Toxicology (Part-08) Treatment of Poison (02) | Activated Charcoal | Universal Antidote | Charcoal

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Activated charcoal adsorbs ingested toxins within the gastrointestinal tract preventing the systemic absorption of that toxin. Activated charcoal only adsorbs toxins that are in the dissolved liquid phase via direct contact. Orally administered activated charcoal does not get absorbed through the gastrointestinal lumen and acts within the gastrointestinal (GI) tract in its unchanged form. Ingested toxins come in contact with activated charcoal if the drug has not yet been absorbed from the gastrointestinal lumen, or via recirculation of the toxin into the gut lumen by either enterohepatic recirculation, or entero-enteric recirculation through active secretion, or passive diffusion.
Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its. It is used as a gastric decontaminant and emergency medication to treat poisonings following excessive oral ingestion of certain medications or poisons by absorbing most drugs and toxins. Active charcoal acts by binding to the pharmaceutical drugs or poisons such as organophosphates and decreasing the systemic absorption of toxic agents. Molecules with a large volume of distribution, thus likely having higher lipid solubility, tends to bind have better absorptive binding to activated charcoal. Following the administration of activated charcoal, cathartics are indicated to evacuate the charcoal-poison bonded complex from the gastrointestinal tract. Activated charcoal may also have an effect on systemic drug levels by lowering the serum levels of already absorbed drugs or toxins. Many absorbed drugs that undergo significant hepatic metabolism and conjugation are eliminated via bile into the small intestines. When they reach the small intestines, drug conjugates can undergo hydrolysis and return to the enterohepatic circulation. Activated charcoal interferes with this process and binds to the conjugated drug before hydrolysis or the free deconjugated drug before reabsorption.
Activated charcoal is used as a gastric decontamination agent in emergency clinical settings in case of poison or medication overdose. Studies show that early administration of one dose of activated charcoal can adsorb poison in the stomach and reduce absorption while it also works long after ingestion, by interruption of enterohepatic and endovascular cycling of poison.
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[@g.schoudhary6287]

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[@solutionpharmacy]

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[@tayyabafridi517]

Thank You Sir for explaining the procedure of using charcoal

[@vedikavya9596]

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[@krishnendukundu6446]

Mera ek neighbours 10 saal ka ladka herpick consume kar liya tha...Dr ne bola gelusil khilao , gelusil and kafi water khane ki bad uska pet fulne lag gaya , due to gas production but jab maine suna ye sab hua then I recommend raw 4-5 egg bottle mein le kar 4 glass water mixed karke bacche ko nose daba kar khila diya , within 2 min vomiting start ho gaya , stomach ekdam wash ho gaya, acid nikal gaya,,,,then boy feel relief..uski bad 2 gelusil khila diya....raw egg is very good treatment for stomach washing in case of poison or acid intake

[@solutionpharmacy]

Be careful. Vomiting is very dangerouse in case of acid poisoning. It may rupture respiratory and GIT track. The effect will not saeen just now butbin future it may affect.

[@prateepsengupta4337]

Sir I have one confusion. In the table you said Activated Charcoal is effective against Alcohol poisoning. In whiteboard you mentioned it is not effective in Ethanol poisoning. Can you please explain which one is correct?

[@solutionpharmacy]

There are many type of alcohol and of its conc. Like laboratory or ethanol or methanol. So as per patient condition it may warry

[@prateepsengupta4337]

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[@dr.shehlasattar1839]

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[@mamtanayak6203]

Sir carosin poisoning me bhi activated charcoal use kr sakte hai kya ?

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Glass dust in blood how to remove ..urine in blood ..organ failure ..glass dust not detected blood cultures test

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[@kaushalrssa]

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[@bhanu90979]

Very good sir but i have doubt charcoal jab administration krange to poison adsorb to kr lega but ab charcol body se elimanate kaisa hoga..

[@solutionpharmacy]

With fecal materials

[@tayyabafridi517]

My dog was poisoned by someone and i could not do anything because i had no charcoal and by the time i arrived,he had died.

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Konsa test kerna chaye glass dust blood me hi so plzzz help

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Sir hamare ghar me chuhe mar poison fail Gaya Hain use powarhin kaise kare

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what of mycotoxin?

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[@Dytto33]

Sir u said alcohol ke liye effective hai activated charcoal then uske baad apne btaya ethanol ke liye nhi use kar skte?? What it means

[@solutionpharmacy]

Alcohol are of 2 types methanol and ethanol it is mostly Used for methanol

[@Dytto33]

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[@surabhinigam9970]

Sir why activated charcoal is not working in case of iron and ethanol

[@solutionpharmacy]

They have interactive property and that may affectbits adsorption

[@surabhinigam9970]

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[@chethankumarpshetty8090]

Sie can u pls get ur numbr bcz my father took poison and he is in icu so i need to know about the stages of this poison

[@devendrakulkarni178]

Sir please help me

[@parveensharma2065]

Sir , water and milk se neutralization kaise hoga ? Plz explain

[@solutionpharmacy]

Reduction in ph

[@parveensharma2065]

@@solutionpharmacy water is neutral , how can it neutralise a base?

[@solutionpharmacy]

@@parveensharma2065 base ?? Why base

[@parveensharma2065]

@@solutionpharmacy if it further decreases the pH of acid , will acid get neutralised?😅 That's why base sir

[@solutionpharmacy]

Ohhhh sorry thats my mistake. I should write reduction in acidity and increase in pH. Sorry for the major mistke of mine

[@dr.chandrakantmagdum1735]

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