PubMed: Search a PICO Question

Step 1: The question: In a 30-year-old male patient diagnosed with depression, is St. John's Wort as effective as SSRIs at reducing depressive symptoms?
Identify best search terms for each PICO concept:
P: Depressive disorder [MeSH searched as keyword] AND
I: Serotonin uptake inhibitors [MeSH searched as keyword] AND
C: (Hypericum [MeSH searched as keyword] OR St. John's Wort)
O: Desired outcome is efficacy, but this term is not part of the search strategy because it is already implied in the search.
Step 2: Use PubMed Advanced search builder to string these terms together with AND (Enter the OR terms in the same line - which is the third line in this demo, and leave the Boolean operator on the left of the search builder as AND) Click search.
Step 3: Apply filters: English, Humans, Systematic Review [subset]
Librarian: J. Cole

[@alidagouver1232]

Best way explained.if my proffesor would have taken her time to explain this in such way we all would have passed this subject!

[@01joseluciano]

Thanks for posting this very good video about EBM, PICO.

[@hassanomoboladale322]

Thank you

[@dianeblier7787]

Extremely helpful!

[@anarkystaubayeva1820]

Thank you so much!!!

[@aymanmag5869]

Thank you so much .

[@hwangdaljeong814]

Thank very much

[@jlin8681]

Great PICO pubmed tutorial. However, I'm confused on why you used "all field" to add each concept instead of using "MeSH" terms, at the final search. I've tried searching pubmed using both "all field" and "MeSH" terms on the given concepts. I had found 60+ articles and 20+ articles for "all field" and "MeSH" terms, respectively. I wonder which one is the correct method. Thank you.

[@jessicacole9926]

Searching All Fields will often retrieve more articles that use your search terms because there is a delay before indexing and MeSH terms are applied in Medline. Ideally, with MeSH, you will get the most relevant articles, but you will not necessarily get those that were most recently published. :)