Stage 1 of Glycolysis (Steps 1,2,3)

[@ericreuben6]

much better than khan academy. it takes forever for them to write things as they are teaching. Keep it up man!

[@AKLECTURES]

+ericreuben6 Thanks Eric, will do!

[@alexanderfuchs770]

You are actually a heroic teacher (not even kidding). I have understood so many things because of your precise explanations. It just sticks. Keep it up!

[@edgaravila2776]

Finally, a lecturer that doesn't talk to me as if I were a fifth grader

[@miguelaretxa]

Nice video! You explain much more better than my biochemistry teacher

[@AKLECTURES]

Miguel Aretxabaleta thank you! appreciate that

[@MrThelovechannel]

You have such a clear and concise way of teaching. I will definitely recommend you to anyone ever needing help in Biochem. Thank you so much for these videos!!!!

[@mcjohnkarshavski1953]

Very great. Can you believe our senior med schoolers are all recommending this you tube channel to us for better explanations of our courses? Great work. Keep it up

[@tomjannace]

its insane how clear and easy to understand these lectures are

[@yasminhalevi1]

AK LECTURES (Andrey K) its Amazing that even though English is not my native language I can understand you better than I understand my professor ! Thank you! And continue spreading your knowledge

[@GingiYume]

I would fight the person who disliked this video...

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U r right...

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HAAHAHA

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Calm down Breath in and out😂

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firstly i love your videos and how to make everything easy to understand and digest. for me the most significant thing you do is how you go over everything throughout the video to ensure that we are following whats happening.

[@personalityquiz2118]

Thanks a lot!! The lectures are really clear and organized!! I’m no longer frustrated about these parts of my medicine curriculum :D

[@laxmiupadhyay2240]

Sir, you surely are a life saver. Foolish are the people who give negative comments, they just don't know what learning actually is. Thanks a lot.

[@midbell]

uhh.. can you make a video where you just explain your life? curious as to why/how you know so much spanning from quantum mechanics to glycolysis, and all in such detail. what was/is your drive and why did you do it?

[@jessicamariposa6726]

I second this notion

[@Bilbus7]

Go to his website and read his about section. Dude graduated with an applied mathematics degree and just graduated from medical school a few years ago.

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@Julian Deville fuck off

[@justinonker8371]

Thank you Jesus for this guy. Man you nail it every time!!! Really love your lectures.

[@taylorthechemist]

To this day, I am using these videos for my college biochemistry courses! They never get old! Thank you

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how u doing?😀

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You are really life saviour, you know? May ALLAH bless and guide you 💓

[@jessicamariposa6726]

Blow away by his precise stream of consciousness on so many different topics. These videos make me make my A's.

[@JKwiatkowski94]

As someone who doesn't know much about the molecular structures, you make the whole process very clear and understandable!

[@hosnearahoimi5243]

Pausing the video just to say a BIG THANK YOU to you from the bottom of my heart! How lucky I would have been if you were my professor at university!

[@rmaguire08]

My Go to for beginning any subject I'm learning. He accomplishes in 20 minutes what takes my professors a week.

[@mohamednur3391]

best.your much better than my biochemistry lecture.love ak lecturers

[@margaretlanahan8696]

Thank you so much! I find this all very difficult. Your explanation was clear and explained why things were occurring instead of just assuming a lot of background knowledge that I do not have. You are a brilliant lecturer. I am so appreciative.

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You really know how to explain something quite complex into something simple that I can digest. Thank you for your help!

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U are the most wonderful lecturer i have ever listened to

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there is something special about your detailed summarised lectures that makes me feel like i have not been to you tube if i have not seen your videos on a topic

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your lecture makes a whole lot of sense.

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I appreciate your explanations! It feels more like learning and less like regurgitating. Definitely going to watch all your videos:)

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You are so dominant and super knowledgeable about the materials.

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Best online lecturer! Thanks for the amazing videos

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I'm just speechless! you are the best!

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It doesn't even feel like work or a chore to learn this material anymore. It feels like this is something i'd want to know for fun now. wow who would have thought? THANK YOU SIR!

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Just excellent and exceptional.

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You have a true gift! Thank you!!!

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God Bless You dude ,you are saving me in many ways right now

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I'm watching these videos on 1.5x playback speed in prep for final exam. Excellent videos for revision!

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my dear your pedagogy is just so awesome 😍😍😍😍

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AK Lectures should be added to the dictionary

[@5475mcga]

OMG thank you so much. your explanations are so thorough. you've explained details that aren't taught in my class and they really help so to understand why things occur the way they do. I hate just memorizing stuff without actually knowing what goes on. Again, THANK YOU.

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Sir you are my hero and an excellent teacher!

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life saver because of you I have As in biochemistry, metabolism and it control you are the best

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Man, why is it that you haven't got at least a million subscribers they key to the city? I've watched a couple of your videos and they are all amazing!

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Clear and concise. Perfect!

[@shwetachillal3780]

I never find such explanations ever.!! Such a huge explanations makes my mind to open towards glycolysis like critical topics. Keep it up gurujee.(sir)

[@areebaali5753]

Seriously, thank you so much for all of your videos. I truly appreciate all the hard work you put into them.

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your explanations are amazing

[@bokbok-oo5sq]

The best teacher of biochemistry ! Thank you so much !

[@MsTD1995]

You are the best!!!!!!! XX from Israel . can't thank you enough

[@Tibetchic]

Thank you for a very in depth explanation!

[@thealarm4470]

UR lectures are reaaly informative and explained in very detailed manner i like it and thankyou for teaching us

[@Lgiasjs]

Your lecture is awesome! One suggestion for improvement would be that you can shift aside when you are explaining the other part written on the board so we can read and at the same time listen to your lecture. Anyway excellent job!

[@MrJayPuff]

Excellent video way better than my professor by far

[@MrXxColexX1]

Nice work, I would like to add a couple things. a high ratio of ATP to ADP will inhibit phosphofructokinase and is allosterically inhibited by citrate. AND phosphofructokinase is activated by AMP because it reverses the inhibitory effect of a high concentration of ATP. However, the most potent activator is fructose-2,6-biphosphate which increases the affinity of PFK for fructose-6-phosphate.

[@citysbandaid]

Cannot thank you enough for these videos! My Biochemistry professor is terrible and the book is confusing. You make it way more simple and interesting! Thanks so much !

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Greatest to ever do it

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oh my god you are the best teacher ever thank you so much

[@MrChadRB]

Your videos are way more useful than my university lectures. I really appreciate them. I wish I could donate, maybe after I graduate.

[@MsBetsyT]

I have my bachelor exam tomorrow. I binge-watched your videos for a week now!

[@trinitaccad3066]

OMG, I didn't know it was this easy. Thank you!

[@rackarayusine8875]

i love how you explain stuff sir, bravo

[@itskia.m]

This was very helpful I can finally say I understand Glycolysis.

[@dyiu38]

Thank you! Thank you for your introduction of phosphate group transfer to lock the glucose molecule movement across cell membrane. Besides removal of all water molecules in the active site also interesting.

[@marianorgr]

You are an incredible human

[@Sveccha93]

Liked. Subscribed. This is a superlative presentation - thank you!

[@fancyday3573]

Thanks to you, I strarted to understand biochemistry.

[@nancydrew5597]

god bless you my whole class has caught onto your videos! Wish I knew about you earlier in the semester.

[@shinn-tyanwu4155]

Clarity of logic 😊

[@skyeblue5134]

Thank you so much for explaining the WHY. :) I think the reason this section has always been difficult for students is because we are forced into memorizing reactions and not understanding the logic behind them. It really helps to know why the reactions take place then simple short term memory.

[@evau3376]

Excellent lecture! It excites my thinking. Finally there is a lecture that reasons the actions, which wows me for the miracle of life. All actions have a reason not a random behavior. BTW, what are the 2 domains called? Where are they from?

[@vranonymous3339]

Also, I'm at an Ivy. I feel like they expect us to just know a lot of things from the start and that we can just piece the information together ourselves. Anyway, thank you for these details lectures! *tears of joy*

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Thank you so much! your videos are always so informative and to the point, super helpful!!

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way better than books, I love it.

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Addicted to your video ❤️

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Amazing explanation 👏🏼

[@Lililili-yf1gp]

You are so great teacher for me, even better than my professor :3

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Genius Teacher!!!

[@asemalsuty446]

I'd like to ask you what prevents ATP from being hydrolyzed by water into ADP before it binds into glucose 1is it its binding to mg 2+ and its role of changing the configuration of ATP or that is only important to cause the ATP to enter the domains of enzyme 2the inward rotation of the two domains of the hexokinase enzyme and its squeezing of water out from the active side or 3both another question is the second phosphorylation of fructose 6 p into fructose 1 6 bis p is it the same of the first one in the enzyme mechanism (the mechanism of hexokinase like phosphofructokinase thank you very much for your videos

[@bolauckner3576]

I would note though that he forgot to draw a hydroxyl group on carbon 2 on fructose-1,6,-bisphosphate. Hardly anything to mention though, this guy is incredible!

[@vizquit5071]

I think you forgot to mention PFK2, the enzyme that converts Fructose 6 Phosphate into Fructose 2,6 biPhosphate (The obligatory activator of PFK1) I'm a big fan of your work, keep it up.

[@oladunnialomaja5783]

I have a chance to pass my final exam b/c of your well-detailed explanation! Thank you!!!

[@TonyandDylan]

Outstanding lecture, happy to say I was the 800th like!

[@WiktoriaSta]

Amazing :) !!! Feel so much more secure about my exam now !

[@parisheth2623]

You may be missing an OH on the fructose 1-6 bisphosphate. Awesome explanations though! Thanks so much!!

[@khaldiaosman5518]

Great MCAT study tool. Thank you

[@Alex-nx6pf]

Excellent video

[@milesholmes9509]

Awesome lecture as ALWAYS!

[@jr1301997]

Thank you! Your videos/lectures gave me an A+ in Biochm 1 : )

[@Juju10985]

+AK Lectures, I really like the way you explain glycolysis thanks a lot for your help. :D

[@AKLECTURES]

+Kelly Merizalde Thanks Kelly! Glad you see you're back

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everyone comes back, ur the best

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YOU ARE A SAINT

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Great lecture

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Thank you so much for this video! You are saving me in biochemistry :)

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Andrey K, I don´t really know how to say it, but, I love you man, you are such as the best explainer I have ever met in my student life. Biochemestry or Physiology professor don´t have comparation with you. I´m Mexican, and I understand everything, I´d like to know if you have an specif accout for donation or something? Btw, would be awesome if you start uploading videos about exercice physiology. Thank you, soooooo much, my friend.

[@DarkChidori93]

Awesome amount of detail and well explained! :D

[@MonkeyDLuffy-xr4fl]

This is brilliant

[@JuicyDryWater]

the first lecure I think i actively paid attention in and didn't have to go to another video cause i didn't fully grasp what was said

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Just wow !!! amazing content

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Amazing work.Keep it up bro.Best of luck for future

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This guy is good!!

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THANK YOU THANK YOU THANK YOU THANK YOU THANK YOU!!!!!!!!!

[@drexelclayton80]

I have a question. At 10:03, you say that the movement of the two domains seals off the glucose, positions the ATP next to it, and prevents the ATP from being hydrolyzed prematurely. If the ATP was hydrolyzed prematurely and a phosphate group was removed, why would that keep the hexokinase from adding a phosphate group to the glucose molecule? Why couldn't the hexokinase take one of the two remaining phosphate groups attached to the adenosine in what is now ADP, and use it to add a phosphate group to the glucose? Hope that makes sense. By the way thanks so much for making these lectures, your teaching style is brilliant and you've helped me learn so much.