Brain Rejuvenation by Partial Cellular Reprogramming | Yuri Deigin

Yuri Deigin, CEO of YouthBio Therapeutics, explores the promising field of partial reprogramming and its potential applications in the brain. Deigin explains his journey as an early advocate for partial reprogramming and its therapeutic possibilities, and discusses how partial reprogramming, a process involving the temporary activation of Yamanaka factors, has gained substantial interest and investment due to its potential to rejuvenate cells and extend lifespan. Deigin highlights various studies demonstrating the effectiveness of partial reprogramming in treating diseases, including Alzheimer’s, and shares his optimism about translating these breakthroughs into clinical therapies.
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[@marquisemfj]

We believe in you! 🙏❤

[@YuriDeigin]

Thank you!

[@InfiniteUniverse88]

I would like to see this topic framed in terms of transcriptomics, personalized medicine, and micro-rna.

[@michaelvescovo]

why only 628 views and not 628 million views? doesn't make any sense.

[@greenstar2108]

Agreed. I'm 39. When I was in my early twenties I started wondering why no one seemed interested in finding ways to circumvent or stop aging using serious biological science (as opposed to fad diets or merely cosmetic interventions). All the trivial things people worried about, yet no one seemed to talk about that sort of thing. Its nothing new alas. Although having said that. in the past several years I am seeing some increasing interest online. I live in hope.

[@greenstar2108]

I'm not a biologist (mere mathematican) but this sounds very interesting. Presumably we would still need to deal with damage to the extracellular matrix even if it is possible to program cells to ignore dysfunctional signals from being in an old matrix, or end up suffering strokes in old age? If so, does anyone know if replacement would still ultimately end up being necessary, or would things like AGE breaking molecules be sufficient (if eventually developed) to prevent ECM degredation in the brain being eventually lethal?

[@comradecapybara]

I'm not a biologist either but presumably we should be able to design enzymes to breakdown any kind of undesirable proteins in the body so a live repair of the ECM may ultimately be realized from computer modeling if that continues to improve rapidly.

[@greenstar2108]

@@comradecapybara - Thanks for the reply. I will confess to not being knowlegdeable enough about computational biology to judge, but I wonder if the elastin protein still would need to be replaced, or if the cellular reprograming could be made to do the job. I guess we'll find out in the coming years.

[@nikosalkis8296]

There is one question WHEN are you going to stop tormenting animals and you start to use this knowledge on humans.

[@YuriDeigin]

We’re anticipating starting a clinical trial in Alzheimer’s within 3 years if our IND-enabling studies go well