Ron Vale (UCSF, HHMI) 3: Molecular Motor Proteins: Regulation of Mammalian Dynein

[@astra-de8ff]

These comprehensive explanations with beautiful illustrations are just amazing.❣❣

[@sweetsue4204]

I watched all three sections and feel like I just took a great course in cellular biology. I’m in awe. 👍🏻

[@williambunting803]

This is all so incredibly thrilling and amazing. I’m blown away by the mechanism of of muscle movement on the one hand, and on the huge amount of molecular material that must some how arrive inside the cell wall to feed the protein builders and then the pace at which all of this must happen. One of the missing pieces is the delivery system to the protein machine. Other animations suggest that the molecular segments just float around in the cellular fluid, whereas this new work here seems to indicate that this is all done by a delivery system on a kind of microtubule scaffold system. Then the next question is how is the order of segment delivery regulated? Then one day I hope to learn how the shape of bones and skeletons is determined by the information in the DNA, bones being one of the most stable constructions in nature, consistent over millions of years of regeneration. Thank you for your fabulous work.

[@dougb70]

It is amazing that you are able to explain these complex topics with ease. Very informative. Thanks for sharing.

[@rockapedra1130]

This series is the coolest, mind-boggliest, awe-inspiringest thing I’ve ever seen! Wow! Thanks so much for sharing! The perseverance and success of your lab and collaborators is nothing short of amazing!

[@LeviSchuck]

These principles were explained well in Parts 1-3 for non-bio viewers. Thank you.

[@merlin5by533]

Brilliant Demonstration and Lecture.

[@contemplatively]

Just wow. This is the kind of stuff that makes me rethink my philosophy in life.

[@OKden2065]

Thank you so much, Ron for sharing all of these videos. I'm in awe of you scientists that figure all of this out. I'm in greater awe of your ability to explain the structure and function of these wonderful motor proteins. But the greatest awe is reserved for the one who designed all of this. I'm a plant scientist and agronomist feeling very, very humble tonight.

[@MrHichammohsen1]

21:02 i think the mobility won't be stopped by junctions but nor go unnoticed. They produce a rotational element around the tube that makes it arrive a bit later than going straight from A to B

[@dhanukrish1765]

How the dye is applied? what is its molecular structure?

[@glenliesegang233]

9:00 so, the cellular highway system and the vehicles on it , with different points of origin, destinations, and unique types of cargo all arose by chance???

[@Dr.JM1]

Evolution gave us the chance to develop the perfect machine, life will never cease to amaze us. Congrats for your research!

[@radiofun232]

Brilliant, many thanks, I learned a lot. I see many "bindings" between "structures" in these video's and am interested in the way the bindings are made on a molecular level.

[@MrHichammohsen1]

10:42 is there another technique used where they use multiple microscope lenses from multiple angles and do it in 3D in real time render using an AI?

[@_John_P]

The microtubules running around was genius (02:44)

[@glenliesegang233]

12:20 if gene, then protein, are the linking proteins for specific types of cargo "irreducibly complex" because without them, the dynein complex cannot transport the proper carrgo?

[@tibetsfinest]

Absolutely fascinating information

[@glenliesegang233]

14:40 the dynein "just sits there", it's "motor" does not run until cargo is attached. Wow!

[@numericalcode]

Fascinating stuff

[@patrickv391]

Correcting my metabolic issues with diet brought me here and its awesome.

[@Sclark2006]

This channel is awesome! Why so few likes?

[@yasirmohammedali]

Hello doctor, thanks for the amazing videos

[@seiran555]

Very interesting lesson. Thank you :)

[@friedchicken1]

My brain is literally turned into soup when I learn about this incredible stuff

[@kokopelli314]

Wonderful nanotechnology.

[@patldennis]

Except true technology is enacted from the top down (I need something to beat this nail into wood->designs hammer) whereas this sort of "nanotech" emerges from the bottom up to produce a derived function

[@davedumas0]

@3:47 tough actin dynactin

[@bryanryan4504]

Haha unfortunately no millennial will understand your joke

[@bzzzvzzze]

Amazing!

[@woloabel]

In vivo studies should be exactly as those of in vitro, but the matter is unnecessarily complicated further for end purpetually be funded and inviegled. The truth is just free and rather unmysterious....

[@simongross3122]

Red, Green and Blue? Have they just invented organic television?

[@sakthishanmugavel1503]

Thanks💗

[@Stoplossed]

yo ron keep on rockin dude

[@jonnes__4657]

For me it is so amazing, that these molecules (proteins) can move in the cells and "explains" how we can live and move via the Myosin motors our body. For me it is not an so important question who started this incredible complex process of life, who developed the first cell? It happened like the universe is here and we do not know why and we never will know? Maybe we are all ETs coming from outside of earth via an Asteroid? The most incredible thing for me is how all the living creatures developed from this first cells in the very long evolution process. Unbelievable... .

[@TheZenytram]

no wonder why evolution stayed at single cell life for 3by, one cell is already so fucking complex

[@naimulhaq9626]

Dynein motility kinesin-myosin nucleotide-driven structure ATP hydrolysis dynactin motor protein Spellbinding insight into the function of a cell in transporting/motility of dynactin/dynein over micro-tubular channels during nucleotide-driven structural changes in the dynein motor domain, opening the door to a possible insight into the role played by quantum computing. The whole universe is quantum mechanical phenomenon, guided by a SINGLE probability wave function, explaining how planets revolve around their stars, how photosynthesis produce food for all plants, how entanglement helps the robin to navigate during migration, how tunneling helps the tadpole to grow limbs etc. Physicist Maldecena thinks the whole universe is a quantum computer. QC also is essential modus operandi for our five senses, our pineal gland, our brain and all our cells equipped with QC capabilities for us to survive and evolve. The following story will illustrate how our metabolism employs QC and protein production is facilitated by a coordination of our senses, our brain and our cells act like a computer with the environment acting like both as input signal, and our brain and our cells act both like the software and hardware of the computer, while the environment acts like the output: Once a patch of a forest was cleared and the trees felled, resulting into the lightly coated rats living there being exposed to predators. But the very next generation of rats were born with dark coat, enabling them to survive the predators, the subsequent generations, due to natural selection also survived. This is what happened: The clearing of the forest was the input that triggered caution in the mind of the original mother rats, to crave for dark coating, this signal was transmitted to the cells in the ovary of the mothers, who produced the necessary proteins needed to produce offsprings with dark coats, impacting the environment (which acts both as input and output to the computer). This example, probably will help us devise a QC, that might work in room temperature. The 3 part video amply shows that the QC, mentioned above works in two stages, our brain (pineal gland) sending signal to the cells, where kinesin-myosin and dynein motility, with the purpose of protein production, was simulated by the QC in the cell (producing the dark coated rats). I am not a biologist, but an electrical engineer, who had to study semiconductors, computers, QM etc. I learned how QC works , with superposition of quantum states of 0 and 1 (QUBITS) and I hope my observations may help make QC more viable and help create one, besides explaining the cells function in a new light, that may answer some of the unexplained questions in this video, treating the cell as a QC.

[@TheZenytram]

dude, what you smoke?

[@brettm4867]

The molecular motors geek me out😂life is fucking weird

[@SimonJackson13]

Tyr for the shrinks art of motion no Tyr for the growing part of cell. Sounds legit...

[@eminemlandsteiner168]

I cannot hold any longer... BIG D!

[@deeveevideos]

Yes?

[@JasminUwU]

Lmao, I was looking for this comment

[@misium]

4:33 Are biologists really that ignorant of unit prefixes or was that just a mistake? Edit: answer at 5:43, thank evolution!

[@patldennis]

It was just a mistake. Try not to miss the big picture bc you're too busy picking nits

[@JamesSamples]

Thanks!

[@tyronebigsby2169]

Let’s gooooooooooo

[@Tlimfree2010]

Dynactic Dynein and BicD complex :D :D

[@silviaalexandrecordeiro8400]

🌹🌎🌍🌏🌹

[@andvokslife9596]

Great thanks and glory to the Creator, for His wisdom!!!!

[@richardwadd9769]

There had to be some idiot who brought god into it.

[@deeveevideos]

Praise God for creating life and its awe inspiring intricacy. Also gave us his son to believe on to gain eternal life! Jesus is our lord and only savior 🙏 🙌 ❤

[@stefan2292]

I don't know about your God (much less his "son"), but somebody or something created this incredible machinery. It certainly could not have resulted from individual mutations and "natural selection" - that's just a fairy tale. What actually happened? We have no idea. My guess is that it will take another 100 years or so to find out.

[@deeveevideos]

@@stefan2292 The problem with that is they'll never use a creator as any legitimate form of explanation. Remember progress is n't going forward non-stop it means figure out you're on the wrong path backing up and then finding the right path. God bless you

[@chintusct5258]

any Indian here?

[@SpiderF27]

Do you looking for Indiana Jones ? ))

[@dr_mohit]

Thanks 👍

[@silviaalexandrecordeiro8400]

🌹🌎🌍🌏🌹