SAR of Loop Diuretics || Furosemide Bumetanide Ethacrynic Acid || Diuretics || Medicinal Chemistry

[@ghazalabhutto660]

Ghazala Parveen 18 1) 5- sulphamoyl-2- aminobenzoic acid e.g : furosemide and azocimide. 5- sulphamoyl-3- benzoic acid e.g: Bumetanide and paritanide. 2) In furosemide EWE group is Cl at 5 position while in Bumetanide contain phenoxy functional group at 4 position. 3) aromatic ring. Methylene butyryl ketone Oxyacetic acid.

[@Anushalearningcenter]

W/salam Sir Naila Ali Ans1: 5- sulphamoyl -2 -Amino benzoic acid. E.g# furosemide and azocemide . 5sulphamoyl-3- amino benzoic acid. E.g: Bumetanide and pritanide. Ans2: In furosemide EWE group is Cl at 5 position while in Bumetanide contain phenoxy functional group at 4 position. Ans3: 1: Aromatic ring 2: Methylene butyryl ketone 3: Oxy acetic acid.

[@soomalsindhi846]

W.salam sir 1)5_sulphamoyl_2_amino benzoic acid and 5_sulphamoyl_3_amino benzoic acid. 2) Furosemide have halogen at 4th position and bumetanide have phenoxy at 4th position. 3) phenoxy acetic acid , aromatic ring and methylene butyryl ketone.

[@aaliarahu9014]

W. Slam sir 1)........(a) 5-sulphamoyl-2-amino benzoic acid eg.. Furosemide and azosemide. b) 5-sulphamoyl-3-amino benzoic acid derivative. Eg... Bumetanide and piretanide. 2)In furosemide there is EW atom(Cl) at the 4th position where as bumetanide contain phenoxy functional group at 4th position 3) ..........(a) Aromatic ring (b) methylenebutyryl ketone (c) Oxy acetic acid

[@Puphocreates420]

1) 5- sulphamoyl-2- aminobenzoic acid e.g : furosemide and azocimide. 5- sulphamoyl-3- benzoic acid e.g: Bumetanide and paritanide. 2) In furosemide EWE group is Cl at 5 position while in Bumetanide contain phenoxy functional group at 4 position. 3) aromatic ring. Methylene butyryl ketone Oxyacetic acid.

[@anitagawasker5152]

Aneeta Lohana 04 1. 5 sulphamoyl 2 amino benzoic acid 5 sulphamoyl 3 amino benzoic acid 2.. furosemide has Cl at 4 position and bumetanide has phenoxy at 4 position 3.. aromatic ring and side chain of ketone and phenoxy acetic acid

[@anaasuhail9276]

Anum Zardari (06).. 1: a) 5- sulphomoyl 2 amino benzoic acid. Ex: Furosemide. b) 5-sulphomoyl 3 amino benzoic acid. Ex: Bumetanide. 2: In Furosemide, there is electron withdrawing halogen group chlorine at C4 position. In Bumetanide, there is phenoxy group at C4 position. 3. *Aromatic ring, * Methylene butyryl ketone, * Oxy acetic acid.

[@bozdar4544]

On the basis of chemical structure loop diuretics are classified into two classes. a) 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide. b) 5- sulphamoyl-3- amino benzoic acid.example: bumetanide, piretanide. 2.In furosemide there is electron withdrawing atom e.g ; Cll at 4th position and in bumetanide there is phenoxy functional group at 4th position. 3. Aromatic ring( benzene) ,side chain of methylene butyryl ketone at C-4 and phenoxy acetic acid at C-1.

[@beenishafzal2630]

W.salam sir . Ans 1) 5 sulphamoyl 2 amino benzoic Ex * furosemide &azosemide. B) 5 sulphamoyl 3rd amino benzoic acid derivatives: .. Bumetanide &pretinide. Ans2. In furosemide there is Electron wothdrawing atom ie cl at 4th position where bumetanide contains ohenoxy functional group at 4th position. Ans3 .. Aromatic Methylenebutyryl ketone Oxy acetic acid.

[@sadorichandio5892]

Q no # 1 Sulphamoyal 2 amino benzoic acid that's furosomide and azosemide. 5 Sulphamoyl 2 amino benzoic acid derivatives : bumetanide and pretanide. Q no # 2 In furosomide electron withdrawing atom that is Cl at 4th position where as bumetanide contains phenoxy functional group at 4th position. Q no # 3 (a) aromatic ring (b) methylenebutyryl keton (c) oxy acetic acid.

[@jotipirbhat]

Q-1 1- 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide 2- 5- sulphamoyl-3- amino benzoic acid.example: bumetanide, piretanide. Q-2 Furosemide has electron withdrawing atom e.g cl at 4th position & bumetanide has phenoxy functional group at 4th position. Q-3 1- aromatic ring(benzene) 2- side chain of methylene butyryl ketone at c-4 3- phenoxy acetic acid at c-1.

[@alinanaeem4594]

1) * 5-sulphamoyl-2- amino bezoic acid Ex: furosemide and azosemide * 5-sulphamoyl-3-amino benzoic acid derivative Ex: bumetanide and piretanide 2) In furosemide there is electron withdrawing atom i.e cl at 4th position where as bumetanide contains phenoxy functional group at 4th position. 3) 1.aromatic ring 2. Methylenebutyryl ketone 3. Oxy acetic acid

[@hiraakbar4261]

1. On the basis of chemical structure loop diuretics are classified into two classes. a) 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide b) 5- sulphamoyl-3- amino benzoic acid.example: bumetanide, piretanide. 2.In furosemide there is electron withdrawing atom e.g cl at 4th position and in bumetanide there is phenoxy functional group at 4th position. 3.Aromatic ring( benzene) ,side chain of methylene butyryl ketone at c-4 and phenoxy acetic acid at c-1

[@Pharmacist0900]

ANS (1): On the basis of chemical structure loop diuretics are classified in two main classes: (i) 5-sulphamoyl-2-amino benzoic acid. Ex: furosemide,Azosemide (ii) 5-sulphamoyl-3-amino benzoic acid derivatives (bumetanide) ANS (2): In furosemide there is electron withdrawing halogen group chlorine at C-4 position whereas in bumetanide there is phenoxy group at C-4 position ANS (3): Aromatic ring (benzene), and side chains of methylene butyryl ketone at C-4 & noxy acetic acid at C-1

[@rimshaurooj263]

Q1: a) 5-sulphomoyl-2-amino benzoic acid (furosemide,azosemide) b) 5-sulphomoyl-3-benzoic acid derivatives (Bumetanide, Piretanide). Q2: At C#4 phenoxy group present in Bumetanide structure while in Furosemide Halogen group (Cl) is present at C#4. Q3: F.groups of Ethacrynic acid. Aromatic ring, methylene butyryl ketone & noxy acetic acid.

[@NehaRani-gl3qt]

Ans1: on the basis of chemical structure loop diuretics they are classified into two main classes: 1: 5-sulphamoyl-2-amino benzoic acid e.g: furosemide, azosemide. 2: 5- sulphamoyl-3-amino benzoic acid derivatives ( bumetanide). Ans2: in furosemide there is electron withdrawing halogen group chlorine at C-4 position where as in bumetanide there is phenoxy group at C-4 position. Ans3: Aromatic ring (benzene) , & side chains of methylene butyryl ketone at C-4 & phenoxy acetic acid at C-1.

[@saver1439]

1) 5 sulphamoyl 2 amino benzoic acid. ie: furosemide & azosemide. B) 5 sulphamoyl 3 amino benzoic acid derivatives: Bumetanide & pretanide. 2) In furosemide there is Electron withdrawing atom ie cl at 4th position where as bumetanide contains phenoxy functional group at 4th position. 3) a)Aromatic ring b)Methylenebutyryl ketone c)Oxy acetic acid.

[@asmaarshad8221]

Q#1: 5 sulphamoyl 2 amino benzoic acid. ie: furosemide & azosemide. B) 5 sulphamoyl 3 amino benzoic acid derivatives: Bumetanide & pretanide. Q#2: In furosemide there is Electron withdrawing atom ie cl at 4th position where as bumetanide contains phenoxy functional group at 4th position. Q#3: a) Aromatic ring b)Methylenebutyryl ketone c)Oxy acetic acid.

[@safderhussain6516]

Ans 3 in aromatic ring benzene methylene butyryl at C4 and phenoxy at C1.

[@safderhussain6516]

Ans2 in furosemide there is electron withdrawing halogen group chlorine is at C4 position and in bumetinide phenoxy group is attached at C4 position.

[@Themovieminds-1]

ans 1. On the basis of chemical structure loop diuretics are classified into two classes. a) 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide b) 5- sulphamoyl-3- amino benzoic acid.example: bumetanide, piretanide. ans 2.In furosemide there is electron withdrawing atom e.g cl at 4th position and in bumetanide there is phenoxy functional group at 4th position. ans 3.Aromatic ring( benzene) ,side chain of methylene butyryl ketone at c-4 and phenoxy acetic acid at c-1

[@Honeybeeee12]

Ans1 5_sulphomoyl_2 amino benzoic acid (furosemide , azosemide) 5_sulphamoyl_3 amino benzoic acid (bumetanide,piratanide) Ans2 In furosemide cl is present at C4 while in bumetanide phenoxy group is present at C4 Ans3 Aromatic ring , methylene butyryl ketone , oxy acetic acid

[@Themovieminds-1]

walikum asalam sir

[@manahilsiyal316]

1. Chemical classes 5-sulphamoyl-2-aminobenzoic acid e.g furosemide & Azosemide 5-sulphamoyl-3-aminobenzoic acid e.g bumetanide & piretanide 2. The structure difference are In bumetanide Phenoxy functional group is present #4 position & butylamine is present #3..In furosemide Cl is present #4 position & furfuryl is present #2 . 3. Functional group of ethacrynic acid are. Aromatic ring Methylene butyryl ketone Oxy acetic acid

[@rabiamalik6502]

Ans 1: 5 sulphamoyl 2 amino benzoic acid i-e: furosemide and azosemide. 5 sulphamoyl 3 amino benzoic acid i-e: bumatenide and piretanide. Ans 2: Furosemide has electron withdrawing group (cl) at 4th position and bumatenide has phenoxy group at 4th position. Ans 3: 1- aromatic ring 2- methylene butyryl ketone 3- oxyacetic acid

[@safderhussain6516]

Ans1) On the basis of chemical structure loop diuretics are classified in two classes. 1) 5 sulphomoyl 2amino benzoic acid example. Furosemide. 2)5 sulphomoyl 3 Amino benzoic acid derivative example.bumetinide.

[@nimrakhan707]

Nimra Khalid Ans 1 5-sulphamoyl-2-amino benzoic acid Ex Furosemide, Azosemide Or 5-sulphamoyl-3-amino benzoic acid Ex Bumetanide, Piretanide Ans 2 In Furosemide EWG at position 5 While in Bumetanide phenoxy group at position 4 Ans 3 Aromatic ring Methylene butyryl ketone Oxy acetic acid

[@asmanawaz2789]

Ans -1 5 sulphamoyl 2 amino benzoic acid i-e furosemide and azosemide B) 5sulphamoyl 3 amino benzoic acid derivatives B) bumetanide and pretanide Q-2 in. Furosemide there is electron withdrawing atom ie cl at 4th position where as bumetanide contains phenoxy functional group at 4th position Ans 3 (1) Aromatic ring (2) methylene butyryl ketone (3) oxy acetic acid

[@emaneman5803]

Ans 1) 5 sulphamoyl 2 amino benzoic Ex * furosemide &azosemide. B) 5 sulphamoyl 2 amino benzoic acid derivatives: .. Bumetanide &pretinide. Ans2. In furosemide there is Electron wothdrawing atom ie cl at 4th position where bumetanide contains ohenoxy functional group at 4th position. Ans3 .. Aromatic Methylenebutyryl ketone Oxy acetic acid.

[@NikitaAdwani1]

A1: Chemical classes of Loop Diuretics: i. 5-sulphamoyl-2-amino benzoic acid. E.g. Furosemide and Azosemide ii. 5-sulphamoyl-3-amino benzoic acid derivatives. E.g. Bumetanide and Piretanide. A2: Structural Differences: => In furosemide at Cl is present at Position 4. Whereas in bumetanide a phenoxy functional group is attached at Position 4. => In furosemide N-furfuryl is present at Position 2. Whereas in bumetanide butylamine is present at Position 3. A3: Structural Components of Ethacrynic Acid: i. Aromatic Ring ii. Methylene butyryl ketone iii. Oxy Acetic acid

[@duaezehra5391]

*Duaa Zehra _11* *Quiz Answers* *A1: Chemical classes of Loop Diuretics:* *i.* 5-sulphamoyl-2-amino benzoic acid. E.g. Furosemide and Azosemide *ii.* 5-sulphamoyl-3-amino benzoic acid derivatives. E.g. Bumetanide and Piretanide. *A2: Structural Differences:* => In furosemide at *Cl* is present at *Position 4.* Whereas in bumetanide a *phenoxy functional group* is attached at *Position 4.* => In furosemide *N-furfuryl* is present at *Position 2.* Whereas in bumetanide *butylamine* is present at *Position 3.* *A3: Structural Components of Ethacrynic Acid:* *i.* Aromatic Ring *ii.* Methylene butyryl ketone *iii.* Oxy Acetic acid

[@asmashafique5998]

Ans 1 Sulfomyl benzoic acid derivatives Phenoxy acetic acid derivatives Ans 2 Furosemide is 5 sulfomyl 2 amino benzoic acid derivative whilr bumetanide is 5 sulfomyl 3 amino benzoic acid derivative Ans 3 Benzene ring Phenoxy acetic acid Methylene butryl

[@mairamehmood2987]

On the basis of chemical structure loop diuretics are classified into two classes. a) 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide. b) 5- sulphamoyl-3- amino benzoic acid.example: bumetanide, piretanide. 2.In furosemide there is electron withdrawing atom e.g ; Cll at 4th position and in bumetanide there is phenoxy functional group at 4th position. 3. Aromatic ring( benzene) ,side chain of methylene butyryl ketone at C-4 and phenoxy acetic acid at C-1.

[@anamsaeed2644]

1. On the basis of chemical structure loop diuretics are classified into two classes. a) 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide b) 5- sulphamoyl-3- amino benzoic acid.example: bumetanide, piretanide. 2.In furosemide there is electron withdrawing atom e.g cl at 4th position and in bumetanide there is phenoxy functional group at 4th position. 3.Aromatic ring( benzene) ,side chain of methylene butyryl ketone at c-4 and phenoxy acetic acid at c-1

[@nimrasamoo1796]

1. * 5-sulphamoyl-2- amino bezoic acid Ex: furosemide and azosemide * 5-sulphamoyl-3-amino benzoic acid derivative Ex: bumetanide and piretanide 2) In furosemide there is electron withdrawing atom i.e cl at 4th position where as bumetanide contains phenoxy functional group at 4th position. 3) 1.aromatic ring 2. Methylenebutyryl ketone 3. Oxy acetic acid

[@doobtinayya9295]

Ans -1 5 sulphamoyl 2 amino benzoic acid i-e furosemide and azosemide B) 5sulphamoyl 3 amino benzoic acid derivatives B) bumetanide and pretanide Q-2 in. Furosemide there is electron withdrawing atom ie cl at 4th position where as bumetanide contains phenoxy functional group at 4th position Ans 3 (1) Aromatic ring (2) methylene butyryl ketone (3) oxy acetic acid

[@uroojfatima4829]

Ans 1) 5 sulphamoyl 2 amino benzoic Ex * furosemide &azosemide. B) 5 sulphamoyl 2 amino benzoic acid derivatives: .. Bumetanide &pretinide. Ans2. In furosemide there is Electron wothdrawing atom ie cl at 4th position where bumetanide contains ohenoxy functional group at 4th position. Ans3 .. Aromatic Methylenebutyryl ketone Oxy acetic acid.

[@kainatkhan9896]

1. On the basis of chemical structure loop diuretics are classified into two classes. a) 5-sulphamoyl-2-amino benzoic acid example: furosemide, azosemide b) 5- sulphamovl-3- amino benzoic acid example:bumetanide, piretanide. 2. In furosemide there is electron withdrawing atom e.g Cl at 4th position and in bumetanide there is phenoxv functional group at 4th position. 3.Aromatic ring (benzene) ,side chain of methylene butyryl ketone at c-4 and phenoxy acetic acid at c-1