Hypersensitivity Reactions Made Simple!

[@farisalshboul998]

so just to summarize : Type 1 : foreign antigen attaches to antibody on mast cell (foreign antigen attack) Type 2 : own antibody attacks own cell's antigens (antibody attack) Type 3 : foreign antigen attaches to antibody in blood making Ag-Ab complex that accumulate in tissues with complement activation (Ag-Ab complex attack) Type 4 : foreign antigen presented by MHC-1 activate CTL (killing cells presenting the Ag) & by MHC-2 (on DC) activate T helper cells (calling macrophages to eat up the remnants) . (CTLs & macrophage attack) hope this helps :D & btw thanks very much for the video , it's extremely helpful & straight forward

[@lilipad4581]

THANK YOU! my immuno midterm is in an hour and my prof was NOT good at explaining these things in a 3 hours lecture which you did in 25 mins. life saver!

[@immanuelangelo1]

people talk days and days on one topic !!!! how consise and precise !! thanks a lot

[@MrDjhume]

I'm a second year medical student in South Africa - this is an excellent explanation. Immunology makes more sense now. Thanks so much!

[@sherylhidalgo3168]

I was hesitant to watch this video because of the length of it but wow am I glad that I did. Thank you for keeping it succinct and mot importantly, engaging. I now understand all 4 hypersensitivity reactions well because of you. Thank you!!

[@dianesteinlein2872]

Well done! After a hiatus of almost 30 years from the subject, you made it as easy as learning to riding a bike again. Bravo!

[@shamariajones4977]

This video is so much easier than the text book, I have a better understanding on hypersensitivity now.

[@lauralakonia]

This is great! I watched this as a review for my immunology exam and it brought together most of the diseases we learned. It made it easy to visualize everything while i was writing! Thank you!

[@ramitarajaa]

This video is AWESOME. I'm gonna tell all my classmates about this. I'm also gonna rock my immunology exam. You're funny too. Thanks for making this :)

[@cecilykoppuzha1873]

thanks! this was well worth the 25 min and saved me a lot of time trying to figure it out on my own.

[@urbansandwich]

You're videos always help me understand concepts better. Thank you for taking your time to do this! It helps a lot for physiology and pathophysiology!

[@yanxia3948]

excellent! good presentation. Clear and simple!

[@elliferousssac9727]

Thank you so much, the video was extremely helpful. I was confused about hypersensitivity in studying for my pathophysiology test and this clarified so much.

[@owenkerk6814]

Thank you! This helped me understand much more clearly than hours of reading!

[@sixtyone5]

hi, hi...... very very impressed or should I say extremely impressed. I needed further information as I am a Trichologist/Cosmetologist. (hair loss practitioner) I study hair loss and scalp issues related to hair loss. earlier in my certification I came across cell mediated immunity T-cells leukocytes fighter T cells Etc. That was in the first few chapters of my certification. Recently, this came across my desk again and I needed further study. My case of study was cell degranulation-mast cell degranulation. The stress that causes inflammation of the hair follicle which lead to hair loss. Your information was priceless! Your information was invaluable as it relates to type 1 through Type 4 sensitivities. My course of study includes sensitivities of the body's hormones mainly,NGF substance p and corticoids that lead to hair loss

[@gerakinagr5910]

THANK YOUUUUUUUU!!!!! YOU ARE FANTASTIC! I couldn' t understand this god damn hypersensitivity from book! thank for your help!!!!!!

[@Imhotep25296]

You are making a difference for many people. Thnak you for the well presented info.

[@evelynrobbins4953]

This was very helpful...taking pathopharm right now in school and I was not understanding the chapter on hypersensitivity even after the lecture...this made it understandable to me and now reading back through the lecture notes I get it. Thanks!

[@fyfyzaky7995]

UR SUCH A GREAT TEACHER WITH NICE PERSONALITY THANK U SO MUCH 4 THE VIDEO THEY R SO HELPFUL, KEEP UP THE GD WORK ^^

[@pm8635]

Excellent video, just makes understanding my notes more clearer. cheers

[@noahtaylor8178]

most helpful video I've seen in all my time as a BSN student

[@tylerscaff3103]

Thank you! I'm a med student and this helped me understand the differences between hypersensitivity reactions very well.

[@Dantron71]

Thanks man, added some visuals to my dry & long lecture. I like to hit it from all angles when I'm studying & this definitely helped.

[@bswgd8]

Great video. Very good overview of hypersensivities that is easier to grasp than most text books. Funny guy too. Also you would pronounce Guillian: Gee-on (like Freon), they were a couple of French dudes.

[@sarahl7786]

This video was amazing, thank you do much for putting it together!

[@47daboro]

Great video. Just to make things clear on HSII, on a second pregnancy of a rh factor sensitive woman , Rh factor-specific IgG influx starts at around the 32nd week (remember igG crosses the placental barrier), which will cause an hemolytic reaction on the fetus which will cause a serious anemia, which, in order to produce more blood, will return the liver to its fetal hematopoietic role, thus stopping the albumine production which will cause a huge case of edema, which in extreme cases turns into a condition known as hydrops fetalis, lethal in most cases. (Sorry for any grammar mistakes, not a native)

[@90sanimemusiclyrics73]

THANK YOU SO MUCH sir!!! You are a genius!!! Hope you add more lectures... # I wish you were our Instructor... MABUHAY!

[@bhs9812299]

This is great stuff man. Been slacking all memorial day wknd in not studying for my MicroBiology test tomm. Think ive covered a good chunk by just watching this video.. Lastly it MAKES SENSE! im sure ill remember "super macrophage" lol Thanks

[@melissanortcliffe1939]

thank you!! I use this video every time I am tested on this haha. Also, you sound like my favourite radio host so it's less like studying.

[@elsabiro]

Thank you. Great job. Well spoken, easy to understand.

[@yasirzainal1]

Man! Ur channel is both great n inspirational Im very thankful to u :)

[@riotwyatt100]

This was an excellent video summarizing hypersensitivity thank you for posting this

[@johnson41449]

has helped a lot in pathophysiology. thanks a lot.

[@charitywalker6962]

Great video! It helped so much with my pathophysiology class!! Thank you!

[@ScienceAnswers101]

Good Q: Eczema is an encompassing term. I have found a very neat and concise explanation from Bruinhd on SDN: "eczema" is usually referring to Dyshidrotic Eczema, a vesicular rash associated with atopy, classified under Type I hypersensitivity. It can be precipitated by episodes of Type IV hypersensitivity such as contact with nickel or other metals (which is where your 48 hr thing comes in to play).So I would classify it as Type I hypersensitivity, with associations to Type IV.

[@monaloones2633]

Thank you so much, clear and concise, exactly what you need for examination!

[@aviyasha]

amazing video, wonderful explanation, thank you so much for the video. i would just like to add that, the ppd test is done intradermally not subcutaneously. once again awesome video, helped me a lot :)

[@pz3j]

Dude! You actually make this shit interesting. I've been listening to BORING!!!! lectures on this for two years and love what you've done! Thanks!

[@GCSEgeek]

This is great! Thanks man! Love your videos!

[@fzmohammed8903]

You make great videos man 👍 Informative and to the point . Please keep it up :)

[@aileahnewbolt4968]

I learn best by looking at pictures and things an this really helped! thank you so much

[@annaloveme89]

u got me at "gone wild". awesome video, thank you!!

[@utr4937]

Thank you Thank you Thank you for this! Helped clear up a lot of things!

[@Leslieqrussell]

This was great, wish my nursing instructor had made it this simplified.

[@keithsimpson8329]

You may have just helped me pass med surg 2. Thank you!

[@SKhan2312]

First time I've seen one of your videos and ill definitely come back here for more help if I ever need it.

[@oioioioioioioio_7659]

Great video. I have a better understanding of this topic thanks to this!

[@nessathecute]

I'm curious, what is your background? I enjoyed the humor (i.e. the spelling jokes) & simple explanations - kept things interesting & very helpful for my review. I would draw out the immune complexes for type III - show how the antibodies bind to the free antigens because the antibodies, due to their structure, can bind to more than one antigen. Type IV was explained more than I needed it to I think, but again, it was still helpful, especially the examples :) Thanks for a great video!

[@julietshrestha2018]

Thank you so much for making this easy to understand video!

[@Secretus]

An important addition to 01:53 (Activation of mastcells through antigenbinding on IgE). The binding of antigen on the membranebound IgE is *not* the signal for degranulation. Rather, the cross-linking of the IgE antibodies because multiple IgE bind to the same antigen causes degranulation. This is an important distinction, because it explains why monovalent antigens cannot cause degranulation, or why anti-Fcε receptor antibodies cause degranulation.

[@semegh3970]

I have an exam tomorrow and I completely understanding from this video thank you

[@honoryflip]

Thanks a lot!!! I've been confusing this for years.

[@coleetihhi14]

thank you for the basics! really helpful in preparing for my exam

[@davidcapito1667]

This is a very good tutorial video. very very understandable.

[@muriellejean-baptiste7511]

I know you meant to say "during PREGNANCY" but I couldn't help laughing everytime you said "during BIRTH" which is when the "kid" is ready to come into the world. Hilarious, please get it together, or not, its hilarious.

[@AmalsadAnahita]

great video! thank you for clarifying this tough concept I couldn't understand :)

[@dianesteinlein2872]

Most excellent review. THANK YOU!!!

[@k8reed]

Fantastic video!!

[@cierawyatt4783]

Thanks! Great job explaining. I appreciate it!

[@maimoonanadeem2853]

this was super helpful. thank you so much 😄😄😄

[@azalraed516]

thanx, your videos always help me since i sleep in classes

[@leoeostewart]

Did anyone else catch the reference " 'Immune system gone wild', kind of like the science version of those movies..." at 3:37 Hahaha classic

[@sergio2020]

Great video! Really helped me with my pathology exam :)

[@anumehta123]

This was awesome. Thank you!

[@heatheryarznbowicz7803]

really good explanation, thanks!

[@kendraw8804]

Very thorough , thank you

[@amandag4482]

I really like how you tried to keep us engaged by changing the colors lol. But seriously, I am in PA school and your videos are very helpful... I do have a question though. My professor gave Eczema as a Type I example. Why wouldn't it be type IV?

[@Theoutdoorsnz]

Very Helpful, thank you.

[@lysan6901]

very good. keep it up

[@onethirdlbofbeef]

that was great- going to kill my quiz tomorrow. thank you so much

[@Imhotep25296]

For B7 i believe you should have said CD 28, since it is the only receptor for B7. Great video btw

[@rhomeshiawilson7990]

Great refresher

[@coreyd8560]

Beautiful video. However I need some clarification - I would have thought a ppd test would fall under the type 3? What did I miss?

[@تسنيمعيد-ز8ث]

thank yoouuuuu this helped me understand it much better

[@car6flas]

thanks a lot .... u removed big stone that was sitting on my heart:)

[@mike0wl853]

Thank you very much for this video

[@nouranas3586]

thank you so much , that was so helpful

[@dukeakshay2817]

thanks, a great video!!

[@yusrahmed7309]

Amazing 🙂🙈

[@renataprospere8507]

Great vid, thanks

[@dennisibrahim1102]

thanks GREAT PIECE

[@Katiefive]

I have af question about the PPD. If the type 4 reaction is not mediated by antibodies, how is it that one uses them for PPD? Does the already excisting antibodies act like opsonins for the injected antigens so the APCs can engulf themeasier, or how does it work? Thanks for a great video :)

[@kranthikarchiluka887]

yes! you are right! the already sensitised t cells ans b cells react against the ppd

[@enlightenedone8670]

Please Can you explain what is happening with Multiple Chemical Sensitivities in Chronic Fatigue Syndrome? Many thanks.

[@karinacarney1]

Thank You!!

[@kimberlychobanianbalash9923]

THANK YOU!

[@vaatimasila]

this is so nice

[@rossakabossakarozay]

THANK YOU SIR!

[@MsMrsMark]

Thank you

[@feedthedonkey1]

haha the immune system gone wild reference ;)

[@rashadferdouse3768]

which softwares or apps did u use in this video

[@zakisudan]

Thank you so much!

[@charlottewalton6774]

Is Grave's disease not classed as type V hypersensitivity and would Hashimoto's disease not be the thyroid type II hypersensitivity (autoimmune)?

[@PaulOBrienChina]

no graves is a stimulatory autoantibody and class 2 , same as hashimotos ....

[@sabarinath2529]

is B cells involved in type 4 hypersensitivity??

[@Sara-fi5nt]

does type4 need a second exposure to be activated ?

[@MohamedAlnuaimi71]

Cealiac what type will be 4? EoE 1?

[@gabrielofochukwu313]

Thanks

[@positivevibes7425]

Why hashimoto's thyroiditis is not considered as type 2 hypersensitivity since the body makes antibodies against thyroid gland and destroys it!?!?

[@kapulachifunda2011]

Anyone with recent information on new classification which includes type 5 and Graves being included as such?

[@PaulOBrienChina]

RA is a type 4 hypersensitivity

[@anamartinez4002]

Are type II Hypersensitivity reactions the same as an autoimmune disease ? Or is it more like Cytotoxic Hypersensitivity ?

[@bswgd8]

Type 2, 3, & 4 hypersensitivities can all be autoimmine if the cell or antigen and they are attacking is your own. Graves disease, rheumatoid arthritis, type 1 diabetes are all autoimmune and represent 2, 3, & 4 respectively. Cytotoxic hypersensitivity is just another name for type 2 hypersensitivity.