Psoriasis - Pathophysiology

[@dryogesh197]

Great and amazing videos sir... Keep it up ..God bless you Sir....so many good wishes from my side.🙏

[@sabhderma]

Thank you so much for your blessings 😊

[@dattalokare3946]

Thank you so much sir Kindly make new videos ASAP please sir

[@sabhderma]

Sure I will. These videos take time to prepare and shoot. And I work alone in these video lectures. Please bear with me. Eventually we will cover all topics in dermatology, venereology, and leprology. Keep watching and sharing these videos. 😊😊

[@gryffindor5345]

Sir please teach Immunobullous disorder Patho physiology and theories .

[@sabhderma]

I am planning to start clinical dermatology too. Would surely teach pathophysiology of other disorders.

[@mugirestianautami2699]

it help me so much to understand it, thank you sir. God bless you

[@sabhderma]

You are most welcome. I am glad you liked this video. There are many more on the channel, and many more to come in the future. 😊😊

[@tyra19tanvi]

The puzzle of my life is finally solved thankyou so much Sir

[@sabhderma]

I am happy this video was fruitful for you. Thank you for watching. I try to make complex mechanisms simple to grasp. Check out other videos, especially on Pathomechanisms of various dermatoses. 😊😊

[@ylvabjorkman1875]

You are really good!! Thank you. I would be great if you have time to discuss, vit D and psoriasis as well as retinoids and UV light

[@sabhderma]

Thank you for your valuable blessings!!! 😊😊 These are good suggestions. I will make videos on vitamin d and its role in dermatology, as it plays an important and varied role in skin physiology. I will be discussing retinoids while discussing acne. 😊😊 Till then, please continue to watch these videos and provide suggestions 🙂🙂

[@mehuldabhi639]

Thank you for amazing lecture. I had question that why there is rebound flare due to use of oral steroid in psoriasis but not in other inflammatory diseases?

[@sabhderma]

That's a good question. Steroid suppresses immunity and inflammatory cytokines. We keep them suppressed till the inflammatory activity quiets down. When the immunity is suppressed, it increases the inflammation as a counter response. Since the suppression by steroids is strong, the moment they are removed, there is a rebound in activity. Hope this helps. Let me know if there are any queries 😊

[@mehuldabhi639]

Thank you sir for reply But what I was trying to ask is that there is a risk of flare in Psoriasis but not in Pemphigus or Pemphigoid even though all are autoimmune diseases.@@sabhderma

[@gryffindor5345]

Thankyou for the videos sir. Very helpful ..

[@sabhderma]

Most welcome!

[@m4motivation181]

Sir really the need of hour please teach residents of dermatology I am md dermatology but deep down inside I missed such lectures you can start paid subscription but please cover dermatology residents course in detail

[@sabhderma]

Thank you so much for your appreciation. I will be making more videos on varied topics. The idea is to discuss academic topics in detail at the post-graduate level. Just keep watching these videos and share with other students. 😊😊

[@m4motivation181]

@@sabhderma yes sir please take pigmentary disorders and malignant tumours including appendageal tumours if possible

[@m4motivation181]

@@sabhderma sir happy Diwali 😊

[@sandeepsairal]

Sir 🙏, what is the role of neutrophils in PSORIASIS, is it marker for severity of PSORIASIS?

[@sabhderma]

That's a good question. Neutrophils are one of the inflammatory cells implicated in the pathogenesis of psoriasis. They act as an important source of crucial inflammatory cytokines required for the disease. Whether their numbers are correlated with disease activity, that could be there since more the inflammatory cytokines more the neutrophils. However, if this has a clinical impact, I will have to get a concrete reference which I will share with you.

[@sandeepsairal]

Thanks for the reply Sir 🙏🙂, We mostly read about (neutrophils/lymphocytes ratio)...to check the severity of the disease.. As this increased in severe( asthma/psoriasis & even sepsis) Please guide 🙏🙂

[@saniyasheikh2139]

Hello Sir, Thank you for the most "precious" video on pathogenesis of psoriasis. Had been breaking my head with the textbook. I wish I had come across this right I my 1st year. Could you please also upload your video about genes in Psoriasis

[@enginekhap2384]

Sir, is their any way to cure psoriasis.

[@sabhderma]

Thank you for asking this good question. Psoriasis is a very difficult disease to manage and patients require help and assistance by a trained dermatologist who can examine them and provide them with the best of options to keep the disease under control. With proper guidance, it can be easily managed so that daily life is not affected. Cure essentially means that the disease will never return, and frankly, that cannot be said for any disorder of any organ. It is very important to consult a trained dermatologist for proper treatment for psoriasis, and with a well designed treatment the disease can easily be controlled.