Sickle Cell Anemia

MEDICAL ANIMATION TRANSCRIPT: Sickle cell anemia is an inherited blood disease that affects your red blood cells. It’s one of the most common and usually most severe forms of a group of red blood cell disorders, called sickle cell disease. In order to survive, your body needs red blood cells to supply oxygen to its tissues. Red blood cells are made inside the center of your bones, called bone marrow. There, immature cells, called blood stem cells, can divide to make all types of blood cells, including red blood cells. Normal red blood cells are disc shaped. Each of them contains protein molecules, called hemoglobin, that carry oxygen, Round, flexible red blood cells flow easily through your bloodstream and pick up oxygen in your lungs. In tiny air sacs in the lungs, called alveoli, oxygen moves into the blood and attaches to the hemoglobin in red blood cells. Then, the red blood cells deliver oxygen to cells throughout the body. In sickle cell anemia, there is a problem with your hemoglobin that makes your red blood cells sickle-shaped instead of round. This is caused by a defective gene that is passed from both parents to children through genetic material in your cells, called DNA. DNA is made up of sections, called genes. Two of the genes, called alpha-globin and beta-globin, contain the “blueprints” for making the hemoglobin proteins. In sickle cell anemia, the beta-globin gene has changed, or mutated. This mutation leads to the formation of an abnormal hemoglobin protein, called hemoglobin S. Hemoglobin S forms into rigid strands inside your red blood cells, which causes the red blood cell to be sickle shaped. Sickle cells can block blood flow, and can cause pain and tissue damage. And, while normal red blood cells last ninety to one hundred and twenty days, sickle cells only last ten to twenty days. Your body may not be able to keep up with how fast the cells are destroyed. As a result, your blood has less red blood cells than normal. This condition is called anemia. The symptoms of sickle cell anemia vary from person to person, but may include episodes of pain in your body parts, such as your hands and feet, lower back, chest, and abdomen; a yellow tint in the whites of the eyes and skin, called jaundice; and feeling tired due to anemia. Over time, sickle cell anemia can lead to complications, such as severe pain; and damage to your eyes, heart, lungs, liver, kidneys, and joints. Damage to your spleen, an organ that makes immune cells, can increase your risk of infections. The risk for sickle cell anemia is highest among people with ancestors from sub-Saharan Africa; Hispanic areas of South America, the Caribbean, and Central America; Saudi Arabia; India; and Mediterranean countries. To find out more about sickle cell anemia, talk to your healthcare provider.
ANH22254
#SickleCellAnemia #BloodDiseases #anemia

[@101nevergiveup]

19 year old sickle cell warrior here! This video is very updated. I was diagnosed with sickle cell disease at the age of three. Drinking plenty of water, eating healthy, taking daily medications and the grace of God has kept me going. My mum started to know more about my disease when she had a Google phone. I was weak when growing up, but it's much better now. My eyes have already been infected by the disease, I'm now on lens. I'm in Medical school now, hoping to help the future generation, so they will not suffer what I/we have already went through. Love ♥️ to all my fellow warriors..... We are strong!

[@luap6149]

❤

[@lilsyy16]

Can this be possible that you have sickle cells in your body but no symptoms or any problem. When I was born doctor told that I have 35% sickle cells in my body but I'm healthy and yeah I never ate any medicine related to this so is this possible?

[@101nevergiveup]

@@lilsyy16 I do have symptoms. I usually have sickle cell crisis. Since I was born, I was not active like my age mates. My mum said I used to get sick frequently. When I was able to talk, I will always tell her my back hurts and I always had a grumpy face, not knowing that I was suffering from sickle cell crisis

[@lilsyy16]

@@101nevergiveup Actually my back hurts too but if we talk about being sick then I don't think I get sick regularly cuz it's been a year since I got last sick. The symptom I have is that my hand trembles a lot if I do any sort of workout or climb stairs or get devastated my hands and legs starts to shake i.e tremors did it happen with you too?

[@101nevergiveup]

@@lilsyy16 yes! They do happen to me too. There was one time my whole leg was trembling for days! It almost took a week for it to stop. Due to that, I was unable to go to college

[@TheAfricanLion69]

I had this disease at the age of eight, my eyes were yellow, and I was feeling tired and painful. My disease was diagnosed and treatment began. Healthy eating played a major role in my recovery. The doctor advised me to stay away from some foods such as foods that contains sugar, tea, coffee, and sweets, and he advised me to eat vegetables, red meat, and liver and everything that contains proteins, and I take a lot of rest, and within a year in this way I started to feel better until I recovered, and now I am 37 years old, in good health.

[@JesusrevealedGlorified35]

I would like to connect, please. My daughter is suffering from this. In fact, she is in bed due to this right now.

[@aishahsaiid5372]

How true? Did u say DAT ur genotype changed?

[@Rajpraful]

Hlooo sir.. Great to hear that.

[@pmoney9131]

Ur lying

[@tarushi8188]

​@@JesusrevealedGlorified35 😢 sorry to hear.. how's her health now.. plz connect bcoz my relative's daughter have same disease

[@sabrinathompson3043]

Sickle cell warrior here been fighting this horrible disease since I was 3 months old we need to talk about this way more to many people suffer in silence

[@ryeoma]

too*

[@mooskamoo]

It is worth knowing that the sickle cell mutation is not just an ‘error’. It actually confers increased resistance to malaria parasites which is why the mutation has survived in the geographical areas stated and why sickle cell anaemia is still relatively widespread.

[@ollielon5926]

That makes sense. I was wondering why such a "bad" mutation would survive.

[@arrialahstock2430]

No wonder why this disease comes from?

[@jovantruss]

@@ollielon5926 malaria is prevalent in those areas and cause a high amount of deaths. Sickle cell/low hemoglobin is natural selection.

[@mauricealgorithm7320]

I just lost my brother who was suffering from sickle cell anemia.May his soul RIP.

[@zactizmgamez4589]

I’m sorry for your loss.

[@simretteklehaimanot7520]

hope u feel better

[@britneysowell6672]

I’m sorry for ur lost. Suffering from sickle cell isn’t easy, nor fun. U miss out on so many activities because of it. Nobody wants to talk about how deep this can really go, which is y they end it with “chronic pain”.

[@ebjebj8350]

Sorry for your loss 😞

[@rubiscoff194]

Rip

[@CorneliusWanjala-b4p]

I knew little about the disease until my own children were diagnosed with the disease, what I can comment is thanks for the information, every 19th June of every year is a world sickle cell awareness day yet little has been done by countries to eliminate the disease through awareness. I have two warriors one 19 yrs and another 10yrs but it is not a walk in the park. I always pray that one day this will end for the better for my children and others who have the same condition. thanks

[@AfiOye]

Tell me how I lived with this for 30 years and was never explained my condition like this. Only knew the basics

[@farahstars8424]

Your videos never let me down. They are always perfect♡♡

[@vealcogaming]

Nucleus was my childhood! I loved it! I used to watch it on my grandmas phone I wish to be like you!

[@archanasharma3271]

its so informative and i recently studied sickle cell thank you so much for this!!!🙏🙏

[@jaelinriley9454]

I got sickle cell and I like looking up thing’s about it for I can know what and what not to do but great video

[@WANGUYA_MUTURI_JESSE]

THANK YOU FOR THIS SIMPLE MEDICAL INFO

[@user-jw8go5kn2f]

Great , excellent, simple explanation 👏🏻👏🏻👏🏻👏🏻

[@farhadhasan829]

Simply outstanding. Please make more video on science lessons.

[@ShivKumar-8368]

You make me always understand better😌😌 than my school teacher.. Thanks for making us understood. 😇 Love your way of explanation. 🥰😍

[@ceomilligang8317]

This video will help many people to understand sickle cell disease

[@منيرةالعنزي-ج7و]

I like those who helps medical students by animation! THANK YOU SO MUCH !!!!

[@owinomparu9646]

I love nucleus when I grow up I want to become a scientist like them.

[@nucleusmedicalmedia]

You can do it!

[@srabonimajumder7098]

@@nucleusmedicalmedia 😉ujm

[@nobleningkan3995]

omg same

@@nucleusmedicalmedia I am developing a mathematical hypothesis to explain the C, N, O and H element cycles in the body. I have a question which its answer can help me to validate and/or modify my hypothesis. How do we know that there is a Fe atom in the Hemoglobin, or what is the scientific method that detected/isolated the Fe from Hemoglobin? My calculations is pointing to the element Phosphorus.

[@Sheaneed93]

If it’s your dream, nothing should stop you

[@ilostmyaccountrip1250]

props to the camera man edit: 69 likes? 🤣

This comment will be on top 🫣

[@ChiefNekrim]

W cameraman

[@douglagyal4364]

This is an animation🙄 People always looking for easy likes.

[@onion3987]

@@douglagyal4364 r/wo- You know what this is too embarrassing to say

[@OlgaPlaysMatch-3Game]

Output: *78*

[@excelist28]

I cant thank you enough. Your animations are very beautiful and informative. 🥇🏆👏

[@mimishaadmasu5956]

The same here, 🙏

[@mrthanush04mpt58]

Thanks for helping doctor

[@marilynvillanueva7333]

I love tò Watch listen and study . This can helps me a lot tò search what Is wrong with physical body . Congratulation have a great job tò teach helps us tò inform our physical body health

[@RehanAnsari-mm3wv]

Plzz make video about cerebral palsy & its treatment

[@rehankhanzimri461]

Loved the way you people are helping us in learning 🥰

[@AIShort586]

Nucleus medical media is always the best for animation about medical education 👏...it's so helpful 🥲...if I didn't understand any concept in classes...I get mastery here 😎

[@rosechild6593]

Please make a video of nasal of nose called sinusitis thanks

[@CityFlowersAndEvents]

A lot of theory can be explained by this wonderful method Great

[@vishesharya5033]

Thank you so much for give this information 👍✨

[@MohammedIbrahim-uc2nf]

Thank you very much for the video with kindness and respect

[@hugyoulikeakid]

amazing video!

[@claudiacmafuta4777]

Very insightful.

[@EssenceForte]

this helped me better understand sickle and how it effects many people thank you!! college student here and I'm def going to suggest this video to others.

[@tarignassr6690]

Thanks for making us understand easily. I think that will help to improve health outcomes through patient education

[@dexdavd]

this voice makes u wanna study biology in details...

[@mimishaadmasu5956]

Yes

[@GamingWorld-dh7mu]

Your videos too good please say me how to create this types of video This types of video very perfect to understand the concept

[@Legendop2627]

Just remarkable ❤️🌟

[@leylaatalay3480]

Böyle yayınlar yapın işe yarasın bilgilenelim teşekkürler

[@Poornima-jp5eb]

very good video i understood now everything is fine really tqq so muchhhhhh ❤️

[@arielbaboolal1561]

How I've only found out I had sickle cell 2 years ago but no one explained the symptoms, now I clearly understand about all the body pains I have the joint pains and belly pains ect...

[@bengood7337]

Hi baby how are you doing now i hope you are really doing good you are awesome looking at you baby makes happy when I look at your picture it is beyond my imagination that a creature like you really exist like a rose you make the garden so beautiful You are a diamond to any man that have eyes to see goodness of a womanhood Baby am Ben easy going person very understandable Am a civil engineer and a contractor I work at so many places like Asia Europe and Africa I love art craft and I write music I like ideal people when I see your picture am impress I want a good woman that understand what real love is all about who will understand me and perfectly be for me So we can build our world strong enough to care for each other I want you to be mine and I hope to hear from you soonest thanks

[@justduro1527]

@@bengood7337 this is not a dating app ben

[@arrialahstock2430]

@@bengood7337 ok you want money

[@bengood7337]

@@arrialahstock2430 how can you say that to me please are you ok am easy going person who are you and where are you located

[@bengood7337]

@@arrialahstock2430 hi baby

[@syraal7729]

Excellent job. This video explained in four minutes what a book can't explain in four pages.

[@nareshsake2089]

thank you so much for valueble information

[@ewuraefuagloria2033]

Nucleus is the best channel ever

[@jhazpermedalla4801]

im overthing rn...thank you for this information

[@KeithsTVHD1]

My cousin passed away from this, she was always in pain.

[@tarushi8188]

so what ? do you want my sympathy 😠 for god sake and for your dead cousin's sake plz don't write these comments it may depress some people or kids having this disease 😠

[@INGEN_Dahnie-el-aha-ha]

​@@tarushi8188 I hope you (or your loved one) recovers from this ❤ Please don't be upset. He didn't mean harm by his comment.

[@mimishaadmasu5956]

Its short and effective, thank you so much

[@bengood7337]

Hi baby how are you doing now i hope you are really doing good you are awesome looking at you baby makes happy when I look at your picture it is beyond my imagination that a creature like you really exist like a rose you make the garden so beautiful You are a diamond to any man that have eyes to see goodness of a womanhood Baby am Ben easy going person very understandable Am a civil engineer and a contractor I work at so many places like Asia Europe and Africa I love art craft and I write music I like ideal people when I see your picture am impress I want a good woman that understand what real love is all about who will understand me and perfectly be for me So we can build our world strong enough to care for each other I want you to be mine and I hope to hear from you soonest thanks

[@mimishaadmasu5956]

@@bengood7337 , nice to meet you Ben 🥰

[@bengood7337]

@@mimishaadmasu5956 😊 hi baby how are you doing I hope you are good am Ben from Austin Texas am glad you really beautiful am easy going person I really want you to be mine so baby let's get to know each other very well where are you from baby

[@mimishaadmasu5956]

@@bengood7337 am happy if we are going to know each 🥰

[@bengood7337]

@@mimishaadmasu5956 OK baby

[@gomezmario.f]

My neighbors kid just passed from this yesterday, and yea, I am from west Africa. This is a terrible disease

[@douglagyal4364]

In Canada and the USA they know how to deal with this. West Africa needs to get up with the times. I know a woman who has this and has two children.

[@gomezmario.f]

@@douglagyal4364 we kinda know how to deal with some cases of it, in this case it is said the parents were negligent of the kids condition, he wasn’t getting proper medication. All this came out after he passed Ofcuz, when it was too late to do anything about, I didn’t even know he was sick. But you’re right, we do need to stepup, this disease kills so many kids here

[@OlgaPlaysMatch-3Game]

Literally very few people in Sakha Republic and Siberia have this disease. This disease mostly come from Mediterranean countries and Caribbean islands. These diseases are the least likely to affect people living in cold regions. My surrounding’s current temperature is -31,7°C.

[@kuluferdinand8762]

@@gomezmario.f hello, my daughter is 10yrs old and she is suffering terribly with this disease . Please how can we treat or take good care of her

[@creneemugo94]

@@kuluferdinand8762 Keep praying and searching for a cure online. I have seen comments on other videos of people knowing a cure. Something involving zinc and other things. Don’t give up on the search.

[@giovannibautista2515]

Even though I already graduated this year from nursing school, it’s always entertaining to go back and watch these types of videos 💙

[@venkateshnarava5417]

What’s the life span of sickle cell patient and how to reduce its impact .

[@elchokssphobe]

@@venkateshnarava5417 54 years

[@hanataki4152]

Good informations

[@Dr-su7um]

Very nice and beautful video.. Thank you ❤️😘

[@An...51]

Though it's an old vid yet it refresh again all the infos😁

[@Dr.GirishSolanki]

Sir your vdos n information is very good, but while showing the countries pls show full INDIAN MAP, its request Sir.

[@KALAMKAARFAN]

I like your videos so much

[@sayedsaleh8391]

Nice but to do it in a comparison with other types of anemia such as favism in one video will be better

[@aliddda328]

Been having this sickness ever since I existed Edit: btw I had to extract the spleen when I was about 6-10 years old because it was absorbing the blood and inflating was this the right choice and is there any special things I have to do now I'm 18 yes I was doing better ever since it was extracted but I just wanna ask and see if there is anything I just don't know

[@sisamkelemzinyati9900]

😢thank you

[@jasmintonni8029]

Very useful🎉🎉🎉🎉🎉🎉🎉Thank you...plz keep it up

[@raghuaily7230]

Good infermation 👏🏻🙏🙏

[@raeganwilliams4666]

Great video!

[@m_m786]

Great 👍🩺♥️

[@cioarasorin5137]

Sickle cell anemia appeared as an adapatation against malaria, since sickle cells can't be paarasitised by the Plasmodium parasite.

[@bonduabhinesh9748]

Thanku for sickle cell anemia

[@carolinatigerlilly]

How does a person know tht he has got sickle cell anaemia Bcz the symptoms are very similar to other diseases also does parents find out abt the mutation after the child birth or ?

[@bint-e-farooq6937]

when you have these symptoms you should concern with your doctor and then they test your genetic report and tell you that if you have or not

[@DianaIvery]

U get tested as a baby and that's how u know. If not go have your lab draw the sooner the better .

[@aartivishwakarma3239]

Bahut achha video hai bana hai but usme Hindi bhi bola jaata toh achha hota ✨👍

[@1994JADID]

toma tu like buen hombre por enseñarme ingles y biologia a la vez

[@shaikabdullah..]

Thank you

[@rosered9692]

My roommate had them she didn't want anyone to know till her mom told me she didn't like that the mother was talking about her sickness. On june 4th me and her were cooking she started asking me about stock and what share I buy , I told her I will write them down and give it to her 3 days went by I didn't see her I slide the list under her door I'm thinking she is in the bathroom since the water was running but its 4 of us in the house, I left on the 11th morning went up to Massachusetts around 10:30pm I got a call my landlord was like your room or her room smells. I'm like ewwu I probably forgot the fish in there , he went on to say I figured it wasn't yours cause we've seen u .ok. well it was her room she passed away. I was shocked .

[@sarahlawal1503]

Painful 😣😣😣 so sorry for your loss.. i hope her mum is ok.

[@rohinirahangdale8045]

can you PLEASE give the CITATION for this video 🙏🙏🙏🙏🙏🙏🙏as I want to you this in my research proposal

[@rchaykovskiy]

Hey, at least they have some advantage when it comes to malaria

[@chidiobiukwu5728]

Pls what are the advantages do they have when it comes to malaria.. I would love to know.. Thanks

[@justduro1527]

@@chidiobiukwu5728 You have a better defense agaisnt it so you are less likely to get infected and if you get infected you are most likely to recover faster and fight the infection better

[@swapnilsontakke4279]

Nice information.

[@yade7263]

thankss

[@Faizan_Sajjad]

Video on Thalassemia

[@frenelynticuala5677]

Can sickle cell anemia be cured through supplementation like (iron). Thank you

[@bengood7337]

Hi baby how are you doing now i hope you are really doing good you are awesome looking at you baby makes happy when I look at your picture it is beyond my imagination that a creature like you really exist like a rose you make the garden so beautiful You are a diamond to any man that have eyes to see goodness of a womanhood Baby am Ben easy going person very understandable Am a civil engineer and a contractor I work at so many places like Asia Europe and Africa I love art craft and I write music I like ideal people when I see your picture am impress I want a good woman that understand what real love is all about who will understand me and perfectly be for me So we can build our world strong enough to care for each other I want you to be mine and I hope to hear from you soonest thanks

[@nataliesanchez871]

I’m not too sure. I still believe you can take vitamin supplements as a treatment.

[@justduro1527]

Nope

[@beekind765]

Sickle cell disease is a lifelong illness. A bone marrow transplant is currently the only cure for sickle cell disease. Gene therapy is also being explored as another potential cure, but there are other effective treatments that can reduce symptoms and prolong life.

[@afzalportugal692]

please update about autism spectrum disorders

[@AnushyaBabu]

Upload a vedio of how does cancer cells formed and how cancer occurs

[@shashiketan]

Explanation is perfect except the Map of India that you showed in the last. I respectfully urge you to correct in your upcoming videos.

[@devin-rm5re]

It's very nice clear explanation. Please help us to explain the iron deficiency anaemia as well... it will be very helpful for us

[@Zakariah1971]

Excellent

[@nikshithreddy1350]

Your channel can make an interested biology student ...a MBBS 2.O...😅😅

[@musikaaffection8570]

thank u so much sir

[@lovepakistan.3008]

Congrats 6m.

[@AditiNath1234]

Great👍👍

[@papichula7319]

Is there a drug or any type of medication that reduces this yellow tint in eyes and skin? The tint in my eye makes me very insecure to look at people.

[@TheBallsInspector]

Maybe liver or something bad bro. Go to doctor

[@logekarl8584]

If you have sickle cell anemia it's very very important to super hydrate with water. That will flush out the bilirubin in your blood. I have 3 children with this and it's a sign that enough water is not being consumed or they're in a very significant pain crisis.

[@vigneshvikky5298]

need more information about the disease

[@madehinlotemitayo2810]

What can I do to be having the red cell always to avoid the pains thanks

[@LeeTheUnicorn]

Thanks!

[@fatmiralukafatmuraluka12-jz4cg]

Flm te gjithve Vella edh mam zot flm aleluja aleluja amen flm te gjithve Vella

I am developing a mathematical hypothesis to explain the C, N, O and H element cycles in the body. I have a question which its answer can help me to validate and/or modify my hypothesis. How do we know that there is a Fe atom in the Hemoglobin, or what is the scientific method that detected/isolated the Fe from Hemoglobin? My calculations is pointing to the element Phosphorus.

[@afzalportugal692]

please update about Parkinson's disease

[@user-pr6ed3ri2k]

uh oh anemia didn't know that's why sickle cell anemia exists

[@user-pr6ed3ri2k]

Idk why I thought jaundice was called bilirubin

[@lillylilly8330]

What should we study in order to become scientist

[@derilriordan4109]

One of any subject in college

[@pedrojbc2007]

شكرا

[@Natrax78]

''Tell your mama i said wagwan''

[@thrisha7598]

Can you give subtitles pls

[@fresherm3396]

Yhanks

[@Sketchy_spectrum18-ml3gs]

You have shown wrong map of India

[@janececelia7448]

I was taught that sickle cell anemia affected only people of African descent, and that the gene mutated to protect some against malaria.

[@justduro1527]

@Y F Sickle blood cells can not be infected.

[@patientestant]

I didn't know other ancestry outside of African had a chance of have the sickle cell gene.

[@YemisiMosakuTV]

How best do one handle an SC child(SC genotype)

[@francisakorful]

Like every SS however they have less severe symptoms especially the anaemia

[@OlgaPlaysMatch-3Game]

The best way to handle such a child would be to have a blood test and get reports from the person who did this test. They should also consume adequate iron mineral to maintain adequate levels hemoglobin inside their body despite the mutation which prevents the body from getting sufficient oxygen. And they should optionally use medical oxygen.

[@ki_Cp]

Long live PRODIGY

[@tossjewellery-wearelaborat4394]

❤️

[@TheTechCguy]

This is why we have to breathe, folks, as well. Your red blood cells need that oxygen to sustain homeostasis and, therefore, life...