Rifampin Mechanism of Action

[@GilbertMwaba-iz6rs]

Just wow…. This was perfectly explained

[@rainbowunicorn3709]

Can you tell me why can Rifampicin attach to that beta position? What part of its structure help it to attach to RNA Polymerase?

[@richardb6825]

Amazing job!

[@honeyb7411]

Thank you so much for the information. I am not a doctor. My doctor ask me to take this meds for latent TB. We all need to know what we are taking and the side effects.

[@enlm769]

Good explanation thank you

[@gloriasiahaan0112]

thank you so much for the information. before it, let me introduce myself. my name is glori and i from indonesia. so, i'm so sorry if my english is not good enough. i have watched this video and i found that "rifampicin clogs the rna exit channel..", but in every journals that i red, it said that "rifampin binds beta subunit of rna polymerase and it inhibits the synthesis of mRNA." is there a connection between these two statements? thank you in advance.

[@MUNYANGELEWISCHEGE]

Do you have any information on rifampin metabolism

[@ErinPeden]

That is not my area of expertise. My video focuses on what rifampin does to sensitive bacterial cells. It is absolutely true that this chemical will be processed by our bodies over time. From what I understand the liver processes the rifampin and it is secreted into bile then leaves the body via the digestive tract. Rifampin also seems to be secreted into urine leaving the body vie the urinary tract. We should all depend on our doctors and our pharmacists to determine if rifampin is safe and effective for us as individuals based on our current health status.

[@luciavasile2895]

Can you have liver toxicity or hepatitis or cardiac arest from this strong Rifampin?😢 i'm so scare to take somenthing that could kill me😭😭😭

[@ErinPeden]

I am not a medical doctor. So, you should definitely ask your doctor. Keep in mind that every chemical can be toxic/harmful. It is possible to die from water poisoning. What is important is that we take appropriate risk when prescribing medicines. Remember that the infection you are treating has risks too. Not treating the infection may be a very dangerous choice. Your doctor knows for sure.

[@Greanestbean]

Thank you

[@RK-wd7db]

Why rifampin is given in combination

[@ErinPeden]

I'm not a medical doctor and I have never prescribed rifampin. So, the honest answer is that I do not know. That being said two antibiotic drugs may be prescribed at the same time to ensure effective elimination of the microbe causing the infection. Sometimes a single drug won't work as well as two given at the same time. In the end we should ask out doctor or our pharmacist why we are receiving two drugs at the same time.