Recent methods for protein structure generation and design

presented by Sergey Ovchinnikov on February 21st 2024
For this meeting I'll give an update of some of the new techniques and protocols added to the ColabDesign framework. The pros and cons. From hallucination to diffusion, including a short tutorial on how to use them.

[@davebruno218]

Thank you sir

[@amelieschreiber6502]

Does the iterative design workflow of filtering with AF2 then redesigning with ProteinMPNN multiple times increase the likelihood of a single conformation for the final sequence (after you've loop through ProteinMPNN-->AF2 multiple times)? see 9:40 timestamp for example. Seriously good content btw. Thank you for this.