Pyruvate Decarboxylation

[@christophertavani5202]

Studying for the 3-packet cumulative exam right now and I would just like you to know how much you have done for me this year. Your videos are the sole reason I know ATP synthase in detail, voltage-gated ion channels, fatty acid degradation/synthesis and much much more. I say this on behalf of my roommate as well who is in the class with me. There were many days/nights where we would have your videos up on the plasma screen in the common room. I've been promoting your videos, I hope it is helping. Keep this up, because it is doing wonders for students like my roommate and I. Happy Holidays

[@AKLECTURES]

+Christopher Tavani They Christopher! Thank you for taking the time to write that! I really appreciate you promoting my videos and its great to hear that you and your room mate are benefiting from them! If you still haven't taken your finals, best of luck on them, let me know how you both do!

[@christophertavani5202]

+AK LECTURES (Andrey K) just got back from the test. It was difficult, but fair. I definitely didn't fail! Thanks again.

[@rashishukla2759]

Christopher Tavani will it help me in msc biotechnology studies of first year

[@sethk4745]

Same here

[@dannydenn9228]

thank you for making medical school A LOOTTTT MORE UNDERSTANDABLE. ak lectures, honestly thank you.

[@cynthiamartinez6583]

Chill it’s not harvard

[@marymontgomery-gomez5314]

You are simply the absolute best teacher on KZbin. Thank you for saving us all and simplifying such difficult concepts so incredibly well. Thank you thank you thank you!!!

[@gabrielshaalukeni9485]

I've learned a lot from all your biochemistry videos that I've watched. your videos are the reason why I got to love biochemistry.

[@veronikae220]

You're amazing! This helped me a lot for my biochem course and it's now helping me study for the MCAT. Thank you for these.

[@dianaethaiya4424]

This is great!!! I wish if you were my professor. You answered all of my questions and you have such a great way to keep people focused with you and follow along. Thank you so much.

[@jchae9820]

how can u be this great!! please don't stop your precious work!! you're a life saver

[@shannonpotts6299]

Your videos have saved my Biochemistry grade. You have no idea how much these videos have helped me!

[@danirurajapaksha7990]

I love this lectures so much. So clear. just nothing to memorize. Explain like the professor who found this . so damn good

[@herespecialnothing]

I showed some of your videos to my classmates (in the class act) using the big screen. You're kind of our hero now. Thank you so much sir

[@kristijan67]

you sir, rock!! thanks for saving my biochemistry exam:)

[@beezybis]

Thank you for your videos 😭 I thought biochemistry was a class I could never pass but I got a B with a lot of help from your videos !!

[@billypho1232]

THIS IS THE KIND OF DETAIL EXAM CREATORS LOVEEEEE TYSM!!!!

[@zahrashahabinezhad]

You are simply amazing. Please never stop making these videos!

[@kittenluv17]

thank you so much, i swear when i have enough money i will be one of your life-long patrons because you are just a lifesaver. i appreciate you so much

[@pigeonlove]

Bullshit

[@gustavs9]

It is a great video indeed. I use it on the 5th year of High school for a lesson on Tiamine ( B1) thank you

[@abdullahirazak8771]

I wish I could get a book that has been written the way you were teaching. You are the best

[@vlr003]

THANK YOU! The exact level of detail needed!

[@Falaxuper]

Man, that was super-clear! Thank you so much!

[@userfriendly97]

THANK GOD I HAVE THIS GUY IN MY LIFE

[@user-vw4zd5hd5e]

والله انك احسن واحد يشرح فالعالمممممممم وكل اللي معاي شهود

[@hinaz6657]

oh he shaved

[@stanleynzioki3572]

😂

[@zannatulferdous9087]

I was struggling to understand this, thank you!

[@tiuskasantana8409]

Lipoamide is actually attached to the lysine residue of the E2 enzyme, not the serine. Please make this note on the video.

[@tiuskasantana8409]

@ 8:40

[@pietroxavier2008]

true, that's why the lipoic acid becomes a lipoamide, because its carboxyl group reacts with the amine group from the side chain of the lysine. this wouldn't be possible with serine, as serine has a OH group on the side chan, which would form a ester if they were condensated.

[@DarkxAbsolut]

This was very very helpful thank you so much!

[@alexandradamico9526]

First things first-your videos are amazing! All the explanations are clear and easy to understand, THANK YOU!!!!!!!! I am confused on one thing though-isn't the lipoamide attached to a lysine residue of E2? Once again, Thank You!!!

[@tiuskasantana8409]

It is.

[@calvinklein6903]

Exactly what I was thinking. It is attached to a lysine, not a serine.

[@NatureDocumentaries]

Excellent performance and delivery!

[@boakyemichealdarkwah1969]

Watching it in 2020 God bless you🙌

[@larisajover8968]

u are simply the best

[@zubariazafar1]

You are just Amazing..... You saved my day. Thank You Sir.

[@matthew_bang]

Got an A+ in biochem and now I’m rewatching your videos to study for the MCAT. You are truly a fantastic teacher

[@andresbeltre7378]

hes making med school doable!!

[@areh0670]

@@andresbeltre7378Are you graduated now ? In which specialty?

[@doni_sinha]

Thanks a lot for such a nice explanation 😊

[@jonantasvinicius4541]

Awesome man, you are a good teacher.

[@roxiegrove2176]

Thank you so much. This is so helpful.

[@shinn-tyanwu4155]

Great presentation as always 😊😊😊

[@akbarhussainwazir9458]

I like this prof a lot .

[@alessela7119]

Amazing content! Thank you.

[@pangjingxuan5117]

savior of med school stud

[@safwanmt23]

Conceptual.... great work

[@rajivpathak1485]

The lipoate is in an amide linkage with the Lysine residue of E2 actually.

[@munsakabeyani8756]

Thank you, you're so good

[@imascully90]

Excellent, as per usual.

[@jagatlalpoddar6201]

Sir you only make me to love biochemistry

[@avtawf]

During Step 2: where did the two H+ go? You said two H+ were added on to the acetyl group to form the Hydroxyethyl-TPP complex, but when the acetyl group is removed from this complex and added onto Lipoamide, they completely disappear.

[@LoversGrief]

slideplayer.com/slide/3419339/

[@BlueSky-lc4gx]

@@LoversGrief what is this link excuse me?

[@jeroendewaal2652]

him: "I didn't have space for the other four steps" me: *looking at my notes page filled to the brim* "understandable have a great day"

[@abdallanagah3554]

you are my super hero man ♥

[@mohamedsoudy2121]

incredibly helpful 👌

[@نیانیایی-ص1ك]

That was awesome 👌🤯🤯

[@rinkytripathi6657]

Thank u sir

[@wizardatmath]

Could u do something on the primary uses of lipoic acid, and which vitamins and minerals are required for its synthesis/regeneration?

[@jakerobinson9867]

In step 2 I can see one H shown in orange bonds with an S in the lipoamide but where does the other orange H go?

[@simsim5265]

Yeah me too I asked myself why but maybe it releases a H+ ion

[@simsim5265]

I looked on Google and actually I think he made a mistake. The lone H on the carbon of the hydroxyethyl-thiamine pyrophosphate (or biphosphate) doesn't actually exist. I think it's a reduced carbon (-1).

[@lalotimes6070]

You are super lec THANKYOU

[@meccarasheed3018]

Hey AK! When you said FAD attached to the enzyme, are you talking about the dihydrolipoyl dehydrogenase?

[@melaniegreen4960]

Isnt lipoamide attached to the lysine residue?

[@zk.a__lift]

thank you

[@janaviramesh4703]

you are a god! i will be eternally grateful

[@DinaAwd]

U r owesome🎓🎓

[@g0ldensurfer]

Why are the orange H+ (from step 1) not in the reaction equation? They need to be inserted to

[@lf8737]

Sir, you need to be a university professor if you are not already. Thank you.

[@tanjimunnabila9115]

When hydroxyethyl TPP is reacting with lipomide and it is forming acetyllipomide, one hydrogen from the hydroxyethyl group is attaching with Sulphur..Now my question is where the other hydrogen from the hydroxyethyl group does go?

[@quincy22]

On the Product side of the net equation, where did the Hydrogen ion come from since FAD transferred the 2 electrons onto NAD?

[@rodrigoferreiradarosa2977]

Isn't lipoamide normally attached to a lysine residue, rather than serine? (8'40")

[@yasmine345]

Thank you so much

[@eliasdavidreyes8611]

Gracias

[@AKLECTURES]

+Reyes Jim?nez El­as Soc 2011 welcome!

[@AK-wk2xk]

great .

[@donmalik8888]

what is the difference between decarboxalses and dehydrogenases in link reaction?

[@scuolascuola2525]

Thank you!!!!!

[@danielavinueza5124]

Thank you!!!!!!!! 👏🏼

[@ashleyli9427]

NAD+ is a cofactor and why is it not regenerated at the end?

[@ahc3363]

Should say "extracts," not abstracts, on the board

[@abhi8388]

where the merch link at? lol

[@AKLECTURES]

www.etsy.com/listing/458728846/short-sleeve-t-shirt-blue?ref=shop_home_active_1&crt=1

[@Theonemen5]

why is a part of the doublebunds from c to o in the co2 group drawn with dots?

[@bandoos4467]

Jamal George because it's a double bond, and in reality, the double bond has resonance over both the oxygens connected to the C

[@faryaarshad9846]

ppl who disliked this video have a special place in..................

[@ItSamiraclelol]

Here's the background image if anyone wants a copy for their notes: imgur.com/Gb7VIBO

[@dhruvpandey8880]

Out of The two h+ ions added in step 1,one gets addded to S- in step 2;what happens to the second one?

[@LoversGrief]

slideplayer.com/slide/3419339/

[@sameerakhan2068]

Just realized acetyl and acetal are different functional groups. WHY LORD

[@LoversGrief]

He seems to like the word "actually" an awful lot.

[@beyzademirtas9768]

please turkish subtitles

[@AyaSharabi]

i love you

[@Lycroo]

Thank you for these video. Help me a loooot

[@mr-wc3xq]

Thank you so much

[@apoorvkirti9129]

Thank you sir