DNA Replication: Copying the Molecule of Life

[@UnironicWizard]

Gotta love how with quarantined schooling teachers have given up on teaching and recognized that people like you have been the ones actually teaching us.

[@Emily-gy8pe]

that why im currently watching this

[@danjbro]

@@Emily-gy8pe same!

[@danjbro]

🙌🏽

[@jenniferstormlambert162]

Professors and teachers are getting lazy and it is so much easier for them to just send us to a website and let someone else explain it! Thank you!

[@esahoosa]

Even with a biology degree and in medical school, this is the most straight forward and easy to understand video on DNA replication. You sir are the GOAT.

[@KB-vd8wq]

You literally just summarized about half of what I learned in an entire semester-long molecular biology class in a 6 minute video. Nice.

[@satinderjit4]

Dang what!?!?!?!

[@Malik-em6ng]

really this is day one for us..... it is fricking hard XD

[@harrietharlow9929]

I love that I can learn by watching videos. I am interested in many subjects and my idea of a good session is learning something new. I will definitely be checking out Professor Dave!

[@nyxieempire8446]

Every time I struggle to understand a course material and find out you have a video for it, I cry tears of joy

[@Sara-by7cf]

You single handedly made me not only pass but EXCEL in my biology 101 class. Thank you professor dave

[@jakarigainer5165]

I just realized something very important in terms of how to interpret your animation. The directionality of the synthesis of the new strand is correct. However, I initially thought that the numbers you put on the leading strand was identifying the ends of the new strand, not the original strand. In other words, the new strand would read/synthesize as such: 3' under the 5' of the leading strand and 5' under the 3' of the leading strand with the arrow going in the same direction.

[@chloeli4405]

5' and 3' DNA template strand should be more specific indicated in the slide. Its a little bit confusing.

[@ProfessorDaveExplains]

yeah a lot of people have mentioned this, i wish i had made it a bit more clear. nothing i can do now!

[@dawncorbin6140]

Yes, he needs to label the new and old strand as it is very confusing (he's labeling the old strand)......this is where students get mixed up often.

[@MuhammadAwais-qc6bh]

@@ProfessorDaveExplains You should make another video... Please sir this is a humble request...

[@jamesbort8242]

All the videos I have viewed on DNA replication struggle to explain the 5'-3' process. Unfortunately, this wasn't any better, but the rest of the video was helpful.

[@jenm1]

@@ProfessorDaveExplains annotations?

[@Bawan2610]

DNA chain can only be synthesized in 5'-to-3' direction, not 3 to 5. As the subunits is being added at the 3' end, that means it runs in 5'-to-3' direction....

[@jdmg7284]

Bawan Colnadar I noticed that error in the vid as well

[@rototon1992]

He's going to get people confused. Need an upgrade.

[@pa800korg92]

Actually he's correct, the DNA polymerase III moves in a direction of 3'- 5' of the preexisting strand. However, the new strand that's being synthesized is 5'-'3. The video is crystal clear .

[@hasnainabdurrehman2426]

The video is correct, but NOT clear. This "Dave" person knows the stuff but doesn't know how to explain it to a naive mind. Someone listening to this for the first time can get confused for all his life ! REPLICATION HAPPENS FROM 5 to 3 END !

[@pa800korg92]

Sounds like you're not interested in using your logic only in memorizing facts.

[@Akuty1]

Thank you Prof. Dave! I spent like two hours trying to understand my professors lecture, and you helped quite a lot! I am really grateful that I found this video online. Thank you for what you do! :)

[@aleynacabuk7352]

Spending hours in boring college lectures with professors that lack the ability to teach and not learning ANYTHİNG vs watching a 6 minute video from a great teacher and understanding everything. I think I have spoken enough

[@myvideosfortheworld6122]

sir you are a really talented teacher and a speaker ...... a process which would take me hrs to understand was made easy by you and i got it in juat 6 mins ! thanks man

[@shanayalnaveed9100]

That Addicted Guy you forgot the 15 seconds

[@lovezaara]

i have a bio final tomorrow i love u professor dave ure the goat

[@adamgurman8756]

A great, fast, easy and organized video! Thanks!

[@lisamathews7971]

You remind me of an off-brand Dave Grohl and it makes studying way easier, thank you

[@moffeevalverde1403]

I love the way you explain each step of DNA replication and other biological processes in your videos, I'm just glad to find your channel :')

[@intellect_junction69]

Bro, why does the microscopic world low key feels like a mini-society

[@harrietharlow9929]

I enjoy that I can learn the basics from your mini-lectures. Great job, Professor Dave. You put me in mind of my late father, a physician, teaching me about reproduction, mitosis, meiosis, etc. He started with onions and went on from there, ending with human reproduction when he felt it was age-appropriate (about 13-14 in my case). This puts me in mind of his teaching methods. I just subscribed a couple of hours ago and will be adding your videos to my Geology/Volcanology and Evolution and Extinctions playlists. So glad I found your channel!

[@jezrhaymagayones8841]

I like the fact that what I learned here was better than what I learned in school, more detailed and compact Keep it up 😊

[@zaraanwari126]

Video was crystal clear . I understood the whole topic In ONLY 6 minutes where I didn’t get one thing through my head in a 80 minute class . Thank you so much Professor Dave !!

[@shayekhabedin4462]

If only I had you as my lecturer ! Absolute legend mate!

[@maddiedoesart4379]

my test is in an hour and your videos are the only thing that has made me understand replication/transcription/translation omg 😭😭😭

[@arhamcollectionofficial]

Thank you sir I spend 2 days on this topic but this 6 minutes video clear my concepts too much

[@mayamade9047]

This is one of the best videos I have seen on DNA Replication!! thanks a whole whole lot!!

[@kellyedsall9715]

This helped me so so much! Your video really cleared this up! Thank you!

[@missjesseduph]

I have a final task in Genetics, thanks for this vid. It means a lot to me!

[@frapechinokelsey6451]

I'm in 12 standard from INDIA 🇮🇳 & I found this video which really boosted my knowledge ☺

[@Carter-wj9wn]

Your videos are so helpful!

[@deepseacocoon]

This man has Taught me for 3 separate courses, its amazing

[@CalvinMathew-t2m]

It is very impressive to listen your explanation specifically biology 🎉🎉🧬🧬🧬

[@sierraschopp4662]

This is such a great video! short and sweet :)

[@ians4987]

hi professor. i thought polymerase creates the leading strand in a 5'-3' direction towards the fork?

[@anonymousplayer6378]

Sir, can you state the difference between DNA polymerase alpha beta, gamma, delta,epsilon and DNA polymerase 1,2,3??

[@sarameame7864]

Its perfect!!!!😍 Each time i want to search for something scientific i find a video for you, your explanation is perfecttttt, keep on Dr.♥️

[@oct_rz4736]

You are awesome.. I was jumping from video to another and I can’t understand that. But with you just in 6 min I take it very well !!

[@Zetsuke4]

I can leisurely watch Professor Dave in my free time and enjoy every second learning as many videos as I can.

[@yashgokhale1460]

Super helpful! Would have taken hours for me to understand just by reading this. Thank you Sir!

[@shaistanazir8752]

it was beautiful sir. it helped me memorize it smoothly.

[@atiyadavids4651]

Best explanation I've ever heard and seen my whole life. Ily.

[@spiritwing9391]

Whenever I am in need of help in biology, I go to this dude! Nice job! 👍🏻

[@spiritwing9391]

Thanks for hearting!

[@joshuahalsey1020]

Makes so much more sense hearing it from you vs. in class

[@vaibhavbaadkar1450]

Explained in very easy and simple manner... Thank u sir

[@ewittka100]

Great explanation, thanks!

[@MyDerpDerpDerp]

As was stated previously, the direction is NOT 3' -5'. According to Mc Graw-Hill 11th ed. Biology, "As with all known DNA polymerases, all three of these enzymes synthesize polynucleotide strands only in the 5'-3' direction and require a primer"

[@ProfessorDaveExplains]

i meant that it moves along the template strand 3'-5', though you are correct the new strand is synthesized 5'-3', perhaps i should have been clearer in the animation.

[@MyDerpDerpDerp]

Thank you for your timely reply! Perhaps it could have been clearer, but you are right as well. Thanks for the video, anyhow :D

[@Ben-kl8do]

Not sure if nitpicky or not but it could help to clarify that DNA polymerase III/I are those used in prokaryotes. I remember in high school still using the terms generically but I believe DNA pol-alpha/delta are the current standards for eukaryotes?

[@tuzannegoe9647]

You have the replication going from 3' --> 5'. This is incorrect. Replication always goes from 5' -->3'.

[@ProfessorDaveExplains]

the daughter strand is 5' to 3'. polymerase moves along the template strand 3' to 5'.

[@elliemcanuff8157]

holy shit i've been looking for videos like this all year

[@ProfessorDaveExplains]

search no longer!

[@italianfire110]

This is the only video I've seen that accurately explains the difference in role of Topoisomerase and Helicase...Thank you

[@josephinekyalo610]

Your explanation is very clear and the footnotes are very helpful, i now can understand the replication process thankyou prof

[@DyanaBunnyPhD]

From Professor to Professor 👉🏼 you are great !!!

[@Daveeff]

Watched so many videos on this and this one finally made sense. Thank you!

[@AdamFlanders]

What software was used to image the DNA molecule in this video (at about time stamp 00:07 - 00:15)?

[@ProfessorDaveExplains]

oh that's just a png i found on google images, i'm not sure what it was made with

[@MVD_1I1]

Thank you couldn’t understand from the biology book with the diagrams you just made me understand in 6 minutes

[@irinabains4300]

hi prof, had a few doubts: 1. after binding the primer to the DNA strand, the primase leaves the spot, and DNA polymerase iii takes the same spot to start adding the free DNA nucleotides? 2. on which strand do the following take place first or do the following processes take place simultaneously (as there is one molecule of enzyme allocated for each strand?) on both the strands? a) exonuclease removing the RNA nucleotides/primers b) DNA polymerase I adding DNA nucleotides in place of the primers c) Primase adding primers d) polymerase III adding free DNA nucleotides

[@sarajakobsen1070]

Its so frustrating, I understand the protein syntecis, the DNAs structure, mitoses and meiose, transcription, translation etc. when I get it explained to me, but there is no way I can repeat it😂😭

[@cristinajones7211]

Thank you for this.. I had no idea what was going on until I saw your videos! Thank you so so much!

[@thumiwemvula3951]

And BOOM!!!! That's how I understood DNA replication!!!

[@mushfiqurrahmanshishir8055]

Thanks for this explanation. Some things are simplified. But this is a very good overview. It was really helpful.

[@boscokimbawala1053]

Thank proff Devi .....am really enjoy your session

[@Arvatly]

Dave, polymerase III reads from 3' to 5' but polymerases new strand from 5' to 3'? But you said polymerase copies 3' to 5'. Did you mean polymerase reads 3' to 5'?

[@ProfessorDaveExplains]

I said moves along the template strand, so yes "reads" would be a good way to interpret that.

[@ambiavanessaanti4911]

Thank you so much Prof Dave I wish you could explain the rolling cycle mechanism too

[@Toothfairy1018]

you're the real MVP! and I love your intro lol it's hella catchy and cute

[@dhritimadas6357]

Easy & concept clear explanation.... thank you sir.

[@lukamtc9188]

Loving the vids, I'm revising what I learned in the balkan equivalent of advanced biology & chemistry highschool. Just one thing: the audio volume is a bit low everywhere except the intro. These are old af but if you plan to make more videos maybe amplify the volume a bit in post.

[@The_end_of_the_f_world]

I'm confused ! isn't it always 5' to 3' direction ? In some videos I heard that DNA polymerase can only move in the (5' → 3') .

[@ProfessorDaveExplains]

direction of motion along template and direction of synthesis are complementary

[@grantcallen9763]

Doesn't polymerase travel 5' to 3' not 3' to 5'?

[@HairyGarry]

Polymerase starts traveling at the 3’ end of the existing strand(so 3’to5’). The new strand it adds would be in the opposite direction. And that is what is confusing you.

[@vlihumbtov4236]

Do you have a video about endogenous retroviruses (ERVs)? Would like to get a better grasp about the subject. Thanks for these videos btw. Really helpful.

[@TKenziefied]

thank you so much, i am so grateful for this video. Explanations are perfect.

[@mdrayhanuddin4350]

Correction : A new DNA is always synthesized in the 5'➤3' direction!!

[@ProfessorDaveExplains]

Yes, so the polymerase moves along the template strand 3' to 5', as I said.

[@bobl9555]

Excellent video, Thanks!

[@pastimepursuit7212]

1:23-1:47!, 2:06, 4:17!, 4:43

[@jinkedewilde4792]

Thank you for saving my exam! Very clear and well structured explanation.

[@memunaissah823]

You’re a life saver Professor Dave..

[@janepiccirilli4654]

Thank you so much! You helped clarify a lot of areas that my textbook failed to properly explain.

[@jxyz9154]

thank you so much for your explaining

[@aneesurrehman7405]

really really helpful video, love you from indian occupied kashmir.

[@purvijoshi2008]

There is only POK because Kashmir was always a part of India.

[@tylergoh2287]

I love u Prof. Dave , u made it simpler

[@ryancullen6301]

I think the video is wrong, nucleotides are laid down from 5' to 3' when building DNA or m-RNA. Please review your content before posting!

[@ProfessorDaveExplains]

Yes, so polymerase travels 3' to 5' along the template strand. Please listen more carefully.

[@ryancullen6301]

@@ProfessorDaveExplains Oh okay I understand now. Sorry for challenging your knowledge, you are such an inspiration to my family 😘

[@zainabhasrat]

The best teacher doesn't exci

[@tcinca168]

Thanks for the help. Now I get DNA replication better than ever!

[@kimia1664]

I got more than I asked for! A lot of these stuff aren’t part of my textbook but I don’t care. I’ve always wanted to learn this anyway.

[@anjalirawatttttt]

Thank you so much sir.... It really helped✌️👌

[@akinyemihafsat3699]

Wow! I love the lecture. Thank you Prof

[@pratapsarkar9693]

Great video... But did you forget SSBPs??

[@linoswater]

you are truly God sent Prof. Dave

[@poodle395]

I like how you dont use gimics at all, you tell what needs to be told and have easy to understand diagrams

[@pradeepajayanetti7500]

This video is perfect thanks a lot sir.

[@subarnikmandal_MUSIC]

U r the best.... Respect SIR. ❤❤❤

[@savinas.577]

Thank you very much for this lecture! But isn't it, that the direction is from 5' to 3' and not the other way around? At least that is what Amboss states.

[@ProfessorDaveExplains]

Watch that section again and listen carefully.

[@dafidtaylor]

great refresher vid, great name

[@dustinkim303]

best DNA replication video!

[@draganmirkovic9377]

What happens to that mutation cells which polymerase and enzymes dont fix. Does that cells turn in cancer cells if immune system dont kill them?

[@ProfessorDaveExplains]

Depends on the mutation. If it's in a proto-oncogene, then maybe.

[@desyjo5547]

Does DNA polymerase III only work on leading strand ? Does DNA polymerase I also work on leading strand to replace RNA nucleotide into DNA nucleotide ?

[@ganeshmath717]

Why RNA primer is used in DNA replication sir??plz reply

[@Ayman-kz7dn]

Dear Prof nice to follow you. you have mentioned tow polymerase : polymerase I and III, what about polymerase II? is there II or not, if isn't, why number II has skipped?

[@medicaldoctor8983]

Polymerase 2 is involved in DNA repiar not in DNA replication.

[@spiritwing9391]

Medical Doctor thanks!

[@Dunger974]

Watching this before my AP bio exam today

[@tobywang9679]

Are DNA polymerases I and III in prokaryotic cells? What are the DNA polymerases in our cells(eukaryotic)?

[@vidyabhushan4381]

Awesome description!!!!

[@mustafafarhati9882]

You just made this shenegan simple.

[@alderamin1402]

Amazing explanation

[@kudzierufasha5793]

Which DNA polymerase are you referring to when you say DNA polymerase proof reads. Polymerase 1 or 3?

[@ProfessorDaveExplains]

i believe all polymerases have proofreading ability

[@DevrimAras]

i believe i can fly