Serotonin and Melatonin Synthesis | Tryptophan Metabolism

Lesson on Serotonin and Melatonin Synthesis from the amino acid Tryptophan. Tryptophan is an essential amino acid, which is used to produce the monoamine neurotransmitter serotonin and the hormone melatonin. Serotonin is important in regulation of mood, appetite and sleep in the central nervous system, whereas melatonin is produced in the pineal gland and is important in regulating circadian rhythms. In the process of converting tryptophan into serotonin and melatonin, several important cofactors are used including tetrahydrobiopterin, s-adenosyl methionine (SAM), and co-enzyme A. Vitamins B5 and B6 are also required for serotonin and melatonin synthesis.
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JJ
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*
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Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@devvildogg1775]

Thank you for making this video! Also I am so grateful we live in an era where awesome people take time out of their day to upload videos like this. I didn’t think I would find such a video on this topic but this helped A TON!!!

[@deannaflynn1104]

This is an absolute lifesaver right now. THANK YOU

[@ozzme9988]

I had the most vivid dreams when on a high Tryptophan diet!!

[@executivezone1]

thank you ill try it

[@MzClementine]

@@executivezone1 mugwort. you're welcome... Make a tea 🍵 enjoy before bed. And smoke it. It's going to be better. Just letting you know. You can also mix it with sleepy time tea and some honey and a bit of lemon which will curb the bitterness. And also if you actually want to know the effects. Set your alarm. Learn your REM cycle. Normally people within the first 90 minutes are going to have a dream. If you go to sleep and you expect to remember and recall your dreams. It's not going to happen if you fall asleep and just sleep. If you really want to dream recall. And you're not one that wakes up. Go ahead and set an alarm. If you have a watch that helps you find your rim cycle that'll help you more. Cheers have fun

[@hosoiarchives4858]

Did you go off it?

[@rafatlatif544]

Me when on SSRI

[@claudiochenlo78]

I’m glad there are people explaining such interesting concepts with such simplicity. Thank you for your clarity and knowledge!!

[@senseofmindshow]

Thank you for the super clear explanation. This is going to be really useful for a project I'm working on!

[@BB-nd7be]

this is fantastic!! thank you so much, after years of being in traditional medicine, I am now learning more about functional medicine. I love it , it totally makes sense.

[@hraqhraq]

I recommend to improve the quality such video, is to mention the location of all these enzymes, namely Cytosolic, and for added clarity you also can mention the gene symbols of the enzymes, so the viewer can go and search for them better. Enzymes gene symbols are: TPH1 orTPH2 then DDC then AANAT then finally ASMT all are cytosolic, then the product which is either Serotonin or Melatonin will go to Vesicles via special channels like VMAT2 Thanks for the video

[@njemilenantan2269]

Brilliant video. Used it to prove a point regarding melatonin and Seratonin. Keep up the good work.

[@sfebus00]

Excellent!! This helped so much with my Orgo 2 project!

[@gamacminisplits8531]

Priceless information! Very understandable for normal people!

[@jjmedicine]

Glad you found it helpful :)

[@munawwarshaikh8010]

I've to give Biochemistry presentation tomorrow on Tyrosine & Tryptophan. Thanks man, you saved my butt 😉

[@dryriverquinnie]

@@ohad9759 he is now

[@Craigdna]

Thank you for sharing as that was an excellent presentation.

[@bluesquirrel2472]

Thank you! Are there any sources for this topic? Any pharmacology books?

[@Johann_]

Hello, very interesting video as usual, thank you very much! When it comes to light, do you know which step does it block for melatonin synthesis ?

[@indigopursue1542]

I still love this litterly I’m a young psychology student! And this is soooo clear and amazing great content very professional and legit🕉💯💯(5-ht2a receptor)

[@GeoffreyDabner]

;)

[@jooky87]

Great video JJ! How long does this process take? Like if I took some tryptophan how long would it be before I had melatonin and serotonin in my brain?

[@lazsatori]

If you take a liquid melatonin, it would enter your brain in 5-10 mins

[@TomHendricksMusea]

What is the connection between gut microbes and the production of serotonin in plants and animals.

[@Calaman345]

Nice work..🔥👌🏽...the methylation of tryptophan to serotonin takes 5 hours...🤔... what is the time frame of SEROTONIN to Melatonin

[@Calaman345]

Does anyone have an answer?😏🤔❓

[@GuacIsExtra99]

No but I’m commenting bc I want to also know the answer lol. I originally thought tryp to serotonin was something closer to 30 mins lmao

[@jamesmorss9940]

Fascinating stuff, thank you for making this.

[@kenshey3912]

Error was not citing the production of melatonin in the gut for bacteria and produced for mitochondria.... Not just for sleep... Thought the body. To stop at sleep is a narrow statement

[@mubashiranaqvi1899]

Great work! Why don’t you guys just make a video on GABA too via the same format, it would be highly appreciable.

[@reinerwilhelms-tricarico344]

Did you know this? - Glyphosate (aka Roundup, herbicide) suppresses a plant enzyme EPSPSthat plants need to synthesize tryptophane and phenylalanine, as well as tyrosine, leading to the death of the plant. But also: These three amino acids, forming the aromatic group of the amino acids are essential for the production of serotonin, dopamine, and melatonine. Just saying. (Now I would like to know how much decades of use of glyphosate have influenced the physiology of the plants we eat, and what this might mean for the mental health of humanity ).

[@TheGrapplingMonkey]

Awesome video, thank you very much. :) How does Dimethyltryptamin fit in this chain?

[@Mago84013]

Joe Rogan has entered the chat.

[@fatimaa6172]

I hope dr explain it at this way , SUPER EASY THANKS A LOT !!!!!!!!!

[@AliceAprilMusic]

Great information! I’m curious how music that activates pineal gland affects our body and if you are familiar with the research on the subject.

[@NMW80]

Great video ty. What parts of our bodies are used in the making of melatonin and serotonin? I know the pineal gland is one but just curious do we have to have healthy kidneys and liver etc for this to work?

[@TRA]

Should I go for 5htp or tryptophan supplement?

[@swen6797]

Melatonin not produced from pineal gland. It is released from there after dark, where it is stored after production in the retina in sunlight exposure upon the melanopsin there.

[@lilolmecj]

My daughter has a high level of Melatonin, and low Vitamin D. She also has nodules on her finger joints. Can anyone lead me in the right direction to recommend nutritional support. From this I am thinking a B Complex, and tryptophan?

[@thenbapple]

Really nice video bro. Helped me a lot with my pharmacology class!! Keep up the good work :)

[@voiceofreason1829]

No problem

[@stephencarlsbad]

So... This is why I crave chocolate and cant sleep at night, lol. Guess I'll take some B6 and see what happens although when I take B complex, my anxiety goes away mostly and I feel more level headed and calm.

[@indigopursue1542]

AWESOME!!!!! GREAT CONTENT AND ENERGY!!🤘🚀

[@jjmedicine]

Glad you enjoyed it! :)

[@thatguitarguyguy]

JJ Medicine can you please explain supplementing L-Tryptophan? I normally take 10mg of Melatonin before bed, but would it be beneficial to also supplement 500mg of L-Tryptophan with the Melatonin before bed?

[@wonghokman8392]

Nice video, but I want to ask if magnesium involved in this reaction? Because magnesium has some positive effect on sleeping ,but it seems not to be relevant to this melatonin synthesis, can you tell me more why magesium is so powerful to help us sleep "deeper"?

[@lazsatori]

Mg acts as a muscle relaxant. Helps the muscles open, relax, detox and let go. Which is essential for sleep. Good day to you.

[@zane003]

thanks. would be great if you can show the molecules in 3d instead of old-textbook 2d drawing

[@tinafatih5011]

You are the best!!! Thank you

[@DenverChiropractor]

Great video

[@user-lv6nh1pn1o]

This video is very nice and beautiful 🌷🌷👍👍

[@benikramer5115]

Dear JJ Thank you. Do the enzymes belong to mitochondria-dna, or to nucleus-dna? Is there a transporter from cytoplasm to mitochondria for serotonin, or just for melatonin?

[@thatguitarguyguy]

JJ Medicine can you please explain supplementing L-Tryptophan? I normally take 10mg of Melatonin before bed, but would it be beneficial to also supplement 500mg of L-Tryptophan with the Melatonin before bed? Thanks

[@kevincanalenutrition]

I would be cautious taking L-Tryptophan as this can also be converted to Quinolinic Acid. This molecule is eventually converted to NAD+ but Quinolinic Acid is toxic in high amounts and is the limiting step of the chemical reaction. If you notice any ill effects after taking L-Tryptophan I would recommend consulting with a trusted medical professional.

[@GuacIsExtra99]

I take 1500 mg nightly but I also don’t consume any dietary tryptophan sources

[@olgabennett692]

@@kevincanalenutritioneventually that leads to NAD as you said - wondering why then this is considered a beneficial pathway …

[@tianzhang1294]

Nice video, meanwhile do you know anything about how sunlights impact these conversions? at which phase of this entire pathway does sunlight takes place? I’m talking about seasonal affective disorder, thanks

[@stefanweilhartner4415]

i suspect the conversion from normelatonin to melatonin. the absence from blue light might be involved in the production of the last methylation enzyme. but that is just guessing from my side. at least a bit of supplementation of tmg and msm can boost this. now i understand why some people (including me) are reporting from vivid dreams when taking msm - which is a methyl donor. taking tmg+msm is something that i do sometimes.

[@aysunaltunkaynak9465]

Dou you have any idea about wake therapy?

[@whothinksforme]

Where in the body does this pathway occur? The brain or the gut?

[@aysunaltunkaynak9465]

Peki ya melatonin sentezini önleyecek bir müdahale yapilsa bu sürece? Böylece ortamda daha fazla serotonin olmasi ve antidepresan etkisi sağlanması mümkün olmaz mı? Tabii sürekli değil, belki birkac günlük bir tedavi... wake therapy for depression and bu serotonin melatonin dönüşümü icin neler soyleyebilirsiniz? Uykusuz kalmak beynin serotonin miktarını artırıp resetleme ihtimali doğurur mu?

[@racu164]

Superb, Well done bro. You are doing great job. Please add TCA cycle and Gycolysis new modified videos like this one.

[@nirmaladatt4456]

Thanks for sharing.

[@saintsfandb9]

Very nice. Thank you!

[@jackerwilly]

Do you believe that N, N-Dimethyltryptamine is synthesized by the human brain? The structure is so closely related to tryptophan and serotonin but there doesn't seem to be any clear answer anywhere. A study has already confirmed that rats synthesize DMT endigenously, however nothing has confirmed this in humans to my knowledge.

[@jackmears3167]

jacker willy r ex

[@jackerwilly]

@@jackmears3167 sorry what?

[@nickjohn2051]

DMT is synthesize from L tryptophan. Not 5 htp. I dont remember the pathways, but to generate DMT on the pineal gland, you need L tryptophan as the genesis.

[@CatboyChemicalSociety]

Theres no evidence for N,N DMT production in the brain but there is evidence of breakdown of melatonin into 5 meo DMT and there's a paper where this was detected in the urine of schizophrenic patients.

[@michaelb1785]

Great video, thanks.

[@dzeky7622]

Great info....

[@napoleonurcuyoramos9220]

Great video!! Thank you!!

[@gabyfridman7475]

Thank You

[@ArattaTube]

Can someone tell me if Vitamin B12 is required to produce Serotonin and Melatonin?

[@f0rsakenPT]

Vitamin B6 is the one to look for.

[@louiseevans5752]

So where & how does one GET Methionine !!??

[@ndukanwankwo8393]

Nice thanks

[@user-fi1kn3oq4m]

I want the initial studies.

[@nikonike163]

hi. Im looking for a pill that have at least 20 mg of each of these items in it. glycine - proline - hydroxidproline - glutamic acid - alanine - arginine - aspartic acid - serine - lycine - leucine - valine - theronine - phenylalanine - hydroxylycine - isoleucine - methionine - histidine - tyrosine is there any ?

[@virtuous8]

drink moringa before sleep, get more vivid dreams

[@jamesgordon8867]

Only total body melatonin produced by the pineal gland is about 5%. You need to learn how important melatonin is 😊

[@Hadegel]

Where does vitamin d play a role

[@mauri123402]

vitamin d increases tryptophan hydroxylase enzyme through a gene

[@Hadegel]

@@mauri123402 thank you

[@redroseeducationalsubkuch4589]

🎈

[@Dragondezznuts]

Tryptophan is a hell of a precursor

[@Stunnafafadef_Utwerk_Iwatch]

Melatonin works serotonin