Senolytic peptides, p53 and Aging - Peter de Keizer

[@TheSheekeyScienceShow]

Hope you enjoyed our discussion!

[@christopherellis2663]

He sounds like he actually understands the complexity of it. So many are attached to their own little world

[@rustybolts8953]

"Life aint fair, just when your beginning to figure things out, you die". Albert Einstein. About time to evolve beyond this evolutionary error but this leap will take wit and deliberate effort. Excellent conversation. Thank you to the two of you.

[@aquamarine99911]

Very, very smart and believable guest. When he says that dietary restriction is not beneficial in older (>50) people, I think he's more talking about protein. Muscle mass promotes longevity, and muscle protein synthesis - our ability to convert amino acids to muscle - declines with age. So older people should be eating MORE protein - and exercising - not less. But too often, they do the opposite.

[@betsysmucker3708]

This is the case with protein. People over the age of 50 are told to eat less red meat and consume less salt. The results are detrimental to their health, but that’s a bonus to the health industry isn’t it…?🧐

[@keng7758]

Great talk, but I’d never previously heard about P53 peptides and I’m somewhat clueless about the long term implications of where this investigation is going. If you have any additional detail in the form of your white-board “chart talks”, I’d be interested in learning more. You do an incredible job with interviews on some of the most complex topics. Thank you for your contributions to health for all humanity. 👍

[@scfrhc9131]

Amazing job interviewing Peter. From where I was sitting it sounded like the field could use your unique insight to break new ground. Please Keep up the great work!

[@AssetH8ut2]

Since were mainly concerned with SASP senescent cells it limits we limit therapeutic targets to a fairly small profile .

[@SlamminGraham]

On his point about worrying about cellular reprogramming not working for the brain because of memory retention, I believe they have demonstrated in mice models already that partial cellular reprogramming reverses the age of the cell to just beyond the stem cell phase, but then no more, so then functional aspects of the cell are retained. Hence the "partial" aging reversal in "partial cellular reprogramming". I'm no expert either, but I know I read something like that recently.

[@bernadettebecher4689]

Thank you for this amazing interview.

[@askingwhy123]

Great interview!

[@weiminyang7206]

Thanks for sharing!

[@Adamcharlie333]

Your doing an amazing job cheers

[@susymay7831]

Excellent timestamps! 😊

[@michaelalexander8926]

Very promising technology...thanks for sharing. Definitely sounds potentially synergistic with the new Deepmind protein folding analysis capability. Hopefully clinical trials will be successful!

[@jaimelulli3772]

Does telomeres shortening play an important role in cells to became senescence.

[@lucaskazama878]

when will I see Sheekey Biotech?

[@jp7357]

I’d love to see a yt on your top 5 senolytucs

[@susymay7831]

What do you think about a senior getting a lot of protein but eating all of their calories within an eight hour window?

[@anonmouse956]

Cancer always goes back to P53.

[@AssetH8ut2]

Clever girl

[@MikeG-js1jt]

dID HE SAY HIS PEPTIDES WERE MADE FROM owl dNA?......... I must be mistaken, right?

[@kindedge]

What time marker?

[@kindedge]

At 17:00 he said the peptides are derived from L-type aminos (better) vs the poorer D-type aminos… perhaps for L- you heard ‘owl?’ This is L and D amino acid classes like L-Cysteine, D-Cysteine, L-Glutamine, D-Glutamine… etc.

[@thenewapollo]

I fully agree with de Keizer (and with Einstein); there should be less room for yin thinking in progressive science!