author's reply: Letter to the Editor: Double counting due to inadequate statistics leads to false-positive findings in "Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials" -> showing no effects in healthy young people in any parameters... even with high doses, only the sleep deprivation study basically...

[@Physionic]

Covered in the next video

[@xylivb]

@@Physioniclooking forward to it👍🏻

[@kayakMike1000]

Jokes on you bruh. I don't have a brain.

[@Physionic]

The joke is, it seems, on me...

[@mlmapot]

Ive tried several times but after a couple days of just 3g it causes really tight calves and my breast a cup size bigger and really sore. Any ideas?

[@mrjamesgordon]

Double to 6g?

[@OrenBroder]

Consumption of creatine among the fitness and bodybuilding community is the highest, but they don't seem to be the most smarterst community, from what I've observed

[@Physionic]

Haha, quite the observation - I don’t think we can blame creatine, though :)

[@nickflynn666]

Some studies have linked steroids to brain shrinkage.

[@flowerpt]

Maybe they're using up all their creatine supplements for muscle recovery? There are some pretty smart quarterback out there too. Their parietal lobes do calculus faster than Mathematica - gotta have good oxygen and strong connectivity to do that.

[@liciniooliveira-becas3618]

Very funny! But they don't just use creatine, do they?

[@famemolto]

I’m a top law school educated business lawyer with a 1st percentile IQ. I’ve been lifting for decades. I have met many, many intelligent, interesting, honorable, virtuous, hardworking people in weight rooms in each of the 17 states I’ve lived. Granted, the juicers aren’t always the smartest, but the men who show up year after year to stay healthy and strong for their children and grandchildren are top flight people.

[@matthewnorman9081]

You didn't scratch your chin in this one, but you pulled up your pants at 3:06 and 5:33. A decent belt or a few extra pounds at the mid-section should fix this 😅

[@kouritasvonkafthor468]

I understand that Ω3 supplements have a positive impact on our body. But can these supplements raise total cholesterol and LDL?

[@randombartz8163]

What about indirect effects due to lowering homocysteine levels and preventing lowering of choline levels by avoiding it's consumption as a methyl donor for endogenous creatine production throughout the body? I always wonder how much of that is having an impact whenever I see a study linking creatine to brain health.

[@seanrowshandel1680]

@@randombartz8163 the most NOTICEABLE things that creatine does are not replication/DNA-related. Not that that's a bad thing to focus on, though. Most notably, creatine upregulates GABA receptors (after causing a deluge of glutamate signalling). I think it might be relevant to think about the time of day of creatine administration in these experiments. There might be different effects depending on the time it's taken. I also think it's definitely not going to have the same effect if you just keep taking more in the same day. Ideally, it would be given about once every 6 days or so in experiments. If not more. I love the replication-centric perspective, but it's kind of a dead end. Who's thinking about that stuff? Are people who think like that even rich? There's some basic demographic stuff that needs to be covered. It's not just for kids. If you invent something scientific, for example, and then it gets used in wars, people need to be able to look up what demographics the inventor was a part of. Sure, you could argue that I'm an inventor who's erased all of my demographics because of this. Glad you noticed. Thank you very much. This Physionic guy is great. I would love to meet him. I really hope we can make him become mainstream.

[@TheMontance]

Would love to get your perspective on whether these and muscle cell effects could be reasonably extrapolated to the pH buffered version of creatine ie kre-alkalyn

[@chrissolo5937]

7:00 bad joke. I know some people will get confused about creatines effect on psd-95 levels after that.

[@Physionic]

If the bar is that low, I can never make another joke again.

[@chrissolo5937]

@@Physionic You can make jokes, but maybe don’t double down on your joke with a big rubric. One doesn’t expect jokes from a science-based channel, so it’s easy to take what is written in text to heart, especially for non-native English speakers. Also, it’s easy to miss the later part where you verbally and pretty swiftly say it’s a joke. I’m sure you know yourself how important clarity is for anything science-based. My point is that the effort to make a joke should not be greater than the effort to clarify that it was just a joke. Long text, but it’s honest feedback. And I know some will get confused by that because I was one of them.

[@MrCarstennielsen]

I have change my diet to include a lot of leafy green vegetables with this is where the bass from Cows creating creatine come from and I get no Effect from eating creatine or in taking creatine anymore.

[@Droidman1231]

Reading these comments reminds me that it's impossible to talk about creatine, something so simple and universally accepted, without a ton of people coming up with crazy theories and symptoms???

[@Physionic]

My arm fell off

[@ExoticalT369]

🥰

[@brulsmurf]

You look a little blurry today. Make sure to take some creatine for your next video.