Mechanisms of DNA Damage and Repair

Remember how the Ninja Turtles came to be? Yes you do. It was the ooze! A radioactive ooze that mutated their DNA in just the right way to give them the ability to walk upright, talk, and do ninjutsu. Now, I'm as a big a Turtle fan as they come (Donatello is my main man) but this is a highly inaccurate way to portray mutation. Let's learn about the real ways that your DNA can become damaged, and the strategies nature has developed to combat these risks.
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[@maria1239876]

I like the preschool vibes i get from the background while I'm learning stuff in my junior year of college :D it makes me feel all warm and fuzzy.

[@daniellewilson8527]

Imagine how smart preschoolers would be by watching this

[@noblevenom2858]

@@daniellewilson8527nah preschoolers are pretty dumb. They can’t do shit

[@dr.bibaswan]

Correct. We are all little kids deep inside. Our official age may be 20 - 30 but we love the vibes of age 2-3 😇

[@personalacc4352]

"Now that we are sufficiently terrified of genetic mutations" 😂

[@sroydetroy6404]

Where did he say this lol?

[@memoryloop5816]

@@sroydetroy6404 5:39

[@anusphoorthi9anuradha968]

Àyy

[@ComandaKronikk]

Dude thanks for getting directly to the point and not fluffing about like so many other youtube videos. U just feed me facts that I CRAVE!!! Professor Dave 4 prime minister 2019

[@Youssef-zo3ls]

Paris Coroneos exactly! He gets directly to the point

[@BishoujoMegami]

Professor Dave, I'm still using your videos at Uni😂 They are so helpful. My genetics lectures are really confusing so far but this is helping consolidate my understanding. Genetics was always my week point in biology🙏🏾

[@alaazein7147]

Me too

[@geetugupta7244]

I don't even have to take biology next year, but I'm forced to learn it this year ...stupid school rules...😭😭

[@hamzazaqut1315]

It seems spelling is your “week” point too.

[@BishoujoMegami]

@hamzazaqut1315 omg, you need to quit your day job and become a stand up comic... you'd be a millionaire...

[@Eagles883]

@@hamzazaqut1315you’re harsh, I was thinking to myself “I’m not going to correct it.”

[@EpicSelenium34]

Thank you professor...another fabulous video. I like how you go deep down into the molecular structures of the mutant amino acids and the pyrimidine dimers (and other such things) instead of just glossing over them. Getting to the chemistry at the heart of what we observe makes the learning experience so much more intuitive!

[@mirarizqah]

This video is great. easy to understand and have a very clear explanation! I love it

[@MrLaTEchno]

For a layman like me this series is fairly easy to follow and understand. I am therefore very grateful and hope to be able to use your work here on Y-T a lot. Greetzzz from Holland [sorry for my bad grammar]

[@alwaysambitious]

I love how clearly you talk! great Videos

[@ravikumarkommareddy3723]

Easy to understand and informative. Thank you very much. Great job

[@renkei7596]

Love your videos to sum up what i learned in biochem :) But could you do a video about molecular cloning and PCR?

[@molecularunity]

Another great vid and, as always, total clarity. Thank you.

[@samlynn7681]

Thank you so much! I couldn't understand mismatch or NER for the life of me for the entire semester. I really needed this explanation for my exam tomorrow!!

[@christopherreed2694]

Thank you Dave for taking 🙏 the time it is appreciated much 👍

[@MyMorghy]

Thank you so much Professor Dave I have an exam of Genetics this Tuesday and you have explained me about half of the themes of the exam in 11 minutes. Fantastic

[@fathimashahabudeen3477]

This video is great now u are my professor.. it’s easy to understand yr videos so simple and made with dedication and love 💕

[@henrynyirongo8761]

Professor Dave is one of the very few that take time to respond to the various comments😊

[@arovana82]

Very good explanation! Thank you!

[@e.c.2215]

Thank you for all your tutorials! From Chemistry to Bio they all have the exact content that I need.

[@VinodGupta-hj8hu]

thank you, Professor Dave your explanations make me learn more. Thank you for producing this videos.

[@roxannemacasinag761]

Thank you Prof! My Go To Guy! I’ve been passing my subjs, partly bc of u! And correctly answering activity sheets because of u! THANK U SO MUCH!

[@iluvbeef11]

hey professor dave. great video! your graphics really illustrate concepts that I've been struggling to grasp since high school. this is honestly the best explanation of mutations I've ever seen. I do have one thing I wanna clarify tho. so in the frame shift mutations, it was one whole base pair that you had deleted. let's say you showed an insertion. would it be an insertion of a whole base pair? or could you have an insertion of a nucleotide on one strand but not on the other strand opposite to that added nucleotide? let me know if my question is confusing lol I'd be happy to rephrase it as best as I can

[@ProfessorDaveExplains]

ooh that's a good question! you know i'm not too sure, i'll have to look into that

[@iluvbeef11]

@@ProfessorDaveExplains awesome, lemme know when ya know! and thanks again for the great vids

[@reemsjourney9070]

Thank you prof Dave, you made me survive my journey in premed 🙏❤️

[@OneWithTheOcean]

Very informative, Thank you!

[@jwh5505]

if this video is that informative to you, i recommend you not to take ap biology

[@nesrineemira6381]

sir u are a life saver..and that intro sends ...

[@iseegoodandbad6758]

I love Dave so much!! The best teacher so far!!

[@camilasousa5853]

Thank you so much!! I was really looking for a class like this

[@joedart1465]

Nice job Dave.

[@DanyalLaghari7]

your videos are still being used after 7 years. Thanks

[@yikotao]

He knows all about science stuff and he is professor dave explains. This song is like gangnam style. I only watched several videos and start singing when I was cooking my dinner!

[@tomservo5007]

cooking and singing will increase dna mutations. good luck.

[@jwh5505]

just keep on cooking

[@thebigtricky9156]

Overtly, I find it annoying, but each to their own.

[@econguyph]

*you helped me in biochem class thank you professor I think thank you isn't enough so grateful ❤️*

[@TutunChanda]

Awesome video proffessor

[@breadbread8759]

This video was tooo good! so perfect!! Thank you!!

[@witty_me]

Thanks, Professor, for explaining it.

[@johnbates3567]

This is excellent Dave, thank you!

[@jayasriramani6718]

John Bates

[@napojusticeramothokoane5536]

Thank you Prof. um thinking, I may as well stop paying my school fees and start paying R5.00 per month for joining your channel, this feels great

[@jeannensantos4296]

brilliant. everything I needed in one video clearly explained

[@annestricker6917]

Thanks! Great presentation, much appreciated!

[@omaimah7366]

thanks.. you explain it so clearly

[@nileflower9181]

you're information is very useful

[@4everanjan]

Fantastic !!! really helpful

[@abidemitoluwaniosho5571]

THANKS MAN, THIS WAS Helpful

[@Surgtari]

thank you jesu.. I mean prof. Dave this was beyond mind blowing

[@patricksarama4963]

Don’t be shy, call him biology Jesus

[@TupeDavid]

This video is great. easy to understand and have a very informative.

[@mymonamkeess6516]

Thanks for the wonderful explain ♡ I loved the song at beginning ^_^

[@jacobguenette273]

Dude I understand everything so well now. Thanks!

[@furkaan346]

Dave, I suggest you first present a summarized outline using a flowchart classifying different mutations and its subtypes. This way it'll be easier to grasp and make notes at the same time. I suggest you apply it to other videos too

[@raoulfulgos8536]

Nice job, would love a homologous and nonhomologous recombination video if you have it in you

[@citysbandaid]

Dave thanks so much for the videos ! Your lectures are complete and easy to understand. :)

[@sciencenerd7639]

very good information, thanks so much

[@raqimafarhad7745]

Very clear and concise 👍

[@geraldwise335]

wow amazing proff Dave

[@dannyfreeman2302]

so great this is awesome information thank you dave

[@lezanibrahim8327]

You saved my life by this video ,thank you

[@GurpreetSingh-jr8kk]

U r fabulous professor ..... u teach better than my teachers in my tutions.... Lots of love from INDIA

[@AyushPramanik]

Could you gimme the details regarding the repairing enzymes? I mean, not all of them. But the main ones.

[@Godessa9shrek]

"Now that we are sufficiently terrified of genetic mutations...", lol...a laugh I needed while late night studying. Thanks!

[@maryamsediqi3625]

Many thanks, was great explanation.

[@joshmemarrynagdey1639]

It's very nice helpful. Thank you

[@abdullahhelal5413]

Informative video.

[@themillennialpa]

I love you PROFESSOR DAVE!!!

[@belgacem_mehdi]

A question : 2:27 you said if the mutation happen outside the gene it does not cause any thing But we know that there many gene that are regulated and activated and deactivated by portions of DNA outside the gene ( epigenic )

[@windyanissarecita]

omg very helpful.. im a big fan

[@skynabendera7854]

Super helpful

[@holden2966]

Thanks Dave

[@abdullahhelal5413]

Dave sir you r great!

[@mapuliclavery9883]

Very nice professor

[@ipanemasalinas]

ily dave 💖

[@sarahward5974]

Really great thank you!

[@AR-rf9hc]

Thank you professor

[@bumblebee434]

Thank you sir ❤️

[@docmaker-italy]

Bravissimo, molto belli i tuoi video, thumbs up!

[@taif.m1303]

thank you !

[@yusuphajallow5646]

thank you Professor its well explained indeed

[@kylahughes4171]

Thank you Professor

[@zollingerellison1998]

thank you,professor👍

[@maavaishno2198]

AWESOME EXPLANATION

[@PitzziMr]

man, you are awesome.

[@maschinenraum]

sunscreen is only good for preventing a serious sun burn. but beside that i do not use sun screen because it reduces the vitamin d level in the body. and with a high vitamin d level there is maybe more DNA repair going on.

[@user-pr1st5rh9r]

that binding of oxidized guanine with A happens when during repair or replication as there should be C there initially ?

[@fredcalledbygod]

Very good teacher👌🏿👍🏿

[@TheAnnie121]

....am I the only one who ALWAYS sings the intro, even though this channel has been accompanying me since my Senior year? :D

[@reginadaka2335]

No u ain't the only one..

[@henrydennis2199]

@ 5:39 Dave: Now that we are sufficiently terrified of genetic mutation.... Me: guuuuuuyyyy!!!😂😂

[@melvyncarrot4741]

What about DNA damaged by antibiotics such as fluroquinolone antibiotics? Can it repair by itself?

[@duolchol3262]

the greater teacher ever

[@Phoenix-np1iu]

is the polymerase used dna polymerase iii? I can never remember which polymerase is which

[@RandomNooby]

One of the greatest mysteries of modern science, is how does Dave have such a derpy haircut and yet manage to ooze cool from every fiber of his being?

[@thebigtricky9156]

Most likely his knowledge of his area of expertise and indeed the subject of the content, I think he uses that to stimulate people's interest and become and thus become charismatic.

[@radhikabiraj5243]

U r amazing sir.....lots of love from india.....ur videos boost my knowledge🤗🙏🙏

[@basmah7837]

Thank you so much you are a life saver😟💕💕💕

[@cindy_le1106]

Interesting!!

[@victoriakathleen9993]

Do you offer worksheets to practice and review the things you teach?

[@ProfessorDaveExplains]

enough people have requested this that i'm thinking of doing it at some point

[@geetugupta7244]

Really urgent doubt : Are cytosine and cytobine the same ?

[@prembhattarai7365]

you're genius. thanks for saving my life

[@MrMagic-bl3ew]

lol aced my genetics final by watching these videos... didn't go a single day to class loooool

[@klutz3955]

College or high school?

[@ThePhoenixstar88]

He always makes me smile if he pops up while I’m scrolling by lol ☺️

[@littlelulu5675]

so professor Dave is it true the number of mutations in human DNA makes it highly unlikely that man is as ancient a creation as we are taught and that we also have an expiration date coming up pretty soon because of those mutations?

[@ProfessorDaveExplains]

No, that's not true, or remotely intelligible.

[@nikhilratna9421]

Did he miss out Single/double strand breaks due to ionising radiation etc?

[@Lalita_Chevaliere_108]

Thank you, Professor! Does this mean that if you avoid sunlight, you will be healthier? Say if you just go in the morning sun for a few minutes, and then stay inside all the time? Or do we need sunlight so much that we can't avoid it, though it comes at a price?

[@ProfessorDaveExplains]

well you need some! but excessive exposure increases the risk of skin cancer certainly. sunscreen!

[@Lalita_Chevaliere_108]

Thank you! I'll remember that ;)

[@jasonl4237]

@@ProfessorDaveExplains What sunscreen type/spf should I choose? Do I need to apply sunscreen to all skin areas (face, neck, hands, arms, legs) exposed to sunlight or only the face? How long should I stay in the sun each day to be healthy? Thanks.

[@MONGTRAN11]

Mutations are classified by heredity or environment factors ?

[@ProfessorDaveExplains]

i think typically by the mechanism of repair as i've done here, but you can certainly classify them by the means you've mentioned as well. i'm not too familiar!

[@samzu9626]

amazing

[@nikokallio8650]

It´s very calming that he talks like for baby to me, after being on lectures where you have 20 seconds time for one dia while professor is speaking,,, to read and understand one dia takes 2 minutes and to listen and understand professor takes another 2 minutes which end up you learning nothing and just skip the lectures and try to find what the hell are we supposed to learn and then find how to learn it.