Solving Structures with MS, IR and NMR Lecture Course: Lesson 3 - Mass Spectrometry

[@maheralghadda5728]

Thank you my guy after your help I might be able to pull a solid B in drug design 🙏🏻

[@jonathansanchez8802]

great videos!

[@Mito_charge]

Do we have to follow the order when we solve the structure?

[@ChemComplete]

When you say this I am assuming you mean start with DOU, then MS, then IR, C13, H1NMR, etc? If so the answer is no. You can start anywhere you would like. I simply try to lay out the most logical flow from my perspective after solving these for 10 years. Do what work best for you!

[@fakhrulnawawi9681]

can u make a video with odd molecular mass because i heard it will lead to existance of atom like nitrogen,oxygen,halogen? thanks u

[@ChemComplete]

What you are referring to is "the nitrogen rule". This rule states provided a compound only contains H, C, O, N, and Halides that any time an odd molecular weight is observed there is an odd number of nitrogens (1, 3, 5, etc). I can look at doing a brief informational side video on this.

[@user-be4yc2vr5c]

Why don't people use mass spec? I was under the impression you could identify elements,samples and drugs etc. with mass spec? Isn't it the most common form of spectrometry?

[@ChemComplete]

People use MS all the time, in fact its use along with HPLC are the most common industry standards. Keep in mind that multiple compounds can share the same mass and molecular formula, therefore advanced knowledge of fragmentation patterns and stability of given fragments is crucial. In university lectures, it is uncommon to rely solely on MS for analysis purposes. NMR is usually the focus in these courses. The most powerful technique is to couple multiple forms of spectroscopy that all lend support to one another.

[@user-be4yc2vr5c]

@@ChemComplete Yeah I'm seeing this now... XD I knew it had to be to good to be true! Thoughtemporium tricked me ;p Seems most testing places combine gas chromatography WITH the mass spec. Then like you said to, I just learned that not everything has it's own unique finger print and things can get crossed... This sucks. The soil and waters are all fked poisoned and doped and people dieing all over from dirty drugs and nothing I can do with these home kits. I just wasted a ton of money and time trying to build. This fragmentation stuff I can't figure out either. Or especially how to apply it to be able to ID stuff real time. Without insanely expensive and big equipment. lol Super depressed now. =/

[@ChemComplete]

@@user-be4yc2vr5c Yes, GC or HPLC are crucial in a setup like this because you can couple a mass (MS) with a retention time (GC/HPLC). Coupling these is far stronger evidence than just one. I am sorry whatever set up you are working with is not what you thought, I am not sure exactly what you are working with, but yes these instruments are typically extremely expensive, even second hand.

[@user-be4yc2vr5c]

@@ChemComplete kzbin.info/www/bejne/pnrOaXxnZb-gj7s You should enjoy that video to. Also that is the mass spec I just built. That I guess is mostly useless =/