Spermidine - autophagy & anti-aging research (2021)

[@TheSheekeyScienceShow]

Cool me a biochemist nerd, but my favourite fact from making this video was the hypusination :D ! What was yours?

[@randenrichards5461]

Your accent lol, but I’m a yank and I dig it and to me it’s also soothing. On the spermidine, it’s so underrated there has been a lot of evidence that it’s effective yet there seems to be no market for it in the supplement area, at least I can’t find any and I was taking a lot of wheat germ to get an effective amount per day until I read some studies that wheat germ has a negative effect on testosterone. My ask is what else is there out there that can give a lot of bang for the buck on spermidine or a supplement I may of missed?

[@rhyothemisprinceps1617]

@@randenrichards5461 Sprouts and microgreens can have a lot; see article by Kralj Cigic et al. 2020 in Foods. IIRC there is discussion of potentially undesirable constituents such as cadaverine and canavanine. From the video it seems it might be possible to get too much spermidine. I think it would benefit my daughter, but she has Celiac and multiple allergies so wheat germ and spermidine supps from wheat germ (there is one, I forget the name) are not suitable. The video reminded me I needed to add some frozen peas to my grocery order.

[@ChillFantasticFive]

@@randenrichards5461 I'm reading studies that wheat germ increases testosterone

[@abritrn]

@@randenrichards5461 Primeadine and Spermadinelife are 2 brands. Very expensive and I think it would be pretty easy to get 1 mg (the amount in those supplements) in the diet- natto, tempeh, edamame, soy nuts, peas, mushrooms, nuts.

[@Celtokee]

The hypusination aspect was enlightening, but also the suggestion that we should limit semen consumption.

[@TonyT-fz8od]

you have the most underrated channel on youtube. amazing content and appreciate all the work you put in. All your videos about longevity and disaease prevention are amazing. thank you!

[@Celtokee]

Agreed. Sheekey and Dr. Michael Lustgarten are the two best reviewers and presenters of relevant current literature, and advancing reasonable hypotheses based on same. But Sheekey gets the nod. Love the way she highlights in color salient sentences.

[@jojoeleven8878]

Sheeky Science Show about healthy lives => 20.000 Views ; Gangnam Style => 40.000.000.000 Views; Nuff Said

[@hannabaal150]

You move right through this information, which requires actually paying attention. My first look at your channel is impressive. Thanks!

[@manuelojeda9144]

Your deligence in this area is remarkable. I have learned a lot. Thanks.

[@mr-nobody-on-youtube]

Thanks for this. Love these videos. A few times you have really helped me to make some informed decisions when looking for treatments for myself. This is one where I am getting more from food than I ever will from a supplement!

[@ericcigs5425]

You are INCREDIBLE.... i hope u get proper recognition!! THANKYOU

[@normjohnson4629]

Very nice. Thanks for not using a robot voice.

[@AdamT2]

Great science communication, you have made me love biochemistry!

[@peterz53]

Thanks for another excellent and detailed review. Given the amounts in food, one wonders why supplement makers are charging high $ for 1 mg doses.

[@manmoth4]

I just add chlorella powder to food. It's basically dried algae standardised to about 1mg spermidine per gram, packet says a couple of level teaspoons would give you 5mg. Doesn't taste bad, but makes things look a bit Chernobyl. I add to food rather than drink.

[@ctguitarguy8510]

@@manmoth4 which supplement is this? Because every chlorella supplement I've seen shows it takes nearly a kilogram of chlorella to get about 1 gram of spermidine. That's a lot.

[@manmoth4]

@@ctguitarguy8510 Yeah, but you only want mgs of spermidine, not grams lol

[@ctguitarguy8510]

@@manmoth4 No, I want grams.

[@manmoth4]

@@ctguitarguy8510 Well, standard supplements are pills of 1mg each, so chlorella are still cheaper per mg either way

[@MrStarchild3001]

Spermidine is a natural polyamine found in many foods like mushrooms, aged cheese, soybeans, and whole grains. As a polyamine, spermidine is attracted to negatively charged compounds like DNA, RNA and proteins, allowing it to be involved in various cellular functions ranging from growth to death. One key cellular process that spermidine activates is autophagy. Autophagy is a mechanism that removes unnecessary or dysfunctional cellular components. It acts as a recycling system to break down these components and generate new functional ones. The life extension seen in model organisms supplemented with spermidine seems to be autophagy-dependent (Eisenberg et al, 2009). In addition to activating autophagy, spermidine supplementation has shown other anti-aging effects in animal studies: - Dietary spermidine extends lifespan in yeast, flies, worms and mice (Eisenberg et al, 2016) - Spermidine improves cardiovascular function and reduces high blood pressure in aged mice (Eisenberg et al, 2016) - Spermidine reduces age-related motor impairment in flies Recent research has also investigated the effects of spermidine on cognitive function. A study by Schroeder et al (2021) found that spermidine supplementation improved memory in both flies and mice: - In aged flies, spermidine feeding for 10 days improved immediate recall memory by 50% compared to controls - In aged mice, 3 months of oral spermidine supplementation improved spatial memory, novel object recognition, and associative memory - Mechanistically, spermidine reduced age-associated brain inflammation and increased levels of the transcription factor TFEB in mice, which regulates autophagy To determine if these cognitive benefits translate to humans, the researchers analyzed data from a long-running population study. They found that higher levels of spermidine intake correlated with better cognitive performance on a memory recall test, even when controlling for age, sex, education and other factors (Schroeder et al, 2021). Those in the highest quartile of spermidine intake (7.89 mg/day) were 60% less likely to have poor memory scores compared to the lowest intake quartile (Schroeder et al, 2021). While these results are promising, clinical trials are still needed to directly test the effects of spermidine supplementation on human health and longevity. A small trial is currently listed on clinicaltrials.gov, but results are not yet available. In terms of dosage, nutritional data suggests average daily spermidine intake is around 7-10 mg per day from foods. Supplements are available but not necessarily recommended, as food sources are likely sufficient. There are also potential risks to consider with high-dose supplementation, as excess polyamines have been linked to conditions like cancer in some studies. In conclusion, spermidine is a promising compound for promoting longevity and healthspan. Its key mechanisms seem to be activating autophagy and improving cognitive function, as shown in animal models and preliminary human data (Eisenberg et al, 2009; Schroeder et al, 2021). However, more research, particularly clinical trials, are needed to confirm efficacy and determine optimal dosing in humans. For now, the safest approach may be to obtain spermidine from dietary sources like mushrooms, legumes, whole grains and aged cheeses. Future studies will continue to elucidate the full potential of this intriguing natural polyamine.

[@Lexington101]

Great video, explained a lot of high science stuff to lay people like me, well done! And great style, I second what Tony T below said.

[@brewhog]

Awesome! Thanks for the upload. Do you mind sharing what software you are using for the whiteboard and the video editing? I love what you are doing!

[@MrDani695]

I second this question, it looks really user-friendly and easy to use!

[@AshrafAli-mr9pz]

Clear explanation. If you've a research done on Olive leaf extract and polyphenols. Could you share a link?

[@elliottrubenstein1746]

Very informative. Love graphics and your accent. Keep up good work.

[@littlevoice_11]

Was I the only one who was very relieved to hear the sources of spermidine weren't as grim as I initially feared 🤮

[@SeganHealthHacker]

Talking about spermwhatever in this English accent n omg-so-cute feminine voice. Learned/understood nothing (n I lived in London) aside from the fact that I'm in love. Cuteness over 9000. Pleasant voice 2 study with.

[@luisfernando55]

Subscribed ! Do you have a video where you explain what kind of tools(software) for making a regular video on your channel ? Thanks !

[@dr.julia-heyakarcic8862]

Thank you for sharing the reference articles.

[@mickmack9333]

hi ms sheekey, i just watched this video on spermidine. u said there could b a correlation of spermidine and cancer. I checked out a couple of papers online and found that spermidine is in fact a mtor inhibitor. in this way spermidine would prevent cancer, right?

[@bogrunberger]

I suggested to my wife that she should be supplementing with spermidine, and she thought I was randy.

[@bornfree3963]

She’s correct!

[@bleu27]

Thank you for the nice illustration! Is there a max dose of Spermidine/day suggested by scientists or nutritionists?

[@TheShazExperience]

I love Sheekey Science Show ❤ A question for you… If you had to choose between taking Spermadine, or doing a Fasting Mimicking Diet what would you choose?

[@adopenmindiswhatyoullfind5305]

I do both. Started the supplement. Stopped to do the fast mimicking diet and then started taking it again. There are other benefits of fasting besides autophagy. I do the diet to lower blood sugar. Some use it for weight loss.

[@hkw53]

Out of all your research 🧐 what is the best supplement you have tried that gave you the best hair growth results?

[@NASkeywest]

You can get finasteride and other hair supplements online.

[@hkw53]

@@NASkeywest Where can I get Finasteride from? How much to take? Thanks

[@OneDayIMay91Bil]

I love your channel I hate that I only just found it

[@manuelojeda9144]

I take QUERCETIN and Fisetin supplements. I eat a lot of ARAGULA and broccoli

[@brewhog]

Is there more info on specific dose levels that would be considered dangerous (Cancer potential)? (Just looking for more reading related to spermidine supplementation)

[@TheSheekeyScienceShow]

The links I provided in the description (particularly the reviews) are best!

[@sergicatala3937]

I love your videos! you are great!!

[@TerryRGraham]

Is Spermidine Trihydrochloride toxic?

[@andrewchristie3139]

Interesting! Curious - why would anyone spend 90 dollars on a Spermidine supplement when you can get it from a single serving of Wheat Germ?

[@theeclectic2919]

Good question. I put wheat germ in my yogurt every morning. I have ZERO age related issues.

[@abritrn]

Wheat germ contains gluten so a person with celiac disease would not be able to tolerate it. But they can get spermidine from other food sources like soy beans, peas, mushrooms.

[@ctguitarguy8510]

The variability in wheat germ is dramatic. They use wheat germ extract, essentially, in these supplements. Only specific types of wheat have high levels and they dont like to share which ones. Wheat germ also goes rancid rather quickly too, unlike the supplements. What would be best is a higher dose product to meet what is consumed naturall but optimal diet like 10-25 grams.

[@luisfernando55]

@@ctguitarguy8510 what kind of food contains it ? Thanks

[@ctguitarguy8510]

@@luisfernando55 The highest known food source is wheat germ.

[@Aryeh-o]

sounds pretty weak compared to the price of the compound and the difficulty of regularly eating wheat germ.

[@titititi2022]

I wonder what would be the human equivalent of 3 mm dose for mices? Any idea? Some supplement manufacturers recommend 1mg per day.

[@ctguitarguy8510]

What are the dosages for human trials? 1mg strikes me as rather low, does it not? That is what is available in supplements at the moment.

[@mylesl2890]

so any nice links to where we can purchase some ??

[@MT-sq3jo]

Being a chemist who knows more about the high toxicity of small poly amine molecules than any health benefits specific polyamines have, I was shocked to see these polyamine molecules highlighted in this video. I’m intrigued but not ready to jump in taking a spermidine supplement. I’ll just eat healthy food and let nature to decide how much my intake will be.

[@DheerajBhaskar]

What was my takeaway from this video? Nothing was actionable.

[@mooinabc1]

How many mg are there in Broccoli sprouts and broccolli seed?

[@asmadak]

Is it safe to take for people who have Cancer?

[@clairebradbury11]

Thank you, very clear and interesting

[@ArticBlueFox96]

This is great

[@blindandlearning9379]

I have a pair in an apple every day do you think that’s enough?

[@victorchan5456]

Can you upload english subtitle ?

[@luckssj]

Have you looked at Glycocalyx Structure and it's effective on death

[@showkatkhan8461]

hi, if i eat peas, mushroom, hard cheese, broccoli do i still need to take spermidine supplement? thank you.

[@larryc1616]

I just make my own whenever I visit a porn site 💋

[@mik19mazz]

It would have been nice if this was explained more in Layman Terms.

[@andreycham4797]

Now I see why women live longer

[@jacklan4103]

I think I'll pass on this one and just take fish oil instead. What am i suppose to tell people if they found out i take spermidine?

[@GGschanel94]

Best spermidine supplements name ?

[@sirt1353]

Could this help with hair regrowth in males as well? If no, is there any other anti-aging supplement that may be good for that?

[@daniellem1838]

Check out More Plates More Dates channel for men and hair loss.

[@sirt1353]

@@daniellem1838 what is the summary of the things he say?

[@-w-.]

And here I was thinking that eating -sperm- is good for longevity.

[@-w-.]

Then again...... It is found in sperm 🤔

[@ThatCatCameBack]

rub it on your face to prevent wrinkles =:3

[@ChrisGroggyCreaser]

- I've been Taking it Approx 2 Weeks & I Havn't felt one iota of difference to my ULTRA-TIREDNESS/BRAIN FOG!!... :(

[@gicuneagu]

try this : electrolyte renewal, you might be having low electrolytes, supplement magnesium, NU salt (salt with potassium chloride) for all meals then reply here if it worked ;)

[@cliffmode2000]

So if I read that table correctly the best food to eat is whole wheat bread? I'm a dumb ape. Help me. 🙏

[@george6252]

I'm going to try mixing wheat germ in yogurt. Wheat bread will cause serious weight gain. The Spermidine supplements on Amazon are wheat germ capsules costing 59 dollars a bottle.

[@manuelojeda9144]

There is a recall on METAFORMIN FOR IMPURITY.

[@panama2468]

Berberine is a great replacement for metformin

[@rhyothemisprinceps1617]

re: sex differences - men are more susceptible to high altitude pulmonary edema, but can achieve higher VO2 max than women. Women are more susceptible to pulmonary arterial hypertension. hmmm ...

[@rhyothemisprinceps1617]

Male babies are also more susceptible to SIDS. I mentioned this and possible relationship to SOX9 above, but there is a recent article that reports a link between SIDS and MAO-A, which is on the X chromosome and is also regulated by SRY (the sex determining gene on the Y chromosome).

[@susymay7831]

Is it best to cut out dinner rather than breakfast if we are trying to eat all our calories within right hours? Or visa versa?

[@FatumAedifico65]

I find I'm more alert and less hungry when I don't eat breakfast than when I do. So cutting out breakfast comes easy for me. But others may have a very different response to breakfast. Listen to your body.

[@acousticmotorbike2118]

Brilliant

[@andyz.5431]

I simply integrated 30g of wheat germs into my breakfast.

[@Michael_RareZebra]

Does roasted wheat germ still have spermadine intact?

[@garroshhellscream8069]

so, can male ejaculation increase longevity while in a fasted state 24+ hours? because i only have sex in a fasted state because i have a better prefformance.

[@curadamortecomespermina]

People are taking spermidine via the wrong route, the wrong way, and using a weaker version of the substance, as SperMINE is more efficient at preventing oxidative damage than spermiDINE. The substance must be absorbed into the blood as a liquid crystal by the intestinal mucosa and by tooth cavities left open but treated by your dentist. And there is only one source, for liquid crystalline spermine = s*men. And that is only half of the equation...because then there is also the problem of deficient nutritional absorption ... That is why I am the only person in the world getting 100% benefit from spermine supplementation. Everyone else is clueless.

[@DBCooper3]

You talk way to evenly and mono the whole time, that all of what you say blurs together

[@charlessavoie2367]

similar to fisetin (strawberries)

[@melodymoore2943]

Maybe you should research fast hair growth shampoo to double hair growth.

[@ketokarbs3671]

It's in MEAT

[@ManoBengaluru]

Semen Retention

[@clarencethomas8906]

Yes SEMEN RETENTION!!! Give NOTHING

[@yosefsugi1808]

❤

[@gravelman5789]

ONATO RULES!!!

[@ts6070]

First

[@tomsport4537]

I wonder if you are 9 years or older 😂😂😂

[@ts6070]

@@tomsport4537 Friend I’m definitely older than you that I’m very sure of as I do remember second boer war..😉

[@theeclectic2919]

@@ts6070 I remember Lincoln!

[@ts6070]

@@theeclectic2919 I was at school with his dad..

[@benv.5170]

Your accent is too strong

[@jedlimen123]

Sorry, does not sound very appetizing.

[@dieudonnecorstjens4138]

If you translate somsing than do it proppely, the translator don't speak british or dutsh or both not ,it is bad.

[@StevieWonders2020]

Interesting---if only it was narrated in English.

[@stephanszwajcar2287]

What is this accent.. i hardly understand a word 😉

[@mayahobsbawm415]

It is Oxford English, the kind that educated people (and also upper class) is speaking!

[@adespade119]

@@mayahobsbawm415 like what I do too.

[@theodorephillipgideon2747]

@@mayahobsbawm415 Sounds more like a black sales assistant from our local B&Q.