Positive and Negative Feedback loops and homeostasis

Brief but detailed description of homeostasis and the feedback mechanisms that help control homeostasis.

[@dommii83]

This was EXTREMELY HELPFUL with online classes due to covid 19 😑 thank you ! ❤

[@duderj0582]

same

[@jawadhamade2762]

Lol I’m in eight grade and I couldn’t really understand it

[@Cass_i]

Straight to the point and right on target. One of the best explanations of -ve and +ve feedback I have seen. I even downloaded it for later reference. Thank you!

[@mutsamutsa3244]

This is the first time I am beginning to understand negative and positive feedback mechanisms, thank you so much

[@jason-ow8cq]

Your doing the lords work professor.

[@cheng-chunglin5099]

THANK YOU DR. Ren Hartung. Your teaching is very valuable.

[@adreejakundu8299]

I am studying with pharmacy and his sessions are so helpful to me ... my concepts gets crystal clear ....

[@christinacooks8012]

Thank you! Very helpful information and examples from you

[@annnguyen6014]

I was so confused, and I have watched so many videos but was still struggling and this one was really helpful! Thank you so much!!!

[@darlenejasmin01]

This is really helpful! Looking forward for more! Thank you!!

[@Mahendrasingh11448]

❤️❤️

[@Mahendrasingh11448]

Hlo i am from India

[@boydmudenda3475]

This has greatly helped me in terms of understanding homeo, keep up the good work Doc😉

[@nardgrum973]

I like the way you explain it thank you!

[@sarahmahamid3031]

Ideal explaination...Thank you Mr H

[@fijifried4612]

Straight to the point, thank you.

[@alfermelia6516]

As a designer and practitioner of control theory to aerospace systems, I am very impressed by the simplicity of explanation of the application of feedback to body mechanisms. Currently the use of feedback systems are being used to QMH (Quantifying Mental Health). For example see: "QMH via Ontological Engineering with a Bias Towards It's Mood Science", Al Fermelia, Stephen Ternyik Lambert Academic Press

[@kaiyeungdaniel3281]

Thank you so much! it is going to be useful and I reprehend a lot from your explanation.

[@Islamdeeenha]

This is very helpfull first time i understand negative and positive feedback

[@firdausfendyharyadie995]

hey, can u give if there any outcomes or effect of this mechanism?

[@gregorrsamsa]

now i understand them. thank you so much.

[@fernandalinhares6048]

Thank you so much for this class! Could you answer me about reflexes being a type of negative feedback please? My professor made a comment that the impulse to immediate retract when we stomp on something pointed to be a kind of negative feedback, but I can't find about it anywhere and I'd like a second opnion.

[@areebatahir3309]

Intellectual way of teaching, 👏

[@ephybrenda6866]

Just great,,lots of love

[@czennie_4ever303]

JUST WOW. Thank you very much!

[@keniavillacres]

Thank God for this man 🙏

[@ashleykindt8844]

This video helped it to finally “click” for me. Thanks!

[@cristi2611]

Really well explained, thank you!

[@stephaniecrochetry4115]

Thank you so much for this video..it's very educating

[@frole9048]

THANK YOU DR. REN HARTUNG!!!!!!! AWESOME TEACHER 😇

[@state2728]

So so useful! Thankyou.

[@idilahmed9257]

thank you so much, very helpful

[@carlenahowell2895]

Thank you for explaining what my professor was trying to teach me.

[@lykebudda]

great information!

[@harshabilakanti6553]

This guy is great

[@madej1858]

Thank goddess for youtube

[@simon_simon146]

Thank you Doctor

[@manishahbazi8092]

Thank you Dr keep it up

[@nwaozuzuemmanuel622]

video was cool, but if you can do for that of feed forward mechanism, I will really appreciate it

[@kristin9874]

THANK YOU!

[@gabbyn.9850]

Thank you!

[@avrilbanque7785]

THANK YOU VERY MUCH SIR!!!

[@shnyarshorsh6255]

Thx for u looking forward for more😍😍

[@menemapatwelsy905]

I don't know how to thank you, but all I can say, is "asante Sana" Kiswahili meaning, thank u sooooo much 🥰

[@mailiayang9870]

Thank you!!!

[@kariithskaren372]

So helpful...Thank you very much

[@chrissilit]

Thank you so much

[@chayapitchas.4722]

Thank you!!

[@vergarajessa8643]

Thank you💖

[@stephenprice3357]

watched his videos for AP1 and 2, Microbiology, and now pathophysiology

[@renhartung]

Shows how important feedback and homeostasis are in living things :)

[@shiamyloveable]

Thank you

[@faithadejumo9727]

God bless you sir

[@nanyonjoshamilah4670]

thank you, but wanna ask is it really the brain that secrete oxytocin to the cervix

[@renhartung]

Well, it's a bit more complicated... There is a structure in the brain called the hypothalamus, this structure contains neurons that produce oxytocin and shuttle the hormone down axons and into an endocrine gland called the pituitary. The oxytocin is released by that gland when it is needed (it's actually released from axon terminals of the same neurons that make the hormone). The oxytocin then travels through the blood stream until it reaches receptors in the uterine wall and has its effects. I hope this helps :)

[@hajarayelwa1697]

Thank you 😩🌹

[@alfredopoku7392]

Nice tuition keep it up 👍

[@hamza-uj9ef]

Big Thanks ❤

[@ankur7247]

sir it was great .

[@Tina-fp3dw]

I just want a quick terminology of positive/negative feedback

[@syedsalman3987]

-ve feedback is bringing homeostasis by going against the change(stimulus) and going with that change to bring homeostasis is what we called +ve feedback.

[@Cass_i]

Negative feedback is as he described, the change is happening in the opposite direction. E.g if blood pressure is too low, the feedback to bring it back up is in the opposite direction; increasing the blood pressure. So that's negative feedback

[@elsakifle7322]

Thanks 🙏 so helpful

[@sushreejena5568]

Thank you sir very much

[@rocioguarniz5186]

Thank you very much for this video! I have a question. Hormones produced by which cells of pars of distalis (pituitary gland) work on negative feedback? Acidophils or Basophils. Thank you!!!!!

[@renhartung]

Wow, you are going deep into the histology and physiology here. Acidophils in the anterior pituitary include two different specific cell types--- mammatrophs (make prolactin) and somatotrophs (make growth hormone). Basophilic cells of the anterior pituitary include three different cell types--- thyrotrophs (produce TSH), gonadotrophs (produce LH and FSH), and corticotrophs (produce ACTH). The basophil cells of the pituitary are more controled through negative feedback than the acidophils.

[@rocioguarniz5186]

@@renhartung I appreciate your taking the time to answer my question! It has really helped me for my NBDE 1 prep.

[@marvinreinartz6957]

So is the action potential in nodal cells of the heart which is initiated by the pacemaker potential of the funny channels a positive feedback loop then?

[@renhartung]

Kind of... the stimulus (the membrane becoming positive past threshold) does lead to an increase of itself (the membrane becomes even more positive)... However, this story is missing the control center so I don't really like talking about action potentials as examples of positive feedback myself. I guess platelet activation has a similar problem though (no control center really).

[@amansaiyed8413]

Awesome sir

[@christybriscoe6136]

Is controling body temperature part of the negative feedback loop?

[@renhartung]

There are negative feedback loops involved in maintaining body temperature. Hope that helps :)

[@dushimejosiane6492]

Thank you . I'm Rwandan . I wish I could see you face to face Doctor

[@heenabasit4379]

u teach well. i have a question . what is the normal blood glucose level? in% also. I also wanna ask why do the vapours come out of our mouth in winters?.is it something related to homeostasis?

[@heenabasit4379]

how the goosebumps help in increasing body temperature?

[@renhartung]

In most humans goose bumps do not help a lot to keep us warm, but some humans have more hair. If a person is very hairy then the goose bumps make the hair stand on end and create a bit of a barrier against wind... this prevents heat loss.

[@mondelinejean2579]

Perfect

[@dushimejosiane6492]

You are intelligent at all

[@hannahmontana4769]

Thanks

[@Mahendrasingh11448]

Thanks sir i am from India ❤️

[@komalkansal1311]

Thanks sir

[@wintur2856]

Thank you. The campbell biology book didnt explain this well.

[@zainabmohmmed5676]

Hi Dr, Could you explain the mechanism of the action of tpo and galectin-3 in the thyroid gland and be grateful to your presence

[@alfredopoku7392]

Can I please get more examples on positive feedback mechanism?

[@renhartung]

The ones I can think of right now: blood clotting, childbirth, fever (when the temp initially goes up), ramping up mild production for a newborn, immune responses.

[@swkao1382]

Wonder you'll have lecture on ALS?

[@renhartung]

No plan at this point. That disease is out of my teaching scope.

[@swkao1382]

@@renhartungAlthough knowing you’re expert of human physiology, anatomy, biochemistry & others, but probably not pathology, still like to inquire whether you’ve given the ALS myth some curious & careful thoughts, like how glutamate, one of the neurotransmitters, will be out of sink with homeostasis, & turned into a gradual toxin & killer of motor neurons in ALS patients? Pardon for my being ignorant! Wouldn’t far more glutamate is produced during the course of a marathon running & thus resulting in motor neuron’s death in large number? Thank you!

[@rachelstews2389]

Wonderful Video, and very helpful

[@saramalik5440]

Positive feedback loop is cumulative and may extend beyond homeostasis like say cell differentiation, muscle memory for instance, you dnt need a perpetual stimulus, it’s a self perpetuating loop once started, for example muscles dnt need to be told everytime like they are muscles, they do their contraction regardless.

[@saramalik5440]

I m talking about cell fate determination , it’s an upsum of positive feedback loops esp ones with all or none response

[@kaankshita581]

Sir I want notes or pdf on basic principles of cell injury and its adaptation

[@renhartung]

Sorry, I don't have anything prepared on that subject.

[@kaankshita581]

Ok sir

[@heenabasit4379]

in positive feedback, the effectors encourage the change(stimulus).they dont bring the physiological change to its normal set point. then why we termed it as homeostasis.

[@renhartung]

In the case of positive feedback, these only occur when something must be done to take the body outside of homeostasis for a short time in order to allow for homeostasis to return in the long run. Example: If a woman enters labor but labor does not complete this puts mother and baby in terrible danger of death (the ultimate non-homeostatic state). The positive feedback loop involved with labor makes sure that the baby is delivered and then mothers body can return to homeostasis and continue to survive In this way positive feedback loops are really part of larger negative feedback loops, when functioning properly the ultimate goal of positive feedback loops is homeostasis.

[@miadimaculangan8391]

♥️♥️♥️🙏

[@kemuelfavour9292]

Wow

[@nepalimaan8532]

This video helped me gain better understanding about feedback loops. But I am still struggling to figure out how positive feedback maintains homeostasis.

[@renhartung]

Positive feedback can help maintain homeostasis in cases where something important must happen in order to prevent even greater homeostatic imbalances. Good examples are the process of labor/childbirth and stopping bleeding (hemostasis). Regarding childbirth-- The increasing of oxytocin and uterine contractions happen by positive feedback in order to deliver the baby... just imagine what might happen if the baby was not completely delivered, this would be bad for both mother and baby's homeostasis. Mom's body can only return to homeostasis if baby gets completely delivered, so the positive feedback loop involved in labor is required for mother's body to return to homeostasis. Stopping bleeding also involves positive feedback loops of platelet and clotting protein activation in order to prevent blood loss. If this positive feedback loop did not happen the person would end op with even greater homeostatic imbalances of lower blood pressure leading eventually to hypovolemic shock. So, the positive feedback loops involved in stopping bleeding ultimately prevent greater life threatening homeostatic imbalances. Because healthy positive feedback loops actually help maintain homeostasis (at least in the long run) we can actually think of these positive feedback loops as being part of larger negative feedback loops that ultimately help the body stay within homeostasis. I hope that helps, please let me know.

[@ambasstitches733]

@@renhartung thank you so for this wonderful explanation

[@Ianarinda]

Why are positive feedback loops dangerous in the body compared to negative feedback loops

[@renhartung]

It's basically because positive feedback loops take us away from homeostasis. If they work right this is not a problem, but if they go too far outside of homeostasis or stay there too long this can be very bad... Example: If a fever goes too hot this can lead to seizures and even death.

[@abdulbasit9892]

I was asked to make 10 questions and answers out of this video can someone help please?

[@renhartung]

Here are a few to get you started: What does the term feedback mean as it relates to homeostasis? What are the components of a feedback loop and what does each part do? How is negative feedback important for health? What are the major similarities between positive and negative feedback mechanisms? What are the major similarities between negative and positive feedback mechanisms? How are positive feedback mechanisms important to health? Describe a specific negative feedback loop, its parts, and how it functions. Describe a specific positive feedback loop, its parts, and how it functions.

[@abdulbasit9892]

@@renhartung thanku sir really thanks from my heart

[@devonholliman8236]

Trigger Deez 😂 Very valuable info🥰

[@dalilurrahmandalilur9451]

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[@abbie645]

1738 aye

[@alexsoncheung4818]

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[@chineduecheruo8872]

Thank you

[@mawandakiriba1748]

Thanks