Sickle cell anemia - causes, symptoms, diagnosis, treatment & pathology

What is sickle cell anemia? Sickle cell anemia is an autosomal recessive genetic condition where the beta-globin protein subunit of hemoglobin is misshapen, which ultimately leads to a sickle-shaped red blood cell, which is prematurely destroyed and can get stuck in small blood vessels. Find our full video library only on Osmosis: osms.it/more.
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[@Luke-pk3rb]

This video is INCREDIBLY well made. I cannot get over how in-depth, informative, and factual it is while still managing to be so concise. Must have taken so long to make so well done to whoever did. I'd love a list of your sources if that is also possible.

[@ashleelarsen5002]

I agree, but what do we use sickles for anymore? Gen Z is only going to know what sickles are for this discussion, they should change it to "crescent moon" disease...

[@fidosa8382]

@@ashleelarsen5002 bruh we know what a sickle is 😭 hmar

[@dinogt8477]

Sickle cell

[@gpsrandhawa8117]

It was my Grade 12 final biology practical and my project was Sickle Cell Anemia. I watched this video a night before and it all went so good. The examiner was so impressed. Thank you 😊

[@snehas9639]

i am doing the same thing

[@the_cracker_boi_4926]

Lol mines 6th grade wow

[@malikgaming3655]

i have sickle cell anemia

[@sportnewstv2749]

@@malikgaming3655 me too, how are you dealing with your situation 😥

[@aishwaryasiva4514]

👏🏻👏🏻

[@sa21539]

If only med school professors taught lectures like this

[@prathameshagrawal2437]

He himself is med school teacher biro

[@adnaansheik7553]

@Sameer Ahmed I agree with you bro. The ones in my Uni are so boring that you might wonder what the heck are we doing with our life and why we chose Medicine.

[@genuine_meteen9169]

Haha...so true, looks like most med schools professors byheart and spit in it in class Without logic.

[@someone-jl9fu]

professors in uni teach like shit they make me wanna kms

[@IsmbbailBb89]

it's not a professional way of learning even if it's simple you should read and be aware of every little detail , i wonder what the face of medicine with students like you

[@khushboogupta8083]

Your videos are really a great help in understanding​ the concepts.

[@ShikaTheGod]

I have Sickle Cell Anemia so I know this is on point, also I haven't had a SCA Pain Crisis since 2012 so hooray!

[@SlickEvan]

2012 wow! Nice work!!

[@alltalentsmediacrayz2798]

Honey which country are u or please inbox me thanks I need to talk to u

[@ShikaTheGod]

@@alltalentsmediacrayz2798 I'm in the US, Texas to be exact

[@alltalentsmediacrayz2798]

Wow dear

[@alltalentsmediacrayz2798]

Are u on watsup dear

[@LSBUFU]

Incredible lecture for nursing students like me. Thank you!

[@RohitPant04]

Thanks for always providing us with extra information on common BioMedical topics like this!

[@oreskoul]

Great video . Well explained . Made it easy . Once again, thank you osmosis ! 🙏🏼

[@docsanti8971]

WOW! Very well explained! Wish we had this kind of resources when I was at Med school. Well done!

[@faijumusic1599]

Check out my Sickle Cell Disease testimonials ❤️❤️❤️ Please subscribe to my channel!

[@otet2004]

😑 omg read the book is much details than this video a lot !! But what i love about the video is so brief and made easy

[@anjalieabhayarathne6314]

This was just so amazing! I had no idea that sickle cell disease was THIS easy to understand. It was very very clear. And I love the attractive pictures. And the narration was so good as well. Thank you so much!!!! Keep up the good work! 😁❤

[@Afton_OnYoutube]

@Daron Brown Aye, I do too

[@patriciacole1117]

No one should born with sickle cell today get tested get tested before you marry or get into a relationship please 🥺

[@alexanderksn2372]

Thanks a lot for your videos! Maybe it was worth paying more attention to prime editing or CRISPR Cas9 or Cpf1 as an innovative approach to treatment?

[@mtorabi6266]

Because of your perfect videos now I can learn and enjoy.thank u

[@BillieB.]

Very good video, I didn't come here to learn though because I unfortunately have sickle cell anemia. But I occasionally watch these videos when I'm dealing with minor pain as weird as that may sound it's comforting 😞

[@osmosis]

We hope that our video was able to help 🙏🏼

[@splendidmercy6567]

Thanks so much for the video

[@mahimasreehari6216]

It's really very helpful, i was literally confused but thanks to you I got it now . Thank you very much ☺

[@legends-og5dx]

Ok

[@milonmitra3584]

You presentation is excellent. I would like to add one point- the lifespan of normal RBC is 120 days but a sickle cell rbc's lifespan is 10-20 days. This cause increased destruction of RBC with anemia.

[@xsx_kingx]

Thank you so much this video helped me a lot I'm 15 and I'm trying to create a cure for sickle cell this video helped me get a lot of notes and I would love to text you and ask you some more questions

[@monoromo]

Good luck on curing it!

[@cristamundil6697]

What are you thinking? How’s it coming along? Don’t give up! That’s wonderful

[@kimeilacampbell2694]

Thanks! I wish you the best

[@everydayshad]

I would like the cure because I’m only 11 and I’m scared of death

[@45_dhruvpandya20]

Um I don't know if you're joking or actually serious. You're 15 and anyone can use the famous Phineas and Ferb line of "Aren't you kids too young for all this ?" But good luck to find the cure. I wish you success !!

[@rubasarkez9917]

Well done thank you so much 👍🏻👍🏻

[@akashkamboj1270]

Sir this is the best video lecture I have ever seen Wish my teacher could teach like you

[@VampireDiariesBiebs]

cant thank you guys enough!

[@justsomeguywithsunglasses3661]

Incredible presentation!

[@zzs8948]

Amazing content indeed ! But the type of hemolysis in Sickle cell anemia is mostly extravascular and abit less intra as far as i know , thank alot

[@Bassman7608]

Just lost a good friend to a sickle cell crisis. This video has taught me more than I could have imagined and I hope I could pass this on to as many as I can

[@osmosis]

We're sorry for your loss, Kevin. 🙏🏼

[@Tanishdutt0007]

I watched Video of Renal Artery Stenosis and made my project of Class 11th And believ me My teachers were so impressed with me. They all appreciated me . But all thanks Goes to OSMOSIS, I LOVE ❤OSMOSIS

[@osmosis]

Wow! That's awesome! Thanks for letting us know, Mamta! 💕

[@Tanishdutt0007]

@@osmosis Yeah!! but that's my mom' name. My name is KRRISH, by the way I loved you replied me after reading my comment. ❤❤

[@justineclark5775]

Wonderful video. Thank you.

[@theenglishfamily5375]

Well appreciated... We look forward to more understandable videos ❤

[@clarycluade666]

I was born as sickle cell I pass throughout a lot of pain I thought my life as come to an end. I lost all my hope until a friend recommend me to baba ifa. BABA IFA thank u for my life may God continue to bless ur good work. no more pain or crisis I'm free indeed, U can so give him a try All u need is to believe [phone]

[@waleedkhalid6908]

Thanks for your wonderful efforts

[@hkhk1901]

I wish I had professors like you in university 🌟amaizing job

[@music_7735]

Simple ,clear and perfect explanation !!👏

[@osmosis]

Thanks, Suharshitha! 🙏🏼

[@Carlos_Jzx]

I have this decease and men o men thanks for the great job on explaining this and this is the best explanation I have found yet!✌🏽

[@rajeshwarijessy7776]

Can u explain your symptoms while affected by this decease

[@Carlos_Jzx]

@@rajeshwarijessy7776 You really want to know. It's very very detailed here I can't add more is a bit different to some of us on how affects you for example I move to the north east and I been here 16 years and the cold has started to bother me in ways I didn't experience before.🤷🏽‍♂️

[@cultclassicz]

@@rajeshwarijessy7776 I have sickle cell and a thing i notice is i cannot take full breaths, my heart races rapidly, and i syruggle to breath when sleeping or laying

[@nakayizaneema2264]

Sure?

[@iggsGH]

Thank you

[@belanabdulla6368]

Very helpful, thanx.

[@toysfunny6944]

Amazing Job thanks

[@TheX7mood]

Outstanding!!

[@user-xu8pt6uy8h]

Whenever we need to learn full medical information with fun and short time Osmosis is here to help. Thank you Osmosis from all my heart. I am the first on my college because of u ♥️♥️🎓♥️♥️

[@osmosis]

Wow! Thanks for letting us know! Our pleasure to be of help in your studies! 🥰

[@kevinsteel7875]

The editing and transitions are seamless, very nice very informative.

[@osmosis]

Glad you think so, Kevin! 💕

[@omnaik5539]

Thankyou for this important information

[@sniyastanlyk7676]

Beautiful narration and presentation ❤.. Loved it ✌

[@osmosis]

Thanks a lot, Sniya! 😊

[@munahiljaved2028]

Very well explained in a much comprehensive way!!

[@osmosis]

Glad you liked it, Munahil! 😊

[@joang.5174]

Hello, good morning. Thank you so much for wonderful lecture/discussion. Your video so helpful to my course. I learn a lot, can I use some of your video like diagnosis,treatment etc. For my project? @Osmosis

[@osmosis]

Hi Joan! Glad that you find our videos helpful. You may reach out to [e-mail] and our team will be glad to assist you on your inquiry. 🙏🏼

[@AlexandraAbia]

Thank you, very informative!

[@ismailissifou2024]

this is awesome and really helpfull, but could you be able (or maybe any reader) tell me what source was used for this vid?

[@zackabdihakim2737]

Thanks. Very well prepared and presented.

[@semsem8801]

Thank you for all videos

[@fasamah.kollie8767]

Splendid ❤ demonstration. A well deserved hats off 🙏🏻😊

[@osmosis]

Glad that you appreciate it, Fasama! Thanks! 💕

[@savannahandrade8188]

Such an informative video

[@raicarab5246]

Thank u so so much

[@srirambhardwaj2343]

Very.helpful.lecture.

[@thathappymind6916]

Very helpful video ! Accurate and easy to understand

[@osmosis]

Glad you think so! 🥰

[@JuliaHelen777]

Where on the axis of Hishimoto-Fybromialgia-MS-CFS-Parkinson do Sickel Cell Disease pass in & what might be the interrealtion? What IF is all due to artificial syntetisation of biologic life? Is there any open source study taking this points of view in consideration? Where can I find more?

[@christinesalami7712]

Your videos are my savior in medical school ❤❤❤ lots of love The most wonderful thing that happend in my medical journey is Knowing and learning from your videos love you a lot ❤❤❤❤❤

[@osmosis]

Our pleasure to be part of your medical journey, Christine! 🥰❤️🙏🏼

[@Sarahwilliam455]

I totally appreciate this Video, I'm in Nigeria and I was able to get hydroxyurea about two years ago which was really helpful but I've been finding it hard to see it in Pharmacies I'm Nigeria, Can you suggest how I can get this Medicine??🙏🙏 I'd appreciate a response Sir.

[@justrandom4304]

Is sickle cell in anyway related to the repetition of getting blood clots coz I have some kind of anemia I just realized that I might have a blood clot near my lungs its a sharp pain when i take a deep breath. I'm going to see a doctor ASAP

[@reginaopoku2203]

Splendid ! I'm a sickle cell carrier and this is very educative . God bless you. I'm watching you from Ghana. Wish you the best in life 🧬

[@osmosis]

Thank you 🙏🏼

[@keziahaddoquaye53]

I’m a 14 year old girl who has sickle cell disease that just wants to know more so thank you

[@cryptomom3170]

Love it!!

[@cryptomom3170]

Well I'm saying. Not that fact u have. I know what it brings my 16yr kld daughter has sc disease. It's just the fact that u want to know more!

[@cryptomom3170]

@Daron Brown stay strong! My daughter has SC disease she's not in & out the hospital as those with ss disease... But when she have episodes it's painful! Prayr to you all😘

[@keziahaddoquaye53]

Daron Brown stay strong 💪

[@vet5838]

@Daron Brown you are a WARRIOR! Praying for you always.

[@nozomiyomi1039]

Wow thank you osmosis.

[@Stubborn214]

Hands down! the best lecture on SCD!! It was palatable ❤

[@osmosis]

Wow, thank you! ❤️

[@DT-el3ty]

Very useful

[@worldgreatempire]

I swear this is great!! Abt Medschool Professors... I suppose it's because we already have a background with Sickle Cell Disease is why it now appears easy... This will be difficult for a newbie! Unless revised over and over

[@osmosis]

Thanks! 💕

[@hanrubuhrmann384]

This was a damn masterpiece

[@minaazeez1311]

That was very helpful. Thank you.

[@osmosis]

Glad it was helpful, Mina! 💖

[@user-gp4qg5tk7e]

I love ur videos 🙏🏻

[@vishalarya5732]

Kindly make videos on gynae

[@japjyotkaurahluwalia8957]

Great job

[@danielkq]

Hello from Brazil!

[@morrenmbilinyi3545]

Really thanks you,that was so helpful

[@osmosis]

You're welcome! 🥰

[@Jeene269]

Thanks for the good explanation ✨

[@osmosis]

You’re welcome! 😊

[@todotvstreaming]

I recently lost a good friend of mine because of sickle desease. She used to have treatment which helped her deal with this disease but she got vaccinated against COVID a few months ago and she started to have more frequent outbreaks. Really sad that she passed away so young, 34 years old. Seems the vaccine increased her risks due to this health condition. May she rest in peace. She was always smiling and happy despite all the pain this sickness caused her 😔

[@DavidJohnson-dc8lu]

You saying Covid vaccinations are bad for SC? Vaccinations does inflame the body!

[@mariaragonese2543]

I'm only here because one of my co-workers has sickle cell as well as one of my customers and I want to better service them. The man actually had jaundice and I had asked him if he was okay. He said he had sickle cell and outside of the fact that mostly black people and Native Americans get it I don't know much about it.

[@KhadeejaMansour]

absolutely helpful, thanks!!!

[@osmosis]

You're welcome, Khadeeja! 😊

[@sumathybalaji5252]

Very nice explanation

[@dikshashelar2508]

nice explain

[@estiakshakil2663]

Excellent explanation...❤️

[@osmosis]

🥰❤️🙏🏼

[@mariaalma6563]

Cramming for my midterms right now. This helps so freaking much. Thanks for existiiiing!

[@SALMA-mq2os]

You always save my brain from any additional requirements 😇 thanks

[@osmosis]

Happy to help! 🥰

[@srajan_shukla]

Could I please please get the pdf of this presentation.... 🙏🏻 🙏🙏🙏

[@jigarsolanki2499]

Thanks sir

[@patrigodomingo4931]

NICE ONE

[@gtgodbear6320]

I have to get for blood transfusion post-op from internal hemorrhaging after getting an appendectomy. Hemoglobin levels just kept dropping and dropping all night. I had to have an emergency surgery and 4 blood transfusions to fill me back up with blood. Doctors were baffled that I wasn't dead. They had to cut me open like an old-time discectomy to find the bleeding and vacuum out all the blood. I had a staple puncturing a small artery at the appendix removal site. Closest I've been to death. Good thing they chose to keep me overnight or I would have died if I was sent home.

[@fahadmunir892]

May I ask Please Have you experienced a sickle cell pain crisis (also known as a vaso-occlusive crisis [VOC] two or more times within the past year?

[@BillieB.]

@@fahadmunir892 I have my friend, I also have SS

[@rahafabdelgafoor4002]

Some informations in the video are correct

[@nabukhanal6519]

my dad at the age of 70 got diagnosed with this . He had dengue few month back since then he had been sick n tired

[@mjk9152]

Thankyou sooo much 💙💙💙💙💙💙💙💙

[@manikandanbalakrishnan3373]

Have Avascular Necrosis, and having same symptoms of sickle cell disease

[@binodadhikari5255]

How sickle cell disease causes osteomyelitis? Any idea plz

[@enriqueermusmd]

great video! thanks!

[@osmosis]

You're welcome, Enrique! 💖

[@yaya-fv9eg]

Thanks ❤❤

[@MuhammadAshraf-ig1qd]

Informative and impressive Vid ❤️

[@osmosis]

Thank you, Muhammad! 🙌

[@pgaspirant1228]

Osmosis is the best thing that can happen to a medical student. ❤️

[@osmosis]

Thanks for your kind words! Always glad to help you in your medical journey!

[@rajeshwarijessy7776]

Tq very much

[@gauri9319]

Chages shape that allows polymerization due to which it forms Cresent shape???... didn't understand...!!!!

[@livingdeadgirla]

1:24 I never knew that before watching this. Extraordinary.

[@drlenton1746]

thanks this is great workout in few minutes

[@osmosis]

Most welcome! 💕

[@billrowe3350]

My beautiful strong wife has Sick cell God bless you all who share this illness our prayers to you warriors!!!!

[@fahadmunir892]

Hope she will get well very soon.

[@fahadmunir892]

May I ask Please Have your wife experienced a sickle cell pain crisis (also known as a vaso-occlusive crisis [VOC] two or more times within the past year?

[@neisha4045]

What is the reason for leukocytosis in SCD patients? Is this as a result of extramedullary haematopoieses?

[@BA-vc9wh]

Very wonderful and informative presentation 👏 👍

[@osmosis]

Thank you! Cheers! 😊

[@reaperofdeath8957]

It's nice to know more about the disease I have.

[@locallife9371]

I have 2

[@SeniorMM2024]

2+

[@streets0ul943]

I did a health genetic and dna test and it shows that I may have sickle cell as it runs in my family which I did not know. I have never been told by a doctor that I have sickle cell but don't regularly go either. As a 41 yr old is it possible to never get diagnosed until later?

[@BillieB.]

While I'm not a hematologist, I do have sickle cell anemia (unfortunately), and I've had it since I was born, and the likelihood of you having SS is VERY slim because pain crises aren't a rare occurrence, and they happen often especially if you aren't on medication. It's something doctors catch pretty much from birth! Not to mention the fact that the life expectancy for SS was around 19 to 20 years old, up until the early 2000s from my understanding. This may sound depressing but the likelihood of you being alive right now with no medication would be VERY low, I honestly don't think it would be possible. Hope that helps just my experience and knowledge tho!

[@KenzyFarid]

Very Excellent!

[@osmosis]

Thank you! Cheers, Heba! 💙

[@user-ve5wx9lz8g]

Well appreciated on well explain lectures

[@osmosis]

So nice of you! Thanks! 🥰

[@barshaacharya6783]

So informative

[@osmosis]

Glad you think so, Barshaa! 💕

[@manuelmorales2413]

I'm sufferring a crisis right now on my left arm, I hate suffer this kind of pain frecuently 😢😥

[@manuelmorales2413]

@Nyla Davenport What is it recommended for?