Psychedelics for the Treatment of Cluster and Migraine - Spotlight on Migraine - Episode 31

In this episode, Dr. Christopher Gottschalk gives a presentation explaining research currently being done at Yale University on the use of psychedelic mushrooms in the treatment of migraine and cluster headache. Additionally, he explains the derivatives and characteristics of drugs currently being used for migraine and cluster treatment and how they compare to psychedelics.
This podcast is sponsored in part by Amgen/Novartis and
Alder BioPharmaceuticals.
*The contents of this podcast/video are intended for general informational purposes only and do not constitute medical or legal advice; the content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The speaker does not recommend or endorse any specific course of treatment, products, procedures, opinions, or other information that may be mentioned. Reliance on any information provided by this content is solely at your own risk.

[@zionnofate]

For anyone reading, I took my first shroom at 47 after a really horrific 6 weeks.. im now 50 and micro every few months. My life has changed. Not one episode. I wish I knew about this 25 years ago.

[@charlieulmer-scrantonscomm2388]

God bless! Comment is giving hope.

[@jamesking7330]

What type of shroom do you use?

[@syleenadawn2038]

Wow, thank you for sharing!

[@frankm3606]

🙏🙏🙏

[@AtaTheKin]

What type of shroom? Please answer

[@manifestgtr]

You guys are the closest people to living saints for someone like me. The amount of suffering you can curtail in this world is absolutely beyond measure. People who don’t get cluster headaches can never know the associated cosmic, existential horror and I’m happy for them, more than they’ll ever know. Much to my surprise, mushrooms have helped me out and the fact that researchers are taking this (among other treatments) seriously is very, VERY good. Keep up the good work, guys. I’m not a religious person but if there’s any sort of reward in the afterlife, you guys are first in line as far as I’m concerned.

[@jermainelove2499]

Did the mushroom’s permanently ease the pain or do you have to microdose

[@vivelachocha2751]

Nobody but a sufferer can understand. Ive never met another ch sufferer feel very alone in this unimaginable neverending nightmare. Mushrooms buy me a couple days but apparently I need to take larger dose according to this video. Pray for me this has to work. I hope you don't have to go through one more brain desolation attack. I wouldn't wish this upon my worst enemy

[@Eh-Way]

When i was younger I would take doses of mushrooms every few months for fun. I was also getting clusters at that time but they seemed to be more one year I would get them some years I wouldn’t. Now putting the pieces together it was likely that I took the mushrooms near an upcoming cycle. I am currently at the start of a cycle and already took a 1 g dose at the beginning and I was attack free for several days. They came back as they usually do, and I’m am about to take a significantly higher dose with hopes of a few more days pain free. Wish me luck. Thank you to the doctors willing to do this research. It means the world to so many.

[@WAgunfun]

Hey man how are you doing regarding the clusters? Im 31 and have my first cluster period just now, its been two weeks so far, with one to two hitting me every day. Im just curious if the psilocybin has continued to help you? This is the most diabolical, paralyzing pain ive ever felt, it truy breaks me. I think am going to give the psilocybin a try to treat these clusters.

[@Lukas-ei7ny]

@@WAgunfun hey man how are you doing with your cluster? Did you tried psilocybin?

[@vicweast]

You should consider the SPUT method as described at clusterbusters. I had my doubts, but it works. Please inform yourself "deeply" before you do this. Works fairly well for me. I have also learned to avoid alcohol when a cluster starts, but that's only to prevent additional individual headaches. @@WAgunfun

[@gusriv9]

The way I describe my cluster to the doctor, is that it feels like the worse brain freeze I ever had or an ice pick from the inside of the eye. I broke my fingers years ago and will gladly trade the pain of broken fingers for a cluster no contest. I was able to sleep with broken fingers for 4 hours, can't do that with my clusters. Once I got the fingers to the doctor he ask why I waited so long and I told him I had a cluster all night and when I broke my fingers it had let up so I slept before I decided to get it treated. Both the nurse and doctor looked at me like I a nut. The mushrooms always worked for me, but the problem was finding it in my area. Hope no one ever has to deal with those and if you do may you find what helps stop them. Good luck and God bless

[@aking8477]

I've been suffering from ch for the last 15 years. I started a new cycle three weeks ago, and I was desperate to find relief. My doctor prescribed prednisone and sumatriptan. That didnt seem to do much to stop the attacks, so I got online and started researching. Out of desperation, I went out and found shrooms. After taking a very small dose, I noticed that the intensity of my headaches reduced that night. I'm on day three now, and my headaches have almost stopped completely.

[@borkel-artproproductions5839]

Same experience. Had migraines and CH for 23 years on a weekly basis. 4 days of psilocybin microdoses in a row and I have not had a single episode in 3 years!

[@vikkivoss6247]

In my experience with cluster headaches and trigeminal neuralgia I started a 5 gram dose once a month and micro dose them to manage the pain when it pops back up. Going on about 8 months and my symptoms have gotten so much better I don’t even have to take high doses monthly anymore. These are truly magic medicine. I hope your doing well and I’m happy to hear they are helping you 🥰🤍🍄🦋

[@julienhenri7296]

Just now ended my normal cycle, 20 years of 2 month periods daily clusters. Triptans were always hit or miss. Self prescribed psilocybin and can't say for sure I'm not a doctor. But indescribably happy to say 2nd year in a row not a single headache. For those of you who have been thru this kinda thing understand how big of a deal this is. In my opinion risk vs reward worth it

[@AtaTheKin]

@@borkel-artproproductions5839 do you still consume them or just that one time help you for all this years?

[@AtaTheKin]

@@julienhenri7296 did you grow them yourself?

[@nygothuey6607]

I hope that this information is a help to those who may be about to give up.

[@tommynorthwood]

All I have to take to help with a migraine is one dried B plus rolled up into a pill size e and swallowed whole. Loke a pill. I don't feel ANY effects of the mushroom, but I do feel IMMEDIATE relief. The first time it happened, the pain went away in pulses and I was completely better in 15 minutes. I cried like a baby seeing this new found knowledge.

[@nancymiller7294]

I had my first full attack at the age of 18. My attack lasted about 3 weeks and most Doctors then and a lot now have never heard of Cluster. My younger years was not fun as my attacks lasted 3 to 5 weeks, then I would be free of them for 2 to 3 months. My parents took me to a specialist that done a brain scan and a blood flow and told me it was cluster, prescribed Cafergot and Codeine. When I had these excruciating Migraines it was hard to get relief without an injection as the chills and dry heaves were severe and it was like a dagger being shoved through your temple. I also had thought about suicide back when I was young because of the nonstop torture. Then you always had some Doctors believing you were at the E.R for pills even though I had never drank alcohol or smoked. After Imitrex came available, it would help if I took it before the vomiting started. The best thing ever that I wish they would have used years ago is BOTOX. The first time I got Botox, I was free of headaches for 15 months.The 2nd time I had no Migraine of any kind for 2 years. I get Botox every 28 to 30 months. Botox has been a miracle for me. I hope this helps some of you.

[@thehomegrownrealtygroup5432]

My wife has cluster headaches. My heart aches for her when she hurts and that I can’t help her! I really would love for her to try this!

[@AtaTheKin]

@TheHomeGrownRealtyGroup did it work?

[@xah-64x24]

I’m chronic. I’m trying psilocybin for the first time today. I’ll update. I’m also currently in a cluster period.

[@aloiseaux767]

Hey man, how are you doing? My girl has chronic, tried magic truffles last December, then was cluster free for two weeks, also tried lsd and mushrooms, psylocybe Cubensis seems to be most effective (in her case) she took a dose of 4 grams crushed and made tea from it with lemon juice (lemon tek).

[@AtaTheKin]

Wating on that update bro

[@davidrockefeller2007]

How did it go?

[@jeanshimp5767]

Thank you for your research!

[@parryhooper]

I take shrooms daily for my cluster headaches. My season is from May to August.. no doubt this works. I would have offd myself already. Shrooms saved life

[@Save-A-DogAps]

Ditto.

[@byee69]

Can I ask was there a specific strain you used and what was your dosage like? I'm experimenting and have been doing microdoses of . 5 to 1 g a day but still getting them.

[@parryhooper]

@@byee69 My preferred strain is B+. My dosage is similar to what you just stated. But it's best to take it before the headache starts. For me the clusters would come in the afternoon (I imagine due to coffee wearing off), so I would take them an hour before it starts. I have them in pill form in which my doses are precise. If you take them during a headache, it might reduce the time, but it also might not. LSD is also something that works, but I can't sleep even on a microdose of that. I can sleep on shrooms though, dreams be wild but better than being up all night in pain.

[@reginablewett2518]

@parryhooper where can I get the B+ pill form PLEASE....

[@Simte]

Thank you for this video.

[@stevenswanson9519]

Very informative, thanks Robert California.

[@shells4donna]

Thank you for giving us hope!

[@ozzyyzzo929]

Neurotech ODT

[@chefdyson2k185]

This was so good and Great to hear a doctor talk about natural ways to cure something this painful. I am going to share this in the CH group I am in and see if we can get some people to volunteer to be apart of this research because I can’t keep living like this lol CH is TERRIBLE!!

[@vardanyanser]

fascinating lecture

[@MadenaRose]

Going to do more research, I hope this helps! I can’t live life normally, it’s so debilitating, and I just want freedom! ✨

[@ZachMolochArt]

please if you find out it helps or if it doesn't, respond back here..best of wishes to you and hopefully a painfree life

[@jhinagarcia3779]

@@ZachMolochArt I started magic mushrooms a few days ago since I started a new cycle of CH so far it has not only aborted a current attack in less than 10 min but also prevent them from coming! Really recommend you to try if you get CH… life saving

[@AtaTheKin]

Did it work?

[@RockHudrock]

Interesting!

[@svetlanak7804]

True, if can cause hallucinations doesn’t mean should be forbidden !

[@knkms.k7007]

I am a woman. I have been having these types headaches

[@knkms.k7007]

I am tired of taking medication. No night without the pain waking me up.

[@davidrockefeller2007]

Oxygen 10 litres a minute with a rebreather masked works for me most of the time. That way I’m off the drugs but I’m going to take pyilocyban next time. I did it for the first time for fun 3 weeks ago, 1gram on empty stomach , dark room, light classical music. It was incredible, I said to myself , I feel sorry for all the people in the world that willl never experience this.

[@coco3045]

Omg I get these headaches steadily and anytime I get my period they are worse I take headache prevention medication I think 2 of them plus we are trying one more I was told in my 20s that my bad teeth were the cause of my headaches and sinus issues no no they were not So I’ve had these awful headaches since I was a child I just power through until I can not no more and I’m a cranky person and just on edge all the time it sucks

[@thalesnemo2841]

The is excellent work. Are those mushrooms by prescription?! Any way what is missing in this complex disorder is the root cause(s) . Without a good handle on the root of the problem a treatment/cure is a akin to throwing ideas or wet towels at a wall and seeing what sticks!

[@michelletaylor5597]

No one knows why them believes it's from blows to the head witch cause concussion which I've had

[@brianbradford4023]

Does this help with neuropathy?

[@gusolive]

Cgrp ihibitors also research if you can’t get shrooms

[@junglie]

I found .5 of a gram of dried mushrooms stop my migraines in their tracks, been getting them a lot less too since i discovered this a couple of years ago by accident.

[@jermainelove2499]

How long do you have between each dose? And does the pain ever stop?

[@junglie]

@@jermainelove2499 just one dose, when you feel one coming on, stops them in their tracks. Not had a bad one for 4 years since I started taking them & neither has my freind who told me about them for migranes either funily. He had them for much longer & much more severe than me too.

[@bjellison905]

Mine come in cycles every year. I normally have a decent late spring through summer. When the seasons change boom it's horrible. Fall and winter suck. I have them for hours and for days. I'm interested in trying psilocybin. I would do anything to make these stop. Its destroyed my life

[@TheFire-fq8fx]

Where are you from?

[@nancymiller7294]

Botox for migraines is a miracle, pain free over a year with one treatment.

[@vivelachocha2751]

Same ughh

[@Bigbagadoosh]

triptans made it worse, ganglion block made it worse , verapamil may or may not work but helps with the hypertension also. A mixture of hydrocodone, ibuprofen, ice packs, traction and laying in bed help to keep it from getting worse sometimes. I think its time to try some shrooms!

[@MykolaZUYEV]

Hey, how is your shrooms xprience?

[@blackngoldfan2004]

Well..... I guess I'll never use nutmeg again!

[@ponzo1967]

35 years of suffering like only a Cluster Head knows and now 5 years no attacks. It literally took one mushroom once a year.

[@mrs_Mccoy]

I'd appreciate your comment

[@mrs_Mccoy]

I got some psilocybin mushrooms from an online store

[@mrs_Mccoy]

FROM CRUISE_MYCOLOGIST.

[@mrs_Mccoy]

0n instagram..

[@mahanassar935]

Blood Patch-It was not the reason they gave me the blood patch but as soon as I received it the attacks (BEAST) stopped instantly. I had them for eight months straight, multiple times a day until the patch was administered. I have not had one since. It has been 6 years with no further episodes

[@leighpowell8544]

How long ago was that please am been having mine now for 5 months having up to 7 attacks a day Ive had them for 9 years now and am running out of hope never heard of a blood patch before please.

[@jeanviales]

Hey there! I know I might be a bit late here, but, can you please tell me if you're using B+ only or if A+ A++ also works for this? Thank you!

[@blazemordly9746]

strangely enough, 35 years of auras are sometimes like seeing psychedelia if i stay up for it instead of trying to nap.

[@russellhill752]

I immediately take something to put me asleep

[@vicweast]

The burning question is less "what is the mechanism by which these serotonin look-alike compounds work" than "what happens with serotonin that causes clusters"???

[@truwinner2]

I only took a gram and the headaches where gone

[@jkane1341]

Migraines and shrooms, 100 times this is the best medicine. Headache hits me and I will take a small does .5 grams and within 30-45 mins my head is back to normal, regular migraine medicine doesnt work for me. slight trippy feelling but Id rather this than head pains.

[@MykolaZUYEV]

Hey, when U say 5gr, is it dried ones?

[@bastianrivero]

@@MykolaZUYEV 0.5 not 5

[@ponzo1967]

Psilocybin is like a Sumatriptan that lasts months if not years. The only real lasting relief ive jad was from psilocybin 5 year remission

[@mrs_Mccoy]

I'd appreciate your comment

[@mrs_Mccoy]

I got some psychedelic products from an online store

[@mrs_Mccoy]

FROM CRUISE_MYCOLOGIST.

[@mrs_Mccoy]

0n instagram

[@jermainelove2499]

what’s the store called

[@francisarledge9981]

Is there a specific strain that works best?

[@francisarledge9981]

Thanks Ashanti! 😊

[@michelletaylor5597]

Take 4 Excedrin migraine 2 antihistamine and a cbg 20mg gummie, and ice pack works well.

[@lopiklop]

Sleep does not stop it.

[@emmagatsbyvstheworld]

How can I be a part of research as I am a severe migraine sufferer, although recently and due to research I am leaning towards thinking that I have cluster headaches also , I hear trials are still occurring and I would like to be a part of that, my daughter is also a sufferer. thank you I would appreciate a response. Emma

[@1N2themystic]

You may have to do your own research. It's easy to self supply, almost zero risk unless you do something really stupid. I like to take 3-5 g. Every couple weeks at least. They can cause a bit of stomach upset which is why I like to make tea or tincture and use ginger. If you are in the PNW, I might be able to help. Also I subbed to your channel. Not my style but you should have more subs. It's not bad.

[@yevettemadonna]

Today, the mushroom compound is being used in clinical trials for end-of-life anxiety, treatment-resistant depression, addiction, eating disorders, cluster headache and other conditions with unprecedented success, and psilocybin-assisted therapy has been given FDA “breakthrough therapy” status as a treatment for depression.

[@yevettemadonna]

xxr_psychedelic Has the best record of good strains n they will teach you all you need to know before dispensing...you gon be grateful

[@amytrumbull156]

I suffer from migraines and daily chronic headaches and I've taken shrooms several times over the last year and it did nothing for my headaches....but I did have fun!

[@rabiumuhammad1613]

I am so much happy I'm back to my health fully by the help of dr Edos he has a good heart of helping and i hope he help us all #dredos

[@MrFlipster]

I need help with my cluster headaches 17 medications later and botox here i am still wishing death on my self i cant compare any of the pain to anything i wake up with headaches and go to sleep with headaches i wake up in the middle of the night from the extreme pain i have kids i have a family that i cant keep up with because im always in so much pain

[@ozzyyzzo929]

Neurotech ODT is mushrooms

[@Demecrys1]

I haven't had these cluster headaches in over two years, now they are back. Has anyone tried going to a chiropractor to see if that helps?

[@aloiseaux767]

My girl did, it got worse.

[@naawakweoseindizhinakaaz2052]

It got way worse for a coworker of mine do not do it

[@michelletaylor5597]

Worse

[@natev9634]

Where can people find them? I know they say to grow them but that could take up to 3 months and my cycle would be over by the time I was able to get a flush..

[@mrs_Mccoy]

I bought some from an online supplier and they are affordable and discreetly delivered

[@mrs_Mccoy]

FROM CRUISE_MYCOLOGIST

[@mrs_Mccoy]

in INSTAGRAM.

[@DR.199]

It's illegal in my country and it unknown how can i get it?

[@pobrez7649]

Internet. Order Psilocybe cubensis spores online and grow them yourself. There's plenty of KZbin videos that will help you grow them

[@jasonborne5359]

I have suffered immensely for a year and a half with vestibular migraines… theyve ruined my life and ive been toying around with trying low dose. But even weed which i used for a decade gives me insane panic attacks. I have a history of panic and anxiety… i want to stop my vestibular migraines but im afraid to even microdose shrooms

[@candy_helpsoninstagram3878]

Dosing is totally safe

[@michelletaylor5597]

Cbg with antihistamine!! Works great

[@chrissmith2734]

Sign me up

[@jakee7669]

Shrooms actually gave me the worst headache I’ve ever had when I woke up the next morning. Had a great trip but woke up in the middle of the night and my head hurt so badly I couldn’t even open my eyes.

[@vivelachocha2751]

This happened to me last week. I really thought I'd be able to sleep through the night having dosed that day but nope. Was the worst night that month. Tried again this week and got one night relief then they came back smh idk if I should take bigger dose but idk if they'll get worse or better at this point feeling pretty discouraged

[@cesarchavez3426]

Anyone in Northern California are that can help me find some of that medicine?

[@mrs_Mccoy]

I'd appreciate your comment, i reside in NC

[@mrs_Mccoy]

I bought some psychedelic products from a Drugstore online and they are affordable and discreetly delivered, i can vouch for that 💯

[@mrs_Mccoy]

FROM TRIP_PHARMACIST.

[@mrs_Mccoy]

check them in instagram.

[@cesarchavez3426]

@@mrs_Mccoy what kind did you get ? I tried microdose of shrooms man they didn't do anything probably not the right dose.

[@lopiklop]

I would do ANYTHING. You have no idea what I would be willing to do to stop a cluster headache attack. I will inject in my gums it stops it.

[@h7opolo]

migraines are neurotoxic. shrooms are nootropic.

[@YourFutureMrOlympia]

If Migraines are a CNS disorder due to an excess of stimuli then how would psychedelics a stiulant help? Because it permanently changes brain chemistry?

[@beendoneagain]

I took magic mushrooms many many times as a teenager and started getting cluster headaches at around the same time. Lasted for 25 years. Figure that one out!

[@vivelachocha2751]

Clusters nor.ally affect men at around 26 were you around that age?

[@CanadianBear47]

I have migraines though have u heard about headaches after using magic mushrooms? Only happens about 40 % of time

[@ratideluxe]

nothing about the protocol Vitamine D3 ?

[@rabiumuhammad1613]

I am so much happy I'm back to my health fully by the help of dr Edos he has a good heart of helping and i hope he help us all #dredos