Steve Ottersberg - Physiological Basis of the Endocannabinoid System, and Phytocannabinoids - AHS19

[@medicinaverde8852]

Thanks for this video, and thanks Steve for your work on this topic. Cheers from Chile!

[@ahamed143]

Excellent talk. Can we have a separate lecture on endocannabinoid degrading enzymes?

[@Thomas-ic4gk]

You should listen to someone else who isn’t kinda wrong for political purposes lol. He skipped over the second half of the neuronal response of CB1. Once the neurotransmitters/modulators attach to the dentrites of the next neuron, that neuron release AEA which travels backwards across the synapse to close the CA+ channels of the firing cells. This prevents ROS from getting into the cells and destroying them.

[@SixOhFive]

@@Thomas-ic4gklike who?

[@The_MissJarvis]

As a cannabis user of over 25 years I truly appreciate this. Highly informative lecture and I’m glad he’s ditching grow bro science for real science. Let’s hope some funding for cannabis research starts here and not just in places like Israel.

[@AmirZenOfficial]

Wow this was such an informative lecture!

[@Thomas-ic4gk]

It is also amazing that much higher doses of ThC release AEA that jump backwards across the synapse to close the CA+ channel which prevents ROS from destroying our cells. Your diagram is missing the last half of the process.

[@thomastousant7178]

Informative, would like to know more. Believe more happens in the body that is natural homeostasis , what does missing part of the intestinal tract due to the equation?

[@CarlosRodriguez-db6sb]

💯🔥great lecture , soon we will know more

[@sharronwells4946]

Do people with the MTHFR gene mutation have a hard time with CBD and cannibus?

[@Healingandchoices]

Never tried the thc version just the hemp variety....cbd. I have been finding cbd a godsend. Pain pain pain and started to really overdue on aleve. Cbd oil works for me so much better and faster and has reduced anxiety too. I have cf and mthfr.

[@Cannabinol]

I like this presentation. However I think the stance on cannabis science as potential cancer treatment is a little needlessly negative. Dr. David (Dedi) Meiri and his team in Israel have demonstrated that certain strains of cannabis are more effective at killing cancer cells than current practiced methods. Not 'bro' science and you shouldn't walk away if someone wants to discuss it, that's just childish and ignorant.

[@thegreenersidechannel]

Exactly. Excellent comment

[@davidvandeusen3424]

My closest friend was diagnosed with stage 1 rectal cancer. She did not do chemo,raciation, or surgery but took high THC concentrated,full spectrum cannabis oil, Host Defense Turkey Tail mycelium, and IV vit C. 19 months later her pet scan and biopsy revealed no cancer. Fact D

[@native_earth916]

Thats the way to do it! ​@davidvandeusen3424

[@mistersir3020]

7:04 still valid

[@thecannabisdoc]

I wish the speaker made less mistakes, would be much easier to follow but great talk overall

[@REAlREAction]

Gods creation is amazing.

[@NoName-fp3jk]

Nature creations....nature my friend...no need for invisible friends in the sky ...educate yourself!

[@pwnage783]

@@NoName-fp3jk if an invisible friend in the sky is what you believe god is then you either need to stop talking religion or actually study it

[@larrytate1657]

@@NoName-fp3jk yeah your DNA with a language in it more complex than any computer program formed on its own from nothing. The universe also started on its own and came from nothing. And all the exact measurements for life came from an explosion that created an endless exact order through the universe for life. Yeah ……. Evolution is more of a stretch than creation. If you don’t like God, call it Aliens. Aliens created us. That’s less of a stretch than evolution once you truly look into it.

[@larrytate1657]

Explosions create disorder not perfect divine order.

[@thegreenersidechannel]

Disappointed by the anti cancer stance. How could he know that without more research? Certainly some things are still yet to be understood, right?

[@jamesreid6526]

I feel its more of a ass cover statement because MORE research needs to be done. I cant tell you how many times a pill got thru to help your heart burn but will give you cancer in 15 years. If we want to saw we do the opposite I want that statement to be tested. That being said I also feel like we can expedite cannabis as a true medication as we have plenty of people who have been smoking for 10+ years, no it wont be definitive because of the untracked variables of exatily what and how much will never be known . These people are still a valuable resource for our scientists to learn from and study.

[@dana102083]

Havent watched it yet but sounds like a conflict of interest. He works with a drug company that makes cancer drugs or something so had to stay in a lane.

[@cannafitnessecstargetthera7857]

I wonder why hemp seed has the perfect ratio of.Omega 3 and omega 6 fatty acid for the human body.

[@Zyklon_B_still_and_know_God]

Nothing perfect about it. ALA is poorly converted to true omega 3s.

[@jamesreid6526]

nothing but lube Steve even said it in the video.

[@dana102083]

@@Zyklon_B_still_and_know_God 100%. We poorly convert. We need DHA from animals and avoid seed and nut oils. 🖖

[@killahills10304]

@@jamesreid6526 hemp seed oil is not an industrial seed oil. He is referring to high omega 6 vegetable oils, sunflower oil etc. The machine lube oils.

[@tyupp77]

THC = THICC

[@cannafitnessecstargetthera7857]

that is why I am seed oil carries the perfect ratio of Omega 3 and 6 fatty acid for the human body is very essential for children hemp seed oil in their diet. I personally think a lot of mental illnesses today our direct result of deficient omega-3 fatty acid endocannabinoid system

[@dana102083]

I gree in concept but nuts in general have a much higher omega6 to 3 ratio. Pink fish would be a much better option and doesnt have antinutrients either. Then theres how its processed.. And how can you trust the stability of oils that knowingly break apart easily? (They have more weak double bonds). I think we need to be careful with nuts as it becomes the replacement for flour. Slightly more ancestrally appropriate but we ate mostly fatty meat.

[@cannafitnessecstargetthera7857]

@@dana102083 higher is not always better. But in the case of onega 3 we need all we can get. Great response

[@jamisonhughes4593]

🐈

[@cannafitnessecstargetthera7857]

You Are limited on your education. Next your going to say chemo therapy should be used with cannabis oil...

[@cannafitnessecstargetthera7857]

I refer to the perfect ratio of Omega 3 and 6 fatty acid I am referring to hemp seed oil that is not industrial seed oil but we'll work as a lubricant

[@cannafitnessecstargetthera7857]

Love the presentation but I'm very disappointed that you do not believe that phytocannabinoids play an essential role in curing cancer. So basically you're saying anyone that scared kid themselves of cancer and cannabis oil is what, lying or not telling the truth? I will inject myself with pure THC to the cancer site before I ever touch the chemotherapy. AKA mustard gas chemical medicine

[@eddiem12eddiem12]

@@cannafitnessecstargetthera7857 Inject into your big toe mate will have same effect... The blood pump these things round at an intense rate WTF 🤣. Endocannabinoids may aid in some cancer survival but probably from them getting converted back to AA then specific prostagnadins, which can induce apoptosis, shift to Type 1 immune response and M1 macrophage shift... Bro PS I'll show you my education if you show me yours