Serine Protease: Background & Catalytic Mechanism - Biochemistry | Lecturio

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This video “Serine Protease: Background & Catalytic Mechanism” is part of the Lecturio course “Biochemistry”
► WATCH the complete course on lectur.io/serineprotease
► LEARN ABOUT:
- Catalytic properties of serine proteases
- Cleave peptide bonds
- Specificity of cutting
- Common active site composition/structure
- Catalytic mechanism of serine proteases
- Cut of the substrate for enzyme
- Location of the peptide bond
- The central part of serine protease
- Common features of the active site of serine proteases
- Enzyme backbone
- Folded polypeptide chain of enzyme
- Catalytic triad of active site
- S1 pocket of enzyme
► THE PROF:
Your lecturer is Professor Kevin Ahern. He is currently teaching biochemistry and biophysics at the Oregon State University, where he has also successfully completed his Ph.D. in biochemistry. Beside writing poetry and songs about several topics including medical ones-believe it or not as well-he has written the popular ebooks “Biochemistry Free and Easy” and "Kevin and Indira's Guide to Getting Into Medical School." His edutaining videos on KZbin were watched over 2.75 million times making him a medical education KZbin star.
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Now it’s your turn! Watch the video and find out the correct answer to the following question: What is the function of S1 pocket of a serine protease?
A. It requires serine for binding.
B. It is the location of the catalytic triad.
C. It determines the binding/cutting specificity of the enzyme.
D. It stabilizes an unstable tetrahedral intermediate.
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[@NoticeMeSenpaiii]

I've spent hours reading trying to understand enzyme mechanisms. This video made this so clear to me. Thank you so much!

[@Bud_wizardz]

Best lecture I can find on Serine Protease! Thank you!

[@vanessapersi9150]

Wow could not be more clear! Thank you, this really prepared me for my biochemistry exam!

[@biomimetica]

This explanation is so crisp and descriptive, it helped me fully understand every step really well :) Thanks!

[@mollyoconnell7847]

I don't know how many hours now that I have been trying to understand serine protease and how they work. Come across this video and get it instantly! Thank you so much!

[@cambeesley]

Perfectly explained. Thank you!

[@aishaliane]

This explanation was EXCELLENT! Two thumbs up 👍👍.

[@akhileshtayade1916]

It's beautifully explained. Thank you!

[@AsherBrandt]

This guy is such a good teacher. Wow

[@sylviecarr1201]

Amazing! So well explained.

[@Veezenn]

I've searched for this a long time. Thank you!! :)

[@lecturiomedical]

+Veezenn Glad you´ve found us! In his advanced biochemistry course (www.lecturio.com/medical-courses/biochemistry-advanced.course) you will find even more detailed explanations. Take a look ;)

[@nehadelsalamouny1786]

Excellent explanation. Thanks a lot!

[@qianyu9477]

Very helpful! Thank you!

[@vkookie459]

Thanks a lot, it's a marvelous explanation

[@blendamedeiros125]

Thanks a lot!! Very good explanation 👏👏

[@jyotikumari-vc4ep]

Thank you for the easy explanation.

[@dnagoatgaming1159]

man this is probably the best

[@SanadAlfadhel]

Great lecture

[@Saed7630]

Amazing!

[@Melanie-zm8ct]

Thank you 👏🏻

[@jessicabednark6710]

Very clear explanation! Thank-you for your help!

[@lecturiomedical]

+Jessica Bednark We have to thank you for such a kind comment. ;)

[@cmlon]

this guy is really great

[@stodd2403]

Really good! well explained and visualized

[@lecturiomedical]

Thanks so much for your support!! We're happy you're enjoying the courses. Also feel free to create a free account at www.lecturio.com to get more free video courses.

[@bnirtlepmc]

omg thamk you so much!! Amazingly clear

[@lecturiomedical]

Thank you :) We are glad to help!

[@tisananitisakulkan9194]

Thank you very much

[@LaplacesDevil2]

Thank you so much! I am studying for biochemistry exam and presentation that we used in lecture is terrible! In this video ı understand this mechanism perfectly! Thank you!

[@lecturiomedical]

Thank you for your comment, do not hesitate to start your free trial as Lecturio could become your best study-buddy. Watch the complete course on lectur.io/serineprotease and figure it out by yourself :)

[@rajarshidey1385]

So indepth and simplified,,,, I swear you are the Real Jesus Sir!!

[@heavyunit161]

I really appreciate this video, sir. 🙏

[@lecturiomedical]

Thank you for your comment! If you enjoyed the video, don't forget to subscribe and turn on notifications to stay updated with all our KZbin videos. 🤗 Additionally, for more learning opportunities, we invite you to sign up here and explore even more of our free content, along with all the study features that can help you ace your exams: lectur.io/freecontentyt

[@kiaraluciano8665]

This was one of the best explanations I've ever had :')

[@onatovonatovic526]

thank you

[@akritino7437]

Kevin Ahern sir ?!?!? I really love the way explains biochemistry concepts !! :D :D :D Amazing professor ! :D

[@lecturiomedical]

Hi :) Prof. Ahern doesn't use KZbin but he will be happy to answer your question at www.lecturio.com/medical-courses/biochemistry.course You need to register first and then will also have access to hundreds of other free medical videos.

[@princessgisy]

Thank You VERY much!!!!!

[@lecturiomedical]

+Giselle Diazzi Hey Giselle, you are welcome! Thx for oyur nice comment and feel free to watch even more free lectures on www.lecturio.com Thanks again!

[@susanredna688]

Kevin Ahern

[@georgiehensman5281]

THANK YOU :)!

[@lecturiomedical]

You're welcome! Do you hesitate to start your FREE trial on our website/app to access much more valuable content: lectur.io/freecontentyt

[@yashparikh7970]

that was an awesome explanation. tysm. sir in 2 nd stem how come the carbon had double bond even after forming tetrahedral confirmation with oh here instead of nh in first step where it was a single bond.

[@lecturiomedical]

+yash parikh Hello Yash, thx for your kind comment. As I am only the KZbin manager at Lecturio Medical Education Videos, this detailed question is a bit to difficult for me to answer. But did you know that we also have an elearning plattform for medical education where you can watch even more free lectures and ask questions to the professors. Try for free at www.lecturio.com/medical-courses Thanks again!

[@angolajuan4044]

Hi, I was wondering is the lecturio app is free? What are the advanced course of biochemistry? Thanks

[@deelupriyadarsh4859]

So what's released is a NH2-R and COOH-R with the enzyme acting as catalyst, here it is seen that amine and an acid is released, this shows that serine protease releases acids and amines, so is the protease inhibitors targeted to supress the release of excess acids and amines, (in this case of the serine protease) of course there are other proteases but an analogy can be assumed

[@dlajapal]

Hi! I followed this to a T, thank you so much for explaining it in such depth. I do however have one question. Around 9:10, right when the NH2R gets released, and the remaining portion of the peptide covalently bonds to Serine, there seems to be a missing CH2 on the serine side-chain. I could be wrong, but that's the only part I am not following. Thank you again!

[@lecturiomedical]

Hey! Thanks for checking us out. Our lecturers do not use KZbin but they will be happy to answer your question at www.lecturio.com/medical-courses/amino-acid-metabolism.course. You need to register first and then will also have access to hundreds of other free medical videos.

[@bonjourno180]

Super clear and very helpful!!!! :D

[@lecturiomedical]

Thank you, Elizabeth. You can also watch this video and many other free lectures at Lecturio: www.lecturio.com/ :)

[@user-iv2ms2zq6c]

Why is there a slow and fast step?