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Dr. Birkin's initial mutation kept much of his body unchanged, with the mutations only being seen on the right side of the body, with the arm, torso and face being affected as it was on this side of the body he was shot. In Resident Evil 2 original and The Darkside Chronicles, the mutation made William's right side of his body grotesquely increase in muscle mass, making his skin tear up and take on a turn a sickly reddish hue, while in most of his shoulder arises a large blood-red eyeball beneath a large bone-like protrusion exposed.