Pyrimidine Synthesis and Salvage Pathway

Lesson on pyrimidine synthesis and metabolism, what it is, medications used to inhibit the pathway and the importance of of the pyrimidine synthesis pathway in human health.
In this lesson, I teach you guys what pyrimidines are, the three pyrimidines (cytosine, uracil, thymine), and an easy way to remember the pyrimidines. I also talk about the critical steps in the pyrimidine synthesis pathway including carbamoyl phosphate synthase 2 (CPS2), orotic acid production, why we need PRPP and the critical importance of thymidylate synthase.
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@Nora-dx9cy]

WHY GOD WHY DO WE HAVE TO STUDY BIOCHEMISTRY

[@charlemengsimon8645]

Aww sorry! I'm majoring in biochemistry by the way

[@drkrunalpatelortho]

Best thing is how highlights clinical points

[@aishaa.1369]

krunal patel.... yeah... most of other youtube tutors don't do that.... and I have to find clinics separately..... but this man saves my time.... I appreciate it a lot....

[@ellengarcia3467]

Thank you so much. You explained this so clearly. I have to present a paper to my class on cytidine deaminase and the pyrimidine salvage pathway and this video helped a lot.

[@davidhansman7190]

Good lecture, just a note: pyrimidine free bases such as cytosine and thymine are rarely salvaged in humans

[@Radjehuty]

Wish I found this before this comment was old, but what you said really interested me. Are you saying free pyrimidine bases get broken down rather than salvaged? Or is it that it's rare for free pyrimidine bases to even form? I always find it hard to look up biochemistry pathways and know if I'm looking at a human pathway or not. So much information isn't clarified.

[@edthoreum7625]

5:30 thymilydate synthases & cancer 9:20 pyrimidine salvage pathway , from cytocine & thymine(folate?)

[@edthoreum7625]

9:20 pyrimidine salvage pathway ,cytoaine

[@katherinecases0918]

Hello! Just a clarification; isn't the first committed enzyme should be named carbamoyl phosphate synthetase since it uses ATP? based on literature, synthase is an enzyme that doesn't use ATP, so I'm just wondering why you're saying it's synthase when it's using ATP. Thank you

[@samirbrahimi5782]

Great explanation

[@Alex-sj9tc]

Will it be possible to have a link of the slides of the lecture as well? :)

[@rehamali3542]

that's great dear doctor

[@salhasaeed6304]

very helpful, thank you

[@oOkramiOo]

What are the end products of dTMP catabolism?

[@mroselli]

great video

[@Datboigioo]

PRPP is not inhibited by ATP it's inhibited by AMP and GMP

[@jacintamuthoni9192]

As well as IMP

[@EtrosMaushe]

You are lieing borther it is inhibited by adp😮

[@shantanuhardiha]

​@@EtrosMaushePRPP synthetase is inhibited by ADP

[@faustinaacquah7173]

Thanks so much

[@alevelsdemystified3410]

awesome 💜

[@SteveSaxony]

is this enough to know about pyrimidine synthesis for usmle step 1? someone who has passed can you telll me/

[@inspirationelham2239]

thank you so much !

[@virtuouswoman6438]

Y did you start at glutamine and not bicarbonate?

[@alevelsdemystified3410]

is di-hydroorotate the first pyrimidine ring or is it orotic acid?

[@thephoenixxx]

It's dihydroorotate

[@imeldaaustin817]

Please what is CpS2?!

[@adhalgoi6937]

Carbamoyl Phosphate Synthetase 2

[@sohailasghar8471]

dTp means?

[@snehachukki5740]

Deoxy thymine monophosphate

[@user-nu3sd7lf5x]

4:03

[@bharathreddy9337]

I think the carbamoyl aspartate structure is wrong. because the amino group of aspartate attacks the carbonyl group of carbamoyl phosphate.

[@magdalenabiesiadecka4236]

Hello, can you write an literature ?

[@aanchalgarg3551]

👍👍

[@fanuelosindi9941]

wow

[@camiyyb7530]

Orotic acid is a cool substance ... coz it sounds like being erotic acid

[@anasazhar2525]

..when I was in 6th grde

[@sanyahmaryam1565]

You know..your lectures are insufficient as all you talk about is how you have mentioned necessary details in other videos. Please tell me how am I supposed to collect information like an old age scholar a day prior to exam. At least do a basic introduction of the stuff. Thank you.

[@TheDeezy250]

maybe dont start studying the day before the exam dipshit?