Scientists Discover Protein That Causes Aging

Duke NUS Scientists Discover Protein That Causes Aging
A research team lead by Anissa A. Widjaja recently published in Nature that inhibiting interleukin-11 extends lifespan by nearly 25% in 75 weeks old mice (55 years of human equivalent age.) Team has discovered the age causing protein. Of course there are more proteins and mechanisms that contribute to aging, however, inflammation is central part of these processes. IL-11 with age start increasing in amount contributing to visceral fat accumulation, muscle wasting, and metabolic irregularities. Let's review the study together.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jul. 26 2024 14:44 PM
Interleukin Linked to Muscle Loss, Fat Accumulation of Aging | Duke Health
corporate.duke...
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan | Nature
www.nature.com...
Inflammation | DrBeen
members.drbeen...
Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity - PMC
www.ncbi.nlm.n...
Scientists discover protein that causes ageing - KZbin
• Scientists discover pr...

[@dr.abdulrhmanm.h.6881]

I am immunologist have phd in clinical immunology and I very benefit from your lectures in immunology thank you so much❤❤❤❤

[@DrBeenMedicalLectures]

You are very welcome.

[@janetmasleid4085]

@@DrBeenMedicalLectures aww wonderful

[@20alphabet]

I'm a lesbian trapped in a man's body, and I benefit from this channel greatly!

[@janetmasleid4085]

@@20alphabet but, the question remains: did you used to be an immunologist?

[@johnwalker1553]

@@20alphabet And what are your qualifications? I'm colorblind but I don't tell everyone that.

[@cynthiaabu-samrah1851]

Liking-in with a hello to @Drbeen Medical Lectures and all KoolBeens!

[@DrBeenMedicalLectures]

Thank you.

[@barbarawarren9443]

Hello, Cynthia! 😊

[@marystolleis9492]

Love your super fun drawings!

[@DrBeenMedicalLectures]

Thank you.

[@l.w.paradis2108]

These are some of his best! Classics!

[@AriePharmD]

Fascinating studies Dr Mobeen Syed. Thanks for sharing!!!

[@DrBeenMedicalLectures]

Glad you enjoyed it!

[@colleen36]

Wow, this is very exciting. Great video.

[@DrBeenMedicalLectures]

Thank you!

[@Earwaxfire909]

I've seen publications suggesting that EPA and DHA inhibits IL-11 pathways and extends lifespan. I've heard dolphin researchers suggest that that C15 saturated fatty acid can also increase lifespan through other pathways. Can you discuss these ideas?

[@MartoDriftz]

Makes sense why so many studies show dairy consumption positively associated with longevity since C15 is most commonly/highly found in dairy fat :)

[@peterraymond1853]

I'm a bit cautious about this C15, as the main supporters are selling the products.. Omega3 is likely as good..

[@l.w.paradis2108]

​@@MartoDriftz Look into goat and sheep dairy. I avoid cow milk products generally. Goat gouda, for example, is high in K2, taurine, and low in fatty acids other than 15. But see what's at NIH, in studies like those Dr. Been cites.

[@taiwanjohn]

Interesting. I think there was a study in the last few years that showed an extension of lifespan for Omega-3s. This paper on Il-11 offers a plausible mechanism for the benefit shown with Omega-3.

[@DrBeenMedicalLectures]

True

[@bencouragedalways]

Found you on a live! Made my day

[@DrBeenMedicalLectures]

Thanks for joining!

[@robertthompson5501]

Diagnosed with fatty liver. I have begun eating a salad with sardines and hard boiled eggs to bring protein up to 50 grams. Amazingly i dropped 5lbs in past week. Now I can attribute some of the weight loss due to Omega 3 of sardines not just caloric restriction. At 70yrs am the oldest OG under the barbell at local YMCA. Does addition of Essential Amino Acids supplement to a wholesome diet decrease inflammation? Thanks for Intel.🏋🏻‍♂️🏊🦊

[@DrBeenMedicalLectures]

Good to know that you are doing better. More success to you! I will have to look up amino acids and inflammation.

[@robertthompson5501]

@DrBeenMedicalLectures Thank you. Dr. Robert Wolfe PhD, a respected medical doctor and researcher, touts and sells Essential Amino Acids. I take a dose along with Collagen Peptides. They curb my appetite and seem to have added to my muscle and strength gain and help with my recovery from strenuous exercise. I am interested in your findings regarding inflammation. 🏋🏻‍♂️🏊🦊

[@CharlesMacri]

Excellent discussion of Inflammation!! Thank you!

[@klondike444]

I'm going to increase my sardine intake. Luckily they're one of my favorite foods, and low on the food chain.

[@taiwanjohn]

Be aware that sardines contain trace amounts of arsenic. (And since they're wild-caught marine fish, they may also contain trace amounts of mercury.) Joe Rogan mentioned this recently, and he eats sardines a lot, and his doctor found borderline-unsafe levels of arsenic in his blood work. They recommend that you not eat sardines more than 3 or 4 times per week. So... enjoy, but in moderation. ;-)

[@LisaLightning]

Increase your whole plant products. Studies for decades have shown that is what will decrease your inflamation and keep you young. I'm the only person I know in my 60s who is not on any meds and has more energy than a 30 year old.

[@geauxp]

@@taiwanjohnthank u for this, I will watch it!!

[@Klonering]

You could use algae oil.

[@trianglesandsquares420]

@@LisaLightningthis doesn't work if you're allergic to most plants, or if they're covered in pesticides

[@vicguani2108]

Sunlight exposure is the key

[@mrnohax5436]

vampires 😂

[@MaryKDayPetrano]

There's a study about how risperdal can cause breast cancer in women who had a prior lesion, via the Jak-STAT pathway. Your video is so very interesting.

[@DrBeenMedicalLectures]

Thank you.

[@robinhood4640]

From the Field to the Laboratory: Air Pollutant-Induced Genomic Effects in Lung Cells. First published online February 18, 2016 "The nine genes that showed significant changes in gene expression in response to ambient air were associated with immune and inflammatory responses - - - Two of these genes were also modulated in response to ozone exposure, namely IL12B and IL11." "For the ozone exposure, both the IL12B and IL11 had increased expression." Does this not mean; air pollution is increasing the process of ageing -> inhibiting IL11 reduces the effect of air pollution on ageing?

[@GDe-gi1kz]

Yes absolutely

[@ushasiroy7497]

Being a beginner in understanding the cellular pathways i am quite curious to know how the il-11 pathway is related to ros generation as it is known reactive oxygen species results in ageing and how antioxidants and il-11 inhibitors can work together to make humans more healthy.

[@DrBeenMedicalLectures]

I will discuss. In the meantime keep an eye on the inflammation course on DrBeen.com. I will be uploading the recording of the 8 most potent inflammatory pathways.

[@mariehughey5390]

I came to this site because there is a KZbinr promoting a series of supplements as IL-11 inhibitors. I can’t find any credentials on him. Just wanted to hear the info explained by someone who knows what they are talking about. Thank you.

[@9111logic]

How very interesting, thank you for presenting this study to us all. 🙏

[@DrBeenMedicalLectures]

My pleasure!

[@wealthychef]

So how do I go about inhibiting my IL-11?

[@edwhite2255]

How much omega 3 to suppress IL 11? Do we know if more EPA or DHA is the most active? Is there anything bad about suppressing IL 11?

[@Roberto-cg2gr]

What is the relationship of IL-11. with fasting, insulin, carbohydrates, ketones?

[@Minarchist088]

So, how much Omega-3 should we be taking approximately to inhibit aging potentially?

[@Roberto-cg2gr]

How much fish do you recommend to eat

[@susanbeever5708]

IL-11 increases with estrogen deficiency and estrogen decreases in males and females. Non-feminizing estrogen helps males with many diseases including heart disease and estradiol in menopausal and postmenopausal women helps significantly to decrease heart disease, bone loss, colon and breast cancer and women and men have a longer lifespan.

[@DrBeenMedicalLectures]

Interesting points. Thank you!

[@timtrainage]

Pardon, I mean no disrespect but that was phrased horribly. How about instead saying: IL-11 is inhibited by increasing non feminizing estrogen.

[@susanbeever5708]

@@timtrainage and estrogen such as estradiol.

[@GDe-gi1kz]

Fool estrogen is feminine

[@trianglesandsquares420]

Does that not also increase cases of cancer?

[@nbrown5907]

Oh my, I don't know if you have seen the movie "In Time" but if this comes to pass we will not all get it I bet. There are many trying to shrink the population so I doubt a life lengthening process will be allowed to be used by the masses.

[@funeats8201]

I liked that movie a lot back in the day.

[@Boyeaton1]

They will contaminate it like they do everything else

[@gardener3017]

Thank you so much Doctor.

[@DrBeenMedicalLectures]

Welcome!

[@briandillon8041]

So, after all that, no diet or over-the-counter recommendations of any kind?

[@lmwlmw4468]

Great video.

[@DrBeenMedicalLectures]

Glad you enjoyed it

[@tonaruch8623]

I love your enthusiasm

[@trafferz]

13:00 First time I've heard Omega 3 spoken of positively in a very long time.

[@felixowaga9049]

Me too

[@rachelmolina3995]

Thank you for a very good video.

[@DrBeenMedicalLectures]

My pleasure!

[@mariawallstrom4731]

I think you should look at connective tissue syndromes like EDS ehlersdanlossyndromes hEDS etc. Probably also( Marfans, osteogenetic imperfecta loey dietz). I' ve written a lot about the connection between EDS and autoimmune disease postinfectious disease and inflammation, immuneresponse, healing problems, scarring, mastcells, weak connective tissue, clotting, bleeding, mithocondria, vitamin enzyme deficiencies, extracellular matrix homeostasis, Genes mutations. I've also written to research institutet univesitys about this.

[@brenharris6214]

Could you give a link to your writing … seems we have EDSand mast cell in some family members .

[@amorris0419]

Yes, my sister with EDS symptoms…can you share links to your writing? Thanks!

[@JohnLavos]

Is there a link between apoptosis and IL-11?

[@DrBeenMedicalLectures]

Will discuss more in detail.

[@funeats8201]

Does Low Dose Naltrexone have any effects on IL-11?

[@DrBeenMedicalLectures]

I will have to find studies about it.

[@DrugHunter-fy6nf]

You cannot ignore mitochondrial biogenesis in any of these conversations. Single cytokine targeting is complex, the immune system responses are unpredictable, and the question is what is driving the induction of IL-11.

[@BastilsBlather818]

Sounds similar to taurine study 😊

[@DrBeenMedicalLectures]

It does.

[@furiousdoe7779]

So Taurine interferes with IL-11🧐 just joking

[@trianglesandsquares420]

Can you elaborate I don't know that one?

[@jimmattox9982]

??? Has anyone studied how vitamin D3 reduces IL11 ??????

[@DrBeenMedicalLectures]

Haven’t seen it yet.

[@ElPapacitoGrande]

Carnivore/ animal based diet for over 6 years and my family is now healthier than our young doctors. Red meat, raw dairy and all other animal parts with a bit of honey or local seasonal fruit on occasion! No meds, no pain, no problems 🥩🥛☀️🧠💪🏼

[@LisaLightning]

Just wait till you're over 60. Been plant-based over here for many years and I'm the only person I know my age who is not on medication. My fiancé switched diets eight years ago and his recovery time after exercise is now hours instead of days. Best of luck but watch out for those sudden heart attacks.

[@geauxp]

What is your crp?

[@geauxp]

@@LisaLightningwhat is your a1c and crp? When I was plant based I became diabetic. I ate whole grains three meals a day. When I started low carb my a1c was 6.3 now it’s 5.0 but my crp has come up over the last few years. Recently gave up dairy to see if that would help and I’m about to go get tested again.

[@geauxp]

Im only on natural thyroid and low dose naltrexone (arthritis)

[@ElPapacitoGrande]

@@geauxp a1c is 5.1 and glucose is 101. I'd have to go looking for results of CRP on my previous health insurance. It was optimal according to my doctor.

[@seanmurphy1704]

Is the inverse of this also true, ie does omega 6 in the form of pufa, become an il 11 promoting agent ?.

[@DrBeenMedicalLectures]

Not sure.

[@gracewhite1601]

I bet it does

[@trianglesandsquares420]

What is pufa and why could m omega 6 be an il11 promoting agent?

[@furiousdoe7779]

Thanks for the Omega 3 tip … 🙏🏽 , the researchers will not be so pleased with it like me 😂

[@DrBeenMedicalLectures]

😀

[@DiscoveryWonders]

I wonder if there is a link between il-11 and metformin.

[@richieheetebrij8189]

Apparently an odd chain fatty acid such as C15 best omega 3 significantly

[@michael-qp9xd]

Hello - please can explain more here on c15? Do u mean c15 boost omega 3 in the blood? So if say take 1 1000mg capsule or epa/dha the amount in blood will increase if taking c15? Or do mean c15 is an omega 3 fat? Which is best then c15 or epa/dha?

[@richieheetebrij8189]

@@michael-qp9xd Just search c15 on KZbin and you will see what I mean. A fairly recent discovery with massive benefits. I think in very short order it will be a number 1 supplement. Cheers

[@pjjmsn]

NAC is used for Acetemeniphen OD so I wonder if it might reduce interlukin 11?

[@oibal60]

Thanks again.

[@ericbwertz]

Why does the body produce IL-11 -- surely there must be an evolutionary reason why it's made in these circumstances in the first place. Stated another way -- what are the downsides of inhibiting IL-11 at this stage of life?

[@trianglesandsquares420]

That may only be found out in human trials. But nature would maybe have a benefit for killing off generations faster. The older a species is, the slower they evolve after all. Although that's not really tru for 25%, and adulthood would stay the same unless you edited the gene out in vitro. That's a good question though, but honestly if there are minimal side effects sounds like a good deal. The only other thing I can think of is that inflammation can help with fighting infection, but that might be a different kind or less severe. I wonder about il 11's effects on other effects of aging, though. Like, are there or were there conditions it helps with.

[@FatherGorgony]

I have noticed that people turn gray in old age. According to your logic, if you cut them every day, then they should live longer than hairy ones. Or maybe it is still better to look for the cause of inflammation and fight it?

[@trianglesandsquares420]

What? How does the logic follow?

[@gigabane7357]

I would love to see the results of improving your gut biome by eating all the right fermented foods and fasting and eating like a walking and emigrating frugivore would have on these interlukin 11 levels...

[@trianglesandsquares420]

I'd love to see the results with _all_ the diets people love. (And of course diets over the course of a life, and for which bodies, is important also)

[@johnwalker1553]

can IL11 affected by the genetically modified mRNA substance?

[@gracewhite1601]

I bet

[@furiousdoe7779]

@@gracewhite1601Covid virus 😂

[@GDe-gi1kz]

Yes

[@sarojtampira632]

Thanks!

[@DrBeenMedicalLectures]

Welcome!

[@furiousdoe7779]

Bedankt

[@DrBeenMedicalLectures]

Thank you 🙏

[@RashidMalik-LabVIEW]

IL-11 is a component of SASP. So increased levels of IL-11 in old age might be connected to senescent cell proliferation (or the converse, as well). "Cytokines are key components of SASP, contributing to inflammation and immune modulation. Notable cytokines include: Interleukins: IL-1, IL-6, IL-8, IL-11, and IL-12 Tumor Necrosis Factor (TNF) Interferons Among these, IL-6 and IL-8 are particularly well-conserved and robust features of SASP, while IL-11 is recognized for its pro-inflammatory and pro-fibrotic roles."

[@HarryJensen-kr4qz]

Yes, and they say what they used to block il11 but didn't give a dosage.

[@DrBeenMedicalLectures]

That is because it is for mice and not humans. Plus, it should be in their study method section.

[@ald770]

How do they delete the gene?

[@trianglesandsquares420]

With gene editing probably but I'm interested if there are mrna gene therapy solutions to this

[@SantiagoHHC]

This information is very interesting! It is good that you provide some suggestion about what natural approach to inhibit IL-11 progression. That is Omega 3. The issue is that omega 3 is a family of various fatty acids; ALA, EPA and DHA, just to mention some. It would be an excellent addition to clarify the type of omega 3 most effective. Don’t you think?

[@DrBeenMedicalLectures]

Thank you. I have done detailed discussion about EPA and DHA earlier.

[@SantiagoHHC]

@@DrBeenMedicalLectures Thank you for taking the time to replay to my comment. The study on the INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE is entitled “Omega‑3 polyunsaturated fatty acids inhibit IL‑11…” Again, my question in relation to this study remains. I don’t think, looking at that paper, that there is a specific answer. If someone wants to inhibit IL-11, Should consume vegetables containing ALA (omega3)? Or should the person take flax oil (high in ALA omega 3)? Or should consume fatty fish? Or should take a supplement of EPA or DHA or a combination of both? They all are omega 3 PUFA’s.

[@soaring-eagle69]

I Tego Arcana Dei... Dear Lord, what this can imply if replicated

[@PetraKann]

Looking at one protein in isolation and coupling correlation with causation with respect to ageing is quite meaningless. The second law of thermodynamics has never been violated.

[@trianglesandsquares420]

Well they extended mice's lifespan by 25% which is a big deal. One wouldn't say it's meaningless.

[@PetraKann]

@@trianglesandsquares420 What other characteristics were altered due to to this 25% increase in life span? Is it clear that there aren't any other detrimental side effects? Indoor mice typically live for about 2 years. So you are saying that the mice extend their lifespan by 6 months? WE cant translate this directly to say a human that may have lived to 80 years and claim that they will extend their life by a further 40 years, allowing them to live until 120. Biological system are extremely complex. The reductionist model that many scientists use is often unproductive, leads to ignorance and in some cases catastrophic outcomes.

[@trianglesandsquares420]

@@PetraKann That's true and I'm against the reductionist model also. But whether it's 6 months or 25% is yet to be determined. In either case, isolating this particular protein made a huge difference for the lifespan and apparent health of those mice.

[@PetraKann]

@@trianglesandsquares420 In mice only. Imagine you get a 25% increase in a human lifespan by manipulating this particular protein formed in the body, but there is a 3% increase in the risk of cancer or a 13% increase in depression or a 21% decrease cognitive abilities or intelligence/problem solving? Scientists often lose sight of the ramifications of their research - and this has become worse in recent decades with the dominance of the Corporate model of short term profits. The corruption of the quest for knowledge is very evident today. The Pandemic showed us how the scientific method itself can be politicised and corrupted.

[@margaretneanover3385]

Duke energy? Yeah , one aging situation. Red light and other therapy. So the opposite had to hold clues .

[@DrBeenMedicalLectures]

Duke NUS-University (National University of Singapore) School of Medicine.

[@bernardbrindley9679]

Which omega 3. 3 or 3S ?

[@ldjt6184]

what the difference between the 2?

[@bernardbrindley9679]

@ldjt6184 one comes from veg, and the conversion rate is poor The other from the sea. I'm sure he did a video on it.oily fish. Salmon is good but depends where it comes from as do most things now. I google most things and what food it's in, but often the makeup of a vitamin has information of what's good. I have tried to generally stick to food based on what I had 40 years ago.

[@ceeemm1901]

I'd worry about you getting enough fiber so that you can have more than one crap per year... eat food, dude, not 'new tree ants'...giddit???

[@ldjt6184]

@@bernardbrindley9679 Thank you, I had never heard the term Omega 3S before.

[@bernardbrindley9679]

@ldjt6184 like k2, I google the food it's in, then actually the parts of its makeup, then google the parts for the best bits.

[@keenie7681]

Late. But hi, Koolbeans and Dr. Been.

[@MadMaltMasher]

Thank you long time listener here. I'd love to buy you a coffee in person. So,.you are saying we should eat avocados 🥑

[@DrBeenMedicalLectures]

Will love to meet someday and have coffee with you too.

[@ginadani9688]

I give a new idea ...the opposite of il11 is il2 .....for more question write me.thanks......

[@BOZ_11]

so omega 3; noice

[@funeats8201]

This is great news. I like the idea of reducing inflammation and improving health but the idea of extending my time here in Clown World is not very appealing to me at all. If there was a way to improve health and shorten the lifespan, I would sign up for that. 🤣

[@gracewhite1601]

Improve your health and take up motorcycle racing , that should do it, or become a Republican

[@Soul_Contract]

Cannabinoids *cough*.👀🔎

[@nickmagrick7702]

Oxygen causes aging, so idk how valuable this info is. Seems kinda obvious before the study was even done.

[@vernonkuhns3561]

A carnivore diet would appear to replicate that..,.

[@ceeemm1901]

We'll have to wait until someone actually does research on the Carnivore diet so that we don't have to keep putting up with their gossipy, anecdotal stories.

[@vernonkuhns3561]

@@ceeemm1901 Sorry if people healing and staying healthy insults your sensibilities!! HAHAHAHAHAHAHAHAHAHAHAHAHAHA

[@charliebrownlives1348]

Agreed. You can count on western health care to push drug, over a proper diet.

[@southern-samurai]

@@ceeemm1901there has been research, not massive amounts, but some, and the results are very promising.

[@ceeemm1901]

@@vernonkuhns3561 Another story...hohum. Do your parents know you're fking around with their computer?

[@GDe-gi1kz]

During corona you said about interlukins i remember

[@davidcoalkey6074]

Omega 3 for the win again.

[@lionelfischer8240]

+1

[@dennistan4663]

Tell your research to the Animals Kingdom. Nothing can stop ageing. Life cycle. 😅😅😅

[@armor1z]

Wish I had better access to fresh sea food where I live

[@GDe-gi1kz]

Tocillizumab reduce il 6

[@EC_ATV_Outdoors]

Within 20 sec you lost me. Some layman's terms might be beneficial to your non-medical followers

[@2piecesofwood1pieceofrope]

His lectures are more for medical students. Modern Healthspan is more for laypeople. But Dr Been has the best illustrations!!

[@EC_ATV_Outdoors]

@@2piecesofwood1pieceofropeI get it, just saying, haven't a clue what was said after one min, so I stopped.

[@furiousdoe7779]

@@EC_ATV_Outdoorsless time outdoors if you are injured …more time to study how to get off the injuries and get into repair mode. yep it takes time.

[@g.s.5868]

*in short FISH OIL* saved you 14 minutes

[@Klonering]

algae oil is better. Fish oil is not sustainable and i am pretty sure, they are not using the good parts of the fish to make the oil.

[@ground752]

Sunflower oil is omega 3

[@larsnystrom6698]

Sunflower oil has a terrible omera-3 to omega-6 ratio of 0.0079. Per 100 g 0.163 g of omega-3 and 20.6 g of omega-6. So, quite worthless as a source of omega-3. Flaxseed oil has an index of 3.7343 almost acceptable, and gives 14.3 g of omega-3 per 100 g.

[@ronaldcarrel5388]

Absolutely not, do some research on good oils.

[@quantumeseboy]

Oh,FFS! Now Putin will never die!

[@synaestesia-bg3ew]

There are worst people than him who will never die.

[@robinhood4640]

If the treatment is equally as effective as some existing drugs, he'll spend 200 000 roubles a month for the rest of his life, die the same day, but early afternoon instead of late morning. Technically, it's a successful treatment.

[@farmer_donny]

You can thank your lucky stars.

[@larsnystrom6698]

Yet another victim of US war propaganda!

[@ronaldcarrel5388]

@@synaestesia-bg3ew Yes Our politicians Nancy Pelosi Chuck Schumer Adam schiff AOC Mitch McConnell Romney Graham Maxine waters And all the other wicked never ending bunch of crooks They say Putin is bad, then he is probably the best around comparatively speaking.

[@peace-love-jus4us]

amazeballs!

[@DrSheenMedicallectures]

Sir excellent ❤❤❤❤❤