Scientist Stories: Gwendalyn Randolph, Peritoneal Macrophages

Gwendalyn J. Randolph, PhD, is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Louis. She is also co-director of the Immunology Graduate Program at Washington University. Her awards include the NIH Director’s Pioneer Award and NIH MERIT Award.
She has expertise in monocyte/macrophage biology and in the lymphatic vasculature. Her laboratory considers how the transit of cells (monocytes and dendritic cells) and molecules (lipoproteins) out of tissue influences the inflammatory microenvironment and inflammation-associated disease. Specifically, her work has defined the identity, subsets, and functions of monocytes in humans and mice, and her laboratory has defined the role of chemokine receptors in monocyte recruitment to atherosclerotic plaques. Her work has defined how monocyte and dendritic cell migration to lymph nodes is regulated, defined universal and tissue-restricted features of macrophages with particular focus in specialized tissue compartments like the peritoneal cavity, and determined how monocyte-derived macrophages are cleared from sites of inflammation during contraction of resolving inflammatory reactions. Her laboratory has also delineated how lipoproteins like HDL traverse tissues to mediate host-protective functions.
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