Regulation of Satellite Cells with Exercise - Dr. Parise

[@Phuktup3]

This video is awesome - I had suspected the SC were influenced by the type of training. I have been focusing on eccentric failure and the results only confirm this. It’s all very miraculous and mind boggling! I had some intuition about the cells response to stretched failure - it’s been the best gains I’ve ever had! Thank you for the video, it flew by, I love stuff this (my guilty pleasure is method of action)😅 we are just cells - it’s crazy to think about. Our primate ancestors were swinging from trees and having to catch themselves and decelerate a lot - that is stretched eccentric work, we just know to go to failure to maximize it. Great stuff!

[@Phuktup3]

It’s makes sense the satellite cells are where they are and respond greater when closer to capillaries, there must be some metabolic signaling from damaged muscle AND signal from motor neurons of the tension being felt. The cells are the perfect spot, they detect the breakdown products and possibly use it to remodel the muscle. It explains why we can perform so many different types of exercise. Seems like the stretched eccentric has another benefit- getting blood to the small capillary beds.

[@sveinung93]

So what exercise strategy is best to increase myonuclei? Eccentric muscle actions? muscle damage in general?

[@LTPottenger]

Muscle damage in general but eccentrics and stretching are the best known, it can be hard to judge damage done by the pain alone.

[@Enhancedgenetics]

Unaccustomed Exercise is.... it's known to cause wide spread muscle damage...

[@LTPottenger]

So the satellite cells are largely there to keep blood flow to the muscles? Interesting if correct.

[@fortnite-cronusmax9055]

@GENETIC BEAST haha not surprising seeing you here.

[@rahimrawji9065]

Are satellite cells and stem cells the same thing?

[@wingtoh4867]

In this context yes

[@Enhancedgenetics]

Yeah