What's in your prostate cancer pathology report? - Dr. David Berman

Dr. Berman is Professor of Pathology and Molecular Medicine and Director of the Queen’s Cancer Research Institute at Queen’s University. His research focuses on basic, translational, and clinical aspects of bladder and prostate cancer. He has authored over 60 scientific publications which have helped establish embryonic signaling pathways as important and useful drug targets in cancer, have identified bladder cancer stem cells, and have helped to shape surgical pathology practice.
Dr. Berman is speaking here on how to interpret a prostate cancer pathology report.
This meeting is a recording from the September 15th, 2020 instalment of Prostate Cancer Foundation BC's Prostate Cancer Awareness Month Speaker Series 2020 which took place over Zoom. Please note that only the speaker portion of the meeting was recorded; the Q&A portion following was not to ensure the privacy of each participant.
This meeting is proudly presented by Prostate Cancer Foundation Canada (formerly Prostate Cancer Foundation BC). For more information, please visit www.prostatecanada.ca
Happy Prostate Cancer Awareness Month!
The views, information, and opinions expressed in this video are those of the individuals involved and do not necessarily reflect the official policy or position of Prostate Cancer Foundation Canada (PCFC) or its employees. PCFC is not responsible and does not verify for accuracy any of the information contained in the videos available for watching on this site. The primary purpose of these videos is to educate and inform, but these videos do not constitute, or replace, medical or other professional advice.

[@warrior5203]

Motivated me to watch and learn by listening to your reason for presenting this video

[@firesafetyhazard]

Thank you for helping me to understand my report. I was underwent a biopsy in 2019 and the Gleason Score was 8 with two samples at a 9. The robotic surgery was completed two months after. The pathology report indicated positive margins; seminal vesicle invasion and positive right side nerve bundles. I received radiation and Androgen Deprivation Therapy the following year and for one year the PSA results were non-detectable. Unfortuately, the PSA levels are rising quickly. In the last 4 months the levels have doubled every two months and the last level was 1.2. A PSMA PET Scan has been scheduled for July 30, 2024.

[@warrior5203]

Ur dad’s story was moving to understanding that you care.

[@WLEE100]

Thank you for an informative presentation. @6:13 I appreciated where you tried to explain the difference between benign glandular structure and cancer cells. BUT unfortunately, it all looks like a Pollock painting to me. It reminded me of when my father's urologist had his prostate up on a sonogram and said, "It looked angry". I was just as confused, BUT I appreciated his attempt. I also liked the pictures sprinkled throughout the presentation

[@JukeboyJoeAxford]

This was a valuable presentation for me. The discussion of mortality in relation to recurrence was especially helpful. My biopsy on 2023-12-20 revealed 3 + 4 = 7, with one core 90% involvement and another had 70%, most others much lower. Half of my cores contained cancer. I'm opting for robot assisted prostatectomy on 2024-04-09. I am 64, athletic, optimal weight and in good health. I do have issues with blood clots so I will be going with an ICV filter. This presentation helps me gain a little more info about what I may be in for long term, thanks a lot.

[@patledoc]

Good luck with your surgery ! 👍🏻

[@joeax61]

Had my surgery on April 22, doing well. Hoping PSA in July is where it needs to be, I really don't want ADT or radiation. Gleason grade 4, Gleason score 8, so we'll see. Hope you are doing well

[@JukeboyJoeAxford]

​@@patledoc Surgery went well. My 30 day post surgery PSA was undetectable. The pathology report post surgery came back with negative margins and no cancer in the lymph nodes or seminal vesicles. I do have perineural invasion, don't know much about that. Was totally incontinent while standing upright, but that is improving significantly. I'm doing okay, thanks for checking in with me.

[@JukeboyJoeAxford]

@@joeax61 Surgery went well. My 30 day post surgery PSA was undetectable. The pathology report post surgery came back with negative margins and no cancer in the lymph nodes or seminal vesicles. I do have perineural invasion, don't know much about that. Was totally incontinent while standing upright, but that is improving significantly. I'm doing okay, thanks for checking in with me. Hoping the best for you, thanks for checking in with me Joe Axford. What part of the world do you live in? I live in Austin, Texas.

[@patledoc]

Great news!

[@warrior5203]

You motivated me to watch by presenting why r doing this.

[@emcinc9654]

Just stumbled across your site. Here is my prostate cancer trip so far. PSA was a 6. Then 11 of 13 needle biopsies were positive. Had robotic surgery about 18 moths ago. Had PSA tests every 3 months. It has gone from .002 to .48 in February 2002. I had a PSMA PET SCAN here also in February February 2002. The only thing that was found was a lymph node in the abdomen. What worries me is is that my RO is unsure how to treat this. I have an appointment with Urologist today. I will get back to you. I have to get ready to go. I will get back to you. If you want to see any of my test results I can send them to you. .

[@bell1095]

What Gleason Stage was diagnosed in biopsy ?

[@allesabintino6455]

Excellent review! Thanks for posting.

[@jazandriz]

For any men with prostate cancer watching this, studies shown here are 15 years old. And if published in 2011 with 20 year survival data it means 1990 treatments were in effect… Prognosis is much better now than it was then.

[@WiktoriaSta]

Thank you for this lecture!

[@nevillebartos2858]

My Current PSA is 13.2, biopsy done last week and pathology due in a week or so. I think I'm in big trouble 😢

[@javar888]

Great video.

[@marcandrechiffert6739]

Thanks!

[@martypate9123]

My urologist never went thr the rectum during my biospy.

[@peterfraser8075]

Me too. Transperineal biopsy. Not sure that biopsies via the rectum are that common anymore.

[@nevillebartos2858]

​@@peterfraser8075 here in Australia it's all transperineal, but it is 2024. I had one last week under general anaesthesia. And it's free in our public healthcare system thank god