Switch maintenance and second-line therapy in G/GEJ cancer

Giovanni Randon, MD, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy, discusses the benefits of switch maintenance and early second-line therapies in the ARMANI trial (NCT02934464) in HER2-negative (HER2-) gastric/gastroesophageal junction (G/GEJ) cancer. Many patients were triple-negative, including PD-L1 low or absent expression, claudin 18.2 negative, and mismatch repair proficient, making them ineligible for targeted inhibitors. These patients could therefore benefit from the switching strategy. Implementing an early second-line therapy, rather than waiting for disease progression, could enhance its benefits. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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