SNP: How Ketones cause Heart Cell Damage [Science Explained]

[@Physionic]

I’ll go ahead and get ahead of this by saying that I do not believe keto is a bad diet for most people, even in face of this study, because as I stated in the video, we need more data. What other data does exist seems to show positive effects of a ketogenic diet. However, there is no denying that the ketone discussed does lead to human heart cell death based on the data I covered in previous videos and we can’t turn a blind eye to a study simply because we don’t have an acceptable explanation to brush it away. I currently (6/14/2021) stand behind the ketogenic diet as a viable option for a variety of health outcomes, but I refuse to not investigate dissenting literature. For a breakdown of the data, click here: kzbin.info/www/bejne/eXLOm6KKZ52skNk

[@littlevoice_11]

I wonder if there are any research pieces looking at ketone meter reading and heart health. I also wonder if the heart muscle implications are specific to a particular age group and particular cell groups? E.g. elderly and in particular those with alzheimer's disease can have better neurons function.

[@Physionic]

@@littlevoice_11 That would be really interesting and a well thought out study, LV.

[@melt7891]

Great statement..all scientists should think this way.

[@odeonhealingfrequencies2743]

Any update to the research on this? I've been doing keto 3 months with great results for overall health, all lipids in normal levels and down 25lbs. interested to see if this is a long term diet I should stick to or just one to get to low BF and re-introduce carbs. Male 44, 5'10, 185lbs 13% bf

[@Pietari55]

I have one question that I have last five years been pondering. After having two heart infarcts in 2016, having three stents and after one year being following the standard good care protocol, dietary guidelines and medication my health just kept deteriorating. In 2017 June my research on issues convinced me to drop all medication and move to full-time keto-diet with intermittent fasting. Today 4 years has passed my heart is healthy, not being sick during this time, twice a year fully checkup on my vitals. My question is, do you think that if the livestock or wildlife were the potential customers of industries of junkfood soft drinks there would be massive build-ups of Chronic Illnesses and life-long series of medicine prescription.

[@vanessam4980]

does this include ketones produced from fasting or is it just the ketogenic diet? (Is there even a difference?)

[@Physionic]

It would include ketones from fasting, yes. No, no difference. Good observation.

[@mico-skywalker]

@@Physionic so I take it, any form of dieting below maintenance will/may somehow contribute to heart damage due to ketones, which, though variable, will exist.

[@andrewshonk6442]

Thank you Nic for this content. I have been doing keto off and on for about 3 years now and with a family history of heart issues I am open to the research out there concerning this. Rather than get emotional one way or another about this I'd rather disseminate the science that is out there. I am becoming a bit skeptical about listening to the "gurus" that seem to have some sort of a hidden agenda.

[@Physionic]

Glad to hear you have an open mind, Andrew. Thank you for being that way. Always follow the data.

[@Jack-wt3pd]

OMG Video quality is excellent and of course as always , excellent content!

[@Physionic]

Thanks, Jack, kind of you to say.

[@Jack-wt3pd]

Physionic you’re most welcome!

[@guillermosanchez1224]

This is heartbreaking :(

[@joshphillips18]

Do you think cycling the keto died monday-friday and then carb refeeding saturday/sunday would significally reduce the heart cell damage? is it consistent high ketone levels that cause the damage or any sort of elevated ketones at any time?

[@Physionic]

5 days of keto may not be enough to raise ketone levels sufficiently, so that may help, but that's pure speculation on my part.

[@joshphillips18]

@@Physionic i combo that with 20 hr IF 4 hour eating window and i feel that im in ketosis by mid morning. Thanks for the reply!

[@studentaccount4354]

Is there a difference between plant based keto diets and animal based? I guess I need to look at this study to see what they ate.

[@Physionic]

Not on these measures, no. The food consumption is in the supplemental section of the study, if you're interested.

[@lndiscalling]

Without the other confounding factors, the fact that Rat's do not have a Gallbladder because their bodies are not designed to eat large amounts of fat, let alone a fat type people on Keto don't ingest in those quantities, kind of makes this sort of study a non-starter. The other part just shows that sick human heart cells in a dish get sicker, well I could've told you this... particularly so when they're not connected to the human body that plays an essential role in their health via many other pathways. I honestly can't believe various institutions actually funded this, if someone had come to me and explained the experiment I would've told them to stop wasting my time and trying to waste my money! 💸

[@cat1racer]

I'm open for debate and study, but I question the intentions of a potentially bias video designed for views or attention. I do enjoy your videos though I am always a skeptic first when it comes to humans.

[@robertrowan9893]

My thoughts are that I hope the serrapeptase complexes I invest in pay biological dividends. In terms of scar tissue breakdown that is. Though I don't believe this is the whole story, it's but one chapter of a convoluted storyline arc. And there's a multiplicity of subtleties and nuances yet to be gleaned as more human study becomes apparent. Look forward to more instalments on this self-care subject in the not so far future.

[@jaredhouston4223]

You do bring up an excellent argument: "Keto might be beneficial in the short term -diabetes, but in the long term, it might have negative effects on the operation of the heart. Read more and wait for more data." Does that about sum it up? Excellent video quality and sound btw.👍

[@Physionic]

That's right, Jared. Cautiously tugging at the problem.

[@leonardokalid]

Nice video. About keto and diabetes, I don´t know if this will be useful, but I can bring annecdotal evidence that it is beneficial even in the long term. My grandfather is 83 year old and has diabetes since 60, his glucose level had even hit almost 400mg/dL various times. For the past 3 years he have been living with me and my mother, and kept an almost keto diet except some beans and other non-processed carbohydrate, and a TRF with 12-14 hours of fasting per day. His glucose in one year went to the normal range and it´s been there since, aside from that he was still taking medicines for diabetes. What is exceptional is that we didn´t have how to buy his medicine for 6 months straight, normally the public health system here in Brazil would deliver, but it didn´t, and his doctor noticed that his glucose stayed in the normal range even wihtout any drugs during this 6 months and now he completed stopped taking it for almost a year. Thanks for the good content, hope that´s helpful and understandable given that my english isn´t the best.

[@jaredhouston4223]

@@leonardokalid Wow, I am amazed by that story. People usually end up on a great amount of medicine when they are elderly and have diabetes.

[@tanjirohaven8229]

So are you going to go against keto?

[@Physionic]

Read the pinned comment, please.

[@kulata]

There are studies saying the opposite. Ketones good for the heart, actually preferential

[@Physionic]

Can you send me the titles to a few? Not links, KZbin deletes them.

[@kulata]

@@Physionic "Give the Heart a Ketone? It May be Beneficial. Review finds emerging evidence ketone therapy holds potential for cardiovascular intervention"

[@kulata]

@@Physionic "Ketone therapy for heart failure: current evidence for clinical use"

[@kulata]

@@Physionic "Ketones can become the major fuel source for the heart but do not increase cardiac efficiency"

[@kulata]

@@Physionic "The Failing Heart Relies on Ketone Bodies as a Fuel"

[@lawreadinggreen7117]

As per usual, your amazing insightful, objective, easily understood videos are great and I hope you continue to keep up the good work.

[@Physionic]

Thank you, Lawreading. I appreciate it.

[@lawreadinggreen7117]

@@Physionic No problem. I do a ketogenic diet and am always interested to know the possible dow falls as well as good parts of the diet. By the way, im interested about your opinion on polyunsaturated fats? Do you think the it is detrimental to human health or is it actually heart health? If yes, can yu send me some studies on the benefits of polyunsaturated fats?

[@Physionic]

@@lawreadinggreen7117 I haven't looked into it, so I can't say at the moment, unfortunately.

[@lawreadinggreen7117]

@@Physionic Do you plan to make a video about polyunsaturated fats anytime in the near future?

[@Constantine-the-Great2000]

I feel smarter already. Thank you Mr. Verhoeven!

[@Physionic]

Happy to hear it, Constantine.