Regulation of Glycolysis | Allosteric vs Hormonal Regulation of Glycolysis | Biochemistry

This video provides a tutorial on regulation of glycolysis pathway. There are three important enzymes that regulate glycolysis pathway. 1. Hexokinase and glucokinase enzymes are allosterically activated by its substrate glucose. Hexokinase is allosterically inhibited by its product fructose-6-phosphate, whereas glucokinase is allosterically inhibited by fructose-6-phosphate. 2. Phosphofructokinase-1 (PFK-1) enzyme is allosterically inhibited by ATP and citrate, whereas it is activated by ADP, AMP and fructose-2,6-bisphosphate. 3. Pyruvate kinase enzyme is allosterically inhibited by ATP, acetyl CoA, alanine and long chain fatty acids, whereas it is activated by fructose-1,6-bisphosphate (an example of feed forward reaction). All three enzymes are inhibited by high glucagon in response to low blood glucose level. They are activated by high insulin in response to high blood glucose levels in the body.
The following topics are covered in this lesson,
1. Allosteric vs hormonal regulation
2. Allosteric regulation of hexokinase enzyme
3. Mechanism of glucokinase regulation in the liver
4. Hormonal regulation of glucokinase enzyme
5. Allosteric & hormonal regulation of phosphofructokinase enzyme
6. Regulation of fructose-2,6-bisphosphate in the liver
7. Role of phosphofructokinase-2/fructosebisphosphatase-2 enzyme in regulating fructose-2,6-bisphosphate
8. Allosteric and hormonal regulation of pyruvate kinase enzyme
9. Pyruvate kinase deficiency
10. Mechanism of arsenic poisoning

[@blessingnwakeoma7039]

Thank you so much...best video for allosteric enzymes generations so far

[@AdeolaAdepoju-tw8wp]

Helpful

[@asmitakumari9572]

Thank you so much ......you presented this topic very well 👌👏👏

[@HouseOfGwengi]

Very practical lesson. Thank you very much and please do more of them

[@amosogaji8953]

Thank you very much. Very informative.

[@jamalshow9187]

Thank you Amazing job

[@nazzindamollygrace4778]

Thanks you have made biochemistry to be easy for me

[@masoodalam4436]

Thank you mam.very impormative and simple explanation.،🇵🇰

[@user-xz6qq9lk8s]

Thanks a lot teacher...u r great

[@karystalhamidi9565]

Very useful

[@SamraSabeen-kf2lo]

Regulations of glycolysis pa lecture da dain

[@AbdulRauf-bh8fm]

Excellent

[@user-sd4lp3sb4g]

Thanks mam

[@AdeolaAdepoju-tw8wp]

I noticed an error,in the conversion from fructose 1,6 bisphosphate to the two triose compounds the enzyme involved is ALDOLASE not ALDOSE -ase is enzyme -ose is sugar Take mote everyone ❤️

[@pcbiochem]

Thank you for pointing that out, really appreciate it :)

[@AdeolaAdepoju-tw8wp]

​@@pcbiochemIt's my pleasure

[@mkkhaann]

Very helpful in fast review,also make videos on lipid metabolism 🙏

[@pcbiochem]

Thank you! I will be doing videos on lipid metabolism soon :)

[@talaiscomingafteru]

Thank uuuuuu

[@Biochemiths]

Nice

[@stellad.koleva8201]

How is alanine inhibiting the glycolysis?

[@rupeshraj7423]

❤

[@fbfan2301]

F. 6.P inhibit G.K or G. 6.P

[@AdeolaAdepoju-tw8wp]

PFK1 is inhibited by ATP, acetylCoA and citrate. Under the conversion of F6P to F1,6bis phosphate

[@bio366geethasankar7]

🙏🙏🏻🥹