pKa - Why most drugs are weak acids or weak bases

[@poojajoshi4013]

My search for understanding pka ph concept ends here...thnks

[@NaDa-vv4nu]

+11111

[@mattpace433]

Current med school student. That means I have had to learn this concept over 10 different times over the years. AND FINALLY! I found an amazing explanation and i clearly understand it. Thank you so much.

[@ahmedassadi9227]

I really need to hug you man, I can’t believe pka is just so simple, my doctors couldn’t get this straight up my head for weeeeeks

[@supernovachampions]

thank you so much for posting this. i am in crna school, and they lecturer was explaining pKa with the assumption that we had a strong understanding of chem - for me that was 10 plus years ago. you put things into plain english for me. i also appreciate your practice of equanimity as you teach.

[@Pharmapedia]

Thank you! Had to actually google equanimity :) My main youtube page is PHRM203. Pharmapedia is a format experiment.

[@andijayy9008]

the fact that i now understand this in 10 minutes whilst my prof has been trying to explain it to me multiple times the last 3 weeks… THANK YOU

[@yash92951]

This man explained in less than 10 min what my professors couldn't do in 2 hours.

[@ludyoviedo4121]

Omg finally I understand this concept. Thank u sooo much

[@animeshmisra9467]

Looking beautiful 😍

[@yadabk8378]

Wow you must be a genius

[@fishribbon]

I am an old fan of this man (I like his videos on pharmacology) I like his face: He's like - 'Take it easy, man'

[@iBuyBitcoin]

This guy is amazing, he genuinely cares about teaching the material

[@ahmedassadi9227]

Trueeeee

[@UtobivbiOghenetega]

After hours of trying to understand pka, my clarity is actualized.

[@beaono8997]

loved it. A whole day of class...could have watched this 9min video...

[@Random24853]

Where’s Woody, Taylor, and Kyle?

[@danamay9081]

It makes so much sense when you explain it what the hell.. It has taken me months to understand this and I could've just watched this vid to begin with

[@yogeshlakshman8488]

I am very grateful to your way of explaining to the basic understanding

[@DavidSmith-dl2yr]

By far the best presentation I have seen on this, thanks!

[@falakjamil3565]

Impressive !!Cleared my confusion :) Thnks a ton and stay blessed :')

[@myyoutube5157]

I understood this concept after 5 years of my graduation here thanks Dr

[@elsalynn9823]

Hallelujah! Thank you so much!

[@hannes_mlbx9599]

Classic Taylor

[@vibackup]

Very good video, just one error at 1:47: HCl is _not_ a white powder, it's a gas above −85.05 °C (−121.09 °F; 188.10 K).

[@rolandmalone5431]

very nice , i'm a pharmD 2nd yr student and this guy shouldve taught in my courses...

[@ASHTUTORIAL]

Best video...thanks sir...great...no words to explain ur teaching clarity

[@paimanehjoohari7391]

Thanks for these simple definition, I had problems with these elements, but now I understand that, again thanks a lot

[@dhandapani9870]

Thank you so much. You’re such a blessing

[@doctort.moahmed645]

This is my second time I saw this video and it's excellent ❤❤

[@glaydleicaro256]

Very clear explanation. Thank you Sir!

[@jazewang3543]

This guy is the best!

[@elvinahandini645]

omg your videos saved my life many times :') thankyou so much

[@jalaluddinnasim8328]

Elvina Handini Can you explain,why most of the drugs are weak acid or weak base? In the video I found that it is because small change is required to shift between ionized or non ionized form But I don't understand how?

[@elvinahandini645]

Most drugs are weak electrolytes, may be weak acids or weak bases. In water, this weak electrolyte will be ionized into its ionic form. For weak acids, a high pH (base atmosphere) will increase its ionization and reduce its nonionic form. In contrast to weak bases, a low pH (acidic atmosphere) that will increase its ionization and reduce its nonion. Only nonionic forms have fat solubility, so only the nonionic and ionic forms are in equilibrium, then after the nonion form is absorbed

[@jalaluddinnasim8328]

Elvina Handini,so,they are weak acid or bases,but why are they not strong acid or base?what is the benefit of that?

[@elvinahandini645]

Drugs that are weak acids will easily penetrate the cell membrane in the acidic atmosphere. Because in an acidic atmosphere, the drug is relatively unionized or the ionic form is small enough to penetrate the cell membrane more easily. strong acids or strong bases will be easily ionized which is cannot be penetrated to the cell membrane.

[@الحكواتيالعجوز]

@@elvinahandini645 thank you ❤️

[@k8reed]

Thank you so much for sharing your video!

[@Lostpanda123]

Great explanation and a great tutor!

[@sabrinadream9178]

Very good explanation sir

[@graceusa3942]

Great teaching, thank you so much.

[@harshitagaur6394]

Thank you sir...so easily explained

[@RomajaneAbrenio]

This is a really good video. Thank you, Sir! 💓

[@johnmiller323]

I understand the concept now... thank you so much

[@jalaluddinnasim8328]

William can you explain why so many drugs are weak acid or base,not strong?

[@harshbirsingh4741]

i am confused about protonated and unprotonated form🤔

[@sainidhi5617]

Finally understood it.... Thanks Alot!

[@JC-xk8vh]

The 33 dislikes are 33 Professors that couldn't explain it any better.

[@priyarajeshanepla9465]

Thank you so much for explaining it in the best way possible!!

[@JN-kk4nk]

this was very clear ! thanks

[@dane3030]

This helps a ton, thank you.

[@joycebritto8111]

excelente explicação. Aprendi mais por aqui do que assistindo em muitos outros vídeos. Grata!

[@fredred476]

awesome vi. subscribed, thanks!

[@jyothishk7557]

Thanks for the video.❤️❤️

[@drsheikh]

FAN-tastic.. Thankyou so much

[@damemochi3322]

Quick question. In the example with aspirin, when it's either in the acidic (HCl) or basic solution (NaOH), does it COMPLETELY dissociate into its respective lipid/water soluble form since aspirin is a weak acid??...or is it more so that in an acidic environment aspirin is MOSTLY lipid soluble while in a basic environment aspirin is MOSTLY water soluble?

[@Pharmapedia]

GREAT QUESTION! I googled it and came across this. www.ausetute.com.au/aspirin.html They show complete dissociation. But your question is not only outside of my clinical knowledge base, it is outside of the point I want to make. Most drugs are weak acids or weak bases because change in pH change their water solubility. This is an essential concept for drugs that cannot be mixed in the IV lines. So running a drug through a piggyback running normal saline as the maintenance solution can cause that drug to come out of solution and form particulates if it is incompatible with the pH of the maintenance solution. Major med error issue in some hospitals. Hope this helps. Thanks for the great question!

[@marceloovg1873]

Suppose you have a closed system like the beaker shown in this video, with a finite amount of plain water , you measure ph and it comes at 6.5, and then you add say 1 gram of powdered HCL and it completely dissociates , it gets the pH of the water to an acid 4, then you add 500 mg of Aspirin (pKa is 3.49) what will happen is Aspirin will slowly dissociate (slowly because the pka is very near the current total solution ph which is 4) until the pH reaches more/less 3.49, then at this moment roughly 50% - 50% of the aspirin will be in the uncharged : ionic (charged) form and right here it will stop dissociating. how much of the aspirin will dissociate? 90% ? 10% it depends how much quantity of it you added , if 500mg was enough to donate enough aditional protons to the already acid solution then ir will stop right there, if not, it will keep dissociating until it reaches the thermodynamic equilibrium constant and will stop dissociating and keep at 50% - 50% no matter how much more aspirin you add it will not lower the pH more. thats what pka means.

[@Simran-jd4wi]

Thank you man ❤

[@naghmeazadi8294]

It really helped.thanks

[@dojrajkhanal9417]

Will the same case be applied to phenol?..just like for aspirin?

[@DylanHart8]

Kyle really thinks he’s some kind of pharmacist now just because he took little acid.

[@arshithgowda8728]

Oh god finally i understand thank u sir 🙏🙏🙏

[@syedataliahaider6578]

thanks to u i understood the concept

[@ED-ez8yd]

So legit. Thanks.

[@flaneurup]

Amazing

[@minabish1783]

Thank you very much

[@thaslima8688]

Thanks a lot completely clear

[@ThePedroCordero]

It helped me a lot...I couldn't understand this shit from books! Thanks a lot!

[@himanshudutt5162]

HCl is white powder??

[@vibehealth6828]

God bless you

[@mithunvb685]

Thank you boss!

[@steveharris1740]

Humm, this is "basically " (haha) acid-base equilibrium.

[@TMTeeandEmm-uc6si]

From galala University thank u ❤️❤️

[@jeevidhabalasubramaniam2341]

Sir y does that substance release the proton instead of releasing electron.. since electron in the Valence is easier to remove than the proton in the nucleus...@0.10 min

[@RahulSharma-ew5zp]

Jeevidha Balasubramaniam h+ ion is considered as proton

[@RahulSharma-ew5zp]

Acid base concepts are based on h+ and oh- and not on electron

[@MrKrishanpatel]

Amazing video and explains everything very clearly! Thanks

[@jaskaur7885]

Thank you so much!!!

[@olalaolala4400]

thank you so much ❤️

[@trickjacko8482]

Thank you

[@aizayy3658]

Om gash Thanks Love ❤️ u🤧🤧🤧🤧🤧🤧

[@damntravis6056]

RSK

[@pain_is_ultimate]

Nice

[@abdallarohi5429]

such an intelligent guy👍

[@brittanym1326]

You’re going to get me thru school

[@sameraahmed7156]

amazing

[@lukehe8663]

Thanks!!

[@yoaimou9798]

I love u man

[@robertamorgado6908]

thank you!!!!

[@RenasAb]

Thanks 🙏🏻 ❤️❤️

[@Peace-fo1vx]

thank you

[@zainjafry2658]

thank you for make so easy

[@dp-mason]

Woody looks really different

[@6sixFace]

0:22 That's Based.

[@pricilladisuang1690]

I completeeeelyyy understand nowww

[@saurabhbhansingh2611]

Thank you sir it's was really helpful

[@countrysafari230]

#Pharmapedia Thank you for this amaizing explaination. I am confused about quinolones, how do they have good absorption from gastrointestinal tract despite that they have a carboxyl group at position 3 and amine group at position 7 which will make them ionized in acidic as well as basic fluids ?

[@artherdoland1050]

thanks

[@cattymed4419]

Thanks

[@netspirit79]

"Hydrogen chloride is a white powder" - WTF?

[@keeskruithof1123]

HCl is at atmospheric conditions a colourless gas. Painfull to eyes.

[@collinsulanja3333]

💪👌

[@luvurenemies6127]

Well, let's take this assidic solution, similar to the asssid in our stomachs. Let's put an ASSSSspirin in. This proton wants to come off the aspirin. BUT IT CAN'T. WHY? because of proton mass AACCtion! ...watever u r having, i need it XDDD

[@BrandonSLockey]

vielen dank

[@smokecurl9437]

Nice lecture. My personal favourite Pharmacology channel is: Dr. Junaid Asghar. Have a look at this topic there and thank me later.

[@hajernt7833]

Amazing

[@motunrayoamoran8945]

Thank you very much

[@iqrabuzzamanshoumik3284]

Thanks